Aliases for MICB Gene
External Ids for MICB Gene
Previous GeneCards Identifiers for MICB Gene
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for MICB Gene
MICB (MHC Class I Polypeptide-Related Sequence B) is a Protein Coding gene. Diseases associated with MICB include Dengue Shock Syndrome and Rheumatoid Arthritis. Among its related pathways are Human cytomegalovirus infection and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is MICA.
UniProtKB/Swiss-Prot Summary for MICB Gene
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.