Aliases for MICAL1 Gene
External Ids for MICAL1 Gene
Previous HGNC Symbols for MICAL1 Gene
Previous GeneCards Identifiers for MICAL1 Gene
This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
GeneCards Summary for MICAL1 Gene
MICAL1 (Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 1) is a Protein Coding gene. Diseases associated with MICAL1 include Anthracosilicosis and Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 2. Among its related pathways are Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include actin binding and Rab GTPase binding. An important paralog of this gene is MICAL3.
UniProtKB/Swiss-Prot for MICAL1 Gene
Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (PubMed:21864500, PubMed:26845023). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking.