Aliases for MICAL2 Gene
External Ids for MICAL2 Gene
Previous GeneCards Identifiers for MICAL2 Gene
The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis. [provided by RefSeq, Oct 2016]
GeneCards Summary for MICAL2 Gene
MICAL2 (Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 2) is a Protein Coding gene. Diseases associated with MICAL2 include Fraser Syndrome 1. Gene Ontology (GO) annotations related to this gene include actin binding and flavin adenine dinucleotide binding. An important paralog of this gene is MICAL3.
UniProtKB/Swiss-Prot Summary for MICAL2 Gene
Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334).