Aliases for MICALL2 Gene
GeneCards Summary for MICALL2 Gene
MICALL2 (MICAL Like 2) is a Protein Coding gene. Diseases associated with MICALL2 include Joubert Syndrome 1 and Retinitis Pigmentosa 44. Among its related pathways are Tight junction. Gene Ontology (GO) annotations related to this gene include actin filament binding and filamin binding. An important paralog of this gene is MICALL1.
UniProtKB/Swiss-Prot Summary for MICALL2 Gene
Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity).