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Aliases for MICAL2 Gene

Aliases for MICAL2 Gene

  • Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 2 2 3 5
  • Molecule Interacting With CasL Protein 2 3 4
  • MICAL2PV1 3 4
  • MICAL2PV2 3 4
  • MICAL-2 3 4
  • Microtubule Associated Monoxygenase, Calponin And LIM Domain Containing 2 3
  • [F-Actin]-Methionine Sulfoxide Oxidase MICAL2 3
  • Protein-Methionine Sulfoxide Oxidase MICAL2 3
  • Flavoprotein Oxidoreductase MICAL2 3
  • [F-Actin]-Monooxygenase MICAL2 3
  • EC 1.14.13.225 4
  • KIAA0750 4

External Ids for MICAL2 Gene

Previous GeneCards Identifiers for MICAL2 Gene

  • GC11P012154
  • GC11P012096
  • GC11P012088
  • GC11P011808

Summaries for MICAL2 Gene

Entrez Gene Summary for MICAL2 Gene

  • The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis. [provided by RefSeq, Oct 2016]

GeneCards Summary for MICAL2 Gene

MICAL2 (Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin binding and flavin adenine dinucleotide binding. An important paralog of this gene is MICAL3.

UniProtKB/Swiss-Prot for MICAL2 Gene

  • Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

Gene Wiki entry for MICAL2 Gene

Additional gene information for MICAL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICAL2 Gene

Genomics for MICAL2 Gene

GeneHancer (GH) Regulatory Elements for MICAL2 Gene

Promoters and enhancers for MICAL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I012109 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 554.2 +18.4 18369 6.7 HDGF CLOCK ARNT ARID4B SIN3A ZNF766 FOS ZNF263 SP3 NFYC MICAL2 MIR6124
GH11I012155 Promoter/Enhancer 2.5 VISTA EPDnew FANTOM5 Ensembl ENCODE dbSUPER 568.1 +79.5 79460 35.4 HDGF PKNOX1 ARNT YBX1 FEZF1 IRF4 YY1 POLR2B ZNF766 ZNF207 MICAL2 MICALCL MIR6124 GC11P012216
GH11I012133 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE dbSUPER 561.4 +40.1 40055 1.5 ESRRA MICAL2 MIR6124
GH11I012094 Enhancer 1 ENCODE dbSUPER 550.8 +1.2 1227 1.4 HDGF HDAC1 TCF12 GATA2 ETV6 ZEB2 ZNF592 NFIC KLF16 SMARCA4 MICAL2 ENSG00000255400 MIR6124
GH11I012093 Enhancer 0.2 dbSUPER 550.8 +0.2 219 0.5 MICAL2 ENSG00000255400 MIR6124
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MICAL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MICAL2 gene promoter:

Genomic Locations for MICAL2 Gene

Genomic Locations for MICAL2 Gene
chr11:12,094,008-12,281,016
(GRCh38/hg38)
Size:
187,009 bases
Orientation:
Plus strand
chr11:12,115,543-12,285,334
(GRCh37/hg19)

Genomic View for MICAL2 Gene

Genes around MICAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICAL2 Gene

Proteins for MICAL2 Gene

  • Protein details for MICAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94851-MICA2_HUMAN
    Recommended name:
    [F-actin]-monooxygenase MICAL2
    Protein Accession:
    O94851
    Secondary Accessions:
    • B4DGZ0
    • B7Z849
    • D3DQW5
    • G3XAC8
    • Q5KTR3
    • Q5KTR4
    • Q7Z3A8

    Protein attributes for MICAL2 Gene

    Size:
    1124 amino acids
    Molecular mass:
    126689 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Interacts with VIM and PLXNA4 (By similarity). Interacts with RAB1B.
    SequenceCaution:
    • Sequence=BAA34470.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MICAL2 Gene

    Alternative splice isoforms for MICAL2 Gene

neXtProt entry for MICAL2 Gene

Post-translational modifications for MICAL2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MICAL2 Gene

Domains & Families for MICAL2 Gene

Gene Families for MICAL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for MICAL2 Gene

Graphical View of Domain Structure for InterPro Entry

O94851

UniProtKB/Swiss-Prot:

MICA2_HUMAN :
  • Belongs to the Mical family.
Family:
  • Belongs to the Mical family.
genes like me logo Genes that share domains with MICAL2: view

Function for MICAL2 Gene

Molecular function for MICAL2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[F-actin]-L-methionine + NADPH + O(2) + H(+) = [F-actin]-L-methionine-(R)-S-oxide + NADP(+) + H(2)O.
UniProtKB/Swiss-Prot EnzymeRegulation:
Specifically inhibited by CCG-1423, a small molecule inhibitor of SRF:MKL1/MRTF-A-dependent transcription.
UniProtKB/Swiss-Prot Function:
Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

Enzyme Numbers (IUBMB) for MICAL2 Gene

Phenotypes From GWAS Catalog for MICAL2 Gene

Gene Ontology (GO) - Molecular Function for MICAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding ISS --
GO:0004497 monooxygenase activity IEA --
GO:0016491 oxidoreductase activity IDA,IEA 24440334
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISS --
GO:0043914 NADPH:sulfur oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with MICAL2: view
genes like me logo Genes that share phenotypes with MICAL2: view

Animal Model Products

miRNA for MICAL2 Gene

miRTarBase miRNAs that target MICAL2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MICAL2 Gene

Localization for MICAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICAL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MICAL2 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MICAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 24440334
genes like me logo Genes that share ontologies with MICAL2: view

Pathways & Interactions for MICAL2 Gene

SuperPathways for MICAL2 Gene

No Data Available

Interacting Proteins for MICAL2 Gene

Gene Ontology (GO) - Biological Process for MICAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001947 heart looping ISS --
GO:0007010 cytoskeleton organization IDA 24440334
GO:0007507 heart development ISS --
GO:0010735 positive regulation of transcription via serum response element binding IMP 24440334
GO:0019417 sulfur oxidation ISS --
genes like me logo Genes that share ontologies with MICAL2: view

No data available for Pathways by source and SIGNOR curated interactions for MICAL2 Gene

Drugs & Compounds for MICAL2 Gene

(3) Drugs for MICAL2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
Oxygen Approved, Vet_approved Pharma 0
Water Approved Pharma 0

(2) Additional Compounds for MICAL2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
NADP
  • Adenine-nicotinamide dinucleotide phosphate
  • b-NADP
  • b-Nicotinamide adenine dinucleotide phosphate
  • b-TPN
  • beta-NADP
53-59-8
nadph
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide
  • 2'-(Dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosylnicotinamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-D-ribofuranosyl-3-pyridinecarboxamide
  • Adenosine 5'-(trihydrogen diphosphate) 2'-(dihydrogen phosphate) P'-5'-ester with 1,4-dihydro-1-beta-delta-ribofuranosyl-3-pyridinecarboxamide
  • b-NADPH
53-57-6
genes like me logo Genes that share compounds with MICAL2: view

Transcripts for MICAL2 Gene

Unigene Clusters for MICAL2 Gene

Microtubule associated monoxygenase, calponin and LIM domain containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MICAL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8: - - - -
SP9:
SP10:
SP11: - -
SP12: - - -
SP13: - -
SP14: - - - - -
SP15: - -
SP16:

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b · 32c ^ 33 ^ 34a · 34b ^ 35a · 35b · 35c ^
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for MICAL2 Gene

GeneLoc Exon Structure for
MICAL2
ECgene alternative splicing isoforms for
MICAL2

Expression for MICAL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MICAL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MICAL2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x8.0) and Brain - Cerebellum (x7.6).

Protein differential expression in normal tissues from HIPED for MICAL2 Gene

This gene is overexpressed in Breast (64.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MICAL2 Gene



NURSA nuclear receptor signaling pathways regulating expression of MICAL2 Gene:

MICAL2

SOURCE GeneReport for Unigene cluster for MICAL2 Gene:

Hs.501928

Evidence on tissue expression from TISSUES for MICAL2 Gene

  • Nervous system(4.9)
  • Intestine(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with MICAL2: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MICAL2 Gene

Orthologs for MICAL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MICAL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MICAL2 33 34
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia MICAL2 33 34
  • 90.46 (n)
cow
(Bos Taurus)
Mammalia MICAL2 33 34
  • 89.54 (n)
mouse
(Mus musculus)
Mammalia Mical2 33 16 34
  • 86.47 (n)
rat
(Rattus norvegicus)
Mammalia Mical2 33
  • 85.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MICAL2 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MICAL2 34
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves MICAL2 33 34
  • 71.06 (n)
lizard
(Anolis carolinensis)
Reptilia MICAL2 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487018 33
  • 66.94 (n)
zebrafish
(Danio rerio)
Actinopterygii mical2b 33 34
  • 68.27 (n)
MICAL2 (3 of 3) 34
  • 63 (a)
OneToMany
mical2a 34
  • 62 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6941 33
fruit fly
(Drosophila melanogaster)
Insecta Mical 34
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1958 33
Species where no ortholog for MICAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MICAL2 Gene

ENSEMBL:
Gene Tree for MICAL2 (if available)
TreeFam:
Gene Tree for MICAL2 (if available)

Paralogs for MICAL2 Gene

(3) SIMAP similar genes for MICAL2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MICAL2: view

Variants for MICAL2 Gene

Sequence variations from dbSNP and Humsavar for MICAL2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs869025227 uncertain-significance, Ductal breast carcinoma 12,256,960(+) A/G coding_sequence_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant
rs1000000236 -- 12,217,952(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000060239 -- 12,224,001(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000066639 -- 12,160,045(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000070024 -- 12,190,658(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MICAL2 Gene

Variant ID Type Subtype PubMed ID
nsv832068 CNV gain 17160897
nsv553546 CNV loss 21841781
nsv553545 CNV loss 21841781
nsv515573 CNV loss 19592680
nsv483000 CNV loss 15286789
nsv472704 CNV novel sequence insertion 20440878
nsv467708 CNV loss 19166990
nsv1151675 CNV deletion 26484159
nsv1076415 CNV deletion 25765185
nsv1049089 CNV loss 25217958
nsv1044963 CNV loss 25217958
esv5666 CNV loss 19470904
esv4083 CNV loss 18987735
esv3625389 CNV loss 21293372
esv3547333 CNV deletion 23714750
esv2744116 CNV deletion 23290073
esv2744115 CNV deletion 23290073
esv2664585 CNV deletion 23128226
esv2252219 CNV deletion 18987734
dgv588n106 CNV deletion 24896259
dgv1059n100 CNV gain 25217958

Variation tolerance for MICAL2 Gene

Residual Variation Intolerance Score: 76.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.95; 68.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MICAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MICAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MICAL2 Gene

Disorders for MICAL2 Gene

Additional Disease Information for MICAL2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MICAL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MICAL2 Gene

Publications for MICAL2 Gene

  1. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. (PMID: 12110185) Terman JR … Kolodkin AL (Cell 2002) 2 3 4 58
  2. Redox modification of nuclear actin by MICAL-2 regulates SRF signaling. (PMID: 24440334) Lundquist MR … Jaffrey SR (Cell 2014) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression. (PMID: 16675569) Ashida S … Nakagawa H (Clinical cancer research : an official journal of the American Association for Cancer Research 2006) 3 4 58
  5. The MICAL proteins and rab1: a possible link to the cytoskeleton? (PMID: 15694364) Fischer J … Barnekow A (Biochemical and biophysical research communications 2005) 3 4 58

Products for MICAL2 Gene

Sources for MICAL2 Gene

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