Aliases for MFSD5 Gene

Aliases for MFSD5 Gene

  • Major Facilitator Superfamily Domain Containing 5 2 3 5
  • HsMOT2 2 3 4
  • Major Facilitator Superfamily Domain-Containing Protein 5 3 4
  • Molybdate Transporter 2 Homolog 3 4
  • Molybdate-Anion Transporter 3 4
  • MGC11308 2
  • MFSD5 5

External Ids for MFSD5 Gene

Previous GeneCards Identifiers for MFSD5 Gene

  • GC12P051932
  • GC12P053645
  • GC12P050689

Summaries for MFSD5 Gene

GeneCards Summary for MFSD5 Gene

MFSD5 (Major Facilitator Superfamily Domain Containing 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include molybdate ion transmembrane transporter activity. An important paralog of this gene is MFSD14A.

UniProtKB/Swiss-Prot Summary for MFSD5 Gene

  • Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.

Additional gene information for MFSD5 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MFSD5 Gene

Genomics for MFSD5 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MFSD5 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MFSD5 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MFSD5

Top Transcription factor binding sites by QIAGEN in the MFSD5 gene promoter:
  • E2F
  • p300
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for MFSD5 Gene

Genomic Locations for MFSD5 Gene
chr12:53,251,251-53,254,406
(GRCh38/hg38)
Size:
3,156 bases
Orientation:
Plus strand
chr12:53,645,035-53,648,190
(GRCh37/hg19)
Size:
3,156 bases
Orientation:
Plus strand

Genomic View for MFSD5 Gene

Genes around MFSD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD5 Gene

Proteins for MFSD5 Gene

  • Protein details for MFSD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6N075-MFSD5_HUMAN
    Recommended name:
    Molybdate-anion transporter
    Protein Accession:
    Q6N075
    Secondary Accessions:
    • G3V1N7
    • Q6NW04
    • Q8N7W8
    • Q8NCK0
    • Q96IA5

    Protein attributes for MFSD5 Gene

    Size:
    450 amino acids
    Molecular mass:
    49765 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC05108.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAE45795.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for MFSD5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MFSD5 Gene

Post-translational modifications for MFSD5 Gene

  • Ubiquitination at Lys367
  • Modification sites at PhosphoSitePlus

Other Protein References for MFSD5 Gene

No data available for DME Specific Peptides for MFSD5 Gene

Domains & Families for MFSD5 Gene

Gene Families for MFSD5 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MFSD5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD5 Gene

GenScript: Design optimal peptide antigens:
  • Major facilitator superfamily domain-containing protein 5 (MFSD5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6N075

UniProtKB/Swiss-Prot:

MFSD5_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD5: view

Function for MFSD5 Gene

Molecular function for MFSD5 Gene

UniProtKB/Swiss-Prot Function:
Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=546 nM for molybdate (when expressed in yeast) {ECO:0000269|PubMed:21464289};

Phenotypes From GWAS Catalog for MFSD5 Gene

Gene Ontology (GO) - Molecular Function for MFSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0015098 molybdate ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with MFSD5: view
genes like me logo Genes that share phenotypes with MFSD5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MFSD5

CRISPR Products

miRNA for MFSD5 Gene

miRTarBase miRNAs that target MFSD5

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MFSD5

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD5 Gene

Localization for MFSD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD5 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD5 gene
Compartment Confidence
plasma membrane 4
nucleus 1
lysosome 1
endoplasmic reticulum 0

Gene Ontology (GO) - Cellular Components for MFSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IBA 21873635
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MFSD5 Gene

Pathways & Interactions for MFSD5 Gene

PathCards logo

SuperPathways for MFSD5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MFSD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0015689 molybdate ion transport IEA --
genes like me logo Genes that share ontologies with MFSD5: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD5 Gene

Drugs & Compounds for MFSD5 Gene

No Compound Related Data Available

Transcripts for MFSD5 Gene

mRNA/cDNA for MFSD5 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MFSD5

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD5 Gene

No ASD Table

Relevant External Links for MFSD5 Gene

GeneLoc Exon Structure for
MFSD5

Expression for MFSD5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MFSD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MFSD5 Gene

This gene is overexpressed in Breast (26.3), Placenta (16.4), Blymphocyte (16.0), and Islet of Langerhans (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MFSD5 Gene



Protein tissue co-expression partners for MFSD5 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MFSD5

SOURCE GeneReport for Unigene cluster for MFSD5 Gene:

Hs.654660

mRNA Expression by UniProt/SwissProt for MFSD5 Gene:

Q6N075-MFSD5_HUMAN
Tissue specificity: Expressed ubiquitously but at relatively higher levels in the olfactory bulb and the skeletal muscle.

Evidence on tissue expression from TISSUES for MFSD5 Gene

  • Nervous system(4.4)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with MFSD5: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFSD5 Gene

Orthologs for MFSD5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MFSD5 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MFSD5 30 31
  • 99.34 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MFSD5 31
  • 92 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia MFSD5 30 31
  • 91.33 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MFSD5 30 31
  • 91.04 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Mfsd5 30 17 31
  • 88.15 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mfsd5 30
  • 87.56 (n)
Chicken
(Gallus gallus)
Aves MFSD5 30
  • 69.37 (n)
Lizard
(Anolis carolinensis)
Reptilia MFSD5 31
  • 76 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mfsd5 30
  • 64.74 (n)
Str.15101 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.19080 30
Zebrafish
(Danio rerio)
Actinopterygii mfsd5 30 31
  • 61.47 (n)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea Y54G2A.4 31
  • 35 (a)
OneToOne
Wheat
(Triticum aestivum)
Liliopsida Ta.1382 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 38 (a)
OneToOne
Species where no ortholog for MFSD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for MFSD5 Gene

ENSEMBL:
Gene Tree for MFSD5 (if available)
TreeFam:
Gene Tree for MFSD5 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MFSD5: view image

Paralogs for MFSD5 Gene

Paralogs for MFSD5 Gene

genes like me logo Genes that share paralogs with MFSD5: view

Variants for MFSD5 Gene

Additional dbSNP identifiers (rs#s) for MFSD5 Gene

Structural Variations from Database of Genomic Variants (DGV) for MFSD5 Gene

Variant ID Type Subtype PubMed ID
nsv472441 CNV novel sequence insertion 20440878
nsv517066 CNV loss 19592680
nsv558994 CNV loss 21841781
nsv558996 CNV loss 21841781
nsv832417 CNV gain 17160897

Variation tolerance for MFSD5 Gene

Residual Variation Intolerance Score: 13.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MFSD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD5

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MFSD5 Gene

Disorders for MFSD5 Gene

No disorders were found for MFSD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD5 Gene

Publications for MFSD5 Gene

  1. Algae and humans share a molybdate transporter. (PMID: 21464289) Tejada-Jiménez M … Fernández E (Proceedings of the National Academy of Sciences of the United States of America 2011) 2 3 4
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4

Products for MFSD5 Gene

Sources for MFSD5 Gene