Aliases for MGP Gene
External Ids for MGP Gene
Previous GeneCards Identifiers for MGP Gene
This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. [provided by RefSeq, Sep 2016]
GeneCards Summary for MGP Gene
MGP (Matrix Gla Protein) is a Protein Coding gene. Diseases associated with MGP include Keutel Syndrome and Peripheral Pulmonary Stenosis. Among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and NOTCH1 regulation of human endothelial cell calcification. Gene Ontology (GO) annotations related to this gene include calcium ion binding and structural constituent of bone.
UniProtKB/Swiss-Prot Summary for MGP Gene
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.