Aliases for MGAT1 Gene
External Ids for MGAT1 Gene
Previous HGNC Symbols for MGAT1 Gene
Previous GeneCards Identifiers for MGAT1 Gene
There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MGAT1 Gene
MGAT1 (Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,2-N-Acetylglucosaminyltransferase) is a Protein Coding gene. Diseases associated with MGAT1 include Lysosomal And Lipase Deficiency and Lysosomal Acid Lipase Deficiency. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. Gene Ontology (GO) annotations related to this gene include acetylglucosaminyltransferase activity and alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity. An important paralog of this gene is POMGNT1.
UniProtKB/Swiss-Prot Summary for MGAT1 Gene
Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.