MGC16025 Gene (RNA Gene)

Uncharacterized LOC85009

GC02M239222
GIFtS:
15
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Aliases for MGC16025 Gene

Data sources for MGC16025 Gene:

RNA type for MGC16025 Gene

lncRNA

Aliases for MGC16025 Gene

External Ids for MGC16025 Gene

Previous GeneCards Identifiers for MGC16025 Gene

  • GC02M238057
  • GC02M238688
  • GC02M240030
  • GC02M240327
  • GC02U900722
  • GC02M239781
  • GC02M240115
  • GC02M239197
  • GC02M239198
  • GC02M239215
  • GC02M239217
  • GC02M239220

Summaries for MGC16025 Gene

GeneCards Summary for MGC16025 Gene

MGC16025 (Uncharacterized LOC85009) is an RNA Gene, and is affiliated with the lncRNA class. Among its related pathways are Cyclins and Cell Cycle Regulation and Macrophage Differentiation and Growth Inhibition by METS.

Additional gene information for MGC16025 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MGC16025 Gene

Genomics for MGC16025 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MGC16025 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH02J239195 Enhancer 0.5 Ensembl dbSUPER 250.7 +1.4 1356 0.2 CTCF RAD21 ENSG00000287405 MGC16025 HDAC4 lnc-TWIST2-3 lnc-NDUFA10-4 TWIST2
GH02J239194 Enhancer 0.3 Ensembl dbSUPER 250.7 +0.1 57 2 ENSG00000287405 MGC16025 HDAC4 HDAC4-AS1 lnc-NDUFA10-4 TWIST2
GH02J239193 Enhancer 0.3 Ensembl dbSUPER 250.7 +1.9 1856 0.4 ENSG00000287405 MGC16025 lnc-TWIST2-3 HDAC4 lnc-NDUFA10-4 TWIST2
GH02J239220 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.3 -29.2 -29195 8.1 JUND ATF2 CEBPA ATF3 ZIC2 YY1 FOXA2 SMAD4 RXRA SAP130 HDAC4 HDAC4-AS1 MGC16025 lnc-NDUFA10-5 lnc-NDUFA10-4 TWIST2
GH02J239238 Promoter/Enhancer 1.6 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.3 -44.4 -44363 3.2 NCOR1 YY1 RXRA JUND SPI1 MAX POLR2A HNF4A ZEB2 RAD21 HDAC4 lnc-NDUFA10-5 MGC16025 lnc-NDUFA10-4 TWIST2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MGC16025 on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the MGC16025 gene promoter:
  • c-Myc
  • E2F
  • E2F-1
  • HEN1
  • Max1
  • NF-1
  • NF-1/L
  • Nkx5-1
  • Roaz
  • XBP-1

Genomic Locations for MGC16025 Gene

Latest Assembly
chr2:239,193,330-239,195,457
(GRCh38/hg38)
Size:
2,128 bases
Orientation:
Minus strand

Previous Assembly
chr2:240,115,027-240,117,153
(GRCh37/hg19 by Entrez Gene)
Size:
2,127 bases
Orientation:
Minus strand

Genomic View for MGC16025 Gene

Genes around MGC16025 on UCSC Golden Path with GeneCards custom track
MGC16025 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Cytogenetic band:
MGC16025 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGC16025 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MGC16025 Gene

Proteins for MGC16025 Gene

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  • Protein details for MGC16025 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q53SM2-Q53SM2_HUMAN
    Recommended name:
    Histone deacetylase
    Protein Accession:
    Q53SM2

    Protein attributes for MGC16025 Gene

    Size:
    1052 amino acids
    Molecular mass:
    115600 Da
    Quaternary structure:
    No Data Available

  • Protein details for MGC16025 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Q53SB4-Q53SB4_HUMAN
    Recommended name:
    Uncharacterized protein MGC16025
    Protein Accession:
    Q53SB4

    Protein attributes for MGC16025 Gene

    Size:
    31 amino acids
    Molecular mass:
    3359 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MGC16025 Gene

Post-translational modifications for MGC16025 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MGC16025 Gene

Domains & Families for MGC16025 Gene

Gene Families for MGC16025 Gene

Unknown:
  • Belongs to the histone deacetylase family. HD type 2 subfamily.

Protein Domains for MGC16025 Gene

InterPro:
Blocks:
  • Histone deacetylase superfamily signature
genes like me logo Genes that share domains with MGC16025: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MGC16025 Gene

Function for MGC16025 Gene

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  6. Cell Lines for research

Molecular function for MGC16025 Gene

UniProtKB/TrEMBL CatalyticActivity:
Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089, ChEBI:CHEBI:61930; EC=3.5.1.98; Evidence={ECO:0000256|ARBA:ARBA00001028};.
  • Q53SM2

Enzyme Numbers (IUBMB) for MGC16025 Gene

Phenotypes From GWAS Catalog for MGC16025 Gene

CRISPR products for research

Inhibitory RNAs for research

No data available for Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MGC16025 Gene

Localization for MGC16025 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MGC16025 Gene

Pathways & Interactions for MGC16025 Gene

PathCards logo

SuperPathways for MGC16025 Gene

SuperPathway Contained pathways
1 Cyclins and Cell Cycle Regulation
Cyclins and Cell Cycle Regulation
.67
G1-S Phase Transition
.67
2 Macrophage Differentiation and Growth Inhibition by METS
DNA Methylation and Transcriptional Repression
.30
Macrophage Differentiation and Growth Inhibition by METS
.30
3 BRCA1 Pathway
BRCA1 Pathway
-
4 GPCR Pathway
Estrogen Pathway
.55
5 PEDF Induced Signaling
Glucocorticoid Receptor Signaling
.43
genes like me logo Genes that share pathways with MGC16025: view

Pathways by source for MGC16025 Gene

15 Qiagen pathways for MGC16025 Gene
  • BRCA1 Pathway
  • Cyclins and Cell Cycle Regulation
  • DNA Methylation and Transcriptional Repression
  • Estrogen Pathway
  • G1-S Phase Transition

Gene Ontology (GO) - Biological Process for MGC16025 Gene

None

No data available for Interacting Proteins and SIGNOR curated interactions for MGC16025 Gene

Drugs & Compounds for MGC16025 Gene

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No Compound Related Data Available

Transcripts for MGC16025 Gene

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Non-coding RNA (ncRNA) Transcripts from RNAcentral for MGC16025 Gene

GeneCaRNA:The Human ncRNA Database 2021 Publication

RNAcentral Transcript ID RNA Type Length (nts) # of Sources Source Identifiers and Annotations
URS000075B25B_9606 lncRNA 2127 3

RefSeq: NR_026664,

LNCipedia: lnc-NDUFA10-2:1,

NONCODE: NONHSAT077791.2,

URS0001BD8BE1_9606 lncRNA 2127 1

LncBook: HSALNT0049616,

MGC16025 in the GeneCaRNA (GeneCards ncRNA compendium) hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for MGC16025 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :

CRISPR products for research

Inhibitory RNAs for research

Alternative Splicing Database (ASD) splice patterns (SP) for MGC16025 Gene

No ASD Table

Relevant External Links for MGC16025 Gene

GeneLoc Exon Structure for
MGC16025

Expression for MGC16025 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MGC16025 Gene

mRNA expression in normal human tissues for MGC16025 Gene
mRNA expression by BioGPS for MGC16025 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MGC16025

SOURCE GeneReport for Unigene cluster for MGC16025 Gene:

Hs.744565
genes like me logo Genes that share expression patterns with MGC16025: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MGC16025 Gene

Orthologs for MGC16025 Gene

No data available for Orthologs and Evolution for MGC16025 Gene

Paralogs for MGC16025 Gene

(6) SIMAP similar genes for MGC16025 Gene using alignment to 2 proteins:

  • Q53SB4_HUMAN
  • Q53SM2_HUMAN
genes like me logo Genes that share paralogs with MGC16025: view

No data available for Paralogs for MGC16025 Gene

Variants for MGC16025 Gene

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  1. SNP Genotyping and Copy Number Assays for research

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MGC16025 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MGC16025 Gene

Variant ID Type Subtype PubMed ID
dgv4195n100 CNV gain 25217958
nsv1010141 CNV loss 25217958
nsv834582 CNV loss 17160897

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP , Variation tolerance and Additional Variant Information for MGC16025 Gene

Disorders for MGC16025 Gene

No disorders were found for MGC16025 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for MGC16025 Gene

Publications for MGC16025 Gene

  1. IRES-dependent translation of the long non coding RNA meloe in melanoma cells produces the most immunogenic MELOE antigens. (PMID: 27486971) Charpentier M … Lang F (Oncotarget 2016) 3
  2. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. (PMID: 23453885) Cross-Disorder Group of the Psychiatric Genomics Consortium (Lancet (London, England) 2013) 3
  3. The melanoma antigens MELOE-1 and MELOE-2 are translated from a bona fide polycistronic mRNA containing functional IRES sequences. (PMID: 24086473) Carbonnelle D … Lang F (PloS one 2013) 3
  4. Overexpression of meloe gene in melanomas is controlled both by specific transcription factors and hypomethylation. (PMID: 24086527) Bobinet M … Moreau-Aubry A (PloS one 2013) 3
  5. Frequent occurrence of high affinity T cells against MELOE-1 makes this antigen an attractive target for melanoma immunotherapy. (PMID: 20217862) Godet Y … Labarrière N (European journal of immunology 2010) 3

No data available for Mastermind for MGC16025 Gene

Products for MGC16025 Gene

Sources for MGC16025 Gene