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Aliases for MIER1 Gene

Aliases for MIER1 Gene

  • MIER1 Transcriptional Regulator 2 3 5
  • Mesoderm Induction Early Response 1, Transcriptional Regulator 2 3
  • MI-ER1 3 4
  • ER1 3 4
  • Mesoderm Induction Early Response 1 Homolog (Xenopus Laevis) 2
  • Mesoderm Induction Early Response 1 Homolog 3
  • Mesoderm Induction Early Response Protein 1 3
  • Early Response 1 4
  • KIAA1610 4
  • HMi-Er1 4

External Ids for MIER1 Gene

Previous GeneCards Identifiers for MIER1 Gene

  • GC01P067103
  • GC01P067390
  • GC01P065499

Summaries for MIER1 Gene

Entrez Gene Summary for MIER1 Gene

  • This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]

GeneCards Summary for MIER1 Gene

MIER1 (MIER1 Transcriptional Regulator) is a Protein Coding gene. Diseases associated with MIER1 include Regular Astigmatism. Gene Ontology (GO) annotations related to this gene include chromatin binding and signal transducer activity. An important paralog of this gene is MIER3.

UniProtKB/Swiss-Prot for MIER1 Gene

  • Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.

Gene Wiki entry for MIER1 Gene

Additional gene information for MIER1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIER1 Gene

Genomics for MIER1 Gene

GeneHancer (GH) Regulatory Elements for MIER1 Gene

Promoters and enhancers for MIER1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I066923 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 571.2 +0.6 610 4.3 HDGF CLOCK ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B ZNF213 WDR78 MIER1 TCTEX1D1 SLC35D1
GH01I066929 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 560.2 +7.6 7576 6.9 HDGF PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF213 MIER1 WDR78 TCTEX1D1 SLC35D1
GH01I067681 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 29.4 +761.2 761152 8.3 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZFP41 MEF2D GADD45A MIER1 SERBP1 WDR78 LOC105378781
GH01I067427 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 23.7 +504.9 504887 5.4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SERBP1 MIER1 RNU6-387P
GH01I066329 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.7 -590.8 -590758 9.3 HDGF PKNOX1 SMAD1 SIN3A FEZF1 IRF4 YY1 ZNF207 ZNF143 ATF7 PDE4B MIER1 SLC35D1 GC01P066323 GC01P066373
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIER1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MIER1 gene promoter:

Genomic Locations for MIER1 Gene

Genomic Locations for MIER1 Gene
chr1:66,924,895-66,988,619
(GRCh38/hg38)
Size:
63,725 bases
Orientation:
Plus strand
chr1:67,390,578-67,454,302
(GRCh37/hg19)

Genomic View for MIER1 Gene

Genes around MIER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIER1 Gene

Proteins for MIER1 Gene

  • Protein details for MIER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N108-MIER1_HUMAN
    Recommended name:
    Mesoderm induction early response protein 1
    Protein Accession:
    Q8N108
    Secondary Accessions:
    • C9JFD4
    • Q08AE0
    • Q32NC4
    • Q5T104
    • Q5TAD1
    • Q5TAD2
    • Q5TAD4
    • Q5TAD5
    • Q6AHY8
    • Q86TB4
    • Q8N156
    • Q8N161
    • Q8NC37
    • Q8NES4
    • Q8NES5
    • Q8NES6
    • Q8WWG2
    • Q9HCG2

    Protein attributes for MIER1 Gene

    Size:
    512 amino acids
    Molecular mass:
    57983 Da
    Quaternary structure:
    • Interacts with HDAC1. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2.
    SequenceCaution:
    • Sequence=AAH17423.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS. Probable cloning artifact due to reverse transcription from RNA internal poly-A tracts.; Evidence={ECO:0000305}; Sequence=AAM76041.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM97500.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM97503.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAM97506.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAC11339.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. C-terminal is identical to the product of the WLS gene.; Evidence={ECO:0000305}; Sequence=CAD89921.1; Type=Miscellaneous discrepancy; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for MIER1 Gene

neXtProt entry for MIER1 Gene

Post-translational modifications for MIER1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIER1 Gene

Domains & Families for MIER1 Gene

Gene Families for MIER1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transcription factors

Protein Domains for MIER1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIER1: view

No data available for UniProtKB/Swiss-Prot for MIER1 Gene

Function for MIER1 Gene

Molecular function for MIER1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor regulating the expression of a number of genes including SP1 target genes. Probably functions through recruitment of HDAC1 a histone deacetylase involved in chromatin silencing.

Phenotypes From GWAS Catalog for MIER1 Gene

Gene Ontology (GO) - Molecular Function for MIER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0004407 histone deacetylase activity IDA 28046085
GO:0004871 signal transducer activity HMP,IMP 12761501
GO:0005515 protein binding IPI 12482978
GO:0042826 histone deacetylase binding IPI 28046085
genes like me logo Genes that share ontologies with MIER1: view

Phenotypes for MIER1 Gene

genes like me logo Genes that share phenotypes with MIER1: view

Animal Models for MIER1 Gene

MGI Knock Outs for MIER1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MIER1 Gene

Localization for MIER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIER1 Gene

Isoform 1: Nucleus.
Isoform 2: Nucleus.
Isoform 3: Nucleus.
Isoform 4: Cytoplasm.
Isoform 5: Cytoplasm.
Isoform 6: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIER1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MIER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 28046085
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0017053 transcriptional repressor complex IDA 12482978
GO:0043234 protein complex IDA 28046085
genes like me logo Genes that share ontologies with MIER1: view

Pathways & Interactions for MIER1 Gene

SuperPathways for MIER1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007165 signal transduction IEA --
GO:0016575 histone deacetylation IDA 28046085
GO:0031937 positive regulation of chromatin silencing IDA 12482978
genes like me logo Genes that share ontologies with MIER1: view

No data available for Pathways by source and SIGNOR curated interactions for MIER1 Gene

Drugs & Compounds for MIER1 Gene

No Compound Related Data Available

Transcripts for MIER1 Gene

Unigene Clusters for MIER1 Gene

Mesoderm induction early response 1 homolog (Xenopus laevis):
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIER1 Gene

No ASD Table

Relevant External Links for MIER1 Gene

GeneLoc Exon Structure for
MIER1
ECgene alternative splicing isoforms for
MIER1

Expression for MIER1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MIER1 Gene

This gene is overexpressed in Plasma (21.1), Peripheral blood mononuclear cells (15.0), and Blymphocyte (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MIER1 Gene



Protein tissue co-expression partners for MIER1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MIER1 Gene:

MIER1

SOURCE GeneReport for Unigene cluster for MIER1 Gene:

Hs.605432

mRNA Expression by UniProt/SwissProt for MIER1 Gene:

Q8N108-MIER1_HUMAN
Tissue specificity: Ubiquitously expressed, but at very low levels. However, consistent level of expression are observed in heart, testis, thyroid, ovary and adrenal gland. Transcripts are up-regulated in breast carcinoma cell lines and tumor.

Evidence on tissue expression from TISSUES for MIER1 Gene

  • Liver(4.4)
  • Lung(4.4)
  • Muscle(4.3)
  • Eye(4.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with MIER1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIER1 Gene

Orthologs for MIER1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIER1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIER1 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MIER1 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MIER1 34
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mier1 33
  • 91.7 (n)
mouse
(Mus musculus)
Mammalia Mier1 33 16 34
  • 90.59 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MIER1 34
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MIER1 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves MIER1 34
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MIER1 34
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mi-er1-prov 33
zebrafish
(Danio rerio)
Actinopterygii mier1a 33
  • 62.95 (n)
mier1b 34
  • 59 (a)
OneToOne
wufb30a02 33
fruit fly
(Drosophila melanogaster)
Insecta CG1620 34
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F10E7.11 34
  • 26 (a)
ManyToMany
T07F8.4 34
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
OneToOne
Species where no ortholog for MIER1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIER1 Gene

ENSEMBL:
Gene Tree for MIER1 (if available)
TreeFam:
Gene Tree for MIER1 (if available)

Paralogs for MIER1 Gene

Paralogs for MIER1 Gene

(2) SIMAP similar genes for MIER1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MIER1: view

Variants for MIER1 Gene

Sequence variations from dbSNP and Humsavar for MIER1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000075971 -- 66,978,183(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000109274 -- 66,930,846(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000135598 -- 66,986,348(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000168630 -- 66,953,947(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000274356 -- 66,962,823(+) A/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MIER1 Gene

Variant ID Type Subtype PubMed ID
nsv1078294 OTHER inversion 25765185
esv3398423 CNV insertion 20981092
esv3309013 CNV mobile element insertion 20981092

Variation tolerance for MIER1 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MIER1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIER1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIER1 Gene

Disorders for MIER1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIER1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
regular astigmatism
- elite association - COSMIC cancer census association via MalaCards
Search MIER1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MIER1

genes like me logo Genes that share disorders with MIER1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIER1 Gene

Publications for MIER1 Gene

  1. Genomic organization of the human mi-er1 gene and characterization of alternatively spliced isoforms: regulated use of a facultative intron determines subcellular localization. (PMID: 12242014) Paterno GD … Gillespie LL (Gene 2002) 2 3 4 22 58
  2. Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain. (PMID: 12482978) Ding Z … Paterno GD (Molecular and cellular biology 2003) 2 3 4 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for MIER1 Gene

Sources for MIER1 Gene

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