Aliases for MICU2 Gene
External Ids for MICU2 Gene
Previous HGNC Symbols for MICU2 Gene
Previous GeneCards Identifiers for MICU2 Gene
GeneCards Summary for MICU2 Gene
MICU2 (Mitochondrial Calcium Uptake 2) is a Protein Coding gene. Diseases associated with MICU2 include Myopathy With Extrapyramidal Signs and Cataract 3, Multiple Types. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is MICU3.
UniProtKB/Swiss-Prot Summary for MICU2 Gene
Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927).