This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene... See more...

Aliases for MGST3 Gene

Aliases for MGST3 Gene

  • Microsomal Glutathione S-Transferase 3 2 3 4 5
  • Microsomal Glutathione S-Transferase III 2 3 4
  • Microsomal GST-III 2 3 4
  • Microsomal GST-3 2 3 4
  • Glutathione Peroxidase MGST3 3 4
  • LTC4 Synthase MGST3 3 4
  • GST-III 2 3
  • EC 1.11.1.- 4
  • EC 4.4.1.20 4
  • MGST3 5

External Ids for MGST3 Gene

Previous GeneCards Identifiers for MGST3 Gene

  • GC01P163234
  • GC01P161251
  • GC01P162296
  • GC01P162787
  • GC01P162332
  • GC01P163866
  • GC01P136847

Summaries for MGST3 Gene

Entrez Gene Summary for MGST3 Gene

  • This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]

GeneCards Summary for MGST3 Gene

MGST3 (Microsomal Glutathione S-Transferase 3) is a Protein Coding gene. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include glutathione transferase activity and glutathione peroxidase activity. An important paralog of this gene is MGST2.

UniProtKB/Swiss-Prot Summary for MGST3 Gene

  • Catalyzes oxydation of hydroxy-fatty acids (PubMed:9278457). Also catalyzes the conjugation of a reduced glutathione to leukotriene A4 in vitro (PubMed:9278457). May participate in the lipid metabolism (PubMed:9278457).

Gene Wiki entry for MGST3 Gene

Additional gene information for MGST3 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MGST3 Gene

Genomics for MGST3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MGST3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J165629 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 643.8 +0.5 506 5.4 SP1 GATAD2A PRDM10 ZNF629 TFE3 RFX1 SIX5 LEF1 IKZF1 KDM1A MGST3 lnc-ALDH9A1-3 lnc-LRRC52-3 ENSG00000215835 LRRC52 ALDH9A1 lnc-LRRC52-2
GH01J165649 Promoter 0.3 EPDnew 600.4 +18.6 18581 0.1 lnc-ALDH9A1-1 MGST3 MN309009 lnc-LRRC52-3 ALDH9A1
GH01J165601 Enhancer 0.9 Ensembl ENCODE 30.6 -29.9 -29912 1.8 CTCF JUND ZNF143 PRDM1 REST RAD21 KAT8 RCOR1 TRIM22 YY1 MGST3 LRRC52 RXRG ENSG00000236206 lnc-ALDH9A1-3
GH01J165695 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.9 +66.4 66370 4 ARHGAP35 CTCF PRDM10 ZNF629 REST IKZF1 NFKBIZ POLR2A RCOR2 LARP7 ALDH9A1 LOC440700 lnc-MGST3-2 ENSG00000215835 MGST3 UCK2 lnc-MGST3-4
GH01J165640 Enhancer 1.1 Ensembl ENCODE dbSUPER 21.1 +12.7 12688 8.6 SP1 DPF2 SCRT2 CEBPB ZNF766 CTBP1 RUNX3 NFE2 FOXA2 POLR2A lnc-LRRC52-2 MGST3 LRRC52 lnc-ALDH9A1-1 lnc-LRRC52-3 ALDH9A1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MGST3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MGST3

Top Transcription factor binding sites by QIAGEN in the MGST3 gene promoter:
  • AP-2gamma
  • Bach2
  • C/EBPalpha
  • E47
  • GATA-1
  • GATA-6
  • HNF-1
  • HNF-1A
  • Pbx1a
  • RSRFC4

Genomic Locations for MGST3 Gene

Genomic Locations for MGST3 Gene
chr1:165,631,213-165,661,796
(GRCh38/hg38)
Size:
30,584 bases
Orientation:
Plus strand
chr1:165,600,098-165,631,033
(GRCh37/hg19)
Size:
30,936 bases
Orientation:
Plus strand

Genomic View for MGST3 Gene

Genes around MGST3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGST3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGST3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGST3 Gene

Proteins for MGST3 Gene

  • Protein details for MGST3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14880-MGST3_HUMAN
    Recommended name:
    Microsomal glutathione S-transferase 3
    Protein Accession:
    O14880
    Secondary Accessions:
    • B2R592
    • Q6ICN4

    Protein attributes for MGST3 Gene

    Size:
    152 amino acids
    Molecular mass:
    16516 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MGST3 Gene

Post-translational modifications for MGST3 Gene

  • Ubiquitination at Lys111
  • Modification sites at PhosphoSitePlus

Other Protein References for MGST3 Gene

No data available for DME Specific Peptides for MGST3 Gene

Domains & Families for MGST3 Gene

Gene Families for MGST3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for MGST3 Gene

InterPro:
Blocks:
  • Flavoprotein
  • Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)
ProtoNet:

Suggested Antigen Peptide Sequences for MGST3 Gene

GenScript: Design optimal peptide antigens:
  • Microsomal GST-III (MGST3_HUMAN)
  • Microsomal glutathione S-transferase 3 (Q5VV89_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14880

UniProtKB/Swiss-Prot:

MGST3_HUMAN :
  • Belongs to the MAPEG family.
Family:
  • Belongs to the MAPEG family.
genes like me logo Genes that share domains with MGST3: view

Function for MGST3 Gene

Molecular function for MGST3 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes oxydation of hydroxy-fatty acids (PubMed:9278457). Also catalyzes the conjugation of a reduced glutathione to leukotriene A4 in vitro (PubMed:9278457). May participate in the lipid metabolism (PubMed:9278457).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:48620, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90632; Evidence={ECO:0000269|PubMed:9278457};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=leukotriene C4 = glutathione + leukotriene A4; Xref=Rhea:RHEA:17617, ChEBI:CHEBI:57463, ChEBI:CHEBI:57925, ChEBI:CHEBI:57973; EC=4.4.1.20; Evidence={ECO:0000269|PubMed:9278457};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=21 uM for (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate {ECO:0000269|PubMed:9278457};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by MK-886 and leukotriene C4.
GENATLAS Biochemistry:
glutathione-S-transferase 3,microsomal,16.5kDa,widely distributed,predominantly expressed in heart,skeletal muscle,adrenal cortex,microsomal GST superfamily

Enzyme Numbers (IUBMB) for MGST3 Gene

Phenotypes From GWAS Catalog for MGST3 Gene

Gene Ontology (GO) - Molecular Function for MGST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 NOT glutathione transferase activity IDA 9278457
GO:0004464 leukotriene-C4 synthase activity IDA 9278457
GO:0004602 glutathione peroxidase activity IDA 9278457
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with MGST3: view
genes like me logo Genes that share phenotypes with MGST3: view

Animal Models for MGST3 Gene

MGI Knock Outs for MGST3:
  • Mgst3 Mgst3<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MGST3

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MGST3 Gene

Localization for MGST3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGST3 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein. Microsome membrane. Multi-pass membrane protein. Microsome membrane. Lipid-anchor. Membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MGST3 gene
Compartment Confidence
nucleus 4
endoplasmic reticulum 4
extracellular 2
mitochondrion 2
cytosol 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MGST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IBA 21873635
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA,IDA 9278457
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MGST3: view

Pathways & Interactions for MGST3 Gene

genes like me logo Genes that share pathways with MGST3: view

Pathways by source for MGST3 Gene

2 GeneGo (Thomson Reuters) pathways for MGST3 Gene
  • Glutathione metabolism
  • HETE and HPETE biosynthesis and metabolism

Gene Ontology (GO) - Biological Process for MGST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IDA 9278457
GO:0006805 xenobiotic metabolic process TAS --
GO:0010243 response to organonitrogen compound IEA --
GO:0019370 leukotriene biosynthetic process IDA 9278457
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with MGST3: view

No data available for SIGNOR curated interactions for MGST3 Gene

Drugs & Compounds for MGST3 Gene

(6) Drugs for MGST3 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Trichloroethylene Approved Pharma 0
Water Approved Pharma 0
Hydrochloric acid Experimental Pharma 0
Sulfate Experimental, Investigational Pharma 0

(38) Additional Compounds for MGST3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
  • (1S,2R)-Naphthalene epoxide
1,1-Dichloroethylene epoxide
  • 2,2-Dichlorooxirane

(1) ApexBio Compounds for MGST3 Gene

Compound Action Cas Number
Ezatiostat hydrochloride GST inhibitor 286942-97-0
genes like me logo Genes that share compounds with MGST3: view

Drug Products

Transcripts for MGST3 Gene

mRNA/cDNA for MGST3 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
14 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MGST3

Alternative Splicing Database (ASD) splice patterns (SP) for MGST3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: -
SP10:
SP11: - - - -
SP12: - -

Relevant External Links for MGST3 Gene

GeneLoc Exon Structure for
MGST3

Expression for MGST3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MGST3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MGST3 Gene

This gene is overexpressed in Nasal epithelium (22.3), Heart (8.0), and Fetal heart (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MGST3 Gene



Protein tissue co-expression partners for MGST3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MGST3

SOURCE GeneReport for Unigene cluster for MGST3 Gene:

Hs.191734

mRNA Expression by UniProt/SwissProt for MGST3 Gene:

O14880-MGST3_HUMAN
Tissue specificity: Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain, placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for MGST3 Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Liver(4.6)
  • Kidney(4.6)
  • Muscle(3.2)
  • Heart(3.1)
  • Skin(2.9)
  • Intestine(2.6)
  • Stomach(2.5)
  • Adrenal gland(2.4)
  • Thyroid gland(2.4)
  • Eye(2.3)
  • Blood(2)
genes like me logo Genes that share expression patterns with MGST3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MGST3 Gene

Orthologs for MGST3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MGST3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MGST3 30 31
  • 99.78 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MGST3 30 31 31
  • 91.01 (n)
OneToMany
Cow
(Bos Taurus)
Mammalia MGST3 30 31
  • 89.04 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mgst3 30
  • 84.65 (n)
Mouse
(Mus musculus)
Mammalia Mgst3 30 17 31
  • 83.77 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MGST3 31
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MGST3 31
  • 82 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MGST3 30 31
  • 74.29 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MGST3 31
  • 78 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mgst3 30
  • 71.43 (n)
Str.10366 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.11525 30
Zebrafish
(Danio rerio)
Actinopterygii mgst3 30 31
  • 60.43 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13985 30
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT1G65820 30
  • 53.02 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0709000 30
  • 53.12 (n)
Species where no ortholog for MGST3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MGST3 Gene

ENSEMBL:
Gene Tree for MGST3 (if available)
TreeFam:
Gene Tree for MGST3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MGST3: view image

Paralogs for MGST3 Gene

Paralogs for MGST3 Gene

(1) SIMAP similar genes for MGST3 Gene using alignment to 3 proteins:

  • MGST3_HUMAN
  • Q5VV87_HUMAN
  • Q5VV89_HUMAN
genes like me logo Genes that share paralogs with MGST3: view

Variants for MGST3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MGST3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1802087 - p.Gly15Cys
rs1802088 - p.Pro48Ser

Additional dbSNP identifiers (rs#s) for MGST3 Gene

Structural Variations from Database of Genomic Variants (DGV) for MGST3 Gene

Variant ID Type Subtype PubMed ID
dgv611n54 CNV loss 21841781
dgv612n54 CNV loss 21841781
esv28160 CNV loss 19812545
nsv548090 CNV loss 21841781
nsv548096 CNV loss 21841781

Variation tolerance for MGST3 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MGST3 Gene

Human Gene Mutation Database (HGMD)
MGST3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MGST3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGST3 Gene

Disorders for MGST3 Gene

Additional Disease Information for MGST3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for MGST3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MGST3 Gene

Publications for MGST3 Gene

  1. Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities. (PMID: 9278457) Jakobsson PJ … Ford-Hutchinson AW (The Journal of biological chemistry 1997) 2 3 4 23
  2. Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians. (PMID: 12898215) Thameem F … Prochazka M (Human genetics 2003) 3 23 41
  3. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney SJ … AddNeuroMed Consortium (Molecular psychiatry 2011) 3 41
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 41

Products for MGST3 Gene

  • Signalway Proteins for MGST3

Sources for MGST3 Gene