Aliases for MGA Gene
External Ids for MGA Gene
Previous GeneCards Identifiers for MGA Gene
GeneCards Summary for MGA Gene
MGA (MAX Dimerization Protein MGA) is a Protein Coding gene. Diseases associated with MGA include Spindle Cell Sarcoma and Blue Toe Syndrome. Among its related pathways are Pathways Affected in Adenoid Cystic Carcinoma. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity. An important paralog of this gene is TBX6.
UniProtKB/Swiss-Prot Summary for MGA Gene
Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).