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Aliases for MICA Gene

Aliases for MICA Gene

  • MHC Class I Polypeptide-Related Sequence A 2 3 3 5
  • PERB11.1 3 4
  • MIC-A 3 4
  • Truncated MHC Class I Polypeptide-Related Sequence A 3
  • MHC Class I Chain-Related Protein A 3
  • Stress Inducible Class I Homolog 3
  • MHC Class I Related Sequence A 3
  • MHC Class I Related Chain A 3
  • HLA Class I Antigen 3

External Ids for MICA Gene

Previous GeneCards Identifiers for MICA Gene

  • GC06P031425
  • GC06P031140
  • GC06P031471
  • GC06P031475
  • GC06P031479
  • GC06Pf31500
  • GC06Pc31510
  • GC06P031371
  • GC06P031370
  • GC06P031373

Summaries for MICA Gene

Entrez Gene Summary for MICA Gene

  • This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for MICA Gene

MICA (MHC Class I Polypeptide-Related Sequence A) is a Protein Coding gene. Diseases associated with MICA include Spondylitis and Psoriatic Arthritis. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Innate Immune System. Gene Ontology (GO) annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is MICB.

UniProtKB/Swiss-Prot for MICA Gene

  • Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.

Additional gene information for MICA Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MICA Gene

Genomics for MICA Gene

GeneHancer (GH) Regulatory Elements for MICA Gene

Promoters and enhancers for MICA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J031398 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 679.4 +2.1 2128 5.8 MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC MEF2D MICA ENSG00000199332 GC06M031411 HCP5 MICA-AS1 DDX39B DHX16 SKIV2L MICB ATF6B
GH06J031538 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 63.6 +141.4 141355 4.9 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 DDX39B DDX39B-AS1 GC06M031542 GC06M031543 GC06M031550 GC06M031555 GC06M031573 GC06M032007 GC06M032013 GC06M032015
GH06J031733 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 48.1 +337.7 337671 8.5 CLOCK MLX ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 MSH5 CLIC1 MSH5-SAPCD1 DDX39B LY6G5B ATF6B LSM2 SKIV2L CSNK2B GPANK1
GH06J031545 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 53.1 +147.7 147748 3.2 CLOCK MLX YBX1 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 NFKBIL1 ATP6V1G2-DDX39B ATP6V1G2 DDX39B ATF6B LY6G5B LSM2 DHX16 MDC1 PPP1R10
GH06J030611 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 42 -784.2 -784232 8.7 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PPP1R10 MRPS18B MDC1 DDX39B TRIM39 NRM DHX16 ZNRD1 ABCF1 TRIM26
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MICA on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MICA gene promoter:
  • AP-1
  • Sp1
  • ATF-2
  • c-Jun
  • c-Fos

Genomic Locations for MICA Gene

Genomic Locations for MICA Gene
chr6:31,399,784-31,415,315
(GRCh38/hg38)
Size:
15,532 bases
Orientation:
Plus strand
chr6:31,367,561-31,383,092
(GRCh37/hg19)
Size:
15,532 bases
Orientation:
Plus strand

Genomic View for MICA Gene

Genes around MICA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MICA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MICA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MICA Gene

Proteins for MICA Gene

  • Protein details for MICA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q29983-MICA_HUMAN
    Recommended name:
    MHC class I polypeptide-related sequence A
    Protein Accession:
    Q29983
    Secondary Accessions:
    • A8KQR0
    • A9LRW5
    • A9QVE0
    • B1VJF1
    • O60917
    • O60918
    • O60919
    • O60920
    • O60933
    • O77956
    • O78150
    • O78151
    • O78152
    • O78153
    • O97987
    • O97988
    • O97989
    • O97990
    • O97991
    • O97992
    • O97993
    • O97994
    • O97995
    • O98234
    • O98235
    • O98236
    • O98237
    • O98238
    • P79506
    • P79507
    • P79508
    • P79509
    • P79510
    • P79511
    • P79512
    • P79513
    • P79514
    • P79515
    • P79516
    • P79517
    • P79518
    • P79519
    • P79520
    • P79521
    • Q5C9P8
    • Q5XM81
    • Q70I48
    • Q70I49
    • Q7JFH9
    • Q7JFI0
    • Q7JFI1
    • Q7JFI2
    • Q7YQ98
    • Q861I1
    • Q95464
    • Q95HA2
    • Q95HD6
    • Q95HN4
    • Q95HN5
    • Q95HN6
    • Q95IB2
    • Q95IY7
    • Q99692
    • Q9BCR3
    • Q9BCR4
    • Q9BCR5
    • Q9BCR6
    • Q9BCR7
    • Q9BCR8
    • Q9BCR9
    • Q9BCS0
    • Q9BCS1
    • Q9BCS2
    • Q9BCS3
    • Q9BCS4
    • Q9BD20
    • Q9GIZ1
    • Q9GIZ2
    • Q9GIZ3
    • Q9GIZ4
    • Q9GIZ5
    • Q9GIZ6
    • Q9GJ01
    • Q9GJ02
    • Q9GJ03
    • Q9GJ04
    • Q9GJ05
    • Q9GJ06
    • Q9GJ07
    • Q9GJ08
    • Q9GJ09
    • Q9MY21
    • Q9TQ86
    • Q9TQ87
    • Q9TQ88
    • Q9TQ89
    • Q9TQ92
    • Q9TQ93
    • Q9TQ94
    • Q9TQ95
    • Q9TQ96
    • Q9TQ97
    • Q9TQ98
    • Q9TQ99
    • Q9TQA0
    • Q9TQA1
    • Q9TQA2
    • Q9TQA3
    • Q9TQA4
    • Q9TQI9
    • Q9TQJ0
    • Q9TQJ1
    • Q9TQJ9
    • Q9TQK0
    • Q9TQK1
    • Q9TQK2
    • Q9TQK8
    • Q9TQK9
    • Q9TQL0
    • Q9TQL1
    • Q9TQL2
    • Q9TQL3
    • Q9TQL4
    • Q9UE04
    • Q9UE05
    • Q9UE06
    • Q9UE11

    Protein attributes for MICA Gene

    Size:
    383 amino acids
    Molecular mass:
    42915 Da
    Quaternary structure:
    • Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICA while HCST acts as an adapter molecule which enables signal transduction. Interacts with PDIA6 on the surface of tumor cells, leading to disulfide bond reduction which is required for release of MICA from tumor cells. Interacts with human cytomegalovirus/HHV-5 protein UL142.
    Miscellaneous:
    • Recognized by antibodies in the sera of some organ transplant recipients and may be a target molecule in allograft rejection.

    Three dimensional structures from OCA and Proteopedia for MICA Gene

    Alternative splice isoforms for MICA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MICA Gene

Post-translational modifications for MICA Gene

  • N-glycosylated. Glycosylation is not essential for interaction with KLRK1/NKG2D but enhances complex formation.
  • Proteolytically cleaved and released from the cell surface of tumor cells which impairs KLRK1/NKG2D expression and T-cell activation.
  • Glycosylation at posLast=261261, isoforms=2220, posLast=210210, isoforms=125, posLast=7979, and isoforms=231
  • Modification sites at PhosphoSitePlus

Other Protein References for MICA Gene

No data available for DME Specific Peptides for MICA Gene

Domains & Families for MICA Gene

Gene Families for MICA Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

Q29983

UniProtKB/Swiss-Prot:

MICA_HUMAN :
  • Belongs to the MHC class I family. MIC subfamily.
Family:
  • Belongs to the MHC class I family. MIC subfamily.
genes like me logo Genes that share domains with MICA: view

Function for MICA Gene

Molecular function for MICA Gene

UniProtKB/Swiss-Prot Function:
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
UniProtKB/Swiss-Prot Induction:
By heat shock, by infection with human cytomegalovirus (HCMV), human adenovirus 5, M.tuberculosis and diarrheagenic E.coli, and by exposure to DNA damaging conditions such as high doses of ionizing radiation, chromatin-modifying treatments and inhibitors of DNA replication. The HCMV UL142 protein causes down-regulation of the full-length protein but not of the truncated MICA*008 allele.
GENATLAS Biochemistry:
MHC class I,chain-related gene A,43kDa,preferentially expressed in fibroblast and epithelial cell,with a repeat polymorphism in TM region possibly associated with Behcet disease,not involved in ankylosing spondylitis

Phenotypes From GWAS Catalog for MICA Gene

Gene Ontology (GO) - Molecular Function for MICA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11323699
GO:0030881 NOT beta-2-microglobulin binding IDA 8901601
GO:0046703 natural killer cell lectin-like receptor binding IPI 10426993
genes like me logo Genes that share ontologies with MICA: view
genes like me logo Genes that share phenotypes with MICA: view

Animal Model Products

miRNA for MICA Gene

miRTarBase miRNAs that target MICA

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MICA Gene

Localization for MICA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MICA Gene

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes retention in the endoplasmic reticulum. {ECO:0000269 PubMed:10363723, ECO:0000269 PubMed:18287244, ECO:0000269 PubMed:8901601}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MICA gene
Compartment Confidence
plasma membrane 3
extracellular 2
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MICA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18676862
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 18676862
GO:0009986 cell surface IDA 8901601
genes like me logo Genes that share ontologies with MICA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MICA Gene

Pathways & Interactions for MICA Gene

genes like me logo Genes that share pathways with MICA: view

Interacting Proteins for MICA Gene

Selected Interacting proteins: Q29983-MICA_HUMAN for MICA Gene via UniProtKB IID MINT

Symbol External ID(s) Details
HLA-B
HLA-A
HLA-C
LGALS3
KLRK1

Gene Ontology (GO) - Biological Process for MICA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001913 T cell mediated cytotoxicity IDA 10426993
GO:0002418 immune response to tumor cell IDA 10359807
GO:0006974 cellular response to DNA damage stimulus IDA 15995699
GO:0009408 response to heat IDA 8901601
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with MICA: view

No data available for SIGNOR curated interactions for MICA Gene

Drugs & Compounds for MICA Gene

No Compound Related Data Available

Transcripts for MICA Gene

mRNA/cDNA for MICA Gene

(5) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MICA Gene

MHC class I polypeptide-related sequence A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MICA Gene

No ASD Table

Relevant External Links for MICA Gene

GeneLoc Exon Structure for
MICA
ECgene alternative splicing isoforms for
MICA

Expression for MICA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MICA Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MICA Gene



NURSA nuclear receptor signaling pathways regulating expression of MICA Gene:

MICA

SOURCE GeneReport for Unigene cluster for MICA Gene:

Hs.130838

mRNA Expression by UniProt/SwissProt for MICA Gene:

Q29983-MICA_HUMAN
Tissue specificity: Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassals corpuscles within the medulla of normal thymus. In skin, expressed mainly in the keratin layers, basal cells, ducts and follicles. Also expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In thyomas, overexpressed in cortical and medullar epithelial cells. Tumors expressing MICA display increased levels of gamma delta T-cells.

Evidence on tissue expression from TISSUES for MICA Gene

  • Blood(2.7)
genes like me logo Genes that share expression patterns with MICA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MICA Gene

Orthologs for MICA Gene

This gene was present in the common ancestor of chordates.

Orthologs for MICA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MICB 34
  • 73 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 34
  • 37 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MILL-LIKE 34
  • 26 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mill1 34
  • 26 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 18 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 34
  • 28 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 22 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-147g22.4 34
  • 23 (a)
ManyToMany
si:ch211-147g22.1 34
  • 20 (a)
ManyToMany
mhc1zca 34
  • 20 (a)
ManyToMany
mhc1zea 34
  • 20 (a)
ManyToMany
BX572619.3 34
  • 20 (a)
ManyToMany
mhc1uba 34
  • 20 (a)
ManyToMany
CR339041.1 34
  • 19 (a)
ManyToMany
si:dkey-52p2.7 34
  • 19 (a)
ManyToMany
mhc1uca 34
  • 19 (a)
ManyToMany
BX572619.1 34
  • 18 (a)
ManyToMany
CU571323.1 34
  • 18 (a)
ManyToMany
si:dkey-52p2.6 34
  • 18 (a)
ManyToMany
BX572619.2 34
  • 18 (a)
ManyToMany
si:ch211-147g22.3 34
  • 18 (a)
ManyToMany
mhc1zfa 34
  • 18 (a)
ManyToMany
BX682558.1 34
  • 18 (a)
ManyToMany
DARE-ZE*0601 34
  • 17 (a)
ManyToMany
CABZ01031753.1 34
  • 17 (a)
ManyToMany
mhc1zba 34
  • 17 (a)
ManyToMany
mhc1zaa 34 34
  • 17 (a)
ManyToMany
si:ch211-147g22.2 34
  • 17 (a)
ManyToMany
arpc1a 34
  • 16 (a)
ManyToMany
si:dkey-52p2.4 34
  • 16 (a)
ManyToMany
CR339041.2 34
  • 16 (a)
ManyToMany
CABZ01031754.1 34
  • 15 (a)
ManyToMany
zgc:113060 34
  • 15 (a)
ManyToMany
Species where no ortholog for MICA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli