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Aliases for MGAT4C Gene
Aliases for MGAT4C Gene
- MGAT4 Family Member C 2 3 5
- Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase, Isozyme C (Putative) 2 3
- UDP-N-Acetylglucosamine: Alpha-1,3-D-Mannoside Beta-1,4-N-Acetylglucosaminyltransferase IVc 3 4
- N-Glycosyl-Oligosaccharide-Glycoprotein N-Acetylglucosaminyltransferase IVc 3 4
- Alpha-1,3-Mannosyl-Glycoprotein 4-Beta-N-Acetylglucosaminyltransferase C 3 4
- N-Acetylglucosaminyltransferase IV Homolog 3 4
- N-Acetylglucosaminyltransferase IVc 3 4
- GlcNAc-T IVc 3 4
External Ids for MGAT4C Gene
- HGNC: 30871
- NCBI Entrez Gene: 25834
- Ensembl: ENSG00000182050
- OMIM®: 607385
- UniProtKB/Swiss-Prot: Q9UBM8
Previous GeneCards Identifiers for MGAT4C Gene
- GC12M084876
- GC12M086372
- GC12M083429
Summaries for MGAT4C Gene
GeneCards Summary for MGAT4C Gene
MGAT4C (MGAT4 Family Member C) is a Protein Coding gene. Diseases associated with MGAT4C include Congenital Muscular Dystrophy-Dystroglycanopathy Type A11 and Glycogen Storage Disease Iii. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring hexosyl groups and alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is MGAT4A.
UniProtKB/Swiss-Prot Summary for MGAT4C Gene
-
Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity).
Additional gene information for MGAT4C Gene
- HGNC (30871)
- NCBI Entrez Gene (25834)
- Ensembl (ENSG00000182050)
- OMIM® (607385)
- UniProtKB/Swiss-Prot (Q9UBM8)
- Open Targets Platform(ENSG00000182050)
- Search for MGAT4C at DataMed
- Search for MGAT4C at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MGAT4C Gene
Genomics for MGAT4C Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MGAT4C Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH12J086838 | Promoter/Enhancer | 0.9 | EPDnew Ensembl | 250.7 | +1.1 | 1099 | 2.6 | MAFF ZNF316 MAFK MAFG CTCF POLR2A RAD21 EMSY | ENSG00000258185 MGAT4C piR-30126-002 NTS | |
| GH12J086256 | Promoter | 0.6 | EPDnew | 250 | +582.6 | 582595 | 0.1 | PKNOX1 POLR2A RAD21 | lnc-MGAT4C-1 MGAT4C LOC105369877 HSALNG0092839 NTS ENSG00000258185 | |
| GH12J086199 | Promoter | 0.3 | EPDnew | 257.8 | +639.7 | 639655 | 0.1 | MGAT4C HSALNG0092839 piR-31199-072 lnc-MGAT4C-1 NTS ENSG00000258185 | ||
| GH12J085947 | Enhancer | 0.6 | Ensembl ENCODE | 25.3 | +890.3 | 890316 | 2.5 | ETS1 EGR1 SP1 POU5F1 NANOG | MGAT4C NTS ENSG00000258178 HSALNG0092832 piR-56133-059 | |
| GH12J085952 | Enhancer | 0.3 | Ensembl | 25.1 | +886.5 | 886499 | 0.6 | CTCF RAD21 | MGAT4C HSALNG0092832 piR-56133-059 NTS |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MGAT4C on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MGAT4C
- Top Transcription factor binding sites by QIAGEN in the MGAT4C gene promoter:
-
- FOXI1
- FOXJ2
- FOXJ2 (long isoform)
- HFH-3
- HOXA9
- HOXA9B
- Meis-1
- Meis-1a
- Msx-1
- POU6F1 (c2)
Genomic Locations for MGAT4C Gene
Latest Assembly
- chr12:85,955,666-86,839,000
- (GRCh38/hg38)
- Size:
- 883,335 bases
- Orientation:
- Minus strand
Previous Assembly
- chr12:86,349,446-87,232,777
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 883,332 bases
- Orientation:
- Minus strand
- chr12:86,372,516-87,232,681
- (GRCh37/hg19 by Ensembl)
- Size:
- 860,166 bases
- Orientation:
- Minus strand
Genomic View for MGAT4C Gene
Genes around MGAT4C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q21.31-q21.32 by HGNC
- 12q21.31-q21.32 by Entrez Gene
- 12q21.32 by Ensembl
MGAT4C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MGAT4C Gene
Proteins for MGAT4C Gene
-
Protein details for MGAT4C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UBM8-MGT4C_HUMAN
- Recommended name:
- Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C
- Protein Accession:
- Q9UBM8
- B4DRH2
- Q4G199
- Q9UIU5
Protein attributes for MGAT4C Gene
- Size:
- 478 amino acids
- Molecular mass:
- 56061 Da
- Cofactor:
- Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH26068.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Protein Expression for MGAT4C Gene
Selected DME Specific Peptides for MGAT4C Gene
- Q9UBM8:
-
- WVTLEFSKLGYIGKLY
- KPSLFQH
- LTIGLSSV
- FRSKQNVDY
- FYQEMPCD
Post-translational modifications for MGAT4C Gene
Other Protein References for MGAT4C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for MGAT4C
- Novus Biologicals Antibodies for MGAT4C
- Invitrogen Antibodies for MGAT4C (AFLGC-MGAT4C)
-
Biorbyt antibodies for MGAT4C
-
Custom Antibody ServicesProSci Antibodies for MGAT4C
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MGAT4C
- Origene Custom Protein Services for MGAT4C
- Novus Biologicals proteins for MGAT4C
- antibodies-online: Show 4 available MGAT4C Proteins ranked by validation data
- Compare Top MGAT4C Proteins
-
Quality Products:
Assay products for research
- antibodies-online: Show 2 available MGAT4C Elisa Kits ranked by validation data
- Compare Top MGAT4C Elisa Kits
-
Quality Products:
Domains & Families for MGAT4C Gene
Gene Families for MGAT4C Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted membrane proteins
Protein Domains for MGAT4C Gene
- InterPro:
- Blocks:
-
- Like-Sm ribonucleoprotein-related, core
- ProtoNet:
Suggested Antigen Peptide Sequences for MGAT4C Gene
- GenScript: Design optimal peptide antigens:
-
- UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc (MGT4C_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9UBM8- Family:
-
- Belongs to the glycosyltransferase 54 family.
Function for MGAT4C Gene
Molecular function for MGAT4C Gene
- UniProtKB/Swiss-Prot Function:
- Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP; Xref=Rhea:RHEA:16057, Rhea:RHEA-COMP:13526, Rhea:RHEA-COMP:14374, ChEBI:CHEBI:15378, ChEBI:CHEBI:57705, ChEBI:CHEBI:58223, ChEBI:CHEBI:60651, ChEBI:CHEBI:139507; EC=2.4.1.145;.
Enzyme Numbers (IUBMB) for MGAT4C Gene
Phenotypes From GWAS Catalog for MGAT4C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008375 | acetylglucosaminyltransferase activity | IBA | 21873635 |
| GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for MGAT4C Gene
- MGI mutant phenotypes for MGAT4C:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MGAT4C:
Animal Models for MGAT4C Gene
- MGI Knock Outs for MGAT4C:
-
- Mgat4c Mgat4c<tm1a(EUCOMM)Wtsi>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MGAT4C - Starting at $85 >
- * MGAT4C CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MGAT4C
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MGAT4C
-
Santa Cruz Biotechnology (SCBT) CRISPR for MGAT4C
miRNA for MGAT4C Gene
- miRTarBase miRNAs that target MGAT4C
-
- hsa-miR-335-3p (MIRT449054)
- hsa-miR-1305 (MIRT449055)
- hsa-miR-5584-5p (MIRT449056)
- hsa-miR-607 (MIRT449057)
- hsa-miR-1277-5p (MIRT514082)
- hsa-miR-496 (MIRT514083)
- hsa-miR-656-3p (MIRT514084)
- hsa-miR-410-3p (MIRT514085)
- hsa-miR-3924 (MIRT541520)
- hsa-miR-190a-3p (MIRT541521)
- hsa-miR-4789-5p (MIRT541522)
- hsa-miR-98-3p (MIRT541523)
- hsa-let-7f-1-3p (MIRT541524)
- hsa-let-7b-3p (MIRT541525)
- hsa-let-7a-3p (MIRT541526)
- hsa-miR-4666a-5p (MIRT541527)
- hsa-miR-5011-5p (MIRT541528)
- hsa-miR-4666a-3p (MIRT541529)
- hsa-miR-381-3p (MIRT541530)
- hsa-miR-300 (MIRT541531)
- hsa-miR-4789-3p (MIRT541532)
- hsa-miR-4719 (MIRT549531)
- hsa-miR-4801 (MIRT549532)
- hsa-miR-4731-3p (MIRT549533)
- hsa-miR-4797-5p (MIRT607501)
- hsa-miR-8485 (MIRT607502)
- hsa-miR-377-3p (MIRT608756)
- hsa-miR-3614-3p (MIRT608757)
- hsa-miR-1287-3p (MIRT671090)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MGAT4C
- Browse OriGene Inhibitory RNA Products For MGAT4C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MGAT4C
Clone products for research
- Applied Biological Materials (abm): Clones for MGAT4C - Starting at $45 >
- * MGAT4C as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG216822
- MG218262
- MG219215
- MR216822
- MR216822L3
- MR216822L4
- MR218262
- MR218262L3
- MR218262L4
- MR219215
- MR219215L3
- MR219215L4
- MR230112
- RC209602
- RC209602L1
- RC209602L2
- RC209602L3
- RC209602L4
- RG209602
- RR203273
- RR203273L3
- RR203273L4
- MR216822L3V
- MR216822L4V
- MR218262L3V
- MR218262L4V
- MR219215L3V
- MR219215L4V
- RC209602L1V
- RC209602L2V
- RC209602L3V
- RC209602L4V
- RR203273L3V
- RR203273L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MGAT4C
- Addgene plasmids for MGAT4C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MGAT4C
Cell Lines for research
-
Horizon Cell Lines for MGAT4C
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MGAT4C Gene
Localization for MGAT4C Gene
Subcellular locations from UniProtKB/Swiss-Prot for MGAT4C Gene
- Golgi apparatus membrane. Single-pass type II membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| cytosol | 1 |
| lysosome | 1 |
| cytoskeleton | 0 |
- Centriolar satellite (2)
- Plasma membrane (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | TAS | -- |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for MGAT4C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | N-Glycan biosynthesis | ||
| 2 | Transport to the Golgi and subsequent modification | ||
| 3 | Metabolism of proteins | ||
| 4 | N-glycan antennae elongation in the medial/trans-Golgi | ||
| 5 | Metabolism | ||
Pathways by source for MGAT4C Gene
3 KEGG pathways for MGAT4C Gene
UniProtKB/Swiss-Prot Q9UBM8-MGT4C_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for MGAT4C Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| B4GALT6 | ||
| CSGALNACT2 | ||
| GAL | ||
| LARGE2 | ||
| LDLR |
GPS-Prot Interaction Network for MGAT4C
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006486 | protein glycosylation | IEA | -- |
| GO:0006487 | protein N-linked glycosylation | IBA | 21873635 |
| GO:0018215 | protein phosphopantetheinylation | IEA | -- |
No data available for SIGNOR curated interactions for MGAT4C Gene
Drugs & Compounds for MGAT4C Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Uridine 5'-diphosphate | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Uridine diphosphate-N-acetylglucosamine |
|
528-04-1 |
|
Transcripts for MGAT4C Gene
mRNA/cDNA for MGAT4C Gene
- 10 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000547225 1423 nts (view in UCSC)
- ENST00000548651 2159 nts (view in UCSC)
- ENST00000550365 508 nts (view in UCSC)
- ENST00000551751 502 nts (view in UCSC)
- ENST00000551921 558 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for MGAT4C - Starting at $85 >
- * MGAT4C CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for MGAT4C
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MGAT4C
-
Santa Cruz Biotechnology (SCBT) CRISPR for MGAT4C
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MGAT4C
- Browse OriGene Inhibitory RNA Products For MGAT4C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MGAT4C
Clone products for research
- Applied Biological Materials (abm): Clones for MGAT4C - Starting at $45 >
- * MGAT4C as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG216822
- MG218262
- MG219215
- MR216822
- MR216822L3
- MR216822L4
- MR218262
- MR218262L3
- MR218262L4
- MR219215
- MR219215L3
- MR219215L4
- MR230112
- RC209602
- RC209602L1
- RC209602L2
- RC209602L3
- RC209602L4
- RG209602
- RR203273
- RR203273L3
- RR203273L4
- MR216822L3V
- MR216822L4V
- MR218262L3V
- MR218262L4V
- MR219215L3V
- MR219215L4V
- RC209602L1V
- RC209602L2V
- RC209602L3V
- RC209602L4V
- RR203273L3V
- RR203273L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MGAT4C
- Addgene plasmids for MGAT4C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MGAT4C
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||
| SP4: | - | - | - | - | - |
Relevant External Links for MGAT4C Gene
- GeneLoc Exon Structure for
- MGAT4C
Expression for MGAT4C Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Colon (Gastrointestinal Tract)
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for MGAT4C Gene
This gene is overexpressed in Thyroid (x5.4), Brain - Nucleus accumbens (basal ganglia) (x4.6), Testis (x4.4), and Brain - Caudate (basal ganglia) (x4.0).
This gene is overexpressed in Bone marrow mesenchymal stem cell (48.2) and Bone marrow stromal cell (20.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MGAT4C Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MGAT4C
SOURCE GeneReport for Unigene cluster for MGAT4C Gene:
Hs.589093mRNA Expression by UniProt/SwissProt for MGAT4C Gene:
Q9UBM8-MGT4C_HUMAN
Tissue specificity:
Expressed in heart, adrenal gland, testis, liver, brain and fetal brain. Not expressed in pancreas.
Evidence on tissue expression from TISSUES for MGAT4C Gene
- Nervous system(2.5)
Primer products for research
-
OriGene qPCR primer pairs for MGAT4C
-
OriGene qPCR primer pairs and template standards for MGAT4C
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MGAT4C Gene
Orthologs for MGAT4C Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MGAT4C 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | MGAT4C 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MGAT4C 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Mgat4c 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Mgat4c 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | MGAT4C 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MGAT4C 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MGAT4C 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MGAT4C 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mgat4c 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mgat4c 31 |
|
OneToOne | |
| LOC100333333 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG17173 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.589 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany |
- Species where no ortholog for MGAT4C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MGAT4C Gene
- ENSEMBL:
- Gene Tree for MGAT4C (if available)
- TreeFam:
- Gene Tree for MGAT4C (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MGAT4C: view image
Paralogs for MGAT4C Gene
(2) SIMAP similar genes for MGAT4C Gene using alignment to 4 proteins:
- MGT4C_HUMAN
- B4DRH2_HUMAN
- F8VTY5_HUMAN
- F8VWY2_HUMAN
Pseudogenes.org Pseudogenes for MGAT4C Gene
Variants for MGAT4C Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MGAT4C Gene
| SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs34663658 | Benign: not provided | 85,979,478(-) |
G/A NM_013244.5(MGAT4C):c.1248C>T (p.Asn416=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
| rs17855890 | - |
p.Thr428Ser |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.05;
50.47% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MGAT4C Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGAT4C Gene
Disorders for MGAT4C Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| congenital muscular dystrophy-dystroglycanopathy type a11 |
|
|
| glycogen storage disease iii |
|
|
| orofacial cleft 1 |
|
|
Search MGAT4C in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for MGAT4C
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for MGAT4C Gene
Publications for MGAT4C Gene
- Cloning and characterization of the human UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homologue (hGnT-IV-H) gene. (PMID: 10570912) Furukawa T … Horii A (Journal of human genetics 1999) 2 3 4 23
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
ExternalLinks
Products for MGAT4C Gene
- Custom Antibody ServicesOriGene Antibodies for MGAT4C
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- High-throughput Antibody Production Service
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Browse Antibodies
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- Invitrogen Antibodies for MGAT4C (AFLGC-MGAT4C)
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- VectorBuilder Viral vectors for MGAT4C (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Stable cell line generation for MGAT4C
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- antibodies-online: Show 10 available MGAT4C Antibodies ranked by validation data
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- Quality Products:
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- Quality Products:
- Horizon Cell Lines for MGAT4C
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MGAT4C
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MGAT4C
- Search GeneCopoeia for miRNA 3'UTR Target clone products for MGAT4C
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MGAT4C
- Biorbyt antibodies for MGAT4C
Sources for MGAT4C Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
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- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
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- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB