Aliases for MGRN1 Gene
External Ids for MGRN1 Gene
Previous GeneCards Identifiers for MGRN1 Gene
Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.[supplied by OMIM, Apr 2004]
GeneCards Summary for MGRN1 Gene
MGRN1 (Mahogunin Ring Finger 1) is a Protein Coding gene. Diseases associated with MGRN1 include Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 3 and Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 4. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF157.
UniProtKB/Swiss-Prot Summary for MGRN1 Gene
E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).