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Aliases for MGST2 Gene

Aliases for MGST2 Gene

  • Microsomal Glutathione S-Transferase 2 2 3 5
  • Microsomal GST-II 3 4
  • Microsomal GST-2 3 4
  • GST2 3 4
  • EC 2.5.1.18 4
  • MGST-II 3

External Ids for MGST2 Gene

Previous GeneCards Identifiers for MGST2 Gene

  • GC04P141492
  • GC04P140886
  • GC04P141053
  • GC04P141164
  • GC04P140944
  • GC04P140586
  • GC04P136315

Summaries for MGST2 Gene

Entrez Gene Summary for MGST2 Gene

  • The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for MGST2 Gene

MGST2 (Microsomal Glutathione S-Transferase 2) is a Protein Coding gene. Diseases associated with MGST2 include Choline Deficiency Disease. Among its related pathways are Glutathione metabolism and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include enzyme activator activity and glutathione peroxidase activity. An important paralog of this gene is LTC4S.

UniProtKB/Swiss-Prot for MGST2 Gene

  • Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.

Gene Wiki entry for MGST2 Gene

Additional gene information for MGST2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGST2 Gene

Genomics for MGST2 Gene

GeneHancer (GH) Regulatory Elements for MGST2 Gene

Promoters and enhancers for MGST2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I139663 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 562.3 +1.3 1337 7.4 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 MGST2 GC04P139684
GH04I139656 Enhancer 1.2 FANTOM5 Ensembl ENCODE 12.8 -7.7 -7686 3 ELF3 ARID4B SIN3A NFXL1 BATF IRF4 THRB RAD21 RARA RFX5 MGST2 LOC101927490
GH04I139659 Enhancer 1 Ensembl ENCODE 11.5 -4.9 -4905 1.8 ELF3 FOXA2 MLX ZSCAN4 ARID4B RAD21 RARA EGR1 CREM MIXL1 MGST2 LOC101927490
GH04I139674 Enhancer 0.8 Ensembl ENCODE 5.5 +9.6 9632 1.2 GATAD2A ZNF680 TEAD1 FOXA3 HLF CEBPB CEBPG NFIL3 CEBPA IKZF1 MGST2 GC04P139684
GH04I139651 Enhancer 1 Ensembl ENCODE 0.4 -14.2 -14155 0.8 RB1 SIN3A ZNF2 RAD21 ZNF335 TCF12 ARID2 ZNF366 SCRT2 ZNF143 LOC101927490 MGST2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MGST2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MGST2 gene promoter:

Genomic Locations for MGST2 Gene

Genomic Locations for MGST2 Gene
chr4:139,665,768-139,740,745
(GRCh38/hg38)
Size:
74,978 bases
Orientation:
Plus strand
chr4:140,586,922-140,661,899
(GRCh37/hg19)

Genomic View for MGST2 Gene

Genes around MGST2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGST2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGST2 Gene

Proteins for MGST2 Gene

  • Protein details for MGST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99735-MGST2_HUMAN
    Recommended name:
    Microsomal glutathione S-transferase 2
    Protein Accession:
    Q99735
    Secondary Accessions:
    • D6RBB5
    • Q7Z5B8

    Protein attributes for MGST2 Gene

    Size:
    147 amino acids
    Molecular mass:
    16621 Da
    Quaternary structure:
    • Homotrimer.

    Alternative splice isoforms for MGST2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGST2 Gene

Post-translational modifications for MGST2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MGST2 Gene

Domains & Families for MGST2 Gene

Gene Families for MGST2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for MGST2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99735

UniProtKB/Swiss-Prot:

MGST2_HUMAN :
  • Belongs to the MAPEG family.
Family:
  • Belongs to the MAPEG family.
genes like me logo Genes that share domains with MGST2: view

Function for MGST2 Gene

Molecular function for MGST2 Gene

GENATLAS Biochemistry:
microsomal glutathione-S-transferase 2,expressed in liver,spleen,heart,skeletal muscle,involved in leukotriene biosynthesis,microsomal,GST superfamily
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.

Enzyme Numbers (IUBMB) for MGST2 Gene

Gene Ontology (GO) - Molecular Function for MGST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity TAS --
GO:0004464 leukotriene-C4 synthase activity IEA,IDA 8703034
GO:0004602 glutathione peroxidase activity IDA,IEA 9278457
GO:0005515 protein binding IPI 25910212
GO:0008047 enzyme activator activity IEA --
genes like me logo Genes that share ontologies with MGST2: view
genes like me logo Genes that share phenotypes with MGST2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MGST2

CRISPR Products

miRNA for MGST2 Gene

Inhibitory RNA Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MGST2 Gene

Localization for MGST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGST2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MGST2 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 5
nucleus 4
extracellular 3
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MGST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IBA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005886 plasma membrane IDA 9092565
genes like me logo Genes that share ontologies with MGST2: view

Pathways & Interactions for MGST2 Gene

genes like me logo Genes that share pathways with MGST2: view

Gene Ontology (GO) - Biological Process for MGST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IDA 9278457
GO:0006691 leukotriene metabolic process IEA --
GO:0006750 glutathione biosynthetic process IDA 8703034
GO:0006805 xenobiotic metabolic process TAS --
GO:0010243 response to organonitrogen compound IEA --
genes like me logo Genes that share ontologies with MGST2: view

No data available for SIGNOR curated interactions for MGST2 Gene

Drugs & Compounds for MGST2 Gene

(5) Drugs for MGST2 Gene - From: DrugBank, FDA Approved Drugs, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Busulfan Approved, Investigational Pharma Enzyme, substrate 569
Busulfex Approved February 1999 Pharma 0
Water Approved Pharma 0
Trichloroethylene Pharma 5

(41) Additional Compounds for MGST2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide
genes like me logo Genes that share compounds with MGST2: view

Transcripts for MGST2 Gene

Unigene Clusters for MGST2 Gene

Microsomal glutathione S-transferase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGST2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: -

Relevant External Links for MGST2 Gene

GeneLoc Exon Structure for
MGST2
ECgene alternative splicing isoforms for
MGST2

Expression for MGST2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MGST2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MGST2 Gene

This gene is overexpressed in Nasal epithelium (15.3), Liver (7.2), and Pancreas (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MGST2 Gene



Protein tissue co-expression partners for MGST2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MGST2 Gene:

MGST2

SOURCE GeneReport for Unigene cluster for MGST2 Gene:

Hs.81874

mRNA Expression by UniProt/SwissProt for MGST2 Gene:

Q99735-MGST2_HUMAN
Tissue specificity: Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow.

Evidence on tissue expression from TISSUES for MGST2 Gene

  • Liver(4.6)
  • Lung(4.3)
  • Heart(2.4)
  • Kidney(2.3)
  • Intestine(2.2)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with MGST2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MGST2 Gene

Orthologs for MGST2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MGST2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGST2 33 34
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia MGST2 33 34
  • 88.28 (n)
dog
(Canis familiaris)
Mammalia MGST2 33 34
  • 86.58 (n)
rat
(Rattus norvegicus)
Mammalia Mgst2 33
  • 81.63 (n)
mouse
(Mus musculus)
Mammalia Mgst2 33 16 34
  • 80.27 (n)
oppossum
(Monodelphis domestica)
Mammalia MGST2 34
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MGST2 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves MGST2 33 34
  • 67.35 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731146 33
  • 59.54 (n)
zebrafish
(Danio rerio)
Actinopterygii mgst2 33 34
  • 56.15 (n)
Species where no ortholog for MGST2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MGST2 Gene

ENSEMBL:
Gene Tree for MGST2 (if available)
TreeFam:
Gene Tree for MGST2 (if available)

Paralogs for MGST2 Gene

Paralogs for MGST2 Gene

(3) SIMAP similar genes for MGST2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MGST2: view

Variants for MGST2 Gene

Sequence variations from dbSNP and Humsavar for MGST2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000018558 -- 139,695,392(+) T/A intron_variant
rs1000019076 -- 139,715,245(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000050834 -- 139,716,498(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000106388 -- 139,722,771(+) A/C genic_downstream_transcript_variant, intron_variant
rs1000124257 -- 139,714,837(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MGST2 Gene

Variant ID Type Subtype PubMed ID
dgv1533e212 CNV loss 25503493
esv3569728 CNV loss 25503493
esv3602439 CNV gain 21293372
esv3602440 CNV gain 21293372
nsv472268 CNV novel sequence insertion 20440878
nsv525242 CNV loss 19592680
nsv830086 CNV gain 17160897
nsv964099 CNV duplication 23825009

Variation tolerance for MGST2 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MGST2 Gene

Human Gene Mutation Database (HGMD)
MGST2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MGST2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGST2 Gene

Disorders for MGST2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MGST2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
choline deficiency disease
  • choline deficiency
- elite association - COSMIC cancer census association via MalaCards
Search MGST2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MGST2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MGST2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MGST2 Gene

Publications for MGST2 Gene

  1. A novel MGST2 non-synonymous mutation in a Chinese pedigree with psoriasis vulgaris. (PMID: 16498398) Yan KL … Liu JJ (The Journal of investigative dermatology 2006) 3 22 44 58
  2. Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population. (PMID: 16773312) Yang S … Liu JJ (Archives of dermatological research 2006) 3 22 44 58
  3. Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase. (PMID: 8703034) Jakobsson PJ … Ford-Hutchinson AW (The Journal of biological chemistry 1996) 2 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 44 58

Products for MGST2 Gene

Sources for MGST2 Gene

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