MIEN1 Gene (Protein Coding)

Migration And Invasion Enhancer 1

GC17M039728
GIFtS:
33
See more...

Aliases for MIEN1 Gene

Aliases for MIEN1 Gene

  • Migration And Invasion Enhancer 1 2 3 4 5
  • XTP4 2 3 4
  • HBV X-Transactivated Gene 4 Protein 3 4
  • HBV XAg-Transactivated Protein 4 3 4
  • C17orf37 3 4
  • RDX12 3 4
  • ORB3 2 3
  • C35 2 3
  • Chromosome 17 Open Reading Frame 37 2
  • Protein C17orf37 3
  • Protein C35 4
  • MGC14832 2
  • MIEN1 5
  • Rdx12 2

External Ids for MIEN1 Gene

Previous HGNC Symbols for MIEN1 Gene

  • C17orf37

Previous GeneCards Identifiers for MIEN1 Gene

  • GC17M037886

Summaries for MIEN1 Gene

GeneCards Summary for MIEN1 Gene

MIEN1 (Migration And Invasion Enhancer 1) is a Protein Coding gene. Diseases associated with MIEN1 include Breast Large Cell Neuroendocrine Carcinoma and Prostate Cancer. Gene Ontology (GO) annotations related to this gene include selenium binding. An important paralog of this gene is SELENOV.

UniProtKB/Swiss-Prot Summary for MIEN1 Gene

  • Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.

Additional gene information for MIEN1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIEN1 Gene

Genomics for MIEN1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MIEN1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIEN1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MIEN1

Genomic Locations for MIEN1 Gene

Genomic Locations for MIEN1 Gene
chr17:39,728,496-39,730,563
(GRCh38/hg38)
Size:
2,068 bases
Orientation:
Minus strand
chr17:37,884,749-37,887,040
(GRCh37/hg19)
Size:
2,292 bases
Orientation:
Minus strand

Genomic View for MIEN1 Gene

Genes around MIEN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIEN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIEN1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIEN1 Gene

Proteins for MIEN1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MIEN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRT3-MIEN1_HUMAN
    Recommended name:
    Migration and invasion enhancer 1
    Protein Accession:
    Q9BRT3

    Protein attributes for MIEN1 Gene

    Size:
    115 amino acids
    Molecular mass:
    12403 Da
    Quaternary structure:
    • Interacts with GPX1.

    Three dimensional structures from OCA and Proteopedia for MIEN1 Gene

neXtProt entry for MIEN1 Gene

Protein Expression for MIEN1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MIEN1 Gene

  • Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MIEN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MIEN1 Gene

Domains & Families for MIEN1 Gene

Gene Families for MIEN1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MIEN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MIEN1 Gene

GenScript: Design optimal peptide antigens:
  • Protein C35 (CQ037_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BRT3

UniProtKB/Swiss-Prot:

MIEN1_HUMAN :
  • Belongs to the SelWTH family.
Family:
  • Belongs to the SelWTH family.
genes like me logo Genes that share domains with MIEN1: view

Function for MIEN1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MIEN1 Gene

UniProtKB/Swiss-Prot Function:
Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process.

Phenotypes From GWAS Catalog for MIEN1 Gene

Gene Ontology (GO) - Molecular Function for MIEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MIEN1: view
genes like me logo Genes that share phenotypes with MIEN1: view

Animal Model Products

CRISPR Products

miRNA for MIEN1 Gene

miRTarBase miRNAs that target MIEN1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIEN1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIEN1 Gene

Localization for MIEN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIEN1 Gene

Cytoplasm, cytosol. Cell membrane. Lipid-anchor. Cytoplasmic side. Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIEN1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
cytoskeleton 3
nucleus 3
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MIEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA,IDA 21628459
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IDA 21628459
genes like me logo Genes that share ontologies with MIEN1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MIEN1 Gene

Pathways & Interactions for MIEN1 Gene

PathCards logo

SuperPathways for MIEN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIEN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0010269 response to selenium ion IBA 21873635
GO:0030335 positive regulation of cell migration IDA 21628459
GO:0043066 negative regulation of apoptotic process IBA,IDA 21068479
GO:0051491 positive regulation of filopodium assembly IBA,IDA 21628459
genes like me logo Genes that share ontologies with MIEN1: view

No data available for Pathways by source and SIGNOR curated interactions for MIEN1 Gene

Drugs & Compounds for MIEN1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIEN1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIEN1 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIEN1

Alternative Splicing Database (ASD) splice patterns (SP) for MIEN1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for MIEN1 Gene

GeneLoc Exon Structure for
MIEN1

Expression for MIEN1 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIEN1 Gene

mRNA expression in normal human tissues for MIEN1 Gene
mRNA expression by GTEx for MIEN1 GenemRNA expression by BioGPS for MIEN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MIEN1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.2), Cervix (8.6), and Fetal Brain (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MIEN1 Gene



Protein tissue co-expression partners for MIEN1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIEN1

SOURCE GeneReport for Unigene cluster for MIEN1 Gene:

Hs.333526

mRNA Expression by UniProt/SwissProt for MIEN1 Gene:

Q9BRT3-MIEN1_HUMAN
Tissue specificity: Among normal tissues, present only in Leydig cells. Strongly up-regulated in breast cancers and in brain cancer distant metastasis (at protein level). Up-regulated in prostate cancer cells and in the higher grades of prostate adenocarcinoma (at protein level).

Evidence on tissue expression from TISSUES for MIEN1 Gene

  • Nervous system(4.4)
  • Skin(2.3)
  • Liver(2.1)
  • Stomach(2)
  • Lung(2)
genes like me logo Genes that share expression patterns with MIEN1: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIEN1 Gene

Orthologs for MIEN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIEN1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MIEN1 30 31
  • 98.84 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia C17ORF37 31
  • 96 (a)
 OneToOne
MIEN1 30
  • 92.75 (n)
Cow
(Bos Taurus)
 Mammalia MIEN1 30 31
  • 91.3 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Mien1 30 17 31
  • 88.7 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia MIEN1 31
  • 51 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves MIEN1 30 31
  • 71.49 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MIEN1 31
  • 79 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia mien1 30
  • 75.99 (n)
Str.15598 30
Zebrafish
(Danio rerio)
 Actinopterygii sepw2a 30 31
  • 62.77 (n)
 OneToMany
sepw2b 31
  • 47 (a)
 OneToMany
Rainbow Trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.8692 30
Fruit Fly
(Drosophila melanogaster)
 Insecta CG15456 31
  • 35 (a)
 OneToOne
Species where no ortholog for MIEN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MIEN1 Gene

ENSEMBL:
Gene Tree for MIEN1 (if available)
TreeFam:
Gene Tree for MIEN1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MIEN1: view image

Paralogs for MIEN1 Gene

Paralogs for MIEN1 Gene

(1) SIMAP similar genes for MIEN1 Gene using alignment to 2 proteins:

  • MIEN1_HUMAN
  • J3KTI2_HUMAN
genes like me logo Genes that share paralogs with MIEN1: view

Variants for MIEN1 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for MIEN1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIEN1 Gene

Variant ID Type Subtype PubMed ID
nsv1056234 CNV gain 25217958
nsv1146669 OTHER inversion 26484159
nsv2048 CNV insertion 18451855

Variation tolerance for MIEN1 Gene

Residual Variation Intolerance Score: 52.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MIEN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIEN1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIEN1 Gene

Disorders for MIEN1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIEN1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast large cell neuroendocrine carcinoma
prostate cancer
  • prostate cancer, somatic
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search MIEN1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MIEN1

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MIEN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIEN1 Gene

Publications for MIEN1 Gene

  1. C35 (C17orf37) is a novel tumor biomarker abundantly expressed in breast cancer. (PMID: 17121940) Evans EE … Zauderer M (Molecular cancer therapeutics 2006) 2 3 4 23
  2. Prenylated c17orf37 induces filopodia formation to promote cell migration and metastasis. (PMID: 21628459) Dasgupta S … Vishwanatha JK (The Journal of biological chemistry 2011) 2 3 4
  3. MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cystein domain. (PMID: 12739007) Katoh M … Katoh M (International journal of oncology 2003) 2 3 23
  4. Solution structure of the oncogenic MIEN1 protein reveals a thioredoxin-like fold with a redox-active motif. (PMID: 23284973) Hsu CH … Huang LY (PloS one 2012) 3 4
  5. Novel gene C17orf37 in 17q12 amplicon promotes migration and invasion of prostate cancer cells. (PMID: 19503095) Dasgupta S … Vishwanatha JK (Oncogene 2009) 3 4

ExternalLinks

View latest publications for MIEN1 gene in Mastermind

Products for MIEN1 Gene

  • Signalway Proteins for MIEN1

Sources for MIEN1 Gene