MGA Gene (Protein Coding)

MAX Dimerization Protein MGA

GC15P041621
GIFtS:
35

Aliases for MGA Gene

Aliases for MGA Gene

  • MAX Dimerization Protein MGA 2 3 5
  • MAX Gene-Associated Protein 3 4
  • MAX Dimerization Protein 5 3 4
  • MAD5 3 4
  • MGA, MAX Dimerization Protein 3
  • MAX Gene Associated 2
  • KIAA0518 4
  • MXD5 3

External Ids for MGA Gene

Previous GeneCards Identifiers for MGA Gene

  • GC15P037399
  • GC15P034928
  • GC15P039612
  • GC15P039677
  • GC15P039749
  • GC15P041952
  • GC15P018801

Summaries for MGA Gene

GeneCards Summary for MGA Gene

MGA (MAX Dimerization Protein MGA) is a Protein Coding gene. Among its related pathways are Pathways Affected in Adenoid Cystic Carcinoma. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity. An important paralog of this gene is TBX2.

UniProtKB/Swiss-Prot Summary for MGA Gene

  • Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).

Additional gene information for MGA Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MGA Gene

Genomics for MGA Gene

GeneHancer (GH) Regulatory Elements for MGA Gene

Promoters and enhancers for MGA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MGA on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MGA

Top Transcription factor binding sites by QIAGEN in the MGA gene promoter:
  • c-Myc
  • HNF-1
  • HNF-1A
  • Ik-1
  • LCR-F1
  • Max
  • N-Myc
  • POU3F2

Genomic Locations for MGA Gene

Genomic Locations for MGA Gene
chr15:41,621,224-41,773,081
(GRCh38/hg38)
Size:
151,858 bases
Orientation:
Plus strand
chr15:41,913,422-42,062,141
(GRCh37/hg19)
Size:
148,720 bases
Orientation:
Plus strand

Genomic View for MGA Gene

Genes around MGA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGA Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MGA Gene

Proteins for MGA Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for MGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWI9-MGAP_HUMAN
    Recommended name:
    MAX gene-associated protein
    Protein Accession:
    Q8IWI9
    Secondary Accessions:
    • B9EGR5
    • E7ENI0
    • F5H7K2
    • Q9H8R3
    • Q9H9N7
    • Q9UG69
    • Q9Y4E9

    Protein attributes for MGA Gene

    Size:
    3065 amino acids
    Molecular mass:
    336159 Da
    Quaternary structure:
    • Interacts with MAX. Requires dimerization with MAX for E-box binding (By similarity). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with ZMYND11.
    SequenceCaution:
    • Sequence=BAB14186.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB14543.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for MGA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGA Gene

Protein Expression for MGA Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MGA Gene

  • Ubiquitination at Lys2374, Lys708, Lys715, Lys1310, and Lys1461
  • Modification sites at PhosphoSitePlus

Other Protein References for MGA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MGA Gene

Domains & Families for MGA Gene

Gene Families for MGA Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MGA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MGA Gene

GenScript: Design optimal peptide antigens:
  • MGA protein (B9EGR5_HUMAN)
  • MAX dimerization protein 5 (MGAP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IWI9

UniProtKB/Swiss-Prot:

MGAP_HUMAN :
  • Transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain.
Domain:
  • Transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain.
genes like me logo Genes that share domains with MGA: view

Function for MGA Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for MGA Gene

UniProtKB/Swiss-Prot Function:
Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).

Phenotypes From GWAS Catalog for MGA Gene

Gene Ontology (GO) - Molecular Function for MGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001102 RNA polymerase II activating transcription factor binding IBA 21873635
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with MGA: view
genes like me logo Genes that share phenotypes with MGA: view

Animal Model Products

CRISPR Products

miRNA for MGA Gene

miRTarBase miRNAs that target MGA

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MGA

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MGA Gene

Localization for MGA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGA Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MGA gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0071339 MLL1 complex IDA 15960975
genes like me logo Genes that share ontologies with MGA: view

Pathways & Interactions for MGA Gene

PathCards logo

SuperPathways for MGA Gene

genes like me logo Genes that share pathways with MGA: view

Pathways by source for MGA Gene

1 BioSystems pathway for MGA Gene

SIGNOR curated interactions for MGA Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0001708 cell fate specification IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
GO:0070317 negative regulation of G0 to G1 transition TAS --
genes like me logo Genes that share ontologies with MGA: view

Drugs & Compounds for MGA Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MGA Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MGA Gene

2 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MGA

Alternative Splicing Database (ASD) splice patterns (SP) for MGA Gene

No ASD Table

Relevant External Links for MGA Gene

GeneLoc Exon Structure for
MGA

Expression for MGA Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MGA Gene

mRNA expression in normal human tissues for MGA Gene
mRNA expression by GTEx for MGA GenemRNA expression by BioGPS for MGA Gene

Protein differential expression in normal tissues from HIPED for MGA Gene

This gene is overexpressed in Hair follicle (57.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MGA Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MGA

SOURCE GeneReport for Unigene cluster for MGA Gene:

Hs.187569

Evidence on tissue expression from TISSUES for MGA Gene

  • Intestine(4.6)
  • Nervous system(4.3)
  • Gall bladder(3.5)
  • Liver(2.9)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with MGA: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MGA Gene

Orthologs for MGA Gene

This gene was present in the common ancestor of animals.

Orthologs for MGA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia MGA 31 30
  • 99.63 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia MGA 31 30
  • 91.51 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia MGA 31 30
  • 90.05 (n)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Mga 30
  • 86.61 (n)
mouse
(Mus musculus)
 Mammalia Mga 17 31 30
  • 86.53 (n)
oppossum
(Monodelphis domestica)
 Mammalia MGA 31
  • 71 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia MGA 31
  • 58 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves MGA 31 30
  • 64.34 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia MGA 31
  • 60 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia mga 30
  • 55.87 (n)
zebrafish
(Danio rerio)
 Actinopterygii MGA (2 of 2) 31
  • 32 (a)
 OneToMany
mgaa 31
  • 27 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea tbx-9 31
  • 36 (a)
 ManyToMany
tbx-8 31
  • 34 (a)
 ManyToMany
tbx-11 31
  • 29 (a)
 ManyToMany
tbx-38 31
  • 27 (a)
 ManyToMany
tbx-43 31
  • 26 (a)
 ManyToMany
tbx-37 31
  • 26 (a)
 ManyToMany
tbx-34 31
  • 25 (a)
 ManyToMany
tbx-42 31
  • 24 (a)
 ManyToMany
tbx-30 31
  • 24 (a)
 ManyToMany
tbx-35 31
  • 22 (a)
 ManyToMany
tbx-39 31
  • 17 (a)
 ManyToMany
tbx-40 31
  • 17 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 33 (a)
 OneToOne
Species where no ortholog for MGA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MGA Gene

ENSEMBL:
Gene Tree for MGA (if available)
TreeFam:
Gene Tree for MGA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MGA: view image

Paralogs for MGA Gene

Paralogs for MGA Gene

(8) SIMAP similar genes for MGA Gene using alignment to 6 proteins:

  • MGAP_HUMAN
  • B9EGR5_HUMAN
  • H3BP52_HUMAN
  • H3BTF4_HUMAN
  • H3BTN2_HUMAN
  • H3BU53_HUMAN
genes like me logo Genes that share paralogs with MGA: view

Variants for MGA Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MGA Gene

SNP ID Clinical significance and condition Chr 15 pos Variation AA Info Type
rs17677811 - p.Cys1270Arg
rs17677991 - p.Pro1523Ala
rs2178004 - p.Thr716Ser
rs3803348 - p.Thr338Ala

Additional dbSNP identifiers (rs#s) for MGA Gene

Structural Variations from Database of Genomic Variants (DGV) for MGA Gene

Variant ID Type Subtype PubMed ID
dgv1203n106 CNV deletion 24896259
dgv2581n100 CNV gain 25217958
dgv449e214 CNV gain 21293372
esv1466405 CNV deletion 17803354
esv2749621 CNV deletion 23290073
esv2760027 CNV loss 17122850
esv3233790 CNV deletion 24192839
esv3415439 CNV insertion 20981092
esv3552369 CNV deletion 23714750
esv3921 CNV loss 18987735
esv6726 CNV loss 19470904
esv988006 CNV deletion 20482838
esv991459 CNV deletion 20482838
nsv1038894 CNV gain 25217958
nsv1041861 CNV loss 25217958
nsv1044347 CNV loss 25217958
nsv1048655 CNV loss 25217958
nsv1049514 CNV gain 25217958
nsv1069857 CNV deletion 25765185
nsv1147042 CNV deletion 26484159
nsv94393 CNV deletion 16902084
nsv957959 CNV deletion 24416366
nsv976925 CNV duplication 23825009

Variation tolerance for MGA Gene

Residual Variation Intolerance Score: 1.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.84; 93.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MGA Gene

Human Gene Mutation Database (HGMD)
MGA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MGA

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGA Gene

Disorders for MGA Gene

Additional Disease Information for MGA

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MGA Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MGA Gene

Publications for MGA Gene

  1. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PMID: 15960975) Dou Y … Roeder RG (Cell 2005) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif. (PMID: 10601024) Hurlin PJ … Eisenman RN (The EMBO journal 1999) 3 23 54
  4. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 3 4 54
  5. Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells. (PMID: 30585729) Abbasi S … Schild-Poulter C (Journal of proteome research 2019) 3 54

ExternalLinks

View latest publications for MGA gene in Mastermind

Products for MGA Gene

  • Addgene plasmids for MGA

Sources for MGA Gene