Aliases for MIER1 Gene
External Ids for MIER1 Gene
Previous GeneCards Identifiers for MIER1 Gene
This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]
GeneCards Summary for MIER1 Gene
MIER1 (MIER1 Transcriptional Regulator) is a Protein Coding gene. Diseases associated with MIER1 include Amelogenesis Imperfecta, Type Ig and Hairy Tongue. Gene Ontology (GO) annotations related to this gene include chromatin binding and obsolete signal transducer activity. An important paralog of this gene is MIER3.
UniProtKB/Swiss-Prot Summary for MIER1 Gene
Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.