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Aliases for MICB Gene

Aliases for MICB Gene

  • MHC Class I Polypeptide-Related Sequence B 2 3 3 5
  • PERB11.2 3 4
  • MHC Class I-Like Molecule PERB11.2-IMX 3
  • MHC Class I Chain-Related Protein B 3
  • Stress Inducible Class I Homolog 3
  • MHC Class I Mic-B Antigen 3
  • MIC-B 4

External Ids for MICB Gene

Previous GeneCards Identifiers for MICB Gene

  • GC06P031519
  • GC06P031421
  • GC06P031233
  • GC06P031570
  • GC06P031574
  • GC06P031576
  • GC06P031465
  • GC06P031252
  • GC06P031500

Summaries for MICB Gene

Entrez Gene Summary for MICB Gene

  • This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for MICB Gene

MICB (MHC Class I Polypeptide-Related Sequence B) is a Protein Coding gene. Diseases associated with MICB include Dengue Shock Syndrome and Asymptomatic Dengue. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. Gene Ontology (GO) annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is MICA.

UniProtKB/Swiss-Prot for MICB Gene

  • Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.

Gene Wiki entry for MICB Gene

Additional gene information for MICB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICB Gene

Genomics for MICB Gene

GeneHancer (GH) Regulatory Elements for MICB Gene

Promoters and enhancers for MICB Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J031493 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 684.4 +2.0 2006 5.8 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B POLR2B ZNF213 MICB ENSG00000201680 GC06M031496 MICB-DT DDX39B ATF6B ATP6V1G2 LSM2 PPP1R10 PSORS1C2
GH06J031412 Promoter 0.5 EPDnew 650.2 -82.2 -82201 0.1 MICB MICA ENSG00000199332 GC06M031411 HCP5 LINC01149
GH06J031567 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.2 +84.1 84142 22.2 HDGF PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 TNF ATP6V1G2 LST1 GC06P032155 GC06P032156 GC06P032157 GC06P032158 GC06P032160 GC06P032161 GC06P032163
GH06J031538 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.7 +46.9 46862 4.9 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 DDX39B DDX39B-AS1 GC06M031542 GC06M031543 GC06M031550 GC06M031555 GC06M031573 GC06M032007 GC06M032013 GC06M032015
GH06J031352 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 18.2 -138.1 -138085 7 HDGF PKNOX1 ATF1 SMAD1 ZNF2 IRF4 GLIS2 ZNF207 ZNF143 FOS HLA-B ENSG00000271581 GC06M031413 GC06M031414 MIR6891 PIR40863 HLA-C DDX39B MICA LY6G5B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MICB on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MICB gene promoter:
  • Sp1
  • POU2F1
  • POU2F1a

Genomic Locations for MICB Gene

Genomic Locations for MICB Gene
16,848 bases
Plus strand
16,244 bases
Plus strand

Genomic View for MICB Gene

Genes around MICB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MICB Gene

  • Protein details for MICB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    MHC class I polypeptide-related sequence B
    Protein Accession:
    Secondary Accessions:
    • A2AC57
    • A6NP85
    • B0UZ10
    • B2RAK2
    • O14499
    • O14500
    • O19798
    • O19799
    • O19800
    • O19801
    • O19802
    • O19803
    • O78099
    • O78100
    • O78101
    • O78102
    • O78103
    • O78104
    • P79525
    • P79541
    • Q5GR31
    • Q5GR37
    • Q5GR41
    • Q5GR42
    • Q5GR43
    • Q5GR44
    • Q5GR46
    • Q5GR48
    • Q5RIY6
    • Q5SSK1
    • Q5ST25
    • Q7JK51
    • Q7YQ89
    • Q861E6
    • Q9MY18
    • Q9MY19
    • Q9MY20
    • Q9UBH4
    • Q9UBZ8
    • Q9UEJ0

    Protein attributes for MICB Gene

    383 amino acids
    Molecular mass:
    42646 Da
    Quaternary structure:
    • Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICB while HCST acts as an adapter molecule which enables signal transduction. Receptor-ligand interaction induces clustering of both proteins in ordered structures called immune synapses and also leads to their intercellular transfer. This is associated with a reduction in the cytotoxicity of KLRK1-expressing cells. Binds to human cytomegalovirus glycoprotein UL16 which causes sequestration of MICB in the endoplasmic reticulum and increases resistance to KLRK1-mediated cytotoxicity.

    Three dimensional structures from OCA and Proteopedia for MICB Gene

    Alternative splice isoforms for MICB Gene


neXtProt entry for MICB Gene

Post-translational modifications for MICB Gene

  • Proteolytically cleaved and released from the cell surface of tumor cells.
  • Ubiquitination at posLast=196196
  • Glycosylation at posLast=261261, isoforms=2220, isoforms=2210, and isoforms=2164
  • Modification sites at PhosphoSitePlus

Other Protein References for MICB Gene

Antibody Products

  • Abcam antibodies for MICB
  • Boster Bio Antibodies for MICB

No data available for DME Specific Peptides for MICB Gene

Domains & Families for MICB Gene

Gene Families for MICB Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MHC class I family. MIC subfamily.
  • Belongs to the MHC class I family. MIC subfamily.
genes like me logo Genes that share domains with MICB: view

Function for MICB Gene

Molecular function for MICB Gene

UniProtKB/Swiss-Prot Function:
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
UniProtKB/Swiss-Prot Induction:
By heat shock, oxidative stress, retinoic acid, IFN-alpha and the DNA methyltransferase inhibitor 5-aza-2-deoxycytidine. Induction by IFN-alpha is impaired in patients with chronic hepatitis C virus infection. Down-regulated by human cytomegalovirus UL112 microRNA during viral infection which leads to decreased binding of KLRK1/NKG2D and reduced killing by natural killer cells.
GENATLAS Biochemistry:
MHC class I,chain-related gene B,preferentially expressed in fibroblast and epithelial cell

Phenotypes From GWAS Catalog for MICB Gene

Gene Ontology (GO) - Molecular Function for MICB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046703 natural killer cell lectin-like receptor binding IDA 11491531
genes like me logo Genes that share ontologies with MICB: view
genes like me logo Genes that share phenotypes with MICB: view

Animal Model Products

miRNA for MICB Gene

miRTarBase miRNAs that target MICB

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MICB Gene

Localization for MICB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICB Gene

Cell membrane; Single-pass type I membrane protein. Note=Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum. {ECO:0000250 UniProtKB:Q29983, ECO:0000269 PubMed:12782710}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MICB gene
Compartment Confidence
plasma membrane 4
extracellular 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MICB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS,IBA --
GO:0009986 cell surface ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MICB: view

Pathways & Interactions for MICB Gene

genes like me logo Genes that share pathways with MICB: view

Interacting Proteins for MICB Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: Q29980-MICB_HUMAN ENSP00000252229 for MICB Gene via IID STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MICB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001913 T cell mediated cytotoxicity IBA --
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0002429 immune response-activating cell surface receptor signaling pathway IDA 11491531
GO:0006979 response to oxidative stress IDA 11287116
genes like me logo Genes that share ontologies with MICB: view

No data available for SIGNOR curated interactions for MICB Gene

Drugs & Compounds for MICB Gene

(3) Drugs for MICB Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Peginterferon alfa-2a Approved, Investigational Pharma 577
Peginterferon alfa-2b Approved Pharma 309
Ribavirin Approved Pharma 1017
genes like me logo Genes that share compounds with MICB: view

Transcripts for MICB Gene

mRNA/cDNA for MICB Gene

Unigene Clusters for MICB Gene

MHC class I polypeptide-related sequence B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MICB Gene

No ASD Table

Relevant External Links for MICB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MICB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MICB Gene

mRNA differential expression in normal tissues according to GTEx for MICB Gene

This gene is overexpressed in Whole Blood (x8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MICB Gene

NURSA nuclear receptor signaling pathways regulating expression of MICB Gene:


SOURCE GeneReport for Unigene cluster for MICB Gene:


mRNA Expression by UniProt/SwissProt for MICB Gene:

Tissue specificity: Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue.

Evidence on tissue expression from TISSUES for MICB Gene

  • Pancreas(4.6)
  • Nervous system(4)
  • Lung(3.4)
  • Blood(2.9)
  • Eye(2.5)
  • Intestine(2.4)
  • Skin(2.4)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with MICB: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MICB Gene

Orthologs for MICB Gene

This gene was present in the common ancestor of chordates.

Orthologs for MICB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MICB 34 33
  • 93.98 (n)
(Bos Taurus)
Mammalia MIC1 33
  • 70.74 (n)
-- 34
  • 46 (a)
(Mus musculus)
Mammalia Mill2 16 34 33
  • 56.11 (n)
(Rattus norvegicus)
Mammalia Micb 33
  • 53.24 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 26 (a)
-- 34
  • 22 (a)
-- 34
  • 22 (a)
-- 34
  • 20 (a)
-- 34
  • 20 (a)
-- 34
  • 19 (a)
-- 34
  • 17 (a)
-- 34
  • 17 (a)
-- 34
  • 17 (a)
(Monodelphis domestica)
Mammalia MILL-LIKE 34
  • 25 (a)
(Gallus gallus)
Aves -- 34
  • 25 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 21 (a)
(Danio rerio)
Actinopterygii si:ch211-147g22.4 34
  • 23 (a)
mhc1uca 34
  • 20 (a)
mhc1uba 34
  • 20 (a)
mhc1zca 34
  • 20 (a)
si:dkey-52p2.7 34
  • 20 (a)
BX572619.3 34
  • 19 (a)
mhc1zea 34
  • 19 (a)
mhc1zfa 34
  • 19 (a)
si:ch211-147g22.3 34
  • 19 (a)
BX682558.1 34
  • 19 (a)
si:ch211-147g22.1 34
  • 19 (a)
BX572619.1 34
  • 19 (a)
BX572619.2 34
  • 19 (a)
CR339041.1 34
  • 19 (a)
si:ch211-147g22.2 34
  • 18 (a)
si:dkey-52p2.6 34
  • 18 (a)
DARE-ZE*0601 34
  • 18 (a)
arpc1a 34
  • 18 (a)
CABZ01031753.1 34
  • 17 (a)
CABZ01031754.1 34
  • 17 (a)
CU571323.1 34
  • 17 (a)
CR339041.2 34
  • 17 (a)
mhc1zaa 34 34
  • 17 (a)
mhc1zba 34
  • 17 (a)
si:dkey-52p2.4 34
  • 16 (a)
zgc:113060 34
  • 14 (a)
Species where no ortholog for MICB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MICB Gene

Gene Tree for MICB (if available)
Gene Tree for MICB (if available)
Evolutionary constrained regions (ECRs) for MICB: view image

Paralogs for MICB Gene

Paralogs for MICB Gene

genes like me logo Genes that share paralogs with MICB: view

Variants for MICB Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MICB Gene

The following alleles of MICB are known: MICB*001, MICB*002, MICB*003, MICB*004, MICB*005, MICB*006, MICB*007, MICB*008, MICB*009N, MICB*010, MICB*011, MICB*012, MICB*013, MICB*014, MICB*015, MICB*016, MICB*018, MICB*019, MICB*020, MICB*021N and MICB*022. MICB*009N and MICB*021N are null alleles which are not expressed. The sequence shown is that of MICB*001.

Sequence variations from dbSNP and Humsavar for MICB Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000282069 -- 31,499,917(+) T/C intron_variant
rs1000436148 -- 31,493,917(+) G/T upstream_transcript_variant
rs1000630874 -- 31,498,405(+) G/ intron_variant
rs1000997582 -- 31,510,246(+) G/A 3_prime_UTR_variant
rs1001040824 -- 31,511,356(+) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MICB Gene

Variant ID Type Subtype PubMed ID
dgv10403n54 CNV loss 21841781
dgv10404n54 CNV loss 21841781
dgv10460n54 CNV gain 21841781
dgv213e55 CNV gain 17911159
dgv215e55 CNV loss 17911159
dgv5942n100 CNV loss 25217958
dgv5943n100 CNV gain+loss 25217958
dgv5944n100 CNV loss 25217958
dgv995e201 CNV deletion 23290073
esv2731822 CNV deletion 23290073
esv2759414 CNV gain+loss 17122850
esv3890821 CNV gain 25118596
nsv1015886 CNV loss 25217958
nsv1018960 CNV gain 25217958
nsv1021578 CNV gain 25217958
nsv1022499 CNV gain 25217958
nsv1025961 CNV loss 25217958
nsv1073969 CNV deletion 25765185
nsv10821 CNV loss 18304495
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv462869 CNV loss 19166990
nsv517441 CNV gain+loss 19592680
nsv601940 CNV loss 21841781

Variation tolerance for MICB Gene

Residual Variation Intolerance Score: 71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.90; 74.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MICB Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

Disorders for MICB Gene

MalaCards: The human disease database

(6) MalaCards diseases for MICB Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search MICB in MalaCards View complete list of genes associated with diseases


  • Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269 PubMed:17003176}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. The MICB*004 allele is associated with rheumatoid arthritis.
  • Note=Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk.

Additional Disease Information for MICB

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MICB: view

No data available for Genatlas for MICB Gene

Publications for MICB Gene

  1. MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility. (PMID: 17003176) López-Arbesu R … González S (Rheumatology (Oxford, England) 2007) 3 4 22 44 58
  2. MICB0106 gene polymorphism is associated with ulcerative colitis in central China. (PMID: 19662431) Li Y … Zhang X (International journal of colorectal disease 2010) 3 22 44 58
  3. Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). (PMID: 19115949) Limou S … ANRS Genomic Group (The Journal of infectious diseases 2009) 3 22 44 58
  4. Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes. (PMID: 18332098) Field SF … Todd JA (Diabetes 2008) 3 22 44 58
  5. Genetic influence of the nonclassical major histocompatibility complex class I molecule MICB in multiple sclerosis susceptibility. (PMID: 18588574) Fernandez-Morera JL … Lopez-Larrea C (Tissue antigens 2008) 3 22 44 58

Products for MICB Gene

  • Boster Bio Antibodies for MICB
  • Boster Bio ELISA Kits for MICB

Sources for MICB Gene