Aliases for MIDN Gene

Aliases for MIDN Gene

  • Midnolin 2 3 4 5
  • Midbrain Nucleolar Protein 3 4

External Ids for MIDN Gene

Previous GeneCards Identifiers for MIDN Gene

  • GC19U990284
  • GC19P001319
  • GC19P001190
  • GC19P001201
  • GC19P001199
  • GC19P001020

Summaries for MIDN Gene

GeneCards Summary for MIDN Gene

MIDN (Midnolin) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include kinase binding.

UniProtKB/Swiss-Prot Summary for MIDN Gene

  • Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.

Additional gene information for MIDN Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIDN Gene

Genomics for MIDN Gene

GeneHancer (GH) Regulatory Elements for MIDN Gene

Promoters and enhancers for MIDN Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIDN on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MIDN gene promoter:
  • AREB6
  • Brachyury
  • E47
  • Lmo2
  • NF-kappaB
  • NF-kappaB1
  • Nkx2-5
  • Pax-5
  • ZID

Genomic Locations for MIDN Gene

Genomic Locations for MIDN Gene
chr19:1,248,553-1,259,143
(GRCh38/hg38)
Size:
10,591 bases
Orientation:
Plus strand
chr19:1,248,552-1,259,142
(GRCh37/hg19)
Size:
10,591 bases
Orientation:
Plus strand

Genomic View for MIDN Gene

Genes around MIDN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIDN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIDN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIDN Gene

Proteins for MIDN Gene

  • Protein details for MIDN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q504T8-MIDN_HUMAN
    Recommended name:
    Midnolin
    Protein Accession:
    Q504T8
    Secondary Accessions:
    • Q96BW8

    Protein attributes for MIDN Gene

    Size:
    468 amino acids
    Molecular mass:
    49213 Da
    Quaternary structure:
    • Interacts with GCK; the interaction occurs preferentially at low glucose levels.

neXtProt entry for MIDN Gene

Post-translational modifications for MIDN Gene

  • Ubiquitination at Lys84, Lys354, and Lys402
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MIDN Gene

Domains & Families for MIDN Gene

Gene Families for MIDN Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MIDN Gene

Suggested Antigen Peptide Sequences for MIDN Gene

GenScript: Design optimal peptide antigens:
  • Midbrain nucleolar protein (MIDN_HUMAN)
genes like me logo Genes that share domains with MIDN: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MIDN Gene

Function for MIDN Gene

Molecular function for MIDN Gene

UniProtKB/Swiss-Prot Function:
Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.

Phenotypes From GWAS Catalog for MIDN Gene

Gene Ontology (GO) - Molecular Function for MIDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IEA --
GO:0019900 kinase binding IEA,ISS 24187134
genes like me logo Genes that share ontologies with MIDN: view
genes like me logo Genes that share phenotypes with MIDN: view

Animal Model Products

CRISPR Products

miRNA for MIDN Gene

miRTarBase miRNAs that target MIDN

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIDN

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIDN Gene

Localization for MIDN Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIDN Gene

Nucleus, nucleolus. Nucleus. Cytoplasm, cytosol. Note=Detected in the nucleus and nucleolus with no expression in the cytoplasm (By similarity). However, a later study finds expression in the nucleus and cytoplasm with no expression in the nucleolus (PubMed:24187134). {ECO:0000250 UniProtKB:Q3TPJ7, ECO:0000269 PubMed:24187134}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIDN gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MIDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IBA 24187134
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IDA,IEA 24187134
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with MIDN: view

Pathways & Interactions for MIDN Gene

PathCards logo

SuperPathways for MIDN Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIDN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0033132 negative regulation of glucokinase activity ISS,IEA 24187134
GO:0046676 negative regulation of insulin secretion IEA,ISS 24187134
genes like me logo Genes that share ontologies with MIDN: view

No data available for Pathways by source and SIGNOR curated interactions for MIDN Gene

Drugs & Compounds for MIDN Gene

No Compound Related Data Available

Transcripts for MIDN Gene

mRNA/cDNA for MIDN Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MIDN

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIDN Gene

No ASD Table

Relevant External Links for MIDN Gene

GeneLoc Exon Structure for
MIDN
ECgene alternative splicing isoforms for
MIDN

Expression for MIDN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIDN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MIDN Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for MIDN Gene

This gene is overexpressed in Urine (58.2) and NK cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MIDN Gene



Protein tissue co-expression partners for MIDN Gene

NURSA nuclear receptor signaling pathways regulating expression of MIDN Gene:

MIDN

SOURCE GeneReport for Unigene cluster for MIDN Gene:

Hs.465529

Evidence on tissue expression from TISSUES for MIDN Gene

  • Kidney(3.5)
  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with MIDN: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIDN Gene

Orthologs for MIDN Gene

This gene was present in the common ancestor of animals.

Orthologs for MIDN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MIDN 32
  • 96.72 (n)
dog
(Canis familiaris)
Mammalia MIDN 33 32
  • 88.12 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MIDN 33 32
  • 87.61 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Midn 17 33 32
  • 84.13 (n)
rat
(Rattus norvegicus)
Mammalia Midn 32
  • 83.59 (n)
oppossum
(Monodelphis domestica)
Mammalia MIDN 33
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MIDN 33
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia midn 32
  • 63.43 (n)
Str.7531 32
African clawed frog
(Xenopus laevis)
Amphibia MGC52897 32
zebrafish
(Danio rerio)
Actinopterygii midn 33 32
  • 68.75 (n)
OneToOne
wufc07f11 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2559 32
fruit fly
(Drosophila melanogaster)
Insecta CG32676 33
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 35 (a)
OneToOne
Species where no ortholog for MIDN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIDN Gene

ENSEMBL:
Gene Tree for MIDN (if available)
TreeFam:
Gene Tree for MIDN (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MIDN: view image

Paralogs for MIDN Gene

No data available for Paralogs for MIDN Gene

Variants for MIDN Gene

Sequence variations from dbSNP and Humsavar for MIDN Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000001508 -- 1,248,017(+) C/A upstream_transcript_variant
rs1000010342 -- 1,249,524(+) C/A intron_variant
rs1000071729 -- 1,253,129(+) C/T intron_variant
rs1000249863 -- 1,257,330(+) C/T 3_prime_UTR_variant
rs1000349535 -- 1,258,196(+) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for MIDN Gene

Variant ID Type Subtype PubMed ID
dgv136n111 CNV deletion 26073780
dgv6197n54 CNV loss 21841781
dgv6198n54 CNV loss 21841781
esv24381 CNV loss 19812545
esv2758743 CNV gain+loss 17122850
nsv1055164 CNV gain 25217958
nsv1058677 CNV loss 25217958
nsv1060536 CNV gain 25217958
nsv1072295 CNV deletion 25765185
nsv1160555 CNV deletion 26073780
nsv470103 CNV gain 18288195
nsv470104 CNV loss 18288195
nsv578268 CNV loss 21841781
nsv578276 CNV gain+loss 21841781
nsv828368 CNV gain 20364138
nsv828369 CNV gain 20364138
nsv828370 CNV loss 20364138
nsv828371 CNV loss 20364138
nsv828372 CNV gain 20364138
nsv953941 CNV deletion 24416366
nsv9662 CNV gain 18304495

Variation tolerance for MIDN Gene

Residual Variation Intolerance Score: 28.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MIDN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIDN

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIDN Gene

Disorders for MIDN Gene

Additional Disease Information for MIDN

No disorders were found for MIDN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIDN Gene

Publications for MIDN Gene

  1. Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner. (PMID: 24187134) Hofmeister-Brix A … Baltrusch S (The Journal of biological chemistry 2013) 3 4 56
  2. Novel nucleolar protein, midnolin, is expressed in the mesencephalon during mouse development. (PMID: 10974535) Tsukahara M … Tsunoo H (Gene 2000) 2 3 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. Midnolin is a novel regulator of parkin expression and is associated with Parkinson's Disease. (PMID: 28724963) Obara Y … Ishii K (Scientific reports 2017) 3 56
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 56

Products for MIDN Gene

Sources for MIDN Gene