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Aliases for MGEA5 Gene

Aliases for MGEA5 Gene

  • Meningioma Expressed Antigen 5 (Hyaluronidase) 2 3 5
  • Nuclear Cytoplasmic O-GlcNAcase And Acetyltransferase 2 3 4
  • N-Acetyl-Beta-D-Glucosaminidase 3 4
  • Meningioma-Expressed Antigen 5 3 4
  • N-Acetyl-Beta-Glucosaminidase 3 4
  • Beta-N-Acetylglucosaminidase 3 4
  • Beta-N-Acetylhexosaminidase 3 4
  • Beta-Hexosaminidase 3 4
  • NCOAT 3 4
  • MEA5 3 4
  • OGA 3 4
  • Hyaluronidase In Meningioma 3
  • Bifunctional Protein NCOAT 3
  • Protein O-GlcNAcase 3
  • EC 3.2.1.169 4
  • O-GlcNAcase 3
  • KIAA0679 4
  • HEXC 4

External Ids for MGEA5 Gene

Previous GeneCards Identifiers for MGEA5 Gene

  • GC10M102437
  • GC10M102777
  • GC10M103675
  • GC10M103208
  • GC10M103534
  • GC10M097174

Summaries for MGEA5 Gene

Entrez Gene Summary for MGEA5 Gene

  • The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]

GeneCards Summary for MGEA5 Gene

MGEA5 (Meningioma Expressed Antigen 5 (Hyaluronidase)) is a Protein Coding gene. Diseases associated with MGEA5 include Gm2-Gangliosidosis, Ab Variant and Diabetes Mellitus, Insulin-Dependent, 24. Among its related pathways are Insulin resistance. Gene Ontology (GO) annotations related to this gene include histone acetyltransferase activity and beta-N-acetylglucosaminidase activity.

UniProtKB/Swiss-Prot for MGEA5 Gene

  • Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).

  • Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.

Gene Wiki entry for MGEA5 Gene

Additional gene information for MGEA5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGEA5 Gene

Genomics for MGEA5 Gene

GeneHancer (GH) Regulatory Elements for MGEA5 Gene

Promoters and enhancers for MGEA5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I101814 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.6 1600 5.9 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A KCNIP2-AS1 MGEA5 PPRC1 HPS6 LDB1 GBF1 MRPL43 TWNK SUFU NPM3
GH10I102000 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.1 -183.7 -183669 4.4 HDGF PKNOX1 SMAD1 ZNF493 ZFP64 BMI1 BATF KLF5 IRF4 ZNF207 HPS6 GBF1 PPRC1 KCNIP2-AS1 LDB1 ARL3 KCNIP2 C10orf76 MGEA5 SFXN2
GH10I102009 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.5 -191.3 -191292 0.4 ELF3 ARID4B SIN3A ZNF2 IRF4 ZSCAN9 RAD21 RFX5 SLC30A9 SCRT2 KCNIP2 C10orf76 HPS6 MGEA5 KCNIP2-AS1 FGF8 POLL DPCD ENSG00000222430
GH10I102111 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2.7 -299.0 -299025 11.6 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B IRF4 LDB1 HPS6 PPRC1 NFKB2 NOLC1 BORCS7 C10orf95 KCNIP2-AS1 KCNIP2 PSD
GH10I101692 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 1.2 +124.4 124362 3.1 HDGF ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 SP3 SP5 FBXW4 PPRC1 GBF1 MRPL43 LDB1 ENSG00000272572 HPS6 TWNK SUFU LZTS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MGEA5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MGEA5 gene promoter:

Genomic Locations for MGEA5 Gene

Genomic Locations for MGEA5 Gene
chr10:101,784,443-101,818,709
(GRCh38/hg38)
Size:
34,267 bases
Orientation:
Minus strand
chr10:103,544,200-103,578,696
(GRCh37/hg19)

Genomic View for MGEA5 Gene

Genes around MGEA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGEA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGEA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGEA5 Gene

Proteins for MGEA5 Gene

  • Protein details for MGEA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60502-OGA_HUMAN
    Recommended name:
    Protein O-GlcNAcase
    Protein Accession:
    O60502
    Secondary Accessions:
    • B7WPB9
    • D3DR79
    • E9PGF9
    • O75166
    • Q86WV0
    • Q8IV98
    • Q9BVA5
    • Q9HAR0

    Protein attributes for MGEA5 Gene

    Size:
    916 amino acids
    Molecular mass:
    102915 Da
    Quaternary structure:
    • Monomer (PubMed:11788610). Interacts with CLOCK (By similarity).
    SequenceCaution:
    • Sequence=AAH47877.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA31654.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MGEA5 Gene

    Alternative splice isoforms for MGEA5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGEA5 Gene

Post-translational modifications for MGEA5 Gene

  • Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity.
  • Ubiquitination at isoforms=2, 3, 487, isoforms=2, 3, 4240, posLast=297297, posLast=723723, isoforms=2, 4858, and isoforms=2, 4869
  • Glycosylation at isoforms=3405
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MGEA5 Gene

Domains & Families for MGEA5 Gene

Gene Families for MGEA5 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

O60502

UniProtKB/Swiss-Prot:

OGA_HUMAN :
  • Belongs to the glycosyl hydrolase 84 family.
Family:
  • Belongs to the glycosyl hydrolase 84 family.
genes like me logo Genes that share domains with MGEA5: view

Function for MGEA5 Gene

Molecular function for MGEA5 Gene

GENATLAS Biochemistry:
meningioma expressed antigen (MEA5) highly homolog to C elegans hyaluronidase with two alternative forms,expressed in many tissues
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.1 mM for pNP-GlcNAc {ECO:0000269 PubMed:11788610}; Vmax=652 umol/min/mg enzyme with pNP-GLcNAc as substrate {ECO:0000269 PubMed:11788610}; pH dependence: Optimum pH is 5.7-7. {ECO:0000269 PubMed:11148210};
UniProtKB/Swiss-Prot CatalyticActivity:
[Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H(2)O = [protein]-L-serine + N-acetyl-D-glucosamine.
UniProtKB/Swiss-Prot CatalyticActivity:
[Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H(2)O = [protein]-L-threonine + N-acetyl-D-glucosamine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by N-acetylglucosamine and not N-acetylgalactosamine.
UniProtKB/Swiss-Prot Function:
Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714).
UniProtKB/Swiss-Prot Function:
Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.

Enzyme Numbers (IUBMB) for MGEA5 Gene

Phenotypes From GWAS Catalog for MGEA5 Gene

Gene Ontology (GO) - Molecular Function for MGEA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004415 hyalurononglucosaminidase activity TAS 9811929
GO:0016231 beta-N-acetylglucosaminidase activity IDA 11148210
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
GO:0102166 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity IEA --
genes like me logo Genes that share ontologies with MGEA5: view
genes like me logo Genes that share phenotypes with MGEA5: view

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MGEA5 Gene

Localization for MGEA5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGEA5 Gene

Isoform 3: Nucleus.
Isoform 1: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MGEA5 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 3
lysosome 3
extracellular 2
mitochondrion 2
endosome 2
cytoskeleton 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MGEA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA 11148210
GO:0016020 membrane HDA,IDA 19946888
genes like me logo Genes that share ontologies with MGEA5: view

Pathways & Interactions for MGEA5 Gene

genes like me logo Genes that share pathways with MGEA5: view

Pathways by source for MGEA5 Gene

1 BioSystems pathway for MGEA5 Gene
1 KEGG pathway for MGEA5 Gene

Gene Ontology (GO) - Biological Process for MGEA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006044 N-acetylglucosamine metabolic process IDA 11148210
GO:0006493 protein O-linked glycosylation NAS 26363795
GO:0006516 glycoprotein catabolic process TAS 9811929
GO:0006517 protein deglycosylation IDA 11148210
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with MGEA5: view

No data available for SIGNOR curated interactions for MGEA5 Gene

Drugs & Compounds for MGEA5 Gene

(7) Drugs for MGEA5 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Streptozocin Approved, Investigational Pharma Target Antibiotic and antitumor agent 11
Water Approved Pharma 0
N-Acetyl-D-glucosamine Approved, Investigational Nutra 0
Coenzyme A Investigational Nutra 0
(Z)-Pugnac Pharma Inhibitor of O-GlcNAcase and β-hexosaminidase 0

(1) Additional Compounds for MGEA5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9

(3) ApexBio Compounds for MGEA5 Gene

Compound Action Cas Number
(Z)-Pugnac Inhibitor of O-GlcNAcase and β-hexosaminidase 132489-69-1
GlcNAcstatin Selective O-GlcNAcase inhibitor 922163-64-2
Thiamet G O-GlcNAcase inhibitor, potent and selective 1009816-48-1
genes like me logo Genes that share compounds with MGEA5: view

Drug Products

Transcripts for MGEA5 Gene

Unigene Clusters for MGEA5 Gene

Meningioma expressed antigen 5 (hyaluronidase):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGEA5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b ·
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - - -
SP7: - -
SP8: - - -
SP9:
SP10: -
SP11:
SP12:
SP13:
SP14:
SP15: - - -
SP16:

ExUns: 16c · 16d · 16e ^ 17 ^ 18a · 18b · 18c · 18d ^ 19a · 19b · 19c ^ 20a · 20b · 20c · 20d · 20e · 20f
SP1: - - -
SP2: - - - -
SP3:
SP4: - - -
SP5:
SP6:
SP7: - - -
SP8: - -
SP9:
SP10:
SP11: - -
SP12: - - - - - - -
SP13: -
SP14:
SP15:
SP16:

Relevant External Links for MGEA5 Gene

GeneLoc Exon Structure for
MGEA5
ECgene alternative splicing isoforms for
MGEA5

Expression for MGEA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MGEA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MGEA5 Gene

This gene is overexpressed in Fetal Brain (12.7), Lymph node (8.2), and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MGEA5 Gene



Protein tissue co-expression partners for MGEA5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MGEA5 Gene:

MGEA5

SOURCE GeneReport for Unigene cluster for MGEA5 Gene:

Hs.500842

mRNA Expression by UniProt/SwissProt for MGEA5 Gene:

O60502-OGA_HUMAN
Tissue specificity: Ubiquitous. Shows highest expression in the brain, placenta and pancreas.

Evidence on tissue expression from TISSUES for MGEA5 Gene

  • Nervous system(5)
  • Eye(4.6)
  • Skin(4.6)
  • Stomach(4.6)
  • Lung(4.1)
  • Kidney(4)
  • Intestine(3.5)
  • Urine(3.5)
  • Blood(3)
  • Heart(2.9)
  • Liver(2.8)
  • Spleen(2.7)
  • Bone marrow(2.6)
  • Muscle(2.6)
genes like me logo Genes that share expression patterns with MGEA5: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MGEA5 Gene

Orthologs for MGEA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for MGEA5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGEA5 33 34
  • 99.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 97 (a)
OneToMany
-- 34
  • 91 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia MGEA5 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGEA5 33 34
  • 94.98 (n)
cow
(Bos Taurus)
Mammalia MGEA5 33 34
  • 94.43 (n)
rat
(Rattus norvegicus)
Mammalia Mgea5 33
  • 91.01 (n)
mouse
(Mus musculus)
Mammalia Mgea5 33 16 34
  • 90.83 (n)
chicken
(Gallus gallus)
Aves MGEA5 33 34
  • 81.21 (n)
lizard
(Anolis carolinensis)
Reptilia MGEA5 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mgea5 33
  • 74.4 (n)
Str.17607 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.17870 33
zebrafish
(Danio rerio)
Actinopterygii mgea5 33 34
  • 74.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta Oga 33 34
  • 52.81 (n)
CG5871 35
  • 30 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002287 33
  • 52.42 (n)
worm
(Caenorhabditis elegans)
Secernentea oga-1 33 34
  • 45.28 (n)
T20B5.3 35
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToOne
Species where no ortholog for MGEA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MGEA5 Gene

ENSEMBL:
Gene Tree for MGEA5 (if available)
TreeFam:
Gene Tree for MGEA5 (if available)

Paralogs for MGEA5 Gene

No data available for Paralogs for MGEA5 Gene

Variants for MGEA5 Gene

Sequence variations from dbSNP and Humsavar for MGEA5 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000059290 -- 101,817,285(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000224430 -- 101,804,565(-) G/A intron_variant
rs1000234527 -- 101,810,934(-) G/A intron_variant
rs1000349212 -- 101,798,596(-) T/C intron_variant
rs1000403832 -- 101,810,630(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MGEA5 Gene

Variant ID Type Subtype PubMed ID
dgv171n67 CNV gain 20364138
esv1006576 CNV deletion 20482838

Variation tolerance for MGEA5 Gene

Residual Variation Intolerance Score: 9.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.18% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MGEA5 Gene

Human Gene Mutation Database (HGMD)
MGEA5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MGEA5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGEA5 Gene

Disorders for MGEA5 Gene

MalaCards: The human disease database

(17) MalaCards diseases for MGEA5 Gene - From: HGMD, DISEASES, and Novoseek

Disorder Aliases PubMed IDs
gm2-gangliosidosis, ab variant
  • hexosaminidase activator deficiency
diabetes mellitus, insulin-dependent, 24
  • iddm24
gangliosidosis gm2
  • gm>2< gangliosidosis
mucolipidosis iv
  • ml4
pyelitis
- elite association - COSMIC cancer census association via MalaCards
Search MGEA5 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MGEA5

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MGEA5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MGEA5 Gene

Publications for MGEA5 Gene

  1. Novel immunogenic antigen homologous to hyaluronidase in meningioma. (PMID: 9811929) Heckel D … Meese E (Human molecular genetics 1998) 2 3 4 22 58
  2. Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase. (PMID: 11341771) Comtesse N … Meese E (Biochemical and biophysical research communications 2001) 3 4 22 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Isoforms of human O-GlcNAcase show distinct catalytic efficiencies. (PMID: 20673219) Li J … Wang P (Biochemistry. Biokhimiia 2010) 3 4 58
  5. Human OGA binds substrates in a conserved peptide recognition groove. (PMID: 20863279) Schimpl M … van Aalten DM (The Biochemical journal 2010) 3 4 58

Products for MGEA5 Gene

Sources for MGEA5 Gene

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