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The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated with the progression of invasive malignancies. [provided by RefSeq, Oct 2011]
MGAT5 (Alpha-1,6-Mannosylglycoprotein 6-Beta-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Diseases associated with MGAT5 include Hepatocellular Carcinoma and Colorectal Cancer. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include acetylglucosaminyltransferase activity and alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is MGAT5B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004864 | protein phosphatase inhibitor activity | IDA | 24846175 |
GO:0008375 | acetylglucosaminyltransferase activity | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity | TAS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | TAS | -- |
GO:0005576 | extracellular region | IEA | -- |
GO:0005794 | Golgi apparatus | IBA | 21873635 |
GO:0016020 | membrane | IEA,IDA | 10395745 |
GO:0016021 | integral component of membrane | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Transport to the Golgi and subsequent modification | ||
2 | Metabolism of proteins | ||
3 | N-glycan antennae elongation in the medial/trans-Golgi | ||
4 | Metabolism | ||
5 | N-Glycan biosynthesis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006486 | protein glycosylation | IEA | -- |
GO:0006487 | protein N-linked glycosylation | IDA | 24846175 |
GO:0018279 | protein N-linked glycosylation via asparagine | IDA | 10395745 |
GO:0030335 | positive regulation of cell migration | IDA | 24846175 |
GO:1903614 | negative regulation of protein tyrosine phosphatase activity | IDA | 24846175 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Uridine 5'-diphosphate | Experimental | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Uridine diphosphate-N-acetylglucosamine |
|
528-04-1 |
|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MGAT5 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MGAT5 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MGAT5 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MGAT5 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mgat5 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mgat5 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | MGAT5 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MGAT5 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MGAT5 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mgat5 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.1926 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mgat5 30 31 |
|
OneToOne | |
Dr.12083 30 |
|
||||
Worm (Caenorhabditis elegans) |
Secernentea | gly-2 30 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
736951 | Likely Benign: not provided | 134,403,077(+) | C/T | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv667n67 | CNV | loss | 20364138 |
esv3368288 | CNV | insertion | 20981092 |
esv3592553 | CNV | loss | 21293372 |
nsv1004271 | CNV | loss | 25217958 |
nsv1004843 | CNV | gain | 25217958 |
nsv1008965 | CNV | loss | 25217958 |
nsv1009691 | CNV | gain | 25217958 |
nsv1142286 | CNV | tandem duplication | 24896259 |
nsv478303 | CNV | novel sequence insertion | 20440878 |
nsv508107 | OTHER | sequence alteration | 20534489 |
nsv834385 | CNV | gain | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
hepatocellular carcinoma |
|
|
colorectal cancer |
|