Aliases for MFSD9 Gene

Aliases for MFSD9 Gene

  • Major Facilitator Superfamily Domain Containing 9 2 3 5
  • Major Facilitator Superfamily Domain-Containing Protein 9 3 4
  • MGC11332 2
  • MFSD9 5

External Ids for MFSD9 Gene

Previous GeneCards Identifiers for MFSD9 Gene

  • GC02M103332
  • GC02M097097

Summaries for MFSD9 Gene

GeneCards Summary for MFSD9 Gene

MFSD9 (Major Facilitator Superfamily Domain Containing 9) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transporter activity and transmembrane transporter activity. An important paralog of this gene is MFSD10.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MFSD9 Gene

Genomics for MFSD9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MFSD9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J102735 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 329.2 +0.4 387 3 MXD4 CEBPA SMAD5 ZNF217 POLR2A ELF1 ZIC2 KDM6A THAP11 SIN3A MFSD9 HSALNG0017440 TMEM182 lnc-RFX8-4 lnc-MFSD9-7 SLC9A2
GH02J102761 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE dbSUPER 58.6 -26.0 -25958 3.1 BCL6 JUND HLF TMEM182 MFSD9 HSALNG0017440 HSALNG0017443
GH02J102697 Enhancer 0.7 Ensembl ENCODE 59.8 +38.6 38587 1 REST FOSL1 NFIB NFIA HLF ATF3 ATF2 NFIC MYC MFSD9 SLC9A2 SLC9A4 HSALNG0017435 HSALNG0017436
GH02J102726 Enhancer 0.4 Ensembl 88.9 +9.4 9387 3.4 CEBPA CEBPG SPI1 RBFOX2 MFSD9 SLC9A2 lnc-MFSD9-7 lnc-RFX8-4
GH02J102801 Enhancer 1.1 Ensembl ENCODE dbSUPER 32.9 -66.1 -66142 3.1 BHLHE40 FOXA2 NBN TAL1 RXRA ZBTB33 SKIL BCL6 JUND SPI1 MFSD9 HSALNG0017443 HSALNG0017440 TMEM182
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MFSD9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MFSD9

Top Transcription factor binding sites by QIAGEN in the MFSD9 gene promoter:
  • c-Ets-1
  • C/EBPalpha
  • C/EBPbeta
  • FOXO1
  • FOXO1a
  • LUN-1
  • SRF
  • SRF (504 AA)
  • STAT5A

Genomic Locations for MFSD9 Gene

Latest Assembly
chr2:102,713,867-102,736,888
(GRCh38/hg38)
Size:
23,022 bases
Orientation:
Minus strand

Previous Assembly
chr2:103,331,089-103,353,347
(GRCh37/hg19 by Entrez Gene)
Size:
22,259 bases
Orientation:
Minus strand

chr2:103,332,299-103,353,347
(GRCh37/hg19 by Ensembl)
Size:
21,049 bases
Orientation:
Minus strand

Genomic View for MFSD9 Gene

Genes around MFSD9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD9 Gene

Proteins for MFSD9 Gene

  • Protein details for MFSD9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBP5-MFSD9_HUMAN
    Recommended name:
    Major facilitator superfamily domain-containing protein 9
    Protein Accession:
    Q8NBP5
    Secondary Accessions:
    • Q4ZG89
    • Q53TU0
    • Q96GQ4
    • Q9BRI8

    Protein attributes for MFSD9 Gene

    Size:
    474 amino acids
    Molecular mass:
    50619 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MFSD9 Gene

Post-translational modifications for MFSD9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MFSD9 Gene

Domains & Families for MFSD9 Gene

Gene Families for MFSD9 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for MFSD9 Gene

Suggested Antigen Peptide Sequences for MFSD9 Gene

GenScript: Design optimal peptide antigens:
  • Major facilitator superfamily domain-containing protein 9 (MFSD9_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NBP5

UniProtKB/Swiss-Prot:

MFSD9_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD9: view

Function for MFSD9 Gene

Phenotypes From GWAS Catalog for MFSD9 Gene

Gene Ontology (GO) - Molecular Function for MFSD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with MFSD9: view
genes like me logo Genes that share phenotypes with MFSD9: view

Animal Models for research

  • Taconic Biosciences Mouse Models for MFSD9

miRNA for MFSD9 Gene

miRTarBase miRNAs that target MFSD9

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MFSD9

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD9 Gene

Localization for MFSD9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD9 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD9 gene
Compartment Confidence
plasma membrane 3
nucleus 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoli rim (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MFSD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD9: view

Pathways & Interactions for MFSD9 Gene

PathCards logo

SuperPathways for MFSD9 Gene

No Data Available

Interacting Proteins for MFSD9 Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000258436 Q8NBP5-MFSD9_HUMAN for MFSD9 Gene via STRING IID

Gene Ontology (GO) - Biological Process for MFSD9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with MFSD9: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD9 Gene

Drugs & Compounds for MFSD9 Gene

No Compound Related Data Available

Transcripts for MFSD9 Gene

mRNA/cDNA for MFSD9 Gene

3 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MFSD9

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD9 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5:

Relevant External Links for MFSD9 Gene

GeneLoc Exon Structure for
MFSD9

Expression for MFSD9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MFSD9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MFSD9 Gene

This gene is overexpressed in Retina (64.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MFSD9 Gene



Protein tissue co-expression partners for MFSD9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MFSD9

SOURCE GeneReport for Unigene cluster for MFSD9 Gene:

Hs.720914

Evidence on tissue expression from TISSUES for MFSD9 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with MFSD9: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFSD9 Gene

Orthologs for MFSD9 Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD9 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MFSD9 30 31
  • 98.73 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia MFSD9 30 31
  • 78.69 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MFSD9 30 31
  • 76.67 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mfsd9 30
  • 76.42 (n)
Mouse
(Mus musculus)
Mammalia Mfsd9 30 17 31
  • 76.03 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MFSD9 31
  • 65 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MFSD9 31
  • 65 (a)
OneToOne
Chicken
(Gallus gallus)
Aves MFSD9 30 31
  • 65.28 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MFSD9 31
  • 58 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mfsd9 30
  • 60.37 (n)
Zebrafish
(Danio rerio)
Actinopterygii mfsd9 30 31
  • 60.94 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea C53B4.3 31
  • 18 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4725 31
  • 29 (a)
OneToOne
Species where no ortholog for MFSD9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MFSD9 Gene

ENSEMBL:
Gene Tree for MFSD9 (if available)
TreeFam:
Gene Tree for MFSD9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MFSD9: view image

Paralogs for MFSD9 Gene

Paralogs for MFSD9 Gene

(2) SIMAP similar genes for MFSD9 Gene using alignment to 5 proteins:

  • MFSD9_HUMAN
  • F2Z2A2_HUMAN
  • F8WDV5_HUMAN
  • F8WE00_HUMAN
  • H7C3S7_HUMAN
genes like me logo Genes that share paralogs with MFSD9: view

Variants for MFSD9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MFSD9 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
rs34096572 Benign: not provided. - 102,718,719(-) C/Tp.Ala376Thr
NM_032718.5(MFSD9):c.1126G>A (p.Ala376Thr)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs34977505 Benign: not provided 102,718,524(-) G/C
NM_032718.5(MFSD9):c.1321C>G (p.Pro441Ala)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs7601509 Benign: not provided. - 102,726,887(-) C/Ap.Ala129Ser
NM_032718.5(MFSD9):c.385G>T (p.Ala129Ser)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
VAR_035966 A breast cancer sample p.Gly59Ala
VAR_035967 A breast cancer sample p.Val84Ala

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MFSD9 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for MFSD9 Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.29; 70.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MFSD9 Gene

Human Gene Mutation Database (HGMD)
MFSD9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD9

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MFSD9 Gene

Disorders for MFSD9 Gene

Additional Disease Information for MFSD9

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for MFSD9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD9 Gene

Publications for MFSD9 Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
  2. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. (PMID: 31586073) Capalbo L … D'Avino PP (Nature communications 2019) 3
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  4. Structural prediction of two novel human atypical SLC transporters, MFSD4A and MFSD9, and their neuroanatomical distribution in mice. (PMID: 29049335) Perland E … Fredriksson R (PloS one 2017) 3
  5. Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. (PMID: 23400010) Del-Aguila JL … Boerwinkle E (The pharmacogenomics journal 2014) 3

Products for MFSD9 Gene

Sources for MFSD9 Gene