Aliases for MIA Gene

Aliases for MIA Gene

  • MIA SH3 Domain Containing 2 3 5
  • Melanoma-Derived Growth Regulatory Protein 3 4
  • Melanoma Inhibitory Activity 2 3
  • Melanoma Inhibitory Activity Protein 4
  • CD-RAP 3

External Ids for MIA Gene

Previous GeneCards Identifiers for MIA Gene

  • GC19P041920
  • GC19P041673
  • GC19P045958
  • GC19P045975
  • GC19P045976
  • GC19P045978
  • GC19P041283
  • GC19P037714

Summaries for MIA Gene

GeneCards Summary for MIA Gene

MIA (MIA SH3 Domain Containing) is a Protein Coding gene. Diseases associated with MIA include Melanoma and Skin Melanoma. Among its related pathways are Neural Crest Differentiation. Gene Ontology (GO) annotations related to this gene include growth factor activity. An important paralog of this gene is MIA-RAB4B.

UniProtKB/Swiss-Prot Summary for MIA Gene

  • Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.

Gene Wiki entry for MIA Gene

Additional gene information for MIA Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MIA Gene

Genomics for MIA Gene

GeneHancer (GH) Regulatory Elements for MIA Gene

Promoters and enhancers for MIA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MIA on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MIA

Top Transcription factor binding sites by QIAGEN in the MIA gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPbeta
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4

Genomic Locations for MIA Gene

Genomic Locations for MIA Gene
chr19:40,771,648-40,777,493
(GRCh38/hg38)
Size:
5,846 bases
Orientation:
Plus strand
chr19:41,277,553-41,283,398
(GRCh37/hg19)
Size:
5,846 bases
Orientation:
Plus strand

Genomic View for MIA Gene

Genes around MIA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIA Gene

Proteins for MIA Gene

  • Protein details for MIA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16674-MIA_HUMAN
    Recommended name:
    Melanoma-derived growth regulatory protein
    Protein Accession:
    Q16674
    Secondary Accessions:
    • Q6FHV3

    Protein attributes for MIA Gene

    Size:
    131 amino acids
    Molecular mass:
    14509 Da
    Quaternary structure:
    • Interacts with FASLG. Interacts with TMIGD2.

    Three dimensional structures from OCA and Proteopedia for MIA Gene

    Alternative splice isoforms for MIA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIA Gene

Post-translational modifications for MIA Gene

Other Protein References for MIA Gene

No data available for DME Specific Peptides for MIA Gene

Domains & Families for MIA Gene

Gene Families for MIA Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for MIA Gene

Blocks:
  • SH3 domain signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MIA Gene

GenScript: Design optimal peptide antigens:
  • Melanoma inhibitory activity protein (MIA_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16674

UniProtKB/Swiss-Prot:

MIA_HUMAN :
  • Belongs to the MIA/OTOR family.
Family:
  • Belongs to the MIA/OTOR family.
genes like me logo Genes that share domains with MIA: view

Function for MIA Gene

Molecular function for MIA Gene

UniProtKB/Swiss-Prot Function:
Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas.
GENATLAS Biochemistry:
melanoma inhibitory activity,11kDa,regulator of cell growth (see TSG19A)

Phenotypes From GWAS Catalog for MIA Gene

Gene Ontology (GO) - Molecular Function for MIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008083 growth factor activity IEA --
genes like me logo Genes that share ontologies with MIA: view
genes like me logo Genes that share phenotypes with MIA: view

Animal Models for MIA Gene

MGI Knock Outs for MIA:
  • Mia Mia<tm1Rbu>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MIA Gene

Localization for MIA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MIA gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 7923218
genes like me logo Genes that share ontologies with MIA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MIA Gene

Pathways & Interactions for MIA Gene

PathCards logo

SuperPathways for MIA Gene

SuperPathway Contained pathways
1 Neural Crest Differentiation
genes like me logo Genes that share pathways with MIA: view

Pathways by source for MIA Gene

1 BioSystems pathway for MIA Gene

Interacting Proteins for MIA Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000263369 Q16674-MIA_HUMAN for MIA Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for MIA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with MIA: view

No data available for SIGNOR curated interactions for MIA Gene

Drugs & Compounds for MIA Gene

No Compound Related Data Available

Transcripts for MIA Gene

mRNA/cDNA for MIA Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIA Gene

No ASD Table

Relevant External Links for MIA Gene

GeneLoc Exon Structure for
MIA

Expression for MIA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MIA Gene

This gene is overexpressed in Nerve - Tibial (x19.5) and Pituitary (x9.7).

Protein differential expression in normal tissues from HIPED for MIA Gene

This gene is overexpressed in Lung (52.1) and Testis (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MIA Gene



Protein tissue co-expression partners for MIA Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MIA

SOURCE GeneReport for Unigene cluster for MIA Gene:

Hs.646364

mRNA Expression by UniProt/SwissProt for MIA Gene:

Q16674-MIA_HUMAN
Tissue specificity: All malignant melanoma cell lines tested and infrequently in glioma cell lines.

Evidence on tissue expression from TISSUES for MIA Gene

  • Skin(4.2)
genes like me logo Genes that share expression patterns with MIA: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MIA Gene

Orthologs for MIA Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 100 (a)
OneToMany
MIA 30
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia MIA 30
  • 89.06 (n)
cow
(Bos Taurus)
Mammalia MIA 31 30
  • 87.69 (n)
OneToMany
mouse
(Mus musculus)
Mammalia Mia 17 31 30
  • 84.62 (n)
Gm21983 31
  • 77 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Mia 30
  • 83.59 (n)
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 67 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mia 30
  • 68.58 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:194158 30
  • 61.28 (n)
MIA 31
  • 55 (a)
OneToMany
Species where no ortholog for MIA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIA Gene

ENSEMBL:
Gene Tree for MIA (if available)
TreeFam:
Gene Tree for MIA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MIA: view image

Paralogs for MIA Gene

(4) SIMAP similar genes for MIA Gene using alignment to 4 proteins:

  • MIA_HUMAN
  • M0QZM4_HUMAN
  • M0R0T9_HUMAN
  • M0R343_HUMAN
genes like me logo Genes that share paralogs with MIA: view

Variants for MIA Gene

Additional dbSNP identifiers (rs#s) for MIA Gene

Structural Variations from Database of Genomic Variants (DGV) for MIA Gene

Variant ID Type Subtype PubMed ID
esv26234 CNV loss 19812545
nsv833832 CNV loss 17160897

Variation tolerance for MIA Gene

Residual Variation Intolerance Score: 56.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MIA Gene

Human Gene Mutation Database (HGMD)
MIA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MIA Gene

Disorders for MIA Gene

MalaCards: The human disease database

(3) MalaCards diseases for MIA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
melanoma
  • malignant melanoma
skin melanoma
  • melanoma, cutaneous malignant
melanoma, uveal
  • uveal melanoma
- elite association - COSMIC cancer census association via MalaCards
Search MIA in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MIA

genes like me logo Genes that share disorders with MIA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIA Gene

Publications for MIA Gene

  1. Structure and promoter analysis of the gene encoding the human melanoma-inhibiting protein MIA. (PMID: 8550608) Bosserhoff AK … Buettner R (The Journal of biological chemistry 1996) 3 4 23 54
  2. Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA. (PMID: 7923218) Blesch A … Bogdahn U (Cancer research 1994) 2 3 4 54
  3. A genome-wide association study identifies three new risk loci for Kawasaki disease. (PMID: 22446962) Onouchi Y … US Kawasaki Disease Genetics Consortium (Nature genetics 2012) 3 41 54
  4. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PMID: 19807924) Voss M … Janssen O (BMC immunology 2009) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for MIA Gene

  • Boster Bio Antibodies for MIA
  • Boster Bio ELISA Kits for MIA

Sources for MIA Gene