Aliases for MGST3 Gene
External Ids for MGST3 Gene
Previous GeneCards Identifiers for MGST3 Gene
This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]
GeneCards Summary for MGST3 Gene
MGST3 (Microsomal Glutathione S-Transferase 3) is a Protein Coding gene. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include glutathione transferase activity and glutathione peroxidase activity. An important paralog of this gene is MGST2.
UniProtKB/Swiss-Prot Summary for MGST3 Gene
Catalyzes oxydation of hydroxy-fatty acids (PubMed:9278457). Also catalyzes the conjugation of a reduced glutathione to leukotriene A4 in vitro (PubMed:9278457). May participate in the lipid metabolism (PubMed:9278457).