Aliases for MID1IP1 Gene

Aliases for MID1IP1 Gene

  • MID1 Interacting Protein 1 2 3 5
  • Mid1-Interacting Protein 1 3 4
  • Spot 14-Related Protein 3 4
  • Spot 14-R 3 4
  • MIG12 3 4
  • S14R 3 4
  • MID1 Interacting Protein 1 (Gastrulation Specific G12-Like (Zebrafish)) 2
  • MID1 Interacting Protein 1 (Gastrulation Specific G12-Like) 3
  • Gastrulation Specific G12 Homolog (Zebrafish) 2
  • Gastrulation-Specific G12-Like Protein 4
  • MID1 Interacting G12-Like Protein 3
  • Gastrulation Specific G12 Homolog 3
  • Mid1-Interacting G12-Like Protein 4
  • Protein STRAIT11499 4
  • STRAIT11499 3
  • G12-Like 3
  • THRSPL 3

External Ids for MID1IP1 Gene

Previous GeneCards Identifiers for MID1IP1 Gene

  • GC0XP038416
  • GC0XP038545
  • GC0XP038660
  • GC0XP036404

Summaries for MID1IP1 Gene

GeneCards Summary for MID1IP1 Gene

MID1IP1 (MID1 Interacting Protein 1) is a Protein Coding gene. Diseases associated with MID1IP1 include Coffin-Siris Syndrome 4 and Gluten Allergy. Among its related pathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to this gene include protein C-terminus binding. An important paralog of this gene is THRSP.

UniProtKB/Swiss-Prot Summary for MID1IP1 Gene

  • Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity).

Additional gene information for MID1IP1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MID1IP1 Gene

Genomics for MID1IP1 Gene

GeneHancer (GH) Regulatory Elements for MID1IP1 Gene

Promoters and enhancers for MID1IP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ038800 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 505 +3.3 3261 8.2 EP300 NRF1 MYC POLR2G USF1 SP1 NCOR1 GTF2E2 POLR2A CLOCK MID1IP1 MID1IP1-AS1 NONHSAG054249.2 LOC105373174 lnc-MID1IP1-4
GH0XJ038801 Enhancer 0.5 ENCODE 500.7 -1.3 -1289 0.2 REST RAD21 CTCF NR2F2 EHMT2 SMC3 LOC105373174 MID1IP1 MID1IP1-AS1 RF00017-8298 NONHSAG054249.2
GH0XJ038982 Enhancer 0.7 Ensembl 12.4 +180.9 180869 1 TGIF2 ZBTB7A FOXA2 SAP130 MXD4 GABPB1 SMAD4 HOMEZ RARA MXI1 MID1IP1-AS1 MID1IP1 HSALNG0137345 HSALNG0137342
GH0XJ038985 Enhancer 0.5 Ensembl 12.6 +185.2 185194 2.4 CTCF REST RAD21 TRIM22 SMC3 ARID3A RAD51 USF1 MID1IP1-AS1 MID1IP1 HSALNG0137345 HSALNG0137342
GH0XJ038983 Enhancer 0.4 Ensembl 12.6 +182.2 182169 0.8 HLTF HDGF ZNF512 MID1IP1-AS1 MID1IP1 HSALNG0137345 HSALNG0137342
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MID1IP1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MID1IP1

Top Transcription factor binding sites by QIAGEN in the MID1IP1 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a

Genomic Locations for MID1IP1 Gene

Genomic Locations for MID1IP1 Gene
chrX:38,801,432-38,806,537
(GRCh38/hg38)
Size:
5,106 bases
Orientation:
Plus strand
chrX:38,660,685-38,665,790
(GRCh37/hg19)
Size:
5,106 bases
Orientation:
Plus strand

Genomic View for MID1IP1 Gene

Genes around MID1IP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MID1IP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MID1IP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MID1IP1 Gene

Proteins for MID1IP1 Gene

  • Protein details for MID1IP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPA3-M1IP1_HUMAN
    Recommended name:
    Mid1-interacting protein 1
    Protein Accession:
    Q9NPA3
    Secondary Accessions:
    • D3DWB2

    Protein attributes for MID1IP1 Gene

    Size:
    183 amino acids
    Molecular mass:
    20202 Da
    Quaternary structure:
    • Homodimer in the absence of THRSP. Heterodimer with THRSP. The homodimer interacts with ACACA and ACACB. Promotes polymerization of Acetyl-CoA carboxylase to form complexes that contain MID1IP1 and ACACA and/or ACACB. Interaction with THRSP interferes with ACACA binding (By similarity).
    SequenceCaution:
    • Sequence=DAA01482.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MID1IP1 Gene

Post-translational modifications for MID1IP1 Gene

  • Ubiquitination at Lys11, Lys124, and Lys173
  • Modification sites at PhosphoSitePlus

Other Protein References for MID1IP1 Gene

No data available for DME Specific Peptides for MID1IP1 Gene

Domains & Families for MID1IP1 Gene

Gene Families for MID1IP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MID1IP1 Gene

Blocks:
  • Thyroid hormone-inducible hepatic Spot 14
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MID1IP1 Gene

GenScript: Design optimal peptide antigens:
  • Spot 14-related protein (M1IP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NPA3

UniProtKB/Swiss-Prot:

M1IP1_HUMAN :
  • Belongs to the SPOT14 family.
Family:
  • Belongs to the SPOT14 family.
genes like me logo Genes that share domains with MID1IP1: view

Function for MID1IP1 Gene

Molecular function for MID1IP1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity).

Phenotypes From GWAS Catalog for MID1IP1 Gene

Gene Ontology (GO) - Molecular Function for MID1IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008022 protein C-terminus binding IEA --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with MID1IP1: view
genes like me logo Genes that share phenotypes with MID1IP1: view

Animal Models for MID1IP1 Gene

MGI Knock Outs for MID1IP1:

Animal Model Products

CRISPR Products

miRNA for MID1IP1 Gene

miRTarBase miRNAs that target MID1IP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MID1IP1 Gene

Localization for MID1IP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MID1IP1 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Associated with microtubules. {ECO:0000250 UniProtKB:Q9CQ20}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MID1IP1 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 4
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MID1IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with MID1IP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MID1IP1 Gene

Pathways & Interactions for MID1IP1 Gene

genes like me logo Genes that share pathways with MID1IP1: view

Gene Ontology (GO) - Biological Process for MID1IP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006853 carnitine shuttle TAS --
GO:0007026 negative regulation of microtubule depolymerization ISS --
GO:0045723 positive regulation of fatty acid biosynthetic process ISS --
GO:0046890 regulation of lipid biosynthetic process IBA,ISS --
genes like me logo Genes that share ontologies with MID1IP1: view

No data available for SIGNOR curated interactions for MID1IP1 Gene

Drugs & Compounds for MID1IP1 Gene

No Compound Related Data Available

Transcripts for MID1IP1 Gene

mRNA/cDNA for MID1IP1 Gene

3 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MID1IP1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2: - -
SP3:

Relevant External Links for MID1IP1 Gene

GeneLoc Exon Structure for
MID1IP1

Expression for MID1IP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MID1IP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MID1IP1 Gene

This gene is overexpressed in Fetal Liver (30.0), Esophagus (16.1), Testis (8.9), Pancreas (7.2), and Spinal cord (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MID1IP1 Gene



Protein tissue co-expression partners for MID1IP1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MID1IP1

SOURCE GeneReport for Unigene cluster for MID1IP1 Gene:

Hs.522605

Evidence on tissue expression from TISSUES for MID1IP1 Gene

  • Nervous system(4.6)
  • Muscle(4.3)
  • Liver(2)
genes like me logo Genes that share expression patterns with MID1IP1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MID1IP1 Gene

Orthologs for MID1IP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MID1IP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MID1IP1 31 30
  • 99.27 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MID1IP1 31 30
  • 92.71 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MID1IP1 31 30
  • 92.49 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mid1ip1 17 31 30
  • 89.87 (n)
rat
(Rattus norvegicus)
Mammalia Mid1ip1 30
  • 89.74 (n)
oppossum
(Monodelphis domestica)
Mammalia MID1IP1 31
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves MID1IP1 30
  • 76.1 (n)
lizard
(Anolis carolinensis)
Reptilia MID1IP1 31
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mid1ip1 30
  • 67.33 (n)
MGC75801 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.1604 30
zebrafish
(Danio rerio)
Actinopterygii mid1ip1b 30
  • 64.84 (n)
mid1ip1a 31
  • 52 (a)
OneToOne
g12 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.423 30
Species where no ortholog for MID1IP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MID1IP1 Gene

ENSEMBL:
Gene Tree for MID1IP1 (if available)
TreeFam:
Gene Tree for MID1IP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MID1IP1: view image

Paralogs for MID1IP1 Gene

Paralogs for MID1IP1 Gene

(1) SIMAP similar genes for MID1IP1 Gene using alignment to 1 proteins:

  • M1IP1_HUMAN
genes like me logo Genes that share paralogs with MID1IP1: view

Variants for MID1IP1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MID1IP1 Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
711083 Benign: not provided 38,805,491(+) G/A MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for MID1IP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MID1IP1 Gene

Variant ID Type Subtype PubMed ID
nsv477121 CNV novel sequence insertion 20440878

Variation tolerance for MID1IP1 Gene

Residual Variation Intolerance Score: 33.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MID1IP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MID1IP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MID1IP1 Gene

Disorders for MID1IP1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for MID1IP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
coffin-siris syndrome 4
  • css4
gluten allergy
  • allergy to gluten
opitz-gbbb syndrome
  • hypertelorism with esophageal abnormality and hypospadias
scoliosis
autosomal dominant non-syndromic intellectual disability
  • autosomal dominant mental retardation
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MID1IP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MID1IP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MID1IP1 Gene

Publications for MID1IP1 Gene

  1. Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules. (PMID: 15070402) Berti C … Meroni G (BMC cell biology 2004) 3 4 23 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  4. Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance. (PMID: 31452512) Pech MF … Settleman J (eLife 2019) 3 54
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54

Products for MID1IP1 Gene

Sources for MID1IP1 Gene