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Aliases for MIB2 Gene

Aliases for MIB2 Gene

  • Mindbomb E3 Ubiquitin Protein Ligase 2 2 3 5
  • Zinc Finger ZZ Type With Ankyrin Repeat Domain Protein 1 3 4
  • Zinc Finger, ZZ Type With Ankyrin Repeat Domain 1 2 3
  • Putative NF-Kappa-B-Activating Protein 002N 3 4
  • RING-Type E3 Ubiquitin Transferase MIB2 3 4
  • Novel Zinc Finger Protein 3 4
  • Mind Bomb Homolog 2 3 4
  • Skeletrophin 3 4
  • Novelzin 3 4
  • ZZANK1 3 4
  • E3 Ubiquitin-Protein Ligase MIB2 3
  • Mindbomb Homolog 2 (Drosophila) 2
  • Mindbomb Homolog 2 3
  • EC 56
  • EC 4
  • EC 6.3.2 56
  • ZZZ5 3
  • SKD 4

External Ids for MIB2 Gene

Previous HGNC Symbols for MIB2 Gene

  • ZZANK1

Previous GeneCards Identifiers for MIB2 Gene

  • GC01P9N0043
  • GC01P001540
  • GC01P000824
  • GC01P001550

Summaries for MIB2 Gene

Entrez Gene Summary for MIB2 Gene

  • The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion. [provided by RefSeq, Mar 2017]

GeneCards Summary for MIB2 Gene

MIB2 (Mindbomb E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Diseases associated with MIB2 include Gastritis, Familial Giant Hypertrophic and Left Ventricular Noncompaction. Among its related pathways are Signaling by NOTCH1 and Innate Immune System. Gene Ontology (GO) annotations related to this gene include actin binding and ubiquitin-protein transferase activity. An important paralog of this gene is MIB1.

UniProtKB/Swiss-Prot for MIB2 Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.

Gene Wiki entry for MIB2 Gene

Additional gene information for MIB2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIB2 Gene

Genomics for MIB2 Gene

GeneHancer (GH) Regulatory Elements for MIB2 Gene

Promoters and enhancers for MIB2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I001613 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.4 433 3.9 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 YBX1 ZNF2 SLC30A9 POLR2B ENSG00000272106 MIB2 GC01M001652 SLC35E2B ATAD3B PUSL1 LOC100129381 SLC35E2 GC01P001590
GH01I001624 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 17.3 +16.7 16689 14.4 HDGF PKNOX1 SREBF2 KLF17 SIN3A KLF5 ZNF335 GLIS2 ZNF207 ZNF143 MMP23B SLC35E2B SLC35E2 LOC100288379 MIB2 LOC100129381 MORN1 LOC105378580 FAAP20 ATAD3B
GH01I002411 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 11.2 +799.5 799456 5.8 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 POLR2B E2F8 ZNF207 ZNF143 PLCH2 PEX10 MORN1 LOC100129381 LOC100129534 SLC35E2 FAAP20 MIB2 ATAD3B SLC35E2B
GH01I002226 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 +616.4 616369 9.9 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SKI SLC35E2 ENSG00000272455 LOC100129381 ENSG00000234396 MORN1 FAAP20 ATAD3B INTS11 LOC100129534
GH01I000998 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.2 -614.5 -614486 3.8 CLOCK MLX FEZF1 DMAP1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ISG15 HES4 ATAD3B ENSG00000230092 WASH7P INTS11 ENSG00000272512 LINC01786 CCNL2 ENSG00000272455
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIB2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MIB2 gene promoter:

Genomic Locations for MIB2 Gene

Genomic Locations for MIB2 Gene
15,636 bases
Plus strand

Genomic View for MIB2 Gene

Genes around MIB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIB2 Gene

Proteins for MIB2 Gene

  • Protein details for MIB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase MIB2
    Protein Accession:
    Secondary Accessions:
    • A2AGM5
    • A2AGM6
    • B3KV93
    • B3KVF4
    • B3KXY1
    • B4DZ57
    • E9PGU1
    • E9PHQ1
    • F8WA73
    • J3KNZ7
    • Q7Z437
    • Q8IY62
    • Q8N786
    • Q8N897
    • Q8N8R2
    • Q8N911
    • Q8NB36
    • Q8NCY1
    • Q8NG59
    • Q8NG60
    • Q8NG61
    • Q8NI59
    • Q8WYN1

    Protein attributes for MIB2 Gene

    1013 amino acids
    Molecular mass:
    109939 Da
    Quaternary structure:
    • Interacts with actin monomer.
    • Sequence=AAH16490.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB82979.1; Type=Frameshift; Positions=193, 205; Evidence={ECO:0000305}; Sequence=BAC03707.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04646.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04752.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04952.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MIB2 Gene

neXtProt entry for MIB2 Gene

Selected DME Specific Peptides for MIB2 Gene


Post-translational modifications for MIB2 Gene

  • Ubiquitinated. Possibly via autoubiquitination (By similarity).
  • Ubiquitination at posLast=427427 and posLast=842842

Domains & Families for MIB2 Gene

Gene Families for MIB2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIB2: view

No data available for UniProtKB/Swiss-Prot for MIB2 Gene

Function for MIB2 Gene

Molecular function for MIB2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.
UniProtKB/Swiss-Prot Induction:
Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene.

Enzyme Numbers (IUBMB) for MIB2 Gene

Phenotypes From GWAS Catalog for MIB2 Gene

Gene Ontology (GO) - Molecular Function for MIB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0004842 ubiquitin-protein transferase activity TAS,IEA --
GO:0004871 signal transducer activity IMP,HMP 12761501
GO:0005515 protein binding IPI 21903422
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MIB2: view
genes like me logo Genes that share phenotypes with MIB2: view

Animal Models for MIB2 Gene

MGI Knock Outs for MIB2:

Animal Model Products

CRISPR Products

Clone Products

  • Addgene plasmids for MIB2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MIB2 Gene

Localization for MIB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIB2 Gene

Cytoplasm. Endosome. Note=Colocalizes with endosomal compartments.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIB2 gene
Compartment Confidence
cytosol 5
endosome 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MIB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
GO:0005737 cytoplasm IBA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MIB2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MIB2 Gene

Pathways & Interactions for MIB2 Gene

genes like me logo Genes that share pathways with MIB2: view

UniProtKB/Swiss-Prot Q96AX9-MIB2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for MIB2 Gene


Gene Ontology (GO) - Biological Process for MIB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0007219 Notch signaling pathway IEA --
GO:0016567 protein ubiquitination IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling HMP,IMP 12761501
genes like me logo Genes that share ontologies with MIB2: view

Drugs & Compounds for MIB2 Gene

No Compound Related Data Available

Transcripts for MIB2 Gene

Unigene Clusters for MIB2 Gene

Mindbomb E3 ubiquitin protein ligase 2:
Representative Sequences:

CRISPR Products

Clone Products

  • Addgene plasmids for MIB2

Alternative Splicing Database (ASD) splice patterns (SP) for MIB2 Gene

No ASD Table

Relevant External Links for MIB2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIB2 Gene

Protein differential expression in normal tissues from HIPED for MIB2 Gene

This gene is overexpressed in Pancreas (24.2), Bone (18.2), Heart (10.8), and Liver, secretome (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MIB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIB2 Gene:


SOURCE GeneReport for Unigene cluster for MIB2 Gene:


mRNA Expression by UniProt/SwissProt for MIB2 Gene:

Tissue specificity: Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.

Evidence on tissue expression from TISSUES for MIB2 Gene

  • Nervous system(4.7)
  • Lung(4.4)
  • Spleen(4.3)
  • Heart(4.2)
  • Liver(4.2)
  • Pancreas(3)
genes like me logo Genes that share expression patterns with MIB2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIB2 Gene

Orthologs for MIB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIB2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MIB2 33
  • 93.31 (n)
(Canis familiaris)
Mammalia MIB2 33 34
  • 89.39 (n)
(Bos Taurus)
Mammalia MIB2 33 34
  • 86.99 (n)
(Mus musculus)
Mammalia Mib2 33 16 34
  • 85.49 (n)
(Rattus norvegicus)
Mammalia Mib2 33
  • 85.1 (n)
(Monodelphis domestica)
Mammalia MIB2 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 68 (a)
-- 34
  • 64 (a)
(Gallus gallus)
Aves MIB2 33 34
  • 67.16 (n)
(Anolis carolinensis)
Reptilia MIB2 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mib2 33
  • 63.82 (n)
(Danio rerio)
Actinopterygii mib2 33
  • 66.9 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008851 33
  • 56.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta mib2 33 34
  • 53.3 (n)
Species where no ortholog for MIB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIB2 Gene

Gene Tree for MIB2 (if available)
Gene Tree for MIB2 (if available)

Paralogs for MIB2 Gene

Paralogs for MIB2 Gene

genes like me logo Genes that share paralogs with MIB2: view

Variants for MIB2 Gene

Sequence variations from dbSNP and Humsavar for MIB2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs199741261 likely-benign, not specified 1,615,612(+) C/A 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, stop_gained, upstream_transcript_variant
rs1000005080 -- 1,620,208(+) T/A intron_variant
rs1000045042 -- 1,629,852(+) A/C intron_variant
rs1000066132 -- 1,614,974(+) C/A upstream_transcript_variant
rs1000071654 -- 1,621,197(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MIB2 Gene

Variant ID Type Subtype PubMed ID
nsv950452 CNV deletion 24416366
nsv822031 CNV loss 20364138
nsv545017 CNV loss 21841781
nsv482937 CNV loss 15286789
nsv1160797 CNV duplication 26073780
nsv1136057 CNV deletion 24896259
nsv1074993 CNV deletion 25765185
nsv1074054 CNV deletion 25765185
nsv10161 CNV gain+loss 18304495
esv3575582 CNV gain 25503493
esv2760410 CNV gain+loss 21179565
esv2758913 CNV gain+loss 17122850
esv2661270 CNV deletion 23128226
esv2659399 CNV deletion 23128226
dgv8n100 CNV loss 25217958
dgv5n111 CNV deletion 26073780

Variation tolerance for MIB2 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.26; 85.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MIB2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIB2 Gene

Disorders for MIB2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIB2 Gene - From: HGMD, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
gastritis, familial giant hypertrophic
  • menetrier disease
left ventricular noncompaction
  • left ventricular hypertrabeculation
  • malignant melanoma
- elite association - COSMIC cancer census association via MalaCards
Search MIB2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MIB2

genes like me logo Genes that share disorders with MIB2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIB2 Gene

Publications for MIB2 Gene

  1. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A … Sugano S (Oncogene 2003) 2 3 4 58
  2. Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma. (PMID: 14507647) Takeuchi T … Ohtsuki Y (The American journal of pathology 2003) 3 4 22 58
  3. A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion. (PMID: 16715130) Takeuchi T … Ohtsuki Y (Oncogene 2006) 3 22 58
  4. Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma. (PMID: 15920166) Takeuchi T … Ohtsuki Y (The American journal of pathology 2005) 3 22 58
  5. Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma. (PMID: 15869411) Takeuchi T … Ohtsuki Y (DNA and cell biology 2005) 3 22 58

Products for MIB2 Gene

Sources for MIB2 Gene

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