The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternat... See more...

Aliases for MGST2 Gene

Aliases for MGST2 Gene

  • Microsomal Glutathione S-Transferase 2 2 3 4 5
  • Microsomal Glutathione S-Transferase II 3 4
  • Leukotriene C4 Synthase MGST2 3 4
  • Glutathione Peroxidase MGST2 3 4
  • Microsomal GST-II 3 4
  • Microsomal GST-2 3 4
  • MGST-II 2 3
  • GST2 3 4
  • EC 2.5.1.18 4
  • EC 1.11.1.- 4
  • EC 4.4.1.20 4
  • MGST2 5

External Ids for MGST2 Gene

Previous GeneCards Identifiers for MGST2 Gene

  • GC04P141492
  • GC04P140886
  • GC04P141053
  • GC04P141164
  • GC04P140944
  • GC04P140586
  • GC04P136315

Summaries for MGST2 Gene

Entrez Gene Summary for MGST2 Gene

  • The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for MGST2 Gene

MGST2 (Microsomal Glutathione S-Transferase 2) is a Protein Coding gene. Diseases associated with MGST2 include Psoriasis 9 and Psoriasis. Among its related pathways are Drug metabolism - cytochrome P450 and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include enzyme activator activity and glutathione peroxidase activity. An important paralog of this gene is LTC4S.

UniProtKB/Swiss-Prot Summary for MGST2 Gene

  • Catalyzes several different glutathione-dependent reactions (PubMed:8703034, PubMed:9278457, PubMed:23409838, PubMed:26656251, PubMed:26066610). Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (PubMed:9278457, PubMed:23409838). Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB) (PubMed:23409838, PubMed:8703034). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (PubMed:23409838, PubMed:26656251). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed:26656251).

Gene Wiki entry for MGST2 Gene

Additional gene information for MGST2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MGST2 Gene

Genomics for MGST2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MGST2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J139663 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 612.2 +1.4 1371 7.4 HNRNPL GATAD2A TEAD4 REST TFE3 LEF1 SOX13 IKZF1 ZNF692 FOXA1 MGST2 NONHSAG038956.2 SETD7 ELMOD2 MAML3 ELF2 RF00100-102 RN7SKP237 lnc-MAML3-1
GH04J139656 Enhancer 1 FANTOM5 ENCODE 12.8 -7.6 -7600 2.9 CTCF ZNF512 REST CEBPA SCRT2 RAD21 TCF7 SP1 UBTF CEBPB MGST2 ENSG00000261268 LOC105377622
GH04J139659 Enhancer 0.8 ENCODE 11.4 -4.9 -4862 1.8 HNRNPL GATAD2A TFE3 RCOR2 ZSCAN4 RXRB SP1 GABPA CEBPA SOX13 MGST2 ENSG00000261268 LOC105377622
GH04J139645 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 6.6 -19.3 -19324 2.8 SP1 CTBP1 NR3C1 PKNOX1 MYC FOSL2 DPF2 SPI1 FOXA1 RCOR1 ENSG00000261268 LOC101927490 SETD7 MGST2 piR-46847-190 LOC105377622
GH04J139655 Enhancer 0.5 Ensembl 11.6 -10.4 -10425 1 CTCF FOXA1 RFX1 RAD21 ZNF654 THRB SMC3 RXRA MGST2 ENSG00000261268 LOC105377622
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MGST2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MGST2

Top Transcription factor binding sites by QIAGEN in the MGST2 gene promoter:
  • aMEF-2
  • AML1a
  • ATF-2
  • Brachyury
  • Evi-1
  • FOXD1
  • GATA-2
  • HOXA5
  • MEF-2
  • MEF-2A

Genomic Locations for MGST2 Gene

Genomic Locations for MGST2 Gene
chr4:139,665,725-139,754,608
(GRCh38/hg38)
Size:
88,884 bases
Orientation:
Plus strand
chr4:140,586,922-140,661,899
(GRCh37/hg19)
Size:
74,978 bases
Orientation:
Plus strand

Genomic View for MGST2 Gene

Genes around MGST2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGST2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGST2 Gene

Proteins for MGST2 Gene

  • Protein details for MGST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99735-MGST2_HUMAN
    Recommended name:
    Microsomal glutathione S-transferase 2
    Protein Accession:
    Q99735
    Secondary Accessions:
    • D6RBB5
    • Q7Z5B8

    Protein attributes for MGST2 Gene

    Size:
    147 amino acids
    Molecular mass:
    16621 Da
    Quaternary structure:
    • Homotrimer.

    Alternative splice isoforms for MGST2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGST2 Gene

Post-translational modifications for MGST2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MGST2 Gene

Domains & Families for MGST2 Gene

Gene Families for MGST2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MGST2 Gene

InterPro:
Blocks:
  • Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG)
ProtoNet:

Suggested Antigen Peptide Sequences for MGST2 Gene

GenScript: Design optimal peptide antigens:
  • Microsomal GST-II (MGST2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99735

UniProtKB/Swiss-Prot:

MGST2_HUMAN :
  • Belongs to the MAPEG family.
Family:
  • Belongs to the MAPEG family.
genes like me logo Genes that share domains with MGST2: view

Function for MGST2 Gene

Molecular function for MGST2 Gene

UniProtKB/Swiss-Prot Function:
Catalyzes several different glutathione-dependent reactions (PubMed:8703034, PubMed:9278457, PubMed:23409838, PubMed:26656251, PubMed:26066610). Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (PubMed:9278457, PubMed:23409838). Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB) (PubMed:23409838, PubMed:8703034). Catalyzes also the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (PubMed:23409838, PubMed:26656251). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed:26656251).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000269|PubMed:23409838, ECO:0000269|PubMed:26066610, ECO:0000269|PubMed:8703034};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+); Xref=Rhea:RHEA:51220, ChEBI:CHEBI:15378, ChEBI:CHEBI:17996, ChEBI:CHEBI:34718, ChEBI:CHEBI:57925, ChEBI:CHEBI:133977; EC=2.5.1.18; Evidence={ECO:0000269|PubMed:23409838, ECO:0000269|PubMed:8703034};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=leukotriene C4 = glutathione + leukotriene A4; Xref=Rhea:RHEA:17617, ChEBI:CHEBI:57463, ChEBI:CHEBI:57925, ChEBI:CHEBI:57973; EC=4.4.1.20; Evidence={ECO:0000269|PubMed:11322876, ECO:0000269|PubMed:23409838, ECO:0000269|PubMed:26656251, ECO:0000269|PubMed:8703034};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O; Xref=Rhea:RHEA:48620, ChEBI:CHEBI:15377, ChEBI:CHEBI:57450, ChEBI:CHEBI:57925, ChEBI:CHEBI:58297, ChEBI:CHEBI:90632; Evidence={ECO:0000269|PubMed:23409838, ECO:0000269|PubMed:9278457};.
UniProtKB/Swiss-Prot Induction:
Upon ER stress with brefeldin A or with tunicamycin, MGST2 is down-regulated, in several non-haematopoietic cell types, during the early, protective phase of the unfolded protein response (UPR), and up-regulated at the late, death-promoting phase of the unfolded protein response (UPR).
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=7 uM for (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate (5-HPETE) {ECO:0000269|PubMed:23409838, ECO:0000269|PubMed:9278457}; KM=28 uM for leukotriene A4 {ECO:0000269|PubMed:11322876}; KM=40 uM for leukotriene A4 {ECO:0000269|PubMed:23409838}; Note=kcat is 0.6 sec(-1) for leukotriene A4 as substrate (PubMed:23409838). kcat is 14.3 sec(-1) for 1-chloro-2,4-dinitrobenzene as substrate (PubMed:23409838). kcat is 0.1 sec(-1) for 5-HPETE as substrate (PubMed:23409838). {ECO:0000269|PubMed:23409838};
UniProtKB/Swiss-Prot EnzymeRegulation:
Each monomer can bind on GSH molecule but only one subunit is catalytically active.
GENATLAS Biochemistry:
microsomal glutathione-S-transferase 2,expressed in liver,spleen,heart,skeletal muscle,involved in leukotriene biosynthesis,microsomal,GST superfamily

Enzyme Numbers (IUBMB) for MGST2 Gene

Phenotypes From GWAS Catalog for MGST2 Gene

Gene Ontology (GO) - Molecular Function for MGST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IBA,IDA 8703034
GO:0004464 leukotriene-C4 synthase activity IEA,IDA 8703034
GO:0004602 glutathione peroxidase activity IEA,IDA 9278457
GO:0005515 protein binding IPI 25910212
GO:0008047 enzyme activator activity IEA --
genes like me logo Genes that share ontologies with MGST2: view
genes like me logo Genes that share phenotypes with MGST2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MGST2

CRISPR Products

miRNA for MGST2 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MGST2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MGST2 Gene

Localization for MGST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGST2 Gene

Endoplasmic reticulum membrane. Multi-pass membrane protein. Microsome membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MGST2 gene
Compartment Confidence
plasma membrane 5
nucleus 4
endoplasmic reticulum 4
extracellular 3
cytoskeleton 1
mitochondrion 1
peroxisome 1
cytosol 1
lysosome 0

Gene Ontology (GO) - Cellular Components for MGST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IBA 21873635
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IBA 21873635
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane IDA 9092565
genes like me logo Genes that share ontologies with MGST2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MGST2 Gene

Pathways & Interactions for MGST2 Gene

genes like me logo Genes that share pathways with MGST2: view

Pathways by source for MGST2 Gene

2 GeneGo (Thomson Reuters) pathways for MGST2 Gene
  • Glutathione metabolism
  • HETE and HPETE biosynthesis and metabolism

Gene Ontology (GO) - Biological Process for MGST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IDA 9278457
GO:0006691 leukotriene metabolic process IEA --
GO:0006750 glutathione biosynthetic process IDA 8703034
GO:0006805 xenobiotic metabolic process TAS --
GO:0010243 response to organonitrogen compound IEA --
genes like me logo Genes that share ontologies with MGST2: view

No data available for SIGNOR curated interactions for MGST2 Gene

Drugs & Compounds for MGST2 Gene

(6) Drugs for MGST2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Busulfan Approved, Investigational Pharma Enzyme, substrate 622
Trichloroethylene Approved Pharma 0
Water Approved Pharma 0
Hydrochloric acid Experimental Pharma 0

(39) Additional Compounds for MGST2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
  • (1S,2R)-Naphthalene epoxide
1,1-Dichloroethylene epoxide
  • 2,2-Dichlorooxirane
genes like me logo Genes that share compounds with MGST2: view

Transcripts for MGST2 Gene

mRNA/cDNA for MGST2 Gene

4 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MGST2

Alternative Splicing Database (ASD) splice patterns (SP) for MGST2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: -

Relevant External Links for MGST2 Gene

GeneLoc Exon Structure for
MGST2

Expression for MGST2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MGST2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MGST2 Gene

This gene is overexpressed in Nasal epithelium (15.3), Liver (7.2), and Pancreas (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MGST2 Gene



Protein tissue co-expression partners for MGST2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MGST2

SOURCE GeneReport for Unigene cluster for MGST2 Gene:

Hs.81874

mRNA Expression by UniProt/SwissProt for MGST2 Gene:

Q99735-MGST2_HUMAN
Tissue specificity: Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow (PubMed:8703034). Abundantly expressed in human umbilical vein endothelial cells (at protein level) (PubMed:11322876).

Evidence on tissue expression from TISSUES for MGST2 Gene

  • Liver(4.6)
  • Lung(4.3)
  • Heart(2.7)
  • Muscle(2.5)
  • Kidney(2.4)
  • Intestine(2.4)
  • Nervous system(2.3)
  • Skin(2.3)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with MGST2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MGST2 Gene

Orthologs for MGST2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MGST2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MGST2 30 31
  • 99.55 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MGST2 30 31
  • 88.28 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MGST2 30 31
  • 86.58 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mgst2 30
  • 81.63 (n)
Mouse
(Mus musculus)
Mammalia Mgst2 30 17 31
  • 80.27 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MGST2 31
  • 67 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MGST2 31
  • 67 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MGST2 30 31
  • 67.35 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC101731146 30
  • 59.54 (n)
Zebrafish
(Danio rerio)
Actinopterygii mgst2 30 31
  • 56.15 (n)
OneToOne
Species where no ortholog for MGST2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MGST2 Gene

ENSEMBL:
Gene Tree for MGST2 (if available)
TreeFam:
Gene Tree for MGST2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MGST2: view image

Paralogs for MGST2 Gene

Paralogs for MGST2 Gene

(3) SIMAP similar genes for MGST2 Gene using alignment to 1 proteins:

  • MGST2_HUMAN
genes like me logo Genes that share paralogs with MGST2: view

Variants for MGST2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MGST2 Gene

SNP ID Clinical significance and condition Chr 04 pos Variation AA Info Type
710321 Benign: not provided 139,695,263(+) C/T SYNONYMOUS_VARIANT,INTRON_VARIANT
790448 Benign: not provided 139,703,502(+) T/C MISSENSE_VARIANT
rs8192111 - p.Ala101Val

Additional dbSNP identifiers (rs#s) for MGST2 Gene

Structural Variations from Database of Genomic Variants (DGV) for MGST2 Gene

Variant ID Type Subtype PubMed ID
dgv1533e212 CNV loss 25503493
esv3569728 CNV loss 25503493
esv3602439 CNV gain 21293372
esv3602440 CNV gain 21293372
nsv472268 CNV novel sequence insertion 20440878
nsv525242 CNV loss 19592680
nsv830086 CNV gain 17160897
nsv964099 CNV duplication 23825009

Variation tolerance for MGST2 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MGST2 Gene

Human Gene Mutation Database (HGMD)
MGST2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MGST2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGST2 Gene

Disorders for MGST2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MGST2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
psoriasis 9
  • psoriasis 9, susceptibility to
psoriasis
- elite association - COSMIC cancer census association via MalaCards
Search MGST2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MGST2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MGST2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MGST2 Gene

Publications for MGST2 Gene

  1. Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population. (PMID: 16773312) Yang S … Liu JJ (Archives of dermatological research 2006) 3 23 41
  2. A novel MGST2 non-synonymous mutation in a Chinese pedigree with psoriasis vulgaris. (PMID: 16498398) Yan KL … Liu JJ (The Journal of investigative dermatology 2006) 3 23 41
  3. Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor. (PMID: 11322876) Sjöström M … Haeggström JZ (European journal of biochemistry 2001) 3 4 23
  4. Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase. (PMID: 8703034) Jakobsson PJ … Ford-Hutchinson AW (The Journal of biological chemistry 1996) 2 3 4
  5. Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity. (PMID: 26066610) Ahmad S … Rinaldo-Matthis A (Biochimica et biophysica acta 2015) 3 4

Products for MGST2 Gene

  • Signalway ELISA kits for MGST2

Sources for MGST2 Gene