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Aliases for MFSD4B Gene

Aliases for MFSD4B Gene

  • Major Facilitator Superfamily Domain Containing 4B 2 3 5
  • KIAA1919 2 3 4
  • Major Facilitator Superfamily Domain-Containing Protein 4B 3 4
  • NaGLT1 3 4
  • Sodium-Dependent Glucose Transporter 1 3

External Ids for MFSD4B Gene

Previous HGNC Symbols for MFSD4B Gene

  • KIAA1919

Summaries for MFSD4B Gene

GeneCards Summary for MFSD4B Gene

MFSD4B (Major Facilitator Superfamily Domain Containing 4B) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. An important paralog of this gene is MFSD4A.

UniProtKB/Swiss-Prot for MFSD4B Gene

  • May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney.

Additional gene information for MFSD4B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD4B Gene

Genomics for MFSD4B Gene

GeneHancer (GH) Regulatory Elements for MFSD4B Gene

Promoters and enhancers for MFSD4B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I111258 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 578.6 +0.8 759 2.9 HDGF CLOCK SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 MFSD4B ENSG00000231046 ENSG00000230177
GH06I111563 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 59.7 +307.1 307106 6.3 PKNOX1 SIN3A FEZF1 ZNF2 ZNF213 ZNF416 ZNF143 FOS ZNF662 REST TRAF3IP2 MFSD4B ENSG00000220506 REV3L BRD7P4 FCF1P5 ENSG00000255389 TRAF3IP2-AS1 TUBE1 ENSG00000272356
GH06I110873 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 41.2 -382.7 -382724 6.6 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC NBN AMD1 MFSD4B ENSG00000220506 BRD7P4 RPF2 CDK19 CNN2P9 FCF1P5 GTF3C6 RNU6-957P
GH06I110813 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 32.6 -444.0 -443972 4.1 CLOCK ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 CDK19 AMD1 MFSD4B ENSG00000220506 FCF1P5 RPF2 CNN2P9 BRD7P4 CDC40
GH06I111599 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.9 +344.1 344055 7.9 HDGF FOXA2 ARNT SIN3A YBX1 FEZF1 DMAP1 ZNF2 YY1 FOS TRAF3IP2 MFSD4B ENSG00000255389 ENSG00000220506 BRD7P4 CNN2P9 TUBE1 FCF1P5 REV3L GC06P111602
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MFSD4B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MFSD4B Gene

Genomic Locations for MFSD4B Gene
11,889 bases
Plus strand

Genomic View for MFSD4B Gene

Genes around MFSD4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD4B Gene

Proteins for MFSD4B Gene

  • Protein details for MFSD4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium-dependent glucose transporter 1
    Protein Accession:
    Secondary Accessions:
    • A8K9M0
    • Q8IYB6
    • Q96PW9
    • Q9P0D6

    Protein attributes for MFSD4B Gene

    518 amino acids
    Molecular mass:
    56218 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MFSD4B Gene

Post-translational modifications for MFSD4B Gene

No Post-translational modifications

Other Protein References for MFSD4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MFSD4B Gene

Domains & Families for MFSD4B Gene

Gene Families for MFSD4B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MFSD4B Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily.
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD4B: view

No data available for Suggested Antigen Peptide Sequences for MFSD4B Gene

Function for MFSD4B Gene

Molecular function for MFSD4B Gene

UniProtKB/Swiss-Prot Function:
May function as a sodium-dependent glucose transporter. Potential channels for urea in the inner medulla of kidney.

Phenotypes From GWAS Catalog for MFSD4B Gene

Gene Ontology (GO) - Molecular Function for MFSD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005355 glucose transmembrane transporter activity IBA --
GO:0015293 symporter activity IEA --
genes like me logo Genes that share ontologies with MFSD4B: view
genes like me logo Genes that share phenotypes with MFSD4B: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD4B Gene

Localization for MFSD4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD4B Gene

Apical cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD4B gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MFSD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with MFSD4B: view

Pathways & Interactions for MFSD4B Gene

genes like me logo Genes that share pathways with MFSD4B: view

Gene Ontology (GO) - Biological Process for MFSD4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with MFSD4B: view

No data available for SIGNOR curated interactions for MFSD4B Gene

Drugs & Compounds for MFSD4B Gene

No Compound Related Data Available

Transcripts for MFSD4B Gene

mRNA/cDNA for MFSD4B Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD4B Gene

No ASD Table

Relevant External Links for MFSD4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MFSD4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of MFSD4B Gene:


Evidence on tissue expression from TISSUES for MFSD4B Gene

  • Blood(4.2)
  • Kidney(4.2)
  • Nervous system(4.1)
  • Intestine(2.3)
genes like me logo Genes that share expression patterns with MFSD4B: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFSD4B Gene

Orthologs for MFSD4B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MFSD4B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KIAA1919 33 34
  • 99.42 (n)
(Bos Taurus)
Mammalia KIAA1919 33 34
  • 87.49 (n)
(Canis familiaris)
Mammalia KIAA1919 33 34
  • 85.69 (n)
(Mus musculus)
Mammalia 2010001E11Rik 34
  • 78 (a)
G630090E17Rik 34
  • 78 (a)
AI317395 33 34
  • 77.65 (n)
AA474331 34
  • 72 (a)
BC021785 34
  • 66 (a)
Mfsd4b1 16
(Rattus norvegicus)
Mammalia RGD1559971 33
  • 77.69 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 65 (a)
-- 34
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia KIAA1919 34
  • 65 (a)
(Gallus gallus)
Aves KIAA1919 33 34
  • 62.59 (n)
(Anolis carolinensis)
Reptilia KIAA1919 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1919 33
  • 62.86 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10832 33
(Danio rerio)
Actinopterygii zgc:162161 33 34
  • 56.32 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
-- 34
  • 28 (a)
Species where no ortholog for MFSD4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MFSD4B Gene

Gene Tree for MFSD4B (if available)
Gene Tree for MFSD4B (if available)

Paralogs for MFSD4B Gene

Paralogs for MFSD4B Gene Pseudogenes for MFSD4B Gene

genes like me logo Genes that share paralogs with MFSD4B: view

Variants for MFSD4B Gene

Sequence variations from dbSNP and Humsavar for MFSD4B Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000236940 -- 111,264,585(+) G/A intron_variant
rs1000344645 -- 111,258,067(+) T/A upstream_transcript_variant
rs1000862400 -- 111,257,855(+) G/A upstream_transcript_variant
rs1000915788 -- 111,262,221(+) A/G intron_variant
rs1000916529 -- 111,268,661(+) C/G/T 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MFSD4B Gene

Variant ID Type Subtype PubMed ID
nsv604517 CNV gain 21841781
nsv1028349 CNV gain 25217958
nsv1020627 CNV gain 25217958
esv3610378 CNV loss 21293372
esv3610377 CNV loss 21293372

Variation tolerance for MFSD4B Gene

Residual Variation Intolerance Score: 26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.89; 48.58% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MFSD4B Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD4B Gene

Disorders for MFSD4B Gene

No disorders were found for MFSD4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD4B Gene

Publications for MFSD4B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for MFSD4B Gene

Sources for MFSD4B Gene

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