Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MGAM Gene

Aliases for MGAM Gene

  • Maltase-Glucoamylase 2 3 5
  • MGA 3 4
  • Maltase-Glucoamylase (Alpha-Glucosidase) 3
  • Maltase-Glucoamylase, Intestinal 3
  • Brush Border Hydrolase 3
  • Alpha-Glucosidase 2
  • MGAML 4
  • MG 3

External Ids for MGAM Gene

Previous GeneCards Identifiers for MGAM Gene

  • GC07P139967
  • GC07P140976
  • GC07P141102
  • GC07P141148
  • GC07P141342
  • GC07P141607
  • GC07P135992
  • GC07P142618
  • GC07P142931
  • GC07P143075
  • GC07P143225
  • GC07P143421
  • GC07P143570
  • GC07P143720
  • GC07P143847

Summaries for MGAM Gene

Entrez Gene Summary for MGAM Gene

  • This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. [provided by RefSeq, Jul 2008]

GeneCards Summary for MGAM Gene

MGAM (Maltase-Glucoamylase) is a Protein Coding gene. Diseases associated with MGAM include Hypomagnesemia 1, Intestinal and Premenstrual Tension. Among its related pathways are Metabolism and Digestion of dietary carbohydrate. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and alpha-1,4-glucosidase activity. An important paralog of this gene is MGAM2.

UniProtKB/Swiss-Prot for MGAM Gene

  • May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.

Gene Wiki entry for MGAM Gene

Additional gene information for MGAM Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGAM Gene

Genomics for MGAM Gene

GeneHancer (GH) Regulatory Elements for MGAM Gene

Promoters and enhancers for MGAM Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J141995 Promoter/Enhancer 0.7 EPDnew ENCODE 650.2 +88.2 88191 1.3 MGAM TAS2R38 MGAM2
GH07J141944 Promoter/Enhancer 1.4 EPDnew FANTOM5 Ensembl ENCODE 0.3 +38.0 37988 2.8 CTCF POLR2A MAX MYC CLEC5A WEE2-AS1 OR9A4 TAS2R38 OR9N1P MGAM
GH07J141960 Enhancer 1.1 FANTOM5 Ensembl ENCODE 0.2 +53.2 53182 0.9 ZBED1 JUNB CEBPG MEF2B ATF2 ATF4 IKZF1 NFATC1 ATF7 ETV6 CLEC5A WEE2-AS1 OR9A4 TAS2R38 MGAM
GH07J141915 Enhancer 0.5 ENCODE 0.4 +8.0 7970 1.1 PKNOX1 POLR2A BACH1 NFE2 MNT FOS SPI1 WEE2-AS1 OR9A4 CLEC5A OR9N1P MGAM
GH07J141975 Enhancer 1 Ensembl ENCODE 0.2 +68.5 68545 1.3 ELF3 RB1 RAD21 RFX5 YY1 ZNF335 ARID2 SCRT2 ZNF143 RCOR1 TAS2R38 MGAM OR9A4 MGAM2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MGAM on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MGAM gene promoter:
  • c-Jun
  • ATF-2
  • AML1a

Genomic Locations for MGAM Gene

Genomic Locations for MGAM Gene
198,935 bases
Plus strand
198,935 bases
Plus strand

Genomic View for MGAM Gene

Genes around MGAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGAM Gene

Proteins for MGAM Gene

  • Protein details for MGAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Maltase-glucoamylase, intestinal
    Protein Accession:
    Secondary Accessions:
    • Q0VAX6
    • Q75ME7
    • Q86UM5

    Protein attributes for MGAM Gene

    1857 amino acids
    Molecular mass:
    209852 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for MGAM Gene

neXtProt entry for MGAM Gene

Post-translational modifications for MGAM Gene

  • N- and O-glycosylated.
  • Does not undergo intracellular or extracellular proteolytic cleavage.
  • Sulfated.
  • Glycosylation at isoforms=1847, posLast=18421842, posLast=16721672, isoforms=1603, isoforms=1388, isoforms=1364, isoforms=1323, posLast=12551255, posLast=989989, posLast=977977, posLast=912912, posLast=885885, posLast=827827, posLast=749749, posLast=707707, isoforms=479, posLast=458458, isoforms=457, isoforms=295, and isoforms=135
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MGAM Gene

Domains & Families for MGAM Gene

Gene Families for MGAM Gene

Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for MGAM Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 31 family.
  • Belongs to the glycosyl hydrolase 31 family.
genes like me logo Genes that share domains with MGAM: view

Function for MGAM Gene

Molecular function for MGAM Gene

UniProtKB/Swiss-Prot Function:
May serve as an alternate pathway for starch digestion when luminal alpha-amylase activity is reduced because of immaturity or malnutrition. May play a unique role in the digestion of malted dietary oligosaccharides used in food manufacturing.
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of terminal, non-reducing (1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose.
UniProtKB/Swiss-Prot CatalyticActivity:
Hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.
GENATLAS Biochemistry:
maltase-glucoamylase,alpha-glucosidase,expressed in the small intestine,member of the glucosyl hydrolase family 31,playing a unique role in the digestion of malted dietary oligosaccharides

Phenotypes From GWAS Catalog for MGAM Gene

Gene Ontology (GO) - Molecular Function for MGAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity TAS 9446624
GO:0004339 glucan 1,4-alpha-glucosidase activity IEA --
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds IEA --
GO:0004558 alpha-1,4-glucosidase activity TAS --
GO:0016160 amylase activity IEA --
genes like me logo Genes that share ontologies with MGAM: view
genes like me logo Genes that share phenotypes with MGAM: view

Animal Models for MGAM Gene

MGI Knock Outs for MGAM:

Animal Model Products

  • Taconic Biosciences Mouse Models for MGAM

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MGAM

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MGAM Gene

Localization for MGAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGAM Gene

Apical cell membrane; Single-pass type II membrane protein. Note=Brush border.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MGAM gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 3
mitochondrion 3
endoplasmic reticulum 3
cytosol 3
nucleus 2
lysosome 2
golgi apparatus 2
peroxisome 1
endosome 1

Gene Ontology (GO) - Cellular Components for MGAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with MGAM: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MGAM Gene

Pathways & Interactions for MGAM Gene

genes like me logo Genes that share pathways with MGAM: view

Gene Ontology (GO) - Biological Process for MGAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000023 maltose metabolic process IEA --
GO:0005975 carbohydrate metabolic process IEA --
GO:0005983 starch catabolic process TAS 9446624
GO:0008152 metabolic process IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with MGAM: view

No data available for SIGNOR curated interactions for MGAM Gene

Drugs & Compounds for MGAM Gene

(38) Drugs for MGAM Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Voglibose Approved, Investigational Pharma inhibitor, Target α-glucosidases inhibitor 23
Acarbose Approved, Investigational Pharma inhibitor, Target Alpha-glucosidase inhibitor, Glucosidase alpha inhibitor (intestinal) 91
Miglitol Approved Pharma inhibitor, Target, antagonist 12
Furan Approved, Experimental, Investigational Pharma 0
Galactose Approved, Investigational Pharma 0

(37) Additional Compounds for MGAM Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Animal starch
  • Liver starch
  • Lyoglycogen
  • Phytoglycogen
  • alpha-D-GLC
  • alpha-Dextrose
  • a-D-GLC
  • α-D-GLC
  • a-D-Glucose
  • British gum
  • Caloreen
  • Corn dextrin
  • Crystal gum
  • Dextrid
  • D-lyxo-2-Hexulose
  • D-lyxo-Hex-2-ulose
  • D-Tag
  • lyxo-2-Hexulose
  • lyxo-Hexulose
  • 6-O-(alpha-D-Galactopyranosyl)-D-mannopyranose
  • 6-O-alpha-D-Mannopyranosyl-alpha-D-galactopyranose
  • 6-O-(a-D-Galactopyranosyl)-D-mannopyranose
  • 6-O-(α-D-galactopyranosyl)-D-mannopyranose
  • 6-O-a-D-Mannopyranosyl-a-D-galactopyranose
genes like me logo Genes that share compounds with MGAM: view

Transcripts for MGAM Gene

Unigene Clusters for MGAM Gene

Maltase-glucoamylase (alpha-glucosidase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MGAM

Alternative Splicing Database (ASD) splice patterns (SP) for MGAM Gene

No ASD Table

Relevant External Links for MGAM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MGAM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MGAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MGAM Gene

This gene is overexpressed in Whole Blood (x36.5) and Small Intestine - Terminal Ileum (x8.8).

Protein differential expression in normal tissues from HIPED for MGAM Gene

This gene is overexpressed in Pancreatic juice (45.3), Urine (11.6), and Neutrophil (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MGAM Gene

NURSA nuclear receptor signaling pathways regulating expression of MGAM Gene:


SOURCE GeneReport for Unigene cluster for MGAM Gene:


mRNA Expression by UniProt/SwissProt for MGAM Gene:

Tissue specificity: Expressed in small intestine, granulocyte, and kidney but not in salivary gland or pancreas.

Evidence on tissue expression from TISSUES for MGAM Gene

  • Intestine(4.5)
  • Blood(3.3)
  • Muscle(3)
  • Nervous system(2.9)
  • Urine(2.8)
  • Heart(2.7)
  • Kidney(2.7)
  • Liver(2.7)
  • Bone(2.5)
  • Stomach(2.2)
  • Skin(2)
genes like me logo Genes that share expression patterns with MGAM: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MGAM Gene

Orthologs for MGAM Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MGAM Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia MGAM 34 33
  • 87.44 (n)
(Bos Taurus)
Mammalia MGAM 34 33
  • 86.93 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 83 (a)
-- 34
  • 77 (a)
-- 34
  • 74 (a)
-- 34
  • 68 (a)
(Mus musculus)
Mammalia Mgam 16 34 33
  • 81.92 (n)
(Rattus norvegicus)
Mammalia LOC679818 33
  • 81.47 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 69 (a)
(Pan troglodytes)
Mammalia MGAM 34
  • 67 (a)
(Gallus gallus)
Aves SI 33
  • 65.31 (n)
-- 34
  • 61 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mgam 33
  • 63.73 (n)
(Danio rerio)
Actinopterygii si 33
  • 61.14 (n)
CABZ01079192.1 34
  • 55 (a)
(Caenorhabditis elegans)
Secernentea aagr-2 33
  • 50.99 (n)
D2096.3 35
  • 39 (a)
R05F9.12 35
  • 38 (a)
F53F4.8 35
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ROT2 34
  • 22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G11720 33
  • 48.78 (n)
(Oryza sativa)
Liliopsida Os06g0676700 33
  • 47.95 (n)
Os.19761 33
bread mold
(Neurospora crassa)
Ascomycetes NCU04674 33
  • 47.44 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 19 (a)
Cin.1518 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1518 33
Species where no ortholog for MGAM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MGAM Gene

Gene Tree for MGAM (if available)
Gene Tree for MGAM (if available)
Evolutionary constrained regions (ECRs) for MGAM: view image

Paralogs for MGAM Gene

Paralogs for MGAM Gene

(2) SIMAP similar genes for MGAM Gene using alignment to 6 proteins:

  • E7ER45_HUMAN
  • E7EW87_HUMAN
  • Q8TE24_HUMAN
  • Q8TE25_HUMAN
genes like me logo Genes that share paralogs with MGAM: view

Variants for MGAM Gene

Sequence variations from dbSNP and Humsavar for MGAM Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000039629 -- 142,000,397(+) A/G intron_variant
rs1000080853 -- 142,040,096(+) T/G intron_variant
rs1000082852 -- 142,089,103(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000091148 -- 142,003,689(+) T/G intron_variant
rs1000126274 -- 142,102,469(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MGAM Gene

Variant ID Type Subtype PubMed ID
dgv1115e201 CNV deletion 23290073
dgv1116e201 CNV deletion 23290073
dgv1136n67 CNV loss 20364138
dgv11627n54 CNV loss 21841781
dgv11628n54 CNV loss 21841781
dgv11629n54 CNV gain 21841781
dgv11630n54 CNV gain 21841781
dgv11631n54 CNV loss 21841781
dgv11632n54 CNV loss 21841781
dgv11633n54 CNV loss 21841781
dgv11634n54 CNV gain+loss 21841781
dgv11635n54 CNV gain+loss 21841781
dgv11636n54 CNV gain+loss 21841781
dgv11637n54 CNV loss 21841781
dgv11638n54 CNV loss 21841781
dgv11639n54 CNV loss 21841781
dgv11640n54 CNV loss 21841781
dgv11641n54 CNV loss 21841781
dgv11642n54 CNV loss 21841781
dgv11643n54 CNV loss 21841781
dgv1242e199 CNV deletion 23128226
dgv1331e214 CNV gain 21293372
dgv1967e212 CNV loss 25503493
dgv451e215 CNV deletion 23714750
dgv6646n100 CNV loss 25217958
dgv6647n100 CNV loss 25217958
dgv6648n100 CNV loss 25217958
dgv6649n100 CNV loss 25217958
dgv6650n100 CNV gain+loss 25217958
dgv6651n100 CNV gain 25217958
dgv6652n100 CNV loss 25217958
dgv6653n100 CNV loss 25217958
dgv6654n100 CNV gain+loss 25217958
dgv6655n100 CNV gain+loss 25217958
dgv6656n100 CNV gain 25217958
dgv6657n100 CNV loss 25217958
dgv6658n100 CNV gain+loss 25217958
dgv6659n100 CNV loss 25217958
dgv6660n100 CNV loss 25217958
dgv6661n100 CNV gain 25217958
dgv6662n100 CNV loss 25217958
dgv6663n100 CNV loss 25217958
dgv6664n100 CNV loss 25217958
dgv6665n100 CNV gain 25217958
dgv832n27 CNV gain 19166990
dgv833n27 CNV gain 19166990
dgv834n27 CNV loss 19166990
dgv835n27 CNV loss 19166990
dgv836n27 CNV loss 19166990
dgv837n27 CNV loss 19166990
dgv838n27 CNV loss 19166990
esv1318675 CNV insertion 17803354
esv1556929 CNV deletion 17803354
esv1780125 CNV insertion 17803354
esv2421934 CNV deletion 20811451
esv25886 CNV gain+loss 19812545
esv2735254 CNV deletion 23290073
esv2735255 CNV deletion 23290073
esv2759568 CNV gain+loss 17122850
esv2761103 CNV loss 21179565
esv2764021 CNV gain+loss 21179565
esv3357589 CNV insertion 20981092
esv3389621 CNV duplication 20981092
esv33962 CNV gain+loss 17666407
esv3584869 CNV loss 24956385
esv3615263 CNV loss 21293372
esv3615264 CNV loss 21293372
esv3615267 CNV loss 21293372
esv3615268 CNV gain 21293372
esv3615269 CNV loss 21293372
esv3891212 CNV loss 25118596
esv3891213 CNV loss 25118596
esv3891214 CNV loss 25118596
nsv1020753 CNV loss 25217958
nsv1022317 CNV gain 25217958
nsv1027137 CNV gain+loss 25217958
nsv1028562 CNV gain 25217958
nsv1035098 CNV loss 25217958
nsv1075064 CNV deletion 25765185
nsv1076006 CNV deletion 25765185
nsv1126811 CNV deletion 24896259
nsv1128959 CNV duplication 24896259
nsv1142028 OTHER inversion 24896259
nsv1161623 CNV deletion 26073780
nsv1161624 CNV duplication 26073780
nsv1161625 CNV deletion 26073780
nsv1161626 CNV deletion 26073780
nsv433239 CNV loss 18776910
nsv433393 CNV gain 18776910
nsv438007 CNV loss 16468122
nsv442187 CNV loss 18776908
nsv464740 CNV loss 19166990
nsv464741 CNV loss 19166990
nsv464790 CNV gain 19166990
nsv465105 CNV gain 19166990
nsv465131 CNV loss 19166990
nsv470395 CNV loss 18288195
nsv473627 CNV novel sequence insertion 20440878
nsv514453 CNV gain+loss 21397061
nsv515542 CNV loss 19592680
nsv516285 CNV gain+loss 19592680
nsv525756 CNV loss 19592680
nsv5975 CNV insertion 18451855
nsv5976 CNV insertion 18451855
nsv608536 CNV gain 21841781
nsv608550 CNV loss 21841781
nsv608565 CNV gain+loss 21841781
nsv608588 CNV loss 21841781
nsv608589 CNV loss 21841781
nsv818558 CNV gain+loss 17921354
nsv818559 CNV loss 17921354
nsv818560 CNV loss 17921354
nsv820289 CNV loss 19587683
nsv8217 CNV loss 18304495
nsv8218 CNV gain+loss 18304495
nsv824323 CNV loss 20364138
nsv824324 CNV gain 20364138
nsv824329 CNV loss 20364138
nsv824330 CNV loss 20364138
nsv831161 CNV loss 17160897
nsv949958 CNV deletion 24416366
nsv958432 CNV deletion 24416366
nsv970587 CNV duplication 23825009
nsv970945 CNV duplication 23825009
nsv971197 CNV duplication 23825009

Variation tolerance for MGAM Gene

Residual Variation Intolerance Score: 98.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.91; 97.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MGAM Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGAM Gene

Disorders for MGAM Gene

MalaCards: The human disease database

(22) MalaCards diseases for MGAM Gene - From: HGMD, DISEASES, and Novoseek

Disorder Aliases PubMed IDs
hypomagnesemia 1, intestinal
  • homg1
premenstrual tension
  • premenstrual syndrome
primary hypomagnesemia
  • hypomagnesemia 1, intestinal
glycogen storage disease ii
  • gsd2
orthostatic intolerance
  • neurocirculatory asthenia
- elite association - COSMIC cancer census association via MalaCards
Search MGAM in MalaCards View complete list of genes associated with diseases

Genatlas disease for MGAM Gene

diarrhea in children associated with starch malabsorption and small intestinal glucoamylase deficiency

Additional Disease Information for MGAM

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MGAM: view

No data available for UniProtKB/Swiss-Prot for MGAM Gene

Publications for MGAM Gene

  1. Human small intestinal maltase-glucoamylase cDNA cloning. Homology to sucrase-isomaltase. (PMID: 9446624) Nichols BL … Sterchi E (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. Human intestinal maltase-glucoamylase: crystal structure of the N-terminal catalytic subunit and basis of inhibition and substrate specificity. (PMID: 18036614) Sim L … Rose DR (Journal of molecular biology 2008) 3 4 22 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains. (PMID: 20356844) Sim L … Rose DR (The Journal of biological chemistry 2010) 3 22 58
  5. Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives. (PMID: 16817895) Rossi EJ … Rose DR (The FEBS journal 2006) 22 25 58

Products for MGAM Gene

Sources for MGAM Gene

Loading form....