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Aliases for MIA-RAB4B Gene

Subcategory (RNA class) for MIA-RAB4B Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for MIA-RAB4B Gene

  • MIA-RAB4B Readthrough (NMD Candidate) 2 3 5

External Ids for MIA-RAB4B Gene

Previous GeneCards Identifiers for MIA-RAB4B Gene

  • GC19U901481
  • GC19P041277

Summaries for MIA-RAB4B Gene

Entrez Gene Summary for MIA-RAB4B Gene

  • This locus represents naturally occurring read-through transcription between the neighboring MIA (melanoma inhibitory activity) and RAB4B (RAB4B, member RAS oncogene family) genes on chromosome 19. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is therefore unlikely to produce a protein product. [provided by RefSeq, Feb 2011]

GeneCards Summary for MIA-RAB4B Gene

MIA-RAB4B (MIA-RAB4B Readthrough (NMD Candidate)) is an RNA Gene, and is affiliated with the ncRNA class. An important paralog of this gene is MIA.

Additional gene information for MIA-RAB4B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIA-RAB4B Gene

Genomics for MIA-RAB4B Gene

GeneHancer (GH) Regulatory Elements for MIA-RAB4B Gene

Promoters and enhancers for MIA-RAB4B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I040776 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 0.4 +6.3 6295 3.3 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A ZNF2 IRF4 RAB4B RAB4B-EGLN2 HNRNPUL1 SNRPA CCDC97 PSMC4 FBL C19orf54 MIA CYP2F2P
GH19I040796 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.3 +30.7 30689 11.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF416 ZNF143 SP3 EGLN2 ENSG00000268797 ZNF780B HNRNPUL1 SNRPA ENSG00000269843 NUMBL CCDC97 ZNF546 COQ8B
GH19I040774 Promoter/Enhancer 0.9 EPDnew ENCODE 0.8 +3.6 3629 1.3 ZFHX2 IKZF1 ZMYM3 MIA C19orf54 SNRPA RNU6-195P ITPKC RAB4B MIA-RAB4B GC19P040724
GH19I040791 Enhancer 0.9 ENCODE dbSUPER 0.3 +21.0 20964 2.3 SCRT1 GATAD2A ZBTB6 HLF CEBPB CEBPG ZNF623 RBAK ZNF366 ZNF157 EGLN2 CYP2T1P COQ8B ENSG00000282951 RAB4B-EGLN2 RAB4B MIA-RAB4B GC19P040724
GH19I040765 Enhancer 0.5 ENCODE 0.4 -5.9 -5879 0.7 ZNF274 NFIC POLR2A ZBED1 ZNF350 KLF9 SUPT5H GC19P040765 SNRPA HNRNPUL1 ENSG00000269843 CCDC97 AKT2 PSMC4 COQ8B MIA MIA-RAB4B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIA-RAB4B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIA-RAB4B Gene

Genomic Locations for MIA-RAB4B Gene
chr19:40,771,648-40,796,944
(GRCh38/hg38)
Size:
25,297 bases
Orientation:
Plus strand
chr19:41,277,553-41,302,849
(GRCh37/hg19)

Genomic View for MIA-RAB4B Gene

Genes around MIA-RAB4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIA-RAB4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIA-RAB4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIA-RAB4B Gene

Proteins for MIA-RAB4B Gene

  • Protein details for MIA-RAB4B Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    W4VSR3
    Recommended name:
    HCG2044074, isoform CRA_c
    Protein Accession:
    W4VSR3

    Protein attributes for MIA-RAB4B Gene

    Size:
    131 amino acids
    Molecular mass:
    14288 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MIA-RAB4B Gene

Post-translational modifications for MIA-RAB4B Gene

No Post-translational modifications

Other Protein References for MIA-RAB4B Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for MIA-RAB4B Gene

Domains & Families for MIA-RAB4B Gene

Protein Domains for MIA-RAB4B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIA-RAB4B: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIA-RAB4B Gene

Function for MIA-RAB4B Gene

Phenotypes From GWAS Catalog for MIA-RAB4B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIA-RAB4B Gene

Localization for MIA-RAB4B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIA-RAB4B Gene

Pathways & Interactions for MIA-RAB4B Gene

SuperPathways for MIA-RAB4B Gene

No Data Available

Interacting Proteins for MIA-RAB4B Gene

Gene Ontology (GO) - Biological Process for MIA-RAB4B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIA-RAB4B Gene

Drugs & Compounds for MIA-RAB4B Gene

No Compound Related Data Available

Transcripts for MIA-RAB4B Gene

mRNA/cDNA for MIA-RAB4B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIA-RAB4B Gene

No ASD Table

Relevant External Links for MIA-RAB4B Gene

GeneLoc Exon Structure for
MIA-RAB4B
ECgene alternative splicing isoforms for
MIA-RAB4B

Expression for MIA-RAB4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIA-RAB4B Gene

genes like me logo Genes that share expression patterns with MIA-RAB4B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIA-RAB4B Gene

Orthologs for MIA-RAB4B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIA-RAB4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 95 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MIA 34
  • 82 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm21983 34
  • 82 (a)
ManyToMany
Mia 34
  • 78 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 63 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii MIA 34
  • 51 (a)
OneToMany
Species where no ortholog for MIA-RAB4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIA-RAB4B Gene

ENSEMBL:
Gene Tree for MIA-RAB4B (if available)
TreeFam:
Gene Tree for MIA-RAB4B (if available)

Paralogs for MIA-RAB4B Gene

Paralogs for MIA-RAB4B Gene

genes like me logo Genes that share paralogs with MIA-RAB4B: view

Variants for MIA-RAB4B Gene

Sequence variations from dbSNP and Humsavar for MIA-RAB4B Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000126726 -- 40,795,782(+) A/T intron_variant
rs1000215381 -- 40,785,366(+) C/G intron_variant
rs1000315692 -- 40,791,205(+) G/A intron_variant
rs1000327350 -- 40,790,981(+) G/T intron_variant
rs1000500606 -- 40,795,993(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MIA-RAB4B Gene

Variant ID Type Subtype PubMed ID
esv26234 CNV loss 19812545
esv2758762 CNV gain+loss 17122850
nsv833832 CNV loss 17160897

Additional Variant Information for MIA-RAB4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIA-RAB4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIA-RAB4B Gene

Disorders for MIA-RAB4B Gene

Additional Disease Information for MIA-RAB4B

No disorders were found for MIA-RAB4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIA-RAB4B Gene

Publications for MIA-RAB4B Gene

  1. A genome-wide association study identifies three new risk loci for Kawasaki disease. (PMID: 22446962) Onouchi Y … US Kawasaki Disease Genetics Consortium (Nature genetics 2012) 3 58
  2. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. (PMID: 22080838) Cho MH … COPDGene Investigators (Human molecular genetics 2012) 3 58
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58

Products for MIA-RAB4B Gene

Sources for MIA-RAB4B Gene

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