Free for academic non-profit institutions. Other users need a Commercial license
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
MICB (MHC Class I Polypeptide-Related Sequence B) is a Protein Coding gene. Diseases associated with MICB include Dengue Shock Syndrome and Rheumatoid Arthritis. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Innate Immune System. Gene Ontology (GO) annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is MICA.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0046703 | natural killer cell lectin-like receptor binding | IDA | 11491531 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IBA | 21873635 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0009897 | external side of plasma membrane | IBA | 21873635 |
GO:0009986 | cell surface | ISS | -- |
GO:0016020 | membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001916 | positive regulation of T cell mediated cytotoxicity | IBA | -- |
GO:0002250 | adaptive immune response | IEA | -- |
GO:0002376 | immune system process | IEA | -- |
GO:0002429 | immune response-activating cell surface receptor signaling pathway | IDA | 11491531 |
GO:0002476 | antigen processing and presentation of endogenous peptide antigen via MHC class Ib | IBA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MICB 30 31 |
|
OneToMany | |
Cow (Bos Taurus) |
Mammalia | MIC1 30 |
|
||
-- 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Mill2 30 17 31 |
|
ManyToMany | |
Rat (Rattus norvegicus) |
Mammalia | Micb 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
-- 31 |
|
ManyToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | MILL-LIKE 31 |
|
OneToMany | |
Chicken (Gallus gallus) |
Aves | -- 31 |
|
OneToMany | |
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-147g22.4 31 |
|
ManyToMany | |
mhc1uca 31 |
|
ManyToMany | |||
mhc1uba 31 |
|
ManyToMany | |||
mhc1zca 31 |
|
ManyToMany | |||
si:dkey-52p2.7 31 |
|
ManyToMany | |||
BX572619.3 31 |
|
ManyToMany | |||
mhc1zea 31 |
|
ManyToMany | |||
mhc1zfa 31 |
|
ManyToMany | |||
si:ch211-147g22.3 31 |
|
ManyToMany | |||
BX682558.1 31 |
|
ManyToMany | |||
si:ch211-147g22.1 31 |
|
ManyToMany | |||
BX572619.1 31 |
|
ManyToMany | |||
BX572619.2 31 |
|
ManyToMany | |||
CR339041.1 31 |
|
ManyToMany | |||
si:ch211-147g22.2 31 |
|
ManyToMany | |||
si:dkey-52p2.6 31 |
|
ManyToMany | |||
DARE-ZE*0601 31 |
|
ManyToMany | |||
arpc1a 31 |
|
ManyToMany | |||
CABZ01031753.1 31 |
|
ManyToMany | |||
CABZ01031754.1 31 |
|
ManyToMany | |||
CU571323.1 31 |
|
ManyToMany | |||
CR339041.2 31 |
|
ManyToMany | |||
mhc1zaa 31 31 |
|
ManyToMany | |||
mhc1zba 31 |
|
ManyToMany | |||
si:dkey-52p2.4 31 |
|
ManyToMany | |||
zgc:113060 31 |
|
ManyToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
713467 | Benign: not provided | 31,509,891(+) | T/C | SYNONYMOUS_VARIANT | |
726697 | Benign: not provided | 31,498,259(+) | C/T | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
rs1051788 | -. - | p.Asp136Asnp.Asp136His | |||
rs1065075 | - | p.Lys80Glu | |||
rs1065076 | - | p.Ala383Thr |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv10403n54 | CNV | loss | 21841781 |
dgv10404n54 | CNV | loss | 21841781 |
dgv10460n54 | CNV | gain | 21841781 |
dgv213e55 | CNV | gain | 17911159 |
dgv215e55 | CNV | loss | 17911159 |
dgv5942n100 | CNV | loss | 25217958 |
dgv5943n100 | CNV | gain+loss | 25217958 |
dgv5944n100 | CNV | loss | 25217958 |
dgv995e201 | CNV | deletion | 23290073 |
esv2731822 | CNV | deletion | 23290073 |
esv2759414 | CNV | gain+loss | 17122850 |
esv3890821 | CNV | gain | 25118596 |
nsv1015886 | CNV | loss | 25217958 |
nsv1018960 | CNV | gain | 25217958 |
nsv1021578 | CNV | gain | 25217958 |
nsv1022499 | CNV | gain | 25217958 |
nsv1025961 | CNV | loss | 25217958 |
nsv1073969 | CNV | deletion | 25765185 |
nsv10821 | CNV | loss | 18304495 |
nsv1112900 | CNV | deletion | 24896259 |
nsv1126749 | CNV | deletion | 24896259 |
nsv462869 | CNV | loss | 19166990 |
nsv517441 | CNV | gain+loss | 19592680 |
nsv601940 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
dengue shock syndrome |
|
|
rheumatoid arthritis |
|
|
behcet syndrome |
|
|
asymptomatic dengue |
|
|
celiac disease 1 |
|