Aliases for MICAL2 Gene
External Ids for MICAL2 Gene
Previous GeneCards Identifiers for MICAL2 Gene
The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis. [provided by RefSeq, Oct 2016]
GeneCards Summary for MICAL2 Gene
MICAL2 (Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin binding and flavin adenine dinucleotide binding. An important paralog of this gene is MICAL3.
UniProtKB/Swiss-Prot for MICAL2 Gene
Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334).