This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardio... See more...

Aliases for MGP Gene

Aliases for MGP Gene

  • Matrix Gla Protein 2 3 4 5
  • Cell Growth-Inhibiting Gene 36 Protein 3 4
  • MGLAP 3 4
  • GIG36 3
  • NTI 3
  • MGP 5

External Ids for MGP Gene

Previous GeneCards Identifiers for MGP Gene

  • GC12M014774
  • GC12M015179
  • GC12M014934
  • GC12M014926
  • GC12M015034

Summaries for MGP Gene

Entrez Gene Summary for MGP Gene

  • This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia. [provided by RefSeq, Sep 2016]

GeneCards Summary for MGP Gene

MGP (Matrix Gla Protein) is a Protein Coding gene. Diseases associated with MGP include Keutel Syndrome and Peripheral Pulmonary Stenosis. Among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and NOTCH1 regulation of human endothelial cell calcification. Gene Ontology (GO) annotations related to this gene include calcium ion binding and structural constituent of bone.

UniProtKB/Swiss-Prot Summary for MGP Gene

  • Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

Gene Wiki entry for MGP Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MGP Gene

Genomics for MGP Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MGP Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J014883 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.9 886 3.2 ZNF629 IKZF2 PKNOX1 DPF2 RUNX3 CTBP1 CBFB ZNF217 BCL11A NBN MGP lnc-ERP27-1 ENSG00000256339 ERP27 PDE6H ART4 SMCO3 ARHGDIB H2AJ H4-16
GH12J014945 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 19.9 -69.5 -69457 19.1 SP1 ATF7 REST ZNF512 RFX1 POLR2A BACH1 JUND LARP7 STAT3 ARHGDIB ERP27 MGP PDE6H WBP11 ART4 H2AJ H4-16 SMCO3 C12orf60
GH12J014927 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 11.3 -43.1 -43117 2.4 ZHX2 FOXA1 ZSCAN4 SP1 CTBP1 ZNF217 GATA3 DPF2 ELF1 STAT1 ERP27 MGP C12orf60 ARHGDIB PDE6H ENSG00000256339 piR-61288-003
GH12J014937 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE dbSUPER 10.2 -53.2 -53213 3.9 CTCF ZNF143 POLR2A SMC3 BCL6 NFATC1 RAD21 SPI1 ERP27 ARHGDIB PDE6H H4-16 ENSG00000256339 MGP C12orf60 MN309451
GH12J015001 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.1 -116.1 -116144 1.2 BCL6 CTCF RAD21 TAF1 TBP EZH2 LINC01489 ARHGDIB ART4 PDE6H ENSG00000256339 SMCO3 H2AJ H4-16 MGP C12orf60
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MGP on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MGP

Top Transcription factor binding sites by QIAGEN in the MGP gene promoter:
  • AML1a
  • AP-1
  • ATF-2
  • c-Jun
  • FOXI1
  • HFH-3
  • MyoD
  • STAT5B

Genomic Locations for MGP Gene

Genomic Locations for MGP Gene
chr12:14,880,864-14,885,857
(GRCh38/hg38)
Size:
4,994 bases
Orientation:
Minus strand
chr12:15,034,115-15,038,860
(GRCh37/hg19)
Size:
4,746 bases
Orientation:
Minus strand

Genomic View for MGP Gene

Genes around MGP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGP Gene

Proteins for MGP Gene

  • Protein details for MGP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08493-MGP_HUMAN
    Recommended name:
    Matrix Gla protein
    Protein Accession:
    P08493
    Secondary Accessions:
    • A0M8W5
    • B2R519
    • J3KMX7
    • Q2TU41
    • Q567P9
    • Q6ICN5

    Protein attributes for MGP Gene

    Size:
    103 amino acids
    Molecular mass:
    12353 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MGP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGP Gene

Post-translational modifications for MGP Gene

  • Requires vitamin K-dependent gamma-carboxylation for its function.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MGP Gene

No data available for DME Specific Peptides for MGP Gene

Domains & Families for MGP Gene

Gene Families for MGP Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for MGP Gene

InterPro:
Blocks:
  • Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
  • Bone matrix GLA domain signature
ProtoNet:

Suggested Antigen Peptide Sequences for MGP Gene

GenScript: Design optimal peptide antigens:
  • Cell growth-inhibiting gene 36 protein (MGP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08493

UniProtKB/Swiss-Prot:

MGP_HUMAN :
  • Belongs to the osteocalcin/matrix Gla protein family.
Family:
  • Belongs to the osteocalcin/matrix Gla protein family.
genes like me logo Genes that share domains with MGP: view

Function for MGP Gene

Molecular function for MGP Gene

UniProtKB/Swiss-Prot Function:
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
GENATLAS Biochemistry:
bone matrix GLA protein,vitamin K dependent,vitamin D regulated

Phenotypes From GWAS Catalog for MGP Gene

Gene Ontology (GO) - Molecular Function for MGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent TAS,RCA 20551380
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 15607035
GO:0008147 structural constituent of bone TAS 9916809
genes like me logo Genes that share ontologies with MGP: view
genes like me logo Genes that share phenotypes with MGP: view

Human Phenotype Ontology for MGP Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MGP Gene

MGI Knock Outs for MGP:
  • Mgp Mgp<tm1Kry>

Animal Model Products

CRISPR Products

miRNA for MGP Gene

miRTarBase miRNAs that target MGP

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MGP

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MGP Gene

Localization for MGP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MGP gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
cytosol 2
golgi apparatus 2
peroxisome 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0031012 extracellular matrix TAS,IBA 21873635
GO:0062023 colocalizes_with collagen-containing extracellular matrix HDA 20551380
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with MGP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MGP Gene

Pathways & Interactions for MGP Gene

genes like me logo Genes that share pathways with MGP: view

Interacting Proteins for MGP Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000228938 P08493-MGP_HUMAN for MGP Gene via STRING IID

Gene Ontology (GO) - Biological Process for MGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001502 cartilage condensation TAS 9916809
GO:0001503 ossification TAS,IEA --
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
GO:0030500 regulation of bone mineralization IEA --
genes like me logo Genes that share ontologies with MGP: view

No data available for SIGNOR curated interactions for MGP Gene

Drugs & Compounds for MGP Gene

(9) Drugs for MGP Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Calcium Nutra Target 6556

(5) Additional Compounds for MGP Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MGP: view

Transcripts for MGP Gene

mRNA/cDNA for MGP Gene

2 REFSEQ mRNAs :
16 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MGP

Alternative Splicing Database (ASD) splice patterns (SP) for MGP Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2: -

Relevant External Links for MGP Gene

GeneLoc Exon Structure for
MGP

Expression for MGP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MGP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MGP Gene

This gene is overexpressed in Artery - Aorta (x12.2) and Artery - Coronary (x5.9).

Protein differential expression in normal tissues from HIPED for MGP Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (27.8), Breast (9.8), and Saliva (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MGP Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MGP

SOURCE GeneReport for Unigene cluster for MGP Gene:

Hs.365706

Evidence on tissue expression from TISSUES for MGP Gene

  • Nervous system(4.9)
  • Heart(4.3)
  • Eye(4.1)
  • Kidney(3.9)
  • Muscle(3.8)
  • Lung(3.7)
  • Intestine(3.6)
  • Stomach(3.6)
  • Adrenal gland(3.3)
  • Skin(3.2)
  • Thyroid gland(3.2)
  • Gall bladder(3.1)
  • Liver(3)
  • Pancreas(3)
  • Spleen(3)
  • Lymph node(2.8)
  • Bone(2.7)
  • Blood(2.7)
  • Bone marrow(2.2)
  • Urine(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MGP Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • immune
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cheek
  • chin
  • ear
  • face
  • forehead
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • middle ear
  • mouth
  • neck
  • nose
  • outer ear
  • pharynx
  • sinus
  • skull
  • vocal cord
Thorax:
  • bronchus
  • chest wall
  • clavicle
  • heart
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • trachea
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • skin
  • spinal column
  • vertebrae
  • white blood cell
genes like me logo Genes that share expression patterns with MGP: view

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MGP Gene

Orthologs for MGP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MGP Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MGP 30 31
  • 99.35 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MGP 30
  • 85.11 (n)
Cow
(Bos Taurus)
Mammalia MGP 30
  • 83.82 (n)
Mouse
(Mus musculus)
Mammalia Mgp 30 17 31
  • 81.23 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mgp 30
  • 79.94 (n)
Oppossum
(Monodelphis domestica)
Mammalia MGP 31
  • 72 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MGP 31
  • 55 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MGP 31
  • 51 (a)
OneToOne
Species where no ortholog for MGP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for MGP Gene

ENSEMBL:
Gene Tree for MGP (if available)
TreeFam:
Gene Tree for MGP (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MGP: view image

Paralogs for MGP Gene

No data available for Paralogs for MGP Gene

Variants for MGP Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MGP Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
728682 Conflicting Interpretations: Keutel syndrome; not provided 14,882,253(-) G/A SYNONYMOUS_VARIANT
734625 Likely Benign: not provided 14,885,759(-) G/A SYNONYMOUS_VARIANT
740943 Likely Benign: not provided 14,885,750(-) C/T SYNONYMOUS_VARIANT
746959 Likely Benign: not provided 14,885,721(-) A/C INTRON_VARIANT
785395 Likely Benign: not provided 14,882,152(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for MGP Gene

Variation tolerance for MGP Gene

Residual Variation Intolerance Score: 82.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.37; 76.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MGP Gene

Human Gene Mutation Database (HGMD)
MGP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MGP

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MGP Gene

Disorders for MGP Gene

MalaCards: The human disease database

(32) MalaCards diseases for MGP Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
keutel syndrome
  • ktls
peripheral pulmonary stenosis
  • branch pulmonary artery stenosis
vitamin k deficiency bleeding
  • deficiency of vitamin k
arteriosclerosis
  • arteriosclerotic vascular disease
hyperphosphatemia
- elite association - COSMIC cancer census association via MalaCards
Search MGP in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MGP_HUMAN
  • Keutel syndrome (KTLS) [MIM:245150]: An autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia. {ECO:0000269 PubMed:9916809}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for MGP

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MGP: view

No data available for Genatlas for MGP Gene

Publications for MGP Gene

  1. Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene. (PMID: 2394711) Cancela L … Price PA (The Journal of biological chemistry 1990) 2 3 4 23
  2. Polymorphisms in MGP gene and their association with lead toxicity. (PMID: 19730704) Shaik AP … Jamil K (Toxicology mechanisms and methods 2009) 3 23 41
  3. Individual susceptibility and genotoxicity in workers exposed to hazardous materials like lead. (PMID: 19327888) Shaik AP … Jamil K (Journal of hazardous materials 2009) 3 23 41
  4. The local calcification inhibitor matrix Gla protein in pseudoxanthoma elasticum. (PMID: 18222176) Hendig D … Götting C (Clinical biochemistry 2008) 3 23 41
  5. A polymorphism of matrix Gla protein gene is associated with kidney stones. (PMID: 17509359) Gao B … Kohri K (The Journal of urology 2007) 3 23 41

Products for MGP Gene

Sources for MGP Gene