Aliases for MICA Gene
External Ids for MICA Gene
Previous GeneCards Identifiers for MICA Gene
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for MICA Gene
MICA (MHC Class I Polypeptide-Related Sequence A) is a Protein Coding gene. Diseases associated with MICA include Spondylitis and Psoriatic Arthritis. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Allograft rejection. Gene Ontology (GO) annotations related to this gene include antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is MICB.
UniProtKB/Swiss-Prot Summary for MICA Gene
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.