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MGA (MAX Dimerization Protein MGA) is a Protein Coding gene. Among its related pathways are Pathways Affected in Adenoid Cystic Carcinoma. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein dimerization activity. An important paralog of this gene is TBX3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001102 | RNA polymerase II activating transcription factor binding | IBA | 21873635 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IBA | 21873635 |
GO:0003677 | DNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0071339 | MLL1 complex | IDA | 15960975 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Pathways Affected in Adenoid Cystic Carcinoma |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0001708 | cell fate specification | IBA | 21873635 |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0070317 | negative regulation of G0 to G1 transition | TAS | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MGA 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MGA 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MGA 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mga 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Mga 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | MGA 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | MGA 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | MGA 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MGA 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mga 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | MGA (2 of 2) 31 |
|
OneToMany | |
mgaa 31 |
|
OneToMany | |||
Worm (Caenorhabditis elegans) |
Secernentea | tbx-9 31 |
|
ManyToMany | |
tbx-8 31 |
|
ManyToMany | |||
tbx-11 31 |
|
ManyToMany | |||
tbx-38 31 |
|
ManyToMany | |||
tbx-43 31 |
|
ManyToMany | |||
tbx-37 31 |
|
ManyToMany | |||
tbx-34 31 |
|
ManyToMany | |||
tbx-42 31 |
|
ManyToMany | |||
tbx-30 31 |
|
ManyToMany | |||
tbx-35 31 |
|
ManyToMany | |||
tbx-39 31 |
|
ManyToMany | |||
tbx-40 31 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
711106 | Benign: not provided | 41,765,070(+) | G/A | INTRON_VARIANT | |
712155 | Benign: not provided | 41,736,607(+) | A/G | MISSENSE_VARIANT | |
715531 | Likely Benign: not provided | 41,669,906(+) | A/G | MISSENSE_VARIANT | |
715863 | Likely Benign: not provided | 41,766,760(+) | A/C | MISSENSE_VARIANT | |
719754 | Benign: not provided | 41,697,032(+) | G/T | INTRON_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1203n106 | CNV | deletion | 24896259 |
dgv2581n100 | CNV | gain | 25217958 |
dgv449e214 | CNV | gain | 21293372 |
esv1466405 | CNV | deletion | 17803354 |
esv2749621 | CNV | deletion | 23290073 |
esv2760027 | CNV | loss | 17122850 |
esv3233790 | CNV | deletion | 24192839 |
esv3415439 | CNV | insertion | 20981092 |
esv3552369 | CNV | deletion | 23714750 |
esv3921 | CNV | loss | 18987735 |
esv6726 | CNV | loss | 19470904 |
esv988006 | CNV | deletion | 20482838 |
esv991459 | CNV | deletion | 20482838 |
nsv1038894 | CNV | gain | 25217958 |
nsv1041861 | CNV | loss | 25217958 |
nsv1044347 | CNV | loss | 25217958 |
nsv1048655 | CNV | loss | 25217958 |
nsv1049514 | CNV | gain | 25217958 |
nsv1069857 | CNV | deletion | 25765185 |
nsv1147042 | CNV | deletion | 26484159 |
nsv94393 | CNV | deletion | 16902084 |
nsv957959 | CNV | deletion | 24416366 |
nsv976925 | CNV | duplication | 23825009 |
No disorders were found for MGA Gene.