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This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013] See more...
Aliases for MIER1 Gene
Aliases for MIER1 Gene
External Ids for MIER1 Gene
- HGNC: 29657
- Entrez Gene: 57708
- Ensembl: ENSG00000198160
- OMIM: 616848
- UniProtKB: Q8N108
Previous GeneCards Identifiers for MIER1 Gene
- GC01P067103
- GC01P067390
- GC01P065499
Summaries for MIER1 Gene
-
This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]
GeneCards Summary for MIER1 Gene
MIER1 (MIER1 Transcriptional Regulator) is a Protein Coding gene. Diseases associated with MIER1 include Amelogenesis Imperfecta, Type Ig and Hairy Tongue. Gene Ontology (GO) annotations related to this gene include chromatin binding and obsolete signal transducer activity. An important paralog of this gene is MIER3.
UniProtKB/Swiss-Prot Summary for MIER1 Gene
-
Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.
Additional gene information for MIER1 Gene
- HGNC(29657)
- Entrez Gene(57708)
- Ensembl(ENSG00000198160)
- OMIM(616848)
- UniProtKB(Q8N108)
- Open Targets Platform(ENSG00000198160)
- Search for MIER1 at DataMed
- Search for MIER1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIER1 Gene
Genomics for MIER1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MIER1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MIER1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MIER1
- Top Transcription factor binding sites by QIAGEN in the MIER1 gene promoter:
-
- AML1a
- FOXF2
- FOXO3
- FOXO3a
- FOXO3b
- Ik-2
- STAT5A
Genomic Locations for MIER1 Gene
Genomic Locations for MIER1 Gene
- chr1:66,924,895-66,988,619
- (GRCh38/hg38)
- Size:
- 63,725 bases
- Orientation:
- Plus strand
- chr1:67,390,578-67,454,302
- (GRCh37/hg19)
- Size:
- 63,725 bases
- Orientation:
- Plus strand
Genomic View for MIER1 Gene
Genes around MIER1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p31.3 by HGNC
- 1p31.3 by Entrez Gene
- 1p31.3 by Ensembl
MIER1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIER1 Gene
Proteins for MIER1 Gene
-
Protein details for MIER1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N108-MIER1_HUMAN
- Recommended name:
- Mesoderm induction early response protein 1
- Protein Accession:
- Q8N108
- C9JFD4
- Q08AE0
- Q32NC4
- Q5T104
- Q5TAD1
- Q5TAD2
- Q5TAD4
- Q5TAD5
- Q6AHY8
- Q86TB4
- Q8N156
- Q8N161
- Q8NC37
- Q8NES4
- Q8NES5
- Q8NES6
- Q8WWG2
- Q9HCG2
Protein attributes for MIER1 Gene
- Size:
- 512 amino acids
- Molecular mass:
- 57983 Da
- Quaternary structure:
-
- Interacts with HDAC1. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2.
- SequenceCaution:
-
- Sequence=AAH17423.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS. Probable cloning artifact due to reverse transcription from RNA internal poly-A tracts.; Evidence={ECO:0000305}; Sequence=AAM76041.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAM97500.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAM97503.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAM97506.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAC11339.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. C-terminal is identical to the product of the WLS gene.; Evidence={ECO:0000305}; Sequence=CAD89921.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 2]: It is uncertain whether Met-1 or Met-55 is the initiator.
- [Isoform 5]: It is uncertain whether Met-1 or Met-55 is the initiator.
Protein Expression for MIER1 Gene
Post-translational modifications for MIER1 Gene
Other Protein References for MIER1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- XP_005271133.1
- XP_011540167.1
- XP_016857408.1
- XP_016857409.1
- XP_016857410.1
- XP_016857411.1
- XP_016857412.1
- XP_016857413.1
- XP_016857414.1
- XP_016857415.1
- XP_016857416.1
- XP_016857417.1
- XP_016857418.1
- XP_016857419.1
- XP_016857420.1
- XP_016857421.1
- XP_016857422.1
- XP_016857423.1
- NP_001071168.2
- NP_001071169.1
- NP_001071170.2
- NP_001071171.2
- NP_001071172.1
- NP_001139582.1
- NP_001139583.1
- NP_001139584.1
- NP_001139585.1
- NP_001265144.1
- NP_001337459.1
- NP_065999.2
Antibody Products
- Creative Diagnostics Anti-MIER1 monoclonal antibody
-
Custom Antibody ServicesOriGene Antibodies for MIER1
- Novus Biologicals Antibodies for MIER1
- Invitrogen Antibodies for MIER1 (AFLGC-MIER1)
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIER1
- Origene Custom Protein Services for MIER1
-
Abcam proteins for MIER1
Assay Products
- antibodies-online: Show 12 available MIER1 Elisa Kits ranked by validation data
- Compare Top MIER1 Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for MIER1
No data available for DME Specific Peptides for MIER1 Gene
Domains & Families for MIER1 Gene
Gene Families for MIER1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for MIER1 Gene
Suggested Antigen Peptide Sequences for MIER1 Gene
- GenScript: Design optimal peptide antigens:
-
- Mesoderm induction early response protein 1 (MIER1_HUMAN)
- cDNA FLJ60095, highly similar to Mesoderm induction early response protein 1 (Q5TAD5_HUMAN)
- MIER1 protein (Q6NXT7_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIER1 Gene
Function for MIER1 Gene
Molecular function for MIER1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.
Phenotypes From GWAS Catalog for MIER1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001103 | RNA polymerase II repressing transcription factor binding | IBA | 21873635 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003714 | transcription corepressor activity | IBA | 21873635 |
| GO:0004407 | contributes_to histone deacetylase activity | IDA | 28046085 |
Phenotypes for MIER1 Gene
- MGI mutant phenotypes for MIER1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MIER1:
Animal Models for MIER1 Gene
- MGI Knock Outs for MIER1:
-
- Mier1 Mier1<tm1a(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIER1 - Select products 50% OFF >
- * MIER1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MIER1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MIER1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MIER1
miRNA for MIER1 Gene
- miRTarBase miRNAs that target MIER1
-
- hsa-miR-1-3p (MIRT024096)
- hsa-miR-30e-5p (MIRT044128)
- hsa-miR-19a-3p (MIRT144488)
- hsa-miR-19b-3p (MIRT144489)
- hsa-miR-580-3p (MIRT285075)
- hsa-miR-4324 (MIRT285076)
- hsa-miR-4251 (MIRT285077)
- hsa-miR-20b-3p (MIRT343874)
- hsa-miR-3137 (MIRT343876)
- hsa-miR-4652-3p (MIRT457057)
- hsa-miR-4743-3p (MIRT457058)
- hsa-miR-3686 (MIRT457059)
- hsa-miR-190a-3p (MIRT535923)
- hsa-miR-298 (MIRT535924)
- hsa-miR-338-3p (MIRT535925)
- hsa-miR-4530 (MIRT535926)
- hsa-miR-922 (MIRT535927)
- hsa-miR-5586-5p (MIRT535928)
- hsa-miR-410-3p (MIRT535929)
- hsa-miR-5197-3p (MIRT535930)
- mmu-miR-128-3p (MIRT600634)
- hsa-miR-450b-5p (MIRT745599)
- hsa-miR-4511 (MIRT745672)
- hsa-miR-4696 (MIRT747209)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MIER1
- Browse OriGene Inhibitory RNA Products For MIER1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIER1
Clone Products
- Applied Biological Materials (abm): Clones for MIER1 - Select products 50% OFF >
- * MIER1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG217117
- MG218535
- MR217117
- MR217117L3
- MR217117L4
- MR218535
- MR218535L3
- MR218535L4
- MR230313
- MR230393
- MR230501
- RC223015
- RC223015L1
- RC223015L2
- RC223015L3
- RC223015L4
- RC223062
- RC223062L3
- RC223062L4
- RC223165
- RC223165L3
- RC223165L4
- RC223221
- RC223221L3
- RC223221L4
- RC228399
- RC228399L3
- RC228399L4
- RC228431
- RC228431L3
- RC228431L4
- RC228852
- RC228852L3
- RC228852L4
- RC228914
- RC228914L3
- RC228914L4
- RC229242
- RC229242L3
- RC229242L4
- RC229288
- RC229288L1
- RC229288L2
- RC229288L3
- RC229288L4
- RC235510
- RG223015
- RG223062
- RG223165
- RG223221
- RG228399
- RG228431
- RG228852
- RG228914
- RG229242
- RG229288
- RR210572
- RR210572L3
- RR210572L4
- MR217117L3V
- MR217117L4V
- MR218535L3V
- MR218535L4V
- RC223015L1V
- RC223015L2V
- RC223015L3V
- RC223015L4V
- RC223062L3V
- RC223062L4V
- RC223165L3V
- RC223165L4V
- RC223221L3V
- RC223221L4V
- RC228399L3V
- RC228399L4V
- RC228431L3V
- RC228431L4V
- RC228852L3V
- RC228852L4V
- RC228914L3V
- RC228914L4V
- RC229242L3V
- RC229242L4V
- RC229288L1V
- RC229288L2V
- RC229288L3V
- RC229288L4V
- RR210572L3V
- RR210572L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MIER1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MIER1
Cell Line Products
-
Horizon Cell Lines for MIER1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MIER1 Gene
Localization for MIER1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MIER1 Gene
- [Isoform 1]: Nucleus.
- [Isoform 2]: Nucleus.
- [Isoform 3]: Nucleus.
- [Isoform 4]: Cytoplasm.
- [Isoform 5]: Cytoplasm.
- [Isoform 6]: Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,IDA | 28046085 |
| GO:0005654 | nucleoplasm | IBA,IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0017053 | transcriptional repressor complex | IDA | 12482978 |
| GO:0032991 | protein-containing complex | IDA | 28046085 |
Pathways & Interactions for MIER1 Gene
Interacting Proteins for MIER1 Gene
Selected Interacting proteins:
Q8N108-MIER1_HUMAN
ENSP00000383820
for MIER1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for MIER1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0016575 | histone deacetylation | IDA | 28046085 |
| GO:0031937 | positive regulation of chromatin silencing | IDA | 12482978 |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | HMP | 12761501 |
No data available for Pathways by source and SIGNOR curated interactions for MIER1 Gene
Transcripts for MIER1 Gene
mRNA/cDNA for MIER1 Gene
- 12 REFSEQ mRNAs :
- 24 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000355356 4818 nts (view in UCSC)
- ENST00000355977 3595 nts (view in UCSC)
- ENST00000357692 4978 nts (view in UCSC)
- ENST00000371012 2420 nts (view in UCSC)
- ENST00000371014 1728 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MIER1 - Select products 50% OFF >
- * MIER1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MIER1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MIER1
-
Santa Cruz Biotechnology (SCBT) CRISPR for MIER1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MIER1
- Browse OriGene Inhibitory RNA Products For MIER1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIER1
Clone Products
- Applied Biological Materials (abm): Clones for MIER1 - Select products 50% OFF >
- * MIER1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG217117
- MG218535
- MR217117
- MR217117L3
- MR217117L4
- MR218535
- MR218535L3
- MR218535L4
- MR230313
- MR230393
- MR230501
- RC223015
- RC223015L1
- RC223015L2
- RC223015L3
- RC223015L4
- RC223062
- RC223062L3
- RC223062L4
- RC223165
- RC223165L3
- RC223165L4
- RC223221
- RC223221L3
- RC223221L4
- RC228399
- RC228399L3
- RC228399L4
- RC228431
- RC228431L3
- RC228431L4
- RC228852
- RC228852L3
- RC228852L4
- RC228914
- RC228914L3
- RC228914L4
- RC229242
- RC229242L3
- RC229242L4
- RC229288
- RC229288L1
- RC229288L2
- RC229288L3
- RC229288L4
- RC235510
- RG223015
- RG223062
- RG223165
- RG223221
- RG228399
- RG228431
- RG228852
- RG228914
- RG229242
- RG229288
- RR210572
- RR210572L3
- RR210572L4
- MR217117L3V
- MR217117L4V
- MR218535L3V
- MR218535L4V
- RC223015L1V
- RC223015L2V
- RC223015L3V
- RC223015L4V
- RC223062L3V
- RC223062L4V
- RC223165L3V
- RC223165L4V
- RC223221L3V
- RC223221L4V
- RC228399L3V
- RC228399L4V
- RC228431L3V
- RC228431L4V
- RC228852L3V
- RC228852L4V
- RC228914L3V
- RC228914L4V
- RC229242L3V
- RC229242L4V
- RC229288L1V
- RC229288L2V
- RC229288L3V
- RC229288L4V
- RR210572L3V
- RR210572L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MIER1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MIER1
Relevant External Links for MIER1 Gene
- GeneLoc Exon Structure for
- MIER1
Expression for MIER1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Plasma (21.1), Peripheral blood mononuclear cells (15.0), and Blymphocyte (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MIER1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIER1
SOURCE GeneReport for Unigene cluster for MIER1 Gene:
Hs.605432mRNA Expression by UniProt/SwissProt for MIER1 Gene:
Q8N108-MIER1_HUMAN
Tissue specificity:
Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor.
Evidence on tissue expression from TISSUES for MIER1 Gene
- Liver(4.5)
- Lung(4.5)
- Muscle(4.5)
- Eye(4.3)
- Nervous system(2.8)
- Skin(2.5)
- Kidney(2.5)
- Spleen(2.4)
- Heart(2.4)
- Intestine(2.4)
- Bone marrow(2.3)
- Blood(2.3)
- Lymph node(2.2)
- Stomach(2.1)
- Adrenal gland(2)
Primer Products
-
OriGene qPCR primer pairs for MIER1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIER1 Gene
Orthologs for MIER1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MIER1 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MIER1 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MIER1 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mier1 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mier1 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MIER1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MIER1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MIER1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MIER1 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | mi-er1-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mier1a 30 |
|
||
| mier1b 31 |
|
OneToOne | |||
| wufb30a02 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG1620 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | T07F8.4 31 |
|
ManyToMany | |
| F10E7.11 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for MIER1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for MIER1 Gene
- ENSEMBL:
- Gene Tree for MIER1 (if available)
- TreeFam:
- Gene Tree for MIER1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MIER1: view image
Paralogs for MIER1 Gene
Variants for MIER1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3309013 | CNV | mobile element insertion | 20981092 |
| esv3398423 | CNV | insertion | 20981092 |
| nsv1078294 | OTHER | inversion | 25765185 |
Residual Variation Intolerance Score:
38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.24;
52.59% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MIER1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIER1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIER1 Gene
Disorders for MIER1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| amelogenesis imperfecta, type ig |
|
|
| hairy tongue |
|
|
| frozen shoulder |
|
|
| teeth hard tissue disease |
|
|
| amelogenesis imperfecta |
|
|
Search MIER1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MIER1
No data available for UniProtKB/Swiss-Prot and Genatlas for MIER1 Gene
Publications for MIER1 Gene
- Genomic organization of the human mi-er1 gene and characterization of alternatively spliced isoforms: regulated use of a facultative intron determines subcellular localization. (PMID: 12242014) Paterno GD … Gillespie LL (Gene 2002) 2 3 4 23
- Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. (PMID: 12482978) Ding Z … Paterno GD (Molecular and cellular biology 2003) 2 3 4
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
ExternalLinks
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Sources for MIER1 Gene
- (1) GeneCards
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- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
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