Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MGST1 Gene

Aliases for MGST1 Gene

  • Microsomal Glutathione S-Transferase 1 2 3 5
  • Microsomal GST-1 3 4
  • Microsomal GST-I 3 4
  • EC 4 56
  • GST12 3 4
  • MGST 3 4
  • Glutathione S-Transferase 12 3
  • MGST-I 3

External Ids for MGST1 Gene

Previous HGNC Symbols for MGST1 Gene

  • GST12

Previous GeneCards Identifiers for MGST1 Gene

  • GC12P016240
  • GC12P016644
  • GC12P016400
  • GC12P016391
  • GC12P016500

Summaries for MGST1 Gene

Entrez Gene Summary for MGST1 Gene

  • The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for MGST1 Gene

MGST1 (Microsomal Glutathione S-Transferase 1) is a Protein Coding gene. Diseases associated with MGST1 include Ewing Sarcoma. Among its related pathways are Innate Immune System and Glutathione metabolism. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and glutathione transferase activity. An important paralog of this gene is PTGES.

UniProtKB/Swiss-Prot for MGST1 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.

Gene Wiki entry for MGST1 Gene

Additional gene information for MGST1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGST1 Gene

Genomics for MGST1 Gene

GeneHancer (GH) Regulatory Elements for MGST1 Gene

Promoters and enhancers for MGST1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I016346 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 574.2 +3.0 2969 6.9 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 FOS RUNX3 MGST1 SLC15A5 GC12P016380
GH12I016389 Enhancer 0.4 ENCODE 11.1 +42.6 42560 0.2 MAX GABPA MGST1 GC12P016380 SUPT16HP1
GH12I016280 Enhancer 0.6 ENCODE 5.7 -65.8 -65764 1.3 RXRA MAX REST RAD21 FOXA1 GABPA YY1 JUND ATF3 HNF4G MGST1 SLC15A5 LOC101928362 PIR41579
GH12I016367 Enhancer 0.2 dbSUPER 11.4 +21.9 21872 3.1 MGST1 ENSG00000256564 LMO3 GC12P016380
GH12I016299 Enhancer 0.3 ENCODE 4.9 -46.8 -46843 1.5 SCRT2 MGST1 PIR41579 SLC15A5 LOC101928362
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MGST1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MGST1 gene promoter:

Genomic Locations for MGST1 Gene

Genomic Locations for MGST1 Gene
262,118 bases
Plus strand

Genomic View for MGST1 Gene

Genes around MGST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGST1 Gene

Proteins for MGST1 Gene

  • Protein details for MGST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Microsomal glutathione S-transferase 1
    Protein Accession:
    Secondary Accessions:
    • A8K533
    • G5EA53

    Protein attributes for MGST1 Gene

    155 amino acids
    Molecular mass:
    17599 Da
    Quaternary structure:
    • Homotrimer; The trimer binds only one molecule of glutathione.

    Alternative splice isoforms for MGST1 Gene


neXtProt entry for MGST1 Gene

Selected DME Specific Peptides for MGST1 Gene


Post-translational modifications for MGST1 Gene

  • Peroxynitrite induces nitration at Tyr-93 which activates the enzyme.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MGST1 Gene

Gene Families for MGST1 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for MGST1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MAPEG family.
  • Belongs to the MAPEG family.
genes like me logo Genes that share domains with MGST1: view

Function for MGST1 Gene

Molecular function for MGST1 Gene

GENATLAS Biochemistry:
microsomal glutathione-S-transferase 1,microsomal,GST superfamily,expressed in the liver and several other tissues
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot EnzymeRegulation:
Can be activated by reagents that attack Cys-50 sulfhydryl, such as N-ethylmaleimide. Activation also occurs via nitration of Tyr-93 by peroxynitrite (By similarity).
UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.

Enzyme Numbers (IUBMB) for MGST1 Gene

Phenotypes From GWAS Catalog for MGST1 Gene

Gene Ontology (GO) - Molecular Function for MGST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity TAS --
GO:0004602 glutathione peroxidase activity IDA 20727966
GO:0005515 protein binding IPI 20195357
GO:0016740 transferase activity IEA --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with MGST1: view
genes like me logo Genes that share phenotypes with MGST1: view

Animal Model Products

miRNA for MGST1 Gene

miRTarBase miRNAs that target MGST1

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MGST1 Gene

Localization for MGST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGST1 Gene

Microsome. Mitochondrion outer membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MGST1 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 5
plasma membrane 4
peroxisome 4
lysosome 4
nucleus 3
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MGST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IEA,IDA 20727966
GO:0005741 mitochondrial outer membrane IEA --
GO:0005778 peroxisomal membrane IEA,ISS --
GO:0005783 endoplasmic reticulum ISS --
genes like me logo Genes that share ontologies with MGST1: view

Pathways & Interactions for MGST1 Gene

genes like me logo Genes that share pathways with MGST1: view

Gene Ontology (GO) - Biological Process for MGST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0010243 response to organonitrogen compound IEA --
GO:0032496 response to lipopolysaccharide IEA --
GO:0033327 Leydig cell differentiation IEA --
GO:0042493 response to drug IEA --
genes like me logo Genes that share ontologies with MGST1: view

No data available for SIGNOR curated interactions for MGST1 Gene

Drugs & Compounds for MGST1 Gene

(9) Drugs for MGST1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Water Approved Pharma 0
Trichloroethylene Pharma 5

(46) Additional Compounds for MGST1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide
genes like me logo Genes that share compounds with MGST1: view

Transcripts for MGST1 Gene

Unigene Clusters for MGST1 Gene

Microsomal glutathione S-transferase 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGST1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: -
SP3: - -
SP4: - - - -
SP6: - -

Relevant External Links for MGST1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MGST1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MGST1 Gene

mRNA differential expression in normal tissues according to GTEx for MGST1 Gene

This gene is overexpressed in Liver (x9.0), Adrenal Gland (x6.8), and Adipose - Visceral (Omentum) (x4.5).

Protein differential expression in normal tissues from HIPED for MGST1 Gene

This gene is overexpressed in Nasal epithelium (17.6) and Liver (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MGST1 Gene

Protein tissue co-expression partners for MGST1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MGST1 Gene:


SOURCE GeneReport for Unigene cluster for MGST1 Gene:


mRNA Expression by UniProt/SwissProt for MGST1 Gene:

Tissue specificity: Highly expressed in liver.

Evidence on tissue expression from TISSUES for MGST1 Gene

  • Liver(4.9)
  • Nervous system(4.6)
  • Lung(3.4)
  • Adrenal gland(3)
  • Kidney(3)
  • Heart(2.6)
  • Intestine(2.5)
  • Gall bladder(2.2)
  • Thyroid gland(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with MGST1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MGST1 Gene

Orthologs for MGST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MGST1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MGST1 33 34
  • 99.57 (n)
(Canis familiaris)
Mammalia MGST1 33 34
  • 88.6 (n)
(Bos Taurus)
Mammalia MGST1 33 34
  • 87.31 (n)
(Mus musculus)
Mammalia Mgst1 33 16 34
  • 79.35 (n)
(Rattus norvegicus)
Mammalia Mgst1 33
  • 77.85 (n)
(Monodelphis domestica)
Mammalia MGST1 34
  • 73 (a)
(Gallus gallus)
Aves MGST1 33 34
  • 72.47 (n)
(Anolis carolinensis)
Reptilia MGST1 34
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mgst1 33
  • 59.35 (n)
(Danio rerio)
Actinopterygii mgst1.1 33 34
  • 57.36 (n)
mgst1.2 34
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mgstl 33 34
  • 51.54 (n)
CG33177 34
  • 36 (a)
CG33178 34
  • 33 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta GSTMIC1 33
  • 49.07 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
-- 34
  • 44 (a)
-- 34
  • 38 (a)
-- 34
  • 33 (a)
Species where no ortholog for MGST1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MGST1 Gene

Gene Tree for MGST1 (if available)
Gene Tree for MGST1 (if available)

Paralogs for MGST1 Gene

Paralogs for MGST1 Gene

(1) SIMAP similar genes for MGST1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MGST1: view

Variants for MGST1 Gene

Sequence variations from dbSNP and Humsavar for MGST1 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000018649 -- 16,359,891(+) T/G intron_variant
rs1000029810 -- 16,359,618(+) A/T intron_variant
rs1000294151 -- 16,366,009(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000337448 -- 16,372,411(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000563723 -- 16,359,772(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MGST1 Gene

Variant ID Type Subtype PubMed ID
esv3892149 CNV loss 25118596
esv3892150 CNV loss 25118596
nsv1036638 CNV loss 25217958
nsv1049805 CNV loss 25217958
nsv832338 CNV gain 17160897

Variation tolerance for MGST1 Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MGST1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGST1 Gene

Disorders for MGST1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MGST1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ewing sarcoma
  • es
- elite association - COSMIC cancer census association via MalaCards
Search MGST1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MGST1

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MGST1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MGST1 Gene

Publications for MGST1 Gene

  1. Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population. (PMID: 17483957) Zhang H … Wu M (International journal of colorectal disease 2007) 3 22 44 58
  2. Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. (PMID: 16384981) Haines JL … Pericak-Vance MA (Investigative ophthalmology & visual science 2006) 3 22 44 58
  3. Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis. (PMID: 15338373) Schneider A … Whitcomb DC (Journal of gastroenterology 2004) 3 22 44 58
  4. Structural organization of the human microsomal glutathione S-transferase gene (GST12). (PMID: 8812420) Kelner MJ … Montoya MA (Genomics 1996) 3 4 22 58
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A … Kamatani N (Journal of human genetics 2009) 3 44 58

Products for MGST1 Gene

Sources for MGST1 Gene

Loading form....