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Aliases for MFSD5 Gene

Aliases for MFSD5 Gene

  • Major Facilitator Superfamily Domain Containing 5 2 3 5
  • Major Facilitator Superfamily Domain-Containing Protein 5 3 4
  • Molybdate Transporter 2 Homolog 3 4
  • HsMOT2 3 4
  • Molybdate-Anion Transporter 3

External Ids for MFSD5 Gene

Previous GeneCards Identifiers for MFSD5 Gene

  • GC12P051932
  • GC12P053645
  • GC12P050689

Summaries for MFSD5 Gene

GeneCards Summary for MFSD5 Gene

MFSD5 (Major Facilitator Superfamily Domain Containing 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include molybdate ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for MFSD5 Gene

  • Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.

Additional gene information for MFSD5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD5 Gene

Genomics for MFSD5 Gene

GeneHancer (GH) Regulatory Elements for MFSD5 Gene

Promoters and enhancers for MFSD5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I053250 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 556 +0.8 800 3 HDGF PKNOX1 FOXA2 ARID4B SIN3A YBX1 ZNF2 YY1 POLR2B ZNF143 MFSD5 PIR31799 PIR41879 ZNF740 AAAS ATF7 LOC100652999 PCBP2 SP1 HOXC5
GH12I053294 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.5 +46.4 46428 6.5 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 MEF2D SSRP1 ZNF610 C12orf10 PFDN5 PIR39957 PIR44034 ESPL1 AAAS ZNF740 ATP5MC2 ENSG00000257605 MFSD5
GH12I053320 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.5 +70.1 70137 2.3 CLOCK FEZF1 DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 AAAS GC12M053328 GC12M053329 PIR38393 PIR33338 ESPL1 SP1 PCBP2 MAP3K12 ENSG00000258344
GH12I053060 Enhancer 1.4 Ensembl ENCODE dbSUPER 9.9 -184.3 -184322 13.5 HDGF PKNOX1 FOXA2 MLX ARID4B NEUROD1 SIN3A YBX1 DMAP1 ZNF2 PCBP2 AAAS ZNF740 ATF7 SP1 PFDN5 EIF4B LOC100652999 CALCOCO1 LOC283335
GH12I053190 Enhancer 0.8 ENCODE 10.8 -61.0 -60969 0.2 ARID4B ZNF76 SIN3A RAD21 SCRT2 ZNF143 BCLAF1 ZNF654 REST ELF1 ESPL1 SOAT2 MFSD5 RNU6-333P C12orf10 CSAD ZNF740 ITGB7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MFSD5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MFSD5 gene promoter:

Genomic Locations for MFSD5 Gene

Genomic Locations for MFSD5 Gene
3,156 bases
Plus strand

Genomic View for MFSD5 Gene

Genes around MFSD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD5 Gene

Proteins for MFSD5 Gene

  • Protein details for MFSD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Molybdate-anion transporter
    Protein Accession:
    Secondary Accessions:
    • G3V1N7
    • Q6NW04
    • Q8N7W8
    • Q8NCK0
    • Q96IA5

    Protein attributes for MFSD5 Gene

    450 amino acids
    Molecular mass:
    49765 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05108.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAE45795.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MFSD5 Gene


neXtProt entry for MFSD5 Gene

Post-translational modifications for MFSD5 Gene

  • Ubiquitination at posLast=367367
  • Modification sites at PhosphoSitePlus

Other Protein References for MFSD5 Gene

No data available for DME Specific Peptides for MFSD5 Gene

Domains & Families for MFSD5 Gene

Gene Families for MFSD5 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MFSD5 Gene


Suggested Antigen Peptide Sequences for MFSD5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily.
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD5: view

Function for MFSD5 Gene

Molecular function for MFSD5 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=546 nM for molybdate (when expressed in yeast) {ECO:0000269 PubMed:21464289};
UniProtKB/Swiss-Prot Function:
Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.

Phenotypes From GWAS Catalog for MFSD5 Gene

Gene Ontology (GO) - Molecular Function for MFSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0015098 molybdate ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with MFSD5: view
genes like me logo Genes that share phenotypes with MFSD5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MFSD5

miRNA for MFSD5 Gene

miRTarBase miRNAs that target MFSD5

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD5 Gene

Localization for MFSD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD5 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MFSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane HDA,IEA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MFSD5 Gene

Pathways & Interactions for MFSD5 Gene

SuperPathways for MFSD5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MFSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0015689 molybdate ion transport IEA --
genes like me logo Genes that share ontologies with MFSD5: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD5 Gene

Drugs & Compounds for MFSD5 Gene

No Compound Related Data Available

Transcripts for MFSD5 Gene

Unigene Clusters for MFSD5 Gene

Major facilitator superfamily domain containing 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD5 Gene

No ASD Table

Relevant External Links for MFSD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MFSD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MFSD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MFSD5 Gene

This gene is overexpressed in Breast (26.3), Placenta (16.4), Blymphocyte (16.0), and Islet of Langerhans (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MFSD5 Gene

Protein tissue co-expression partners for MFSD5 Gene

NURSA nuclear receptor signaling pathways regulating expression of MFSD5 Gene:


SOURCE GeneReport for Unigene cluster for MFSD5 Gene:


mRNA Expression by UniProt/SwissProt for MFSD5 Gene:

Tissue specificity: Expressed ubiquitously but at relatively higher levels in the olfactory bulb and the skeletal muscle.

Evidence on tissue expression from TISSUES for MFSD5 Gene

  • Nervous system(4.4)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with MFSD5: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFSD5 Gene

Orthologs for MFSD5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MFSD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MFSD5 33 34
  • 99.34 (n)
(Monodelphis domestica)
Mammalia MFSD5 34
  • 92 (a)
(Canis familiaris)
Mammalia MFSD5 33 34
  • 91.33 (n)
(Bos Taurus)
Mammalia MFSD5 33 34
  • 91.04 (n)
(Mus musculus)
Mammalia Mfsd5 33 16 34
  • 88.15 (n)
(Rattus norvegicus)
Mammalia Mfsd5 33
  • 87.56 (n)
(Gallus gallus)
Aves MFSD5 33
  • 69.37 (n)
(Anolis carolinensis)
Reptilia MFSD5 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mfsd5 33
  • 64.74 (n)
Str.15101 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19080 33
(Danio rerio)
Actinopterygii mfsd5 33 34
  • 61.47 (n)
(Caenorhabditis elegans)
Secernentea Y54G2A.4 34
  • 35 (a)
(Triticum aestivum)
Liliopsida Ta.1382 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
Species where no ortholog for MFSD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MFSD5 Gene

Gene Tree for MFSD5 (if available)
Gene Tree for MFSD5 (if available)

Paralogs for MFSD5 Gene

No data available for Paralogs for MFSD5 Gene

Variants for MFSD5 Gene

Sequence variations from dbSNP and Humsavar for MFSD5 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001732463 -- 53,254,491(+) /G downstream_transcript_variant
rs1002069568 -- 53,252,701(+) A/C intron_variant
rs1002744927 -- 53,251,415(+) A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1003100687 -- 53,251,828(+) C/G coding_sequence_variant, genic_upstream_transcript_variant, synonymous_variant, upstream_transcript_variant
rs1003697912 -- 53,250,440(+) A/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MFSD5 Gene

Variant ID Type Subtype PubMed ID
nsv472441 CNV novel sequence insertion 20440878
nsv517066 CNV loss 19592680
nsv558994 CNV loss 21841781
nsv558996 CNV loss 21841781
nsv832417 CNV gain 17160897

Variation tolerance for MFSD5 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MFSD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD5 Gene

Disorders for MFSD5 Gene

Additional Disease Information for MFSD5

No disorders were found for MFSD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD5 Gene

Publications for MFSD5 Gene

  1. Algae and humans share a molybdate transporter. (PMID: 21464289) Tejada-Jiménez M … Fernández E (Proceedings of the National Academy of Sciences of the United States of America 2011) 2 3 4 58
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58

Products for MFSD5 Gene

Sources for MFSD5 Gene

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