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This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microgl... See more...
Aliases for MICB Gene
Aliases for MICB Gene
External Ids for MICB Gene
- HGNC: 7091
- NCBI Entrez Gene: 4277
- Ensembl: ENSG00000204516
- OMIM®: 602436
- UniProtKB/Swiss-Prot: Q29980
Previous GeneCards Identifiers for MICB Gene
- GC06P031519
- GC06P031421
- GC06P031233
- GC06P031570
- GC06P031574
- GC06P031576
- GC06P031465
- GC06P031252
- GC06P032306
- GC06P032494
- GC06P032599
- GC06P033390
- GC06P031500
- GC06P032108
- GC06P032112
- GC06P047300
- GC06P049346
Summaries for MICB Gene
-
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for MICB Gene
MICB (MHC Class I Polypeptide-Related Sequence B) is a Protein Coding gene. Diseases associated with MICB include Dengue Shock Syndrome and Rheumatoid Arthritis. Among its related pathways are Human cytomegalovirus infection and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is MICA.
UniProtKB/Swiss-Prot Summary for MICB Gene
-
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Additional gene information for MICB Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MICB Gene
Genomics for MICB Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MICB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MICB on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MICB
- Top Transcription factor binding sites by QIAGEN in the MICB gene promoter:
-
- POU2F1
- POU2F1a
- Sp1
Genomic Locations for MICB Gene
Latest Assembly
- chr6:31,494,881-31,511,124
- (GRCh38/hg38)
- Size:
- 16,244 bases
- Orientation:
- Plus strand
Previous Assembly
- chr6:31,462,695-31,478,901
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 16,207 bases
- Orientation:
- Plus strand
Alternative Locations (GRCh38/hg38)
- chr6(ALT_REF_LOCI_1):2,827,486-2,843,674 (+)
- chr6(ALT_REF_LOCI_2):2,972,259-2,988,464 (+)
- chr6(ALT_REF_LOCI_3):2,742,529-2,758,910 (+)
- chr6(ALT_REF_LOCI_4):2,810,648-2,816,200 (+)
- chr6(ALT_REF_LOCI_5):2,836,873-2,853,071 (+)
- chr6(ALT_REF_LOCI_6):2,750,806-2,767,002 (+)
- chr6(ALT_REF_LOCI_7):2,794,202-2,810,410 (+)
Genomic View for MICB Gene
Genes around MICB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.33 by HGNC
- 6p21.33 by Entrez Gene
- 6p21.33 by Ensembl
MICB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MICB Gene
Proteins for MICB Gene
-
Protein details for MICB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q29980-MICB_HUMAN
- Recommended name:
- MHC class I polypeptide-related sequence B
- Protein Accession:
- Q29980
- A2AC57
- A6NP85
- B0UZ10
- B2RAK2
- O14499
- O14500
- O19798
- O19799
- O19800
- O19801
- O19802
- O19803
- O78099
- O78100
- O78101
- O78102
- O78103
- O78104
- P79525
- P79541
- Q5GR31
- Q5GR37
- Q5GR41
- Q5GR42
- Q5GR43
- Q5GR44
- Q5GR46
- Q5GR48
- Q5RIY6
- Q5SSK1
- Q5ST25
- Q7JK51
- Q7YQ89
- Q861E6
- Q9MY18
- Q9MY19
- Q9MY20
- Q9UBH4
- Q9UBZ8
- Q9UEJ0
- X6R344
Protein attributes for MICB Gene
- Size:
- 383 amino acids
- Molecular mass:
- 42575 Da
- Quaternary structure:
-
- Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICB while HCST acts as an adapter molecule which enables signal transduction. Receptor-ligand interaction induces clustering of both proteins in ordered structures called immune synapses and also leads to their intercellular transfer. This is associated with a reduction in the cytotoxicity of KLRK1-expressing cells.
- (Microbial infection) Interacts with human cytomegalovirus/HHV-5 glycoprotein UL16; this interaction causes sequestration of MICB in the endoplasmic reticulum and increases resistance to KLRK1-mediated cytotoxicity.
- Miscellaneous:
-
- [Isoform 3]: A GC to AG nucleotide substitution in intron 1 generates a splice junction which gives rise to an additional exon between exons 1 and 2. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Protein Expression for MICB Gene
Post-translational modifications for MICB Gene
Other Protein References for MICB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- G Biosciences Immunotag™ MICB Polyclonal Antibody
-
Custom Antibody ServicesOriGene Antibodies for MICB
- Novus Biologicals Antibodies for MICB
-
Abcam antibodies for MICB
- Invitrogen Antibodies for MICB (AFLGC-MICB)
-
Biorbyt antibodies for MICB
-
Boster Bio Antibodies for MICB
-
Custom Antibody ServicesProSci Antibodies for MICB
-
Santa Cruz Biotechnology (SCBT) Antibodies for MICB
- Sino Biological Antibodies for MICB
Protein products for research
-
OriGene Purified Proteins for MICB
- Search Origene for MassSpec and Protein Over-expression Lysates for MICB
- Origene Custom Protein Services for MICB
- Sino Biological Recombinant Proteins for MICB
- Sino Biological Cell Lysates for MICB
- ProSpec Recombinant Proteins for MICB
- antibodies-online: Show 10 available MICB Proteins ranked by validation data
- Compare Top MICB Proteins
-
Quality Products:
-
Abcam proteins for MICB
Assay products for research
- RayBiotech Human MICB ELISA
-
Custom Assay ServicesOriGene ELISA Kits for MICB
- Novus Biologicals ELISA Kits for MICB
- antibodies-online: Show 22 available MICB Elisa Kits ranked by validation data
- Compare Top MICB Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for MICB
- Sino Biological Assays for MICB
No data available for DME Specific Peptides for MICB Gene
Domains & Families for MICB Gene
Gene Families for MICB Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted membrane proteins
Protein Domains for MICB Gene
- InterPro:
- Blocks:
-
- Immunoglobulin C-type
Suggested Antigen Peptide Sequences for MICB Gene
- GenScript: Design optimal peptide antigens:
-
- MHC class I polypeptide-related sequence B (B0S8B5_HUMAN)
- MHC class I polypeptide-related sequence B (B0S8B6_HUMAN)
- cDNA, FLJ94967, Homo sapiens MHC class I polypeptide-related sequence B (MICB),mRNA (B2RAK2_HUMAN)
- MHC class I chain-related molecule B (D2KNA0_HUMAN)
- MHC class I chain-related protein B (E0AG58_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q29980- Family:
-
- Belongs to the MHC class I family. MIC subfamily.
Function for MICB Gene
Molecular function for MICB Gene
- UniProtKB/Swiss-Prot Function:
- Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
- UniProtKB/Swiss-Prot Induction:
- By heat shock, oxidative stress, retinoic acid, IFN-alpha and the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine. Induction by IFN-alpha is impaired in patients with chronic hepatitis C virus infection. Down-regulated by human cytomegalovirus UL112 microRNA during viral infection which leads to decreased binding of KLRK1/NKG2D and reduced killing by natural killer cells.
- GENATLAS Biochemistry:
- MHC class I,chain-related gene B,preferentially expressed in fibroblast and epithelial cell
Phenotypes From GWAS Catalog for MICB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0046703 | natural killer cell lectin-like receptor binding | IDA | 11491531 |
Phenotypes for MICB Gene
- GenomeRNAi human phenotypes for MICB:
-
- Strongly decreased CFP-tsO45G cell surface transport
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability with paclitaxel
- Increased virus production
- Decreased Sindbis virus (SINV) infection
- Increased G2M DNA content
- Increased replication of vaccinia virus (VACV)
- Increased number of mitotic cells
- Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression
- Increased transcriptional activity
- Decreased and increased HIV-LTR-beta-galactosidase protein expression
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MICB - Starting at $85 >
- * MICB CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MICB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MICB
-
Santa Cruz Biotechnology (SCBT) CRISPR for MICB
miRNA for MICB Gene
- miRTarBase miRNAs that target MICB
-
- hsa-miR-17-5p (MIRT100276)
- hsa-miR-20a-5p (MIRT100277)
- hsa-miR-93-5p (MIRT100278)
- hsa-miR-106b-5p (MIRT100281)
- hsa-miR-20b-5p (MIRT100288)
- hsa-miR-519d-3p (MIRT100297)
- hsa-let-7c-5p (MIRT439155)
- hsa-miR-3692-3p (MIRT683779)
- hsa-miR-3977 (MIRT683780)
- hsa-miR-3192-3p (MIRT683781)
- hsa-miR-6848-5p (MIRT683782)
- hsa-miR-6846-5p (MIRT683783)
- hsa-miR-6815-3p (MIRT683784)
- hsa-miR-760 (MIRT683785)
- hsa-miR-103a-2-5p (MIRT683786)
- hsa-miR-3151-3p (MIRT683787)
- hsa-miR-6798-5p (MIRT683788)
- hsa-miR-141-5p (MIRT683789)
- hsa-miR-6805-5p (MIRT683790)
- hsa-miR-5088-5p (MIRT683791)
- hsa-miR-6886-3p (MIRT691418)
- hsa-miR-140-3p (MIRT691419)
- hsa-miR-129-2-3p (MIRT691420)
- hsa-miR-129-1-3p (MIRT691421)
- hsa-miR-6856-3p (MIRT691422)
- hsa-miR-1273h-5p (MIRT736874)
- hsa-miR-149-3p (MIRT737749)
- hsa-miR-1827 (MIRT738120)
- hsa-miR-1910-3p (MIRT738415)
- hsa-miR-2467-3p (MIRT739275)
- hsa-miR-30b-3p (MIRT739764)
- hsa-miR-3160-3p (MIRT740521)
- hsa-miR-3192-5p (MIRT741020)
- hsa-miR-3612 (MIRT741579)
- hsa-miR-3689a-3p (MIRT742266)
- hsa-miR-3689b-3p (MIRT742336)
- hsa-miR-3689c (MIRT742406)
- hsa-miR-377-5p (MIRT742692)
- hsa-miR-4257 (MIRT743415)
- hsa-miR-4487 (MIRT745208)
- hsa-miR-455-3p (MIRT746188)
- hsa-miR-4728-5p (MIRT747845)
- hsa-miR-490-3p (MIRT749171)
- hsa-miR-558 (MIRT751048)
- hsa-miR-6086 (MIRT751846)
- hsa-miR-6499-3p (MIRT752806)
- hsa-miR-650 (MIRT753027)
- hsa-miR-6511a-5p (MIRT753140)
- hsa-miR-6516-5p (MIRT753348)
- hsa-miR-6779-5p (MIRT755505)
- hsa-miR-6780a-5p (MIRT755581)
- hsa-miR-6785-5p (MIRT755840)
- hsa-miR-6799-5p (MIRT756311)
- hsa-miR-6883-5p (MIRT758425)
- hsa-miR-7106-5p (MIRT758866)
- hsa-miR-7851-3p (MIRT759889)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MICB
- Browse OriGene Inhibitory RNA Products For MICB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MICB
Clone products for research
- Applied Biological Materials (abm): Clones for MICB - Starting at $45 >
- * MICB as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for MICB
- Addgene plasmids for MICB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MICB
Cell Lines for research
-
Horizon Cell Lines for MICB
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MICB Gene
Localization for MICB Gene
Subcellular locations from UniProtKB/Swiss-Prot for MICB Gene
- Cell membrane. Single-pass type I membrane protein. Note=Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum. {ECO:0000250 UniProtKB:Q29983, ECO:0000269 PubMed:12782710}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 4 |
| cytoskeleton | 2 |
| nucleus | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| mitochondrion | 1 |
| golgi apparatus | 1 |
- Golgi apparatus (2)
- Nucleoplasm (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IBA | 21873635 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0009897 | external side of plasma membrane | IBA | 21873635 |
| GO:0009986 | cell surface | ISS | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for MICB Gene
Pathways by source for MICB Gene
3 Reactome pathways for MICB Gene
2 KEGG pathways for MICB Gene
Interacting Proteins for MICB Gene
GPS-Prot Interaction Network for MICB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002429 | immune response-activating cell surface receptor signaling pathway | IDA | 11491531 |
| GO:0006955 | immune response | IBA | 21873635 |
| GO:0006979 | response to oxidative stress | IDA | 11287116 |
No data available for SIGNOR curated interactions for MICB Gene
Transcripts for MICB Gene
mRNA/cDNA for MICB Gene
- 3 REFSEQ mRNAs :
- 26 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000252229 2416 nts (view in UCSC)
- ENST00000399150 2346 nts (view in UCSC)
- ENST00000494577 907 nts (view in UCSC)
- ENST00000538442 2411 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MICB - Starting at $85 >
- * MICB CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MICB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MICB
-
Santa Cruz Biotechnology (SCBT) CRISPR for MICB
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MICB
- Browse OriGene Inhibitory RNA Products For MICB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MICB
Clone products for research
- Applied Biological Materials (abm): Clones for MICB - Starting at $45 >
- * MICB as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for MICB
- Addgene plasmids for MICB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MICB
Relevant External Links for MICB Gene
- GeneLoc Exon Structure for
- MICB
Expression for MICB Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
- Mesenchymal Stem Cells (Uncategorized)
- Umbilical Cord (Extraembryonic Tissues)
- Neural Tube (Nervous System)
mRNA differential expression in normal tissues according to GTEx for MICB Gene
This gene is overexpressed in Whole Blood (x8.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MICB Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MICB
SOURCE GeneReport for Unigene cluster for MICB Gene:
Hs.731446mRNA Expression by UniProt/SwissProt for MICB Gene:
Q29980-MICB_HUMAN
Tissue specificity:
Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue.
Evidence on tissue expression from TISSUES for MICB Gene
- Pancreas(4.7)
- Nervous system(4.3)
- Lung(3.8)
- Blood(3.1)
- Skin(3.1)
- Kidney(3.1)
- Intestine(2.9)
- Eye(2.8)
- Liver(2.6)
- Spleen(2.3)
- Lymph node(2.3)
Primer products for research
-
OriGene qPCR primer pairs for MICB
Gene Expression Assays for research
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MICB Gene
Orthologs for MICB Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MICB 29 30 |
|
OneToMany | |
| Cow (Bos Taurus) |
Mammalia | MIC1 29 |
|
||
| -- 30 |
|
OneToMany | |||
| Mouse (Mus musculus) |
Mammalia | Mill2 29 16 30 |
|
ManyToMany | |
| Rat (Rattus norvegicus) |
Mammalia | Micb 29 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
ManyToMany | |
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| -- 30 |
|
ManyToMany | |||
| Oppossum (Monodelphis domestica) |
Mammalia | MILL-LIKE 30 |
|
OneToMany | |
| Chicken (Gallus gallus) |
Aves | -- 30 |
|
OneToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 30 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-147g22.4 30 |
|
ManyToMany | |
| mhc1uca 30 |
|
ManyToMany | |||
| mhc1uba 30 |
|
ManyToMany | |||
| mhc1zca 30 |
|
ManyToMany | |||
| si:dkey-52p2.7 30 |
|
ManyToMany | |||
| BX572619.3 30 |
|
ManyToMany | |||
| mhc1zea 30 |
|
ManyToMany | |||
| mhc1zfa 30 |
|
ManyToMany | |||
| si:ch211-147g22.3 30 |
|
ManyToMany | |||
| BX682558.1 30 |
|
ManyToMany | |||
| si:ch211-147g22.1 30 |
|
ManyToMany | |||
| BX572619.1 30 |
|
ManyToMany | |||
| BX572619.2 30 |
|
ManyToMany | |||
| CR339041.1 30 |
|
ManyToMany | |||
| si:ch211-147g22.2 30 |
|
ManyToMany | |||
| si:dkey-52p2.6 30 |
|
ManyToMany | |||
| DARE-ZE*0601 30 |
|
ManyToMany | |||
| arpc1a 30 |
|
ManyToMany | |||
| CABZ01031753.1 30 |
|
ManyToMany | |||
| CABZ01031754.1 30 |
|
ManyToMany | |||
| CU571323.1 30 |
|
ManyToMany | |||
| CR339041.2 30 |
|
ManyToMany | |||
| mhc1zaa 30 30 |
|
ManyToMany | |||
| mhc1zba 30 |
|
ManyToMany | |||
| si:dkey-52p2.4 30 |
|
ManyToMany | |||
| zgc:113060 30 |
|
ManyToMany |
- Species where no ortholog for MICB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MICB Gene
- ENSEMBL:
- Gene Tree for MICB (if available)
- TreeFam:
- Gene Tree for MICB (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MICB: view image
- Alliance of Genome Resources:
- Additional Orthologs for MICB
Paralogs for MICB Gene
Paralogs for MICB Gene
(62) SIMAP similar genes for MICB Gene using alignment to 8 proteins:
- MICB_HUMAN
- A2AC57_HUMAN
- D2KNA0_HUMAN
- E0AG58_HUMAN
- F5H7Q8_HUMAN
- G1EFQ4_HUMAN
- H9B8I7_HUMAN
- Q0EFB4_HUMAN
- MICA
- HLA-MICA
- DKFZp762B162
- PERB11.1
- HLA-A*0201V3
- HFE
- Cw
- HLA-DQB1
- HLA-A*33
- MHC class I HLA-A
- HLA-H
- HLA-Cw*
- HLA-A24AK
- HLA-A*31
- HLA-A*0226
- HLA-A*02
- B*56
- HLA-Cw*15P
- HLA-DMB
- HLA-Cw3
- HLA
- HLA-A
- HLA-E
- HLA-G
- HLA-B35
- HLA-B*3512
- HLA-A*01
- DKFZp686N10220
- Cw*08
- HLA-F
- HLA-B*
- HLA-B41
- HLA-B*27
- HLA-Cw
- HLA-C
- MHC
- HLAC
- HLA-Bw62.5
- HLA-Bw62.4
- HLA-Bw62.3
- HLA-Bw62.1
- HLA-B57
- B-3501
- B-1510
- HLA-B*1513
- EA2.1
- HLA-B
- HLA-A*03
- HLA-B*35JAC
- B*35
- B*15
- HLA-B18
- HLA B
- HLA-Cw*02023
- HLA-B*3531
- EA1.2
- DKFZp686P19218
- HLA-CW
- HLA-Cw*03MAC
- HLA-B15
- HLA-B*58
- HLA-B*1522
Pseudogenes.org Pseudogenes for MICB Gene
Variants for MICB Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for MICB Gene
- MICB_HUMAN-Q29980
- The following alleles of MICB are known: MICB*001, MICB*002, MICB*003, MICB*004, MICB*005, MICB*006, MICB*007, MICB*008, MICB*009N, MICB*010, MICB*011, MICB*012, MICB*013, MICB*014, MICB*015, MICB*016, MICB*018, MICB*019, MICB*020, MICB*021N and MICB*022. MICB*009N and MICB*021N are null alleles which are not expressed. The three most common MICB alleles in the human population could be MICB*005, MICB*004, and MICB*002. The sequence shown is that of MICB*004.
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MICB Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs142597879 | Benign: not provided | 31,509,891(+) |
T/C NM_005931.5(MICB):c.1134T>C (p.Gly378=) |
SYNONYMOUS | |
| rs752426500 | Benign: not provided | 31,498,259(+) |
C/T NM_005931.5(MICB):c.66C>T (p.Ala22=) |
SYNONYMOUS_VARIANT,INTRON | |
| rs1051788 | -- |
p.Asp136Asnp.Asp136His |
|||
| rs1065075 | -- |
p.Lys80Glu |
|||
| rs1065076 | -- |
p.Thr383Ala |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10403n54 | CNV | loss | 21841781 |
| dgv10404n54 | CNV | loss | 21841781 |
| dgv10460n54 | CNV | gain | 21841781 |
| dgv213e55 | CNV | gain | 17911159 |
| dgv215e55 | CNV | loss | 17911159 |
| dgv5942n100 | CNV | loss | 25217958 |
| dgv5943n100 | CNV | gain+loss | 25217958 |
| dgv5944n100 | CNV | loss | 25217958 |
| dgv995e201 | CNV | deletion | 23290073 |
| esv2731822 | CNV | deletion | 23290073 |
| esv2759414 | CNV | gain+loss | 17122850 |
| esv3890821 | CNV | gain | 25118596 |
| nsv1015886 | CNV | loss | 25217958 |
| nsv1018960 | CNV | gain | 25217958 |
| nsv1021578 | CNV | gain | 25217958 |
| nsv1022499 | CNV | gain | 25217958 |
| nsv1025961 | CNV | loss | 25217958 |
| nsv1073969 | CNV | deletion | 25765185 |
| nsv10821 | CNV | loss | 18304495 |
| nsv1112900 | CNV | deletion | 24896259 |
| nsv1126749 | CNV | deletion | 24896259 |
| nsv462869 | CNV | loss | 19166990 |
| nsv517441 | CNV | gain+loss | 19592680 |
| nsv601940 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
71.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.90;
74.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MICB Gene
SNP Genotyping and Copy Number Assays for research
Disorders for MICB Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dengue shock syndrome |
|
|
| rheumatoid arthritis |
|
|
| asymptomatic dengue |
|
|
| behcet syndrome |
|
|
| celiac disease 1 |
|
|
Search MICB in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MICB_HUMAN- Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269 PubMed:17003176}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry. The MICB*004 allele is associated with rheumatoid arthritis.
- Note=Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk.
Additional Disease Information for MICB
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for MICB Gene
Publications for MICB Gene
- MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility. (PMID: 17003176) López-Arbesu R … González S (Rheumatology (Oxford, England) 2007) 3 4 22 40
- MICB0106 gene polymorphism is associated with ulcerative colitis in central China. (PMID: 19662431) Li Y … Zhang X (International journal of colorectal disease 2010) 3 22 40
- Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). (PMID: 19115949) Limou S … ANRS Genomic Group (The Journal of infectious diseases 2009) 3 22 40
- Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes. (PMID: 18332098) Field SF … Todd JA (Diabetes 2008) 3 22 40
- Associations of MICB with cervical cancer in north-eastern Thais: identification of major histocompatibility complex class I chain-related gene B motifs influencing natural killer cell activation. (PMID: 18505429) Jumnainsong A … Leelayuwat C (Clinical and experimental immunology 2008) 3 22 40
ExternalLinks
Products for MICB Gene
- View all 27 R&D Systems MICB (MICB) Products
- View all 2 R&D Systems MICB (MICB) Proteins and Enzymes
- View all 22 R&D Systems MICB (MICB) Primary Antibodies
- View all R&D Systems MICB (MICB) ELISAs
- View all R&D Systems MICB (MICB) Luminex Assays
- View all R&D Systems MICB (MICB) cDNA Clones
- Learn more about R&D Systems custom MICB antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for MICB
- Custom Assay ServicesOriGene ELISA Kits for MICB
- OriGene Purified Proteins for MICB
- Search Origene for MassSpec and Protein Over-expression Lysates for MICB
- Origene Custom Protein Services for MICB
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MICB
- Browse OriGene Inhibitory RNA Products For MICB
- OriGene qPCR primer pairs for MICB
- OriGene CRISPR knockouts for MICB
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For MICB
- Sino Biological Human cDNA Clone for MICB
- Sino Biological Recombinant Proteins for MICB
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- Sino Biological Antibodies for MICB
- Sino Biological Assays for MICB
- Browse Recombinant Proteins
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for MICB
- Novus Biologicals proteins and lysates for MICB
- Novus Biologicals ELISA Kits for MICB
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- VectorBuilder Custom and pre-made DNA vectors for MICB (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for MICB (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for MICB (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for MICB CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for MICB
- Addgene plasmids for MICB
- antibodies-online: Show 13 available MICB Antibodies ranked by validation data
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- antibodies-online: Show 22 available MICB Elisa Kits ranked by validation data
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- antibodies-online: Show 10 available MICB Proteins ranked by validation data
- Compare Top MICB Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for MICB
- Search Santa Cruz Biotechnology (SCBT) for MICB siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for MICB
- Custom Antibody ServicesProSci Antibodies for MICB
- Search for MICB Proteins at ProSci
- Horizon Cell Lines for MICB
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MICB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MICB
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MICB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MICB
- Biorbyt antibodies for MICB
Sources for MICB Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
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- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
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- (48) Leiden
- (49) miRBase
- (50) DME
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- (59) GenScript
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- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
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- (78) MaxQB
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- (92) GeneReviews
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- (96) ProteomicsDB
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- (102) diseasecard
- (103) NIH Rare Diseases
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