This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cance... See more...

Aliases for MGLL Gene

Aliases for MGLL Gene

  • Monoglyceride Lipase 2 3 4 5
  • Monoacylglycerol Lipase 2 3 4
  • HU-K5 2 3 4
  • MAGL 2 3 4
  • MGL 2 3 4
  • Lysophospholipase Homolog 3 4
  • Lysophospholipase-Like 4
  • EC 3.1.1.23 4
  • HUK5 3
  • MGLL 5

External Ids for MGLL Gene

Previous GeneCards Identifiers for MGLL Gene

  • GC03M124242
  • GC03M127569
  • GC03M128692
  • GC03M128731
  • GC03M128893
  • GC03M127407
  • GC03M124788

Summaries for MGLL Gene

Entrez Gene Summary for MGLL Gene

  • This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for MGLL Gene

MGLL (Monoglyceride Lipase) is a Protein Coding gene. Diseases associated with MGLL include Cannabis Dependence and Hallucinogen Dependence. Among its related pathways are GABAergic synapse and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and lipid binding.

UniProtKB/Swiss-Prot Summary for MGLL Gene

  • Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333).

Tocris Summary for MGLL Gene

  • Monoacylglycerol lipase (MAGL, MGL) is a hydrolase that is involved in endocannabinoid and triglyceride hydrolysis. It is the primary enzyme responsible for the metabolism of 2-arachidonylglycerol (2-AG) in the brain, and is also involved in lipid signaling.

No data available for CIViC Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MGLL Gene

Genomics for MGLL Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MGLL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J127813 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 603.9 +233.3 233339 10.6 CEBPG CREB1 REST KDM1A POLR2A BACH1 TARDBP LARP7 ZIC2 ZSCAN4 MGLL RUVBL1 KBTBD12 TPRA1 lnc-KBTBD12-5 lnc-TPRA1-4 ABTB1
GH03J128051 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 -1.3 -1280 4.9 BRCA1 ATF7 PRDM10 ZNF629 SIX5 ZNF692 POLR2A BACH1 TARDBP LARP7 SEC61A1 LOC102723759 MGLL lnc-RUVBL1-1 piR-41687 RNU2-37P RUVBL1-AS1 RF00017-4107 EEFSEC
GH03J127733 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 607.8 +316.5 316547 4 LARP7 RELA TCF12 IKZF2 POLR2A YY1 PKNOX1 EED DPF2 RELB MGLL TPRA1 lnc-ABTB1-4 AB372640 ABTB1 KBTBD12
GH03J127766 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 +279.1 279146 12.1 ZNF143 RELA ZIC2 TCF12 IKZF2 SP1 CEBPA EED CEBPB DPF2 MCM2 TPRA1 ABTB1 MGLL PODXL2 lnc-ABTB1-3 lnc-TPRA1-4 KBTBD12
GH03J127761 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 8.5 +289.5 289522 3.3 POLR2A LARP7 TCF12 TRIM22 PKNOX1 SIN3A PAX8 DPF2 RELB RUNX3 MGLL MCM2 lnc-TPRA1-3 lnc-ABTB1-3 ABTB1 KBTBD12
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MGLL on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MGLL

Top Transcription factor binding sites by QIAGEN in the MGLL gene promoter:
  • CP2
  • Evi-1
  • FOXI1
  • FOXL1
  • IRF-2

Genomic Locations for MGLL Gene

Genomic Locations for MGLL Gene
chr3:127,689,062-128,052,190
(GRCh38/hg38)
Size:
363,129 bases
Orientation:
Minus strand
chr3:127,407,909-127,542,051
(GRCh37/hg19)
Size:
134,143 bases
Orientation:
Minus strand

Genomic View for MGLL Gene

Genes around MGLL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGLL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGLL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGLL Gene

Proteins for MGLL Gene

  • Protein details for MGLL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99685-MGLL_HUMAN
    Recommended name:
    Monoglyceride lipase
    Protein Accession:
    Q99685
    Secondary Accessions:
    • B3KRC2
    • B7Z9D1
    • Q6IBG9
    • Q96AA5

    Protein attributes for MGLL Gene

    Size:
    303 amino acids
    Molecular mass:
    33261 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAB39616.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH00551.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH06230.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAG37910.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAG33116.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=EAW79330.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=EAW79331.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • Short-term inhibition causes analgesia, while long-term inhibition causes tolerance to endocannabinoids acting on brain cannabinoid receptor CNR1, and a reduction in brain cannabinoid receptor CNR1 activity.

    Three dimensional structures from OCA and Proteopedia for MGLL Gene

    Alternative splice isoforms for MGLL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGLL Gene

Post-translational modifications for MGLL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Boster Bio Antibodies for MGLL

No data available for DME Specific Peptides for MGLL Gene

Domains & Families for MGLL Gene

Gene Families for MGLL Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MGLL Gene

InterPro:
Blocks:
  • Alpha/beta hydrolase fold
  • Lipase, active site
  • Alpha/beta hydrolase fold signature
ProtoNet:

Suggested Antigen Peptide Sequences for MGLL Gene

GenScript: Design optimal peptide antigens:
  • Monoacylglycerol lipase isoform 2 (B2ZGL7_HUMAN)
  • cDNA FLJ54260, highly similar to Monoglyceride lipase (EC 3.1.1.23) (B7Z9D1_HUMAN)
  • Monoacylglycerol lipase (MGLL_HUMAN)
  • cDNA, FLJ96595, Homo sapiens monoglyceride lipase (MGLL), mRNA (Q6IBG9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q99685

UniProtKB/Swiss-Prot:

MGLL_HUMAN :
  • Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family.
genes like me logo Genes that share domains with MGLL: view

Function for MGLL Gene

Molecular function for MGLL Gene

UniProtKB/Swiss-Prot Function:
Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=Hydrolyzes glycerol monoesters of long-chain fatty acids.; EC=3.1.1.23; Evidence={ECO:0000269|PubMed:19029917, ECO:0000269|PubMed:20079333, ECO:0000269|PubMed:21049984, ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24368842};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octanoylglycerol + H2O = glycerol + H(+) + octanoate; Xref=Rhea:RHEA:44328, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:25646, ChEBI:CHEBI:85241; Evidence={ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24368842};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:26132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:52392; Evidence={ECO:0000269|PubMed:19029917, ECO:0000269|PubMed:20079333, ECO:0000269|PubMed:21049984, ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24368842};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-decanoylglycerol + H2O = decanoate + glycerol + H(+); Xref=Rhea:RHEA:44320, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:27689, ChEBI:CHEBI:75547; Evidence={ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24368842};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-dodecanoylglycerol + H2O = dodecanoate + glycerol + H(+); Xref=Rhea:RHEA:44316, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:18262, ChEBI:CHEBI:75539; Evidence={ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24368842};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-tetradecanoylglycerol + H2O = glycerol + H(+) + tetradecanoate; Xref=Rhea:RHEA:44312, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30807, ChEBI:CHEBI:75562; Evidence={ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24368842};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate; Xref=Rhea:RHEA:39963, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:75455; Evidence={ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24368842};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38487, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:75342; Evidence={ECO:0000269|PubMed:20079333, ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24368842};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:38491, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:73990; Evidence={ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24368842};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=2-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+); Xref=Rhea:RHEA:44732, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30245, ChEBI:CHEBI:75457; Evidence={ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24368842};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+); Xref=Rhea:RHEA:44728, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:32395, ChEBI:CHEBI:75612; Evidence={ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24368842};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-(9Z,12Z-octadecadienoyl)-glycerol + H2O = (9Z,12Z)-octadecadienoate + glycerol + H(+); Xref=Rhea:RHEA:48428, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30245, ChEBI:CHEBI:75568; Evidence={ECO:0000269|PubMed:22969151, ECO:0000269|PubMed:24368842};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + glycerol + H(+); Xref=Rhea:RHEA:39955, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:30823, ChEBI:CHEBI:75937; Evidence={ECO:0000250|UniProtKB:O35678};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-hexadecanoylglycerol + H2O = glycerol + H(+) + hexadecanoate; Xref=Rhea:RHEA:39959, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:69081; Evidence={ECO:0000269|PubMed:20079333};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=1-octadecanoylglycerol + H2O = glycerol + H(+) + octadecanoate; Xref=Rhea:RHEA:38363, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:25629, ChEBI:CHEBI:75555; Evidence={ECO:0000269|PubMed:20079333};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + prostaglandin E2 1-glyceryl ester = glycerol + H(+) + prostaglandin E2; Xref=Rhea:RHEA:48296, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:90230, ChEBI:CHEBI:606564; Evidence={ECO:0000269|PubMed:21049984, ECO:0000269|PubMed:24368842};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + prostaglandin D2-1-glycerol ester = glycerol + H(+) + prostaglandin D2; Xref=Rhea:RHEA:45412, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:57406, ChEBI:CHEBI:85232; Evidence={ECO:0000269|PubMed:24368842};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=11-oxo-5Z,9,12E,14E-prostatetraenoate + H2O = 15-deoxy-Delta(12,14)-prostaglandin J2 + glycerol + H(+); Xref=Rhea:RHEA:45416, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:85236, ChEBI:CHEBI:85238; Evidence={ECO:0000269|PubMed:24368842};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + prostaglandin F2alpha 1-glyceryl ester = glycerol + H(+) + prostaglandin F2alpha; Xref=Rhea:RHEA:48300, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:57404, ChEBI:CHEBI:90233; Evidence={ECO:0000269|PubMed:21049984};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=110 uM for 2-arachidonoyglycerol {ECO:0000269|PubMed:22969151}; KM=15 uM for 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) {ECO:0000269|PubMed:24368842}; Vmax=120 nmol/min/mg enzyme toward 2-arachidonoyglycerol {ECO:0000269|PubMed:22969151}; Vmax=89 nmol/min/mg enzyme toward 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) {ECO:0000269|PubMed:24368842};

Enzyme Numbers (IUBMB) for MGLL Gene

Phenotypes From GWAS Catalog for MGLL Gene

Gene Ontology (GO) - Molecular Function for MGLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004622 lysophospholipase activity TAS 9495531
GO:0005515 protein binding IPI 28298427
GO:0016298 lipase activity IBA 21873635
GO:0016787 hydrolase activity IEA --
GO:0042803 protein homodimerization activity IPI 19957260
genes like me logo Genes that share ontologies with MGLL: view
genes like me logo Genes that share phenotypes with MGLL: view

Animal Models for MGLL Gene

MGI Knock Outs for MGLL:
  • Mgll Mgll<tm1.1Rzim>
  • Mgll Mgll<tm1.1Mwa>

Animal Model Products

  • Taconic Biosciences Mouse Models for MGLL

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MGLL

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MGLL Gene

Localization for MGLL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGLL Gene

Cytoplasm, cytosol. Membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MGLL gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
endoplasmic reticulum 4
extracellular 2
cytoskeleton 2
mitochondrion 2
peroxisome 2
lysosome 2
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MGLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005829 cytosol ISS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with MGLL: view

Pathways & Interactions for MGLL Gene

genes like me logo Genes that share pathways with MGLL: view

Pathways by source for MGLL Gene

1 GeneGo (Thomson Reuters) pathway for MGLL Gene
  • Development Alpha-2 adrenergic receptor activation of ERK

UniProtKB/Swiss-Prot Q99685-MGLL_HUMAN

  • Pathway: Glycerolipid metabolism; triacylglycerol degradation.

SIGNOR curated interactions for MGLL Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for MGLL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 9495531
GO:0006631 fatty acid metabolic process IEA --
GO:0006633 fatty acid biosynthetic process IEA --
GO:0006954 inflammatory response TAS 9495531
GO:0009966 regulation of signal transduction ISS --
genes like me logo Genes that share ontologies with MGLL: view

Drugs & Compounds for MGLL Gene

(11) Drugs for MGLL Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycerol Approved, Investigational Pharma 197
Water Approved Pharma 0
Glyceryl Trioleate Investigational Pharma 0
Tricaprylin Investigational Pharma 0
JZL184 Pharma Inhibitor, Inhibition MAGL inhibitor, potent and selective, MAGL inhibitor 0

(71) Additional Compounds for MGLL Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Arachidonylglycerol
  • 2-(5Z,8Z,11Z,14Z-Eicosatetraenoyl)-glycerol
  • 2-AG
  • 2-Ara-GL
  • 2-Arachidonoyl-glycerol
  • 2-Arachidonyl-glycerol
53847-30-6
MG(0:0/14:0/0:0)
  • 2-Monomyristin
  • 2-Monotetradecanoylglycerol
  • 2-Myristoyloxy-propane-1,3-diol
  • Glycerin monomyristate
  • Glyceryl 2-myristate
MG(0:0/14:1(9Z)/0:0)
  • 1-Monoacylglyceride
  • 1-Monoacylglycerol
  • 2-(9Z-Tetradecenoyl)-rac-glycerol
  • 2-Myristoleoyl-glycerol
  • b-Monoacylglycerol
MG(0:0/15:0/0:0)
  • 1-Monoacylglyceride
  • 1-Monoacylglycerol
  • 2-Pentadecanoyl-glycerol
  • 2-Pentadecanoyl-rac-glycerol
  • b-Monoacylglycerol
MG(0:0/16:0/0:0)
  • 1,3-Dihydroxypropan-2-yl palmitate
  • 2-Hexadecanoylglycerol
  • 2-Monopalmitin
  • 2-Monopalmitoylglycerol
  • 2-O-Palmitoylglycerol

(3) Tocris Compounds for MGLL Gene

Compound Action Cas Number
JZL 184 MAGL inhibitor 1101854-58-3
KML 29 Highly potent and selective MAGL inhibitor 1380424-42-9
Pristimerin Potent, reversible MAGL inhibitor 1258-84-0

(1) ApexBio Compounds for MGLL Gene

Compound Action Cas Number
JZL184 MAGL inhibitor, potent and selective 1101854-58-3
genes like me logo Genes that share compounds with MGLL: view

Drug Products

Transcripts for MGLL Gene

mRNA/cDNA for MGLL Gene

3 REFSEQ mRNAs :
32 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MGLL

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGLL Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1: - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - -
SP5: - - -
SP6: - - - - - - - - -
SP7: - - -
SP8: -
SP9:
SP10: - -

Relevant External Links for MGLL Gene

GeneLoc Exon Structure for
MGLL

Expression for MGLL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MGLL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MGLL Gene

This gene is overexpressed in Platelet (18.9), Adipocyte (14.7), and Nasopharynx (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MGLL Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MGLL

SOURCE GeneReport for Unigene cluster for MGLL Gene:

Hs.277035

mRNA Expression by UniProt/SwissProt for MGLL Gene:

Q99685-MGLL_HUMAN
Tissue specificity: Detected in adipose tissue, lung, liver, kidney, brain and heart.

Evidence on tissue expression from TISSUES for MGLL Gene

  • Nervous system(5)
  • Lung(4.7)
  • Liver(4.7)
  • Pancreas(4.4)
  • Skin(3.7)
  • Intestine(3.7)
  • Kidney(3.5)
  • Eye(3.1)
  • Muscle(3.1)
  • Heart(2.9)
  • Blood(2.7)
  • Spleen(2.6)
  • Stomach(2.4)
  • Adrenal gland(2.3)
  • Thyroid gland(2.2)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with MGLL: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MGLL Gene

Orthologs for MGLL Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MGLL Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MGLL 30 31
  • 99.79 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MGLL 30 31
  • 89.99 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MGLL 31
  • 87 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia MGLL 30 31
  • 84.16 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mgll 30 17 31
  • 83.17 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mgll 30
  • 83.17 (n)
Oppossum
(Monodelphis domestica)
Mammalia MGLL 31
  • 75 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MGLL 30 31
  • 71.31 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MGLL 31
  • 61 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mgll 30
  • 63.34 (n)
Str.4432 30
Zebrafish
(Danio rerio)
Actinopterygii mgll 30 31
  • 60.22 (n)
OneToOne
zgc56561 30
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YJU3 31 33
  • 22 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G16120 30
  • 41.7 (n)
Rice
(Oryza sativa)
Liliopsida Os10g0135600 30
  • 41.07 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 40 (a)
OneToMany
CSA.8597 31
  • 37 (a)
OneToMany
Species where no ortholog for MGLL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for MGLL Gene

ENSEMBL:
Gene Tree for MGLL (if available)
TreeFam:
Gene Tree for MGLL (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MGLL: view image

Paralogs for MGLL Gene

(1) SIMAP similar genes for MGLL Gene using alignment to 8 proteins:

  • MGLL_HUMAN
  • B2ZGL7_HUMAN
  • C9J8Q3_HUMAN
  • C9JAM4_HUMAN
  • E7EWX8_HUMAN
  • H7C4E0_HUMAN
  • H7C599_HUMAN
  • H7C5K5_HUMAN
genes like me logo Genes that share paralogs with MGLL: view

No data available for Paralogs for MGLL Gene

Variants for MGLL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MGLL Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
767929 Benign: not provided 127,721,125(-) C/T SYNONYMOUS_VARIANT
767930 Benign: not provided 127,781,859(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for MGLL Gene

Structural Variations from Database of Genomic Variants (DGV) for MGLL Gene

Variant ID Type Subtype PubMed ID
esv1191118 CNV deletion 17803354
esv2659152 CNV deletion 23128226
esv2664028 CNV deletion 23128226
esv27043 CNV loss 19812545
esv2759175 CNV loss 17122850
esv2864236 CNV insertion 24192839
esv3303946 CNV mobile element insertion 20981092
esv3304377 CNV mobile element insertion 20981092
esv3310275 CNV mobile element insertion 20981092
esv3328909 CNV insertion 20981092
esv3395978 CNV duplication 20981092
esv3438361 CNV insertion 20981092
esv3445369 CNV insertion 20981092
esv3562518 CNV deletion 23714750
esv3597696 CNV loss 21293372
esv3597697 CNV loss 21293372
esv3597699 CNV loss 21293372
esv3597700 CNV loss 21293372
esv3597701 CNV loss 21293372
esv3597702 CNV loss 21293372
nsv1002685 CNV gain 25217958
nsv1114424 CNV deletion 24896259
nsv3990 CNV insertion 18451855
nsv460848 CNV loss 19166990
nsv591585 CNV loss 21841781
nsv979875 CNV duplication 23825009

Variation tolerance for MGLL Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MGLL Gene

Human Gene Mutation Database (HGMD)
MGLL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MGLL

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGLL Gene

Disorders for MGLL Gene

MalaCards: The human disease database

(4) MalaCards diseases for MGLL Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cannabis dependence
  • marijuana abuse
hallucinogen dependence
cannabis abuse
  • marijuana abuse
chanarin-dorfman syndrome
  • cds
- elite association - COSMIC cancer census association via MalaCards
Search MGLL in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MGLL

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with MGLL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MGLL Gene

Publications for MGLL Gene

  1. Structural basis for human monoglyceride lipase inhibition. (PMID: 19962385) Bertrand T … Mathieu M (Journal of molecular biology 2010) 3 4 23
  2. Lack of association of genetic variants in genes of the endocannabinoid system with anorexia nervosa. (PMID: 19014633) Müller TD … Hinney A (Child and adolescent psychiatry and mental health 2008) 3 23 41
  3. Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese population. (PMID: 17621164) Iwasaki S … Arinami T (Psychiatric genetics 2007) 3 23 41
  4. Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene. (PMID: 11470505) Karlsson M … Holm C (Gene 2001) 3 4 23
  5. A novel poxvirus gene and its human homolog are similar to an E. coli lysophospholipase. (PMID: 9495531) Wall EM … Upton C (Virus research 1997) 2 3 4

Products for MGLL Gene

Sources for MGLL Gene