Aliases for MICALCL Gene

Aliases for MICALCL Gene

  • MICAL C-Terminal Like 2 3
  • ERK2-Binding Testicular Protein 1 3 4
  • MICAL C-Terminal-Like Protein 3 4
  • Ebitein-1 3 4
  • Mical-CL 3 4
  • Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 2 5
  • Ebitein1 3
  • FLJ14966 2
  • MICAL2 5

External Ids for MICALCL Gene

Previous GeneCards Identifiers for MICALCL Gene

  • GC11P012272
  • GC11P011984
  • GC11P012298

Summaries for MICALCL Gene

GeneCards Summary for MICALCL Gene

MICALCL (MICAL C-Terminal Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include mitogen-activated protein kinase binding. An important paralog of this gene is MICAL3.

UniProtKB/Swiss-Prot Summary for MICALCL Gene

  • May cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic development of round spermatids to spermatozoa. May act as Rab effector protein and play a role in vesicle trafficking.

Additional gene information for MICALCL Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MICALCL Gene

Genomics for MICALCL Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MICALCL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J012094 Enhancer 1 ENCODE dbSUPER 600.7 +1.2 1227 1.4 LEF1 IKZF1 JUND MTA2 DPF2 HDAC1 ETV6 SOX6 TCF12 EP300 MICAL2 MICALCL ENSG00000255400 lnc-DKK3-10 PARVA
GH11J012093 Enhancer 0.2 dbSUPER 600.7 +0.2 219 0.5 MICAL2 MICALCL lnc-DKK3-5 ENSG00000255400 lnc-DKK3-10 PARVA
GH11J012231 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 21.5 +141.0 140962 7.1 CTCF JUND FOXA1 MTA2 RXRB REST RAD21 IRF2 IKZF2 TRIM22 MICALCL ENSG00000254680 MICAL2 NONHSAG007679.2 PARVA
GH11J012218 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 22.1 +128.1 128143 7.4 GATAD2A RCOR2 ZIC2 RXRB NR2C1 IRF2 SP1 PKNOX1 CEBPA POLR2A MICALCL MICAL2 ENSG00000254680 NONHSAG007679.2 PARVA
GH11J012155 Promoter/Enhancer 2.1 VISTA FANTOM5 Ensembl ENCODE dbSUPER 12.5 +80.0 79973 36.4 ARHGAP35 SP1 PRDM10 ZNF629 RFX1 LEF1 IKZF1 KDM1A ZNF692 BACH1 MICAL2 MICALCL MN309334 LOC107984312 MIR6124 PARVA
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MICALCL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MICALCL

Top Transcription factor binding sites by QIAGEN in the MICALCL gene promoter:
  • FOXL1
  • GR
  • GR-alpha
  • GR-beta
  • HSF2
  • NRSF form 1
  • NRSF form 2
  • RREB-1
  • SREBP-1a
  • SREBP-1b

Genomic Locations for MICALCL Gene

Genomic Locations for MICALCL Gene
chr11:12,094,008-12,362,140
(GRCh38/hg38)
Size:
268,133 bases
Orientation:
Plus strand
chr11:12,297,627-12,380,691
(GRCh37/hg19)
Size:
83,065 bases
Orientation:
Plus strand

Genomic View for MICALCL Gene

Genes around MICALCL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICALCL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICALCL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICALCL Gene

Proteins for MICALCL Gene

  • Protein details for MICALCL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZW33-MICLK_HUMAN
    Recommended name:
    MICAL C-terminal-like protein
    Protein Accession:
    Q6ZW33
    Secondary Accessions:
    • Q7RTP7
    • Q96JU6

    Protein attributes for MICALCL Gene

    Size:
    695 amino acids
    Molecular mass:
    77277 Da
    Quaternary structure:
    • Interacts with MAPK1/ERK2 (By similarity). Interacts with RAB1B, RAB35, RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); binding to RAB1B and RAB35 is of low affinity compared to other Rab proteins; at least in case of RAB8A may bind 2 molecules of RAB8A simultaneously through a high and a low affinity binding site, respectively.
    SequenceCaution:
    • Sequence=BAB55422.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MICALCL Gene

neXtProt entry for MICALCL Gene

Post-translational modifications for MICALCL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MICALCL Gene

Domains & Families for MICALCL Gene

Protein Domains for MICALCL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MICALCL Gene

GenScript: Design optimal peptide antigens:
  • Ebitein-1 (MICLK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZW33

UniProtKB/Swiss-Prot:

MICLK_HUMAN :
  • The C-terminal RAB-binding domain (RBD), also described as bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to predominantly Rab8, Rab10, Rab10, Rab13 and Rab15 (in their GTP-bound forms).
  • Belongs to the ebitein family.
Domain:
  • The C-terminal RAB-binding domain (RBD), also described as bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to predominantly Rab8, Rab10, Rab10, Rab13 and Rab15 (in their GTP-bound forms).
Family:
  • Belongs to the ebitein family.
genes like me logo Genes that share domains with MICALCL: view

No data available for Gene Families for MICALCL Gene

Function for MICALCL Gene

Molecular function for MICALCL Gene

UniProtKB/Swiss-Prot Function:
May cooperate with MAPK1/ERK2 via an intracellular signal transduction pathway in the morphogenetic development of round spermatids to spermatozoa. May act as Rab effector protein and play a role in vesicle trafficking.

Phenotypes From GWAS Catalog for MICALCL Gene

Gene Ontology (GO) - Molecular Function for MICALCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0004497 monooxygenase activity IEA --
GO:0005515 protein binding IEA --
GO:0016174 NAD(P)H oxidase activity IEA --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with MICALCL: view
genes like me logo Genes that share phenotypes with MICALCL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MICALCL

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MICALCL Gene

Localization for MICALCL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICALCL Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MICALCL gene
Compartment Confidence
cytoskeleton 3
nucleus 3
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MICALCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA,ISS --
GO:0005815 microtubule organizing center IBA 21873635
GO:0031941 filamentous actin IBA 21873635
genes like me logo Genes that share ontologies with MICALCL: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MICALCL Gene

Pathways & Interactions for MICALCL Gene

PathCards logo

SuperPathways for MICALCL Gene

No Data Available

Gene Ontology (GO) - Biological Process for MICALCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001947 heart looping ISS --
GO:0006887 exocytosis IEA --
GO:0007010 cytoskeleton organization IDA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with MICALCL: view

No data available for Pathways by source and SIGNOR curated interactions for MICALCL Gene

Drugs & Compounds for MICALCL Gene

No Compound Related Data Available

Transcripts for MICALCL Gene

mRNA/cDNA for MICALCL Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
36 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MICALCL

Alternative Splicing Database (ASD) splice patterns (SP) for MICALCL Gene

No ASD Table

Relevant External Links for MICALCL Gene

GeneLoc Exon Structure for
MICALCL

Expression for MICALCL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MICALCL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for MICALCL Gene

This gene is overexpressed in Testis (x12.3), Skin - Sun Exposed (Lower leg) (x8.0), and Skin - Not Sun Exposed (Suprapubic) (x7.9).

Protein differential expression in normal tissues from HIPED for MICALCL Gene

This gene is overexpressed in Plasma (58.5) and Adipocyte (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MICALCL Gene



Protein tissue co-expression partners for MICALCL Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MICALCL

SOURCE GeneReport for Unigene cluster for MICALCL Gene:

Hs.128196

Evidence on tissue expression from TISSUES for MICALCL Gene

  • Thyroid gland(4.1)
genes like me logo Genes that share expression patterns with MICALCL: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MICALCL Gene

Orthologs for MICALCL Gene

This gene was present in the common ancestor of animals.

Orthologs for MICALCL Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MICALCL 30
  • 98.94 (n)
MICAL2 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia MICAL2 31
  • 91 (a)
OneToOne
MICALCL 30
  • 80.88 (n)
Mouse
(Mus musculus)
Mammalia Mical2 31
  • 88 (a)
OneToOne
Micalcl 30 17
  • 74.26 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia MICAL2 31
  • 77 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Micalcl 30
  • 74.52 (n)
Dog
(Canis familiaris)
Mammalia MICAL2 31
  • 52 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MICAL2 31
  • 46 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MICAL2 31
  • 74 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MICAL2 31
  • 71 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii MICAL2 (3 of 3) 31
  • 63 (a)
OneToMany
mical2a 31
  • 62 (a)
OneToMany
mical2b 31
  • 39 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Mical 31
  • 9 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 49 (a)
OneToMany
Species where no ortholog for MICALCL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MICALCL Gene

ENSEMBL:
Gene Tree for MICALCL (if available)
TreeFam:
Gene Tree for MICALCL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MICALCL: view image

Paralogs for MICALCL Gene

(1) SIMAP similar genes for MICALCL Gene using alignment to 2 proteins:

  • MICLK_HUMAN
  • E9PRG5_HUMAN
genes like me logo Genes that share paralogs with MICALCL: view

Variants for MICALCL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MICALCL Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs10741578 - p.Val70Ile
rs12574273 - p.Tyr93Ser
rs1493953 - p.Ala305Thr
rs1493954 - p.Ser313Gly
rs3812753 - p.Asp369Glu

Additional dbSNP identifiers (rs#s) for MICALCL Gene

Structural Variations from Database of Genomic Variants (DGV) for MICALCL Gene

Variant ID Type Subtype PubMed ID
dgv1059n100 CNV gain 25217958
esv2744117 CNV deletion 23290073
esv275255 CNV loss 21479260
esv3350761 CNV insertion 20981092
esv3579370 CNV loss 25503493
esv3625390 CNV gain 21293372
esv3625391 CNV gain 21293372
nsv1039617 CNV loss 25217958
nsv483000 CNV loss 15286789
nsv522844 CNV loss 19592680
nsv527449 CNV gain 19592680
nsv553547 CNV loss 21841781

Variation tolerance for MICALCL Gene

Residual Variation Intolerance Score: 97.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.88; 74.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MICALCL Gene

Human Gene Mutation Database (HGMD)
MICALCL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MICALCL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MICALCL Gene

Disorders for MICALCL Gene

Additional Disease Information for MICALCL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MICALCL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MICALCL Gene

Publications for MICALCL Gene

  1. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PMID: 12110185) Terman JR … Kolodkin AL (Cell 2002) 2 3 4
  2. bMERB domains are bivalent Rab8 family effectors evolved by gene duplication. (PMID: 27552051) Rai A … Müller MP (eLife 2016) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. (PMID: 30639242) Kovalski JR … Khavari PA (Molecular cell 2019) 3

Products for MICALCL Gene

Sources for MICALCL Gene