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Aliases for MFSD14C Gene

Aliases for MFSD14C Gene

  • Major Facilitator Superfamily Domain Containing 14C 2 3 5
  • HIATL2 3 4
  • Major Facilitator Superfamily Domain-Containing 14C 4
  • Hippocampus Abundant Transcript-Like Protein 2 3
  • Hippocampus Abundant Gene Transcript-Like 2 3
  • Hippocampus Abundant Transcript-Like 2 2

External Ids for MFSD14C Gene

Previous HGNC Symbols for MFSD14C Gene

  • HIATL2

Summaries for MFSD14C Gene

GeneCards Summary for MFSD14C Gene

MFSD14C (Major Facilitator Superfamily Domain Containing 14C) is a Protein Coding gene. An important paralog of this gene is MFSD14B.

Additional gene information for MFSD14C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD14C Gene

Genomics for MFSD14C Gene

GeneHancer (GH) Regulatory Elements for MFSD14C Gene

Promoters and enhancers for MFSD14C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I097012 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 550.8 +0.5 508 2.4 ATF1 ARID4B SIN3A DMAP1 ZBTB7B ZNF48 POLR2B GLIS2 ZNF213 E2F8 ZNF782 MFSD14C CTSV AAED1 TDRD7 YRDCP2
GH09I097918 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.2 -907.5 -907530 5.9 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 TRMO NCBP1 TSTD2 ZNF322P1 NUTM2G MFSD14C ZNF782 ANP32B ENSG00000236896 HEMGN
GH09I097979 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.2 -970.1 -970098 8.3 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ANP32B NANS NCBP1 MFSD14C ZNF782 TSTD2 ZNF322P1 ENSG00000254633 XPA TRMO
GH09I097631 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.2 -619.7 -619706 4 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 NCBP1 TSTD2 MFSD14C ZNF782 NUTM2G ZNF322P1 ENSG00000224848 ZNF510 ENSG00000254633 XPA
GH09I096416 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 +594.7 594731 5.4 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ZNF367 PIR44583 ERCC6L2 ENSG00000271155 ZNF782 ZNF322P1 EIF4BP3 ENSG00000254633 NUTM2G MFSD14C
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MFSD14C on UCSC Golden Path with GeneCards custom track

Genomic Locations for MFSD14C Gene

Genomic Locations for MFSD14C Gene
chr9:96,897,917-97,013,708
(GRCh38/hg38)
Size:
115,792 bases
Orientation:
Minus strand
chr9:99,660,348-99,775,862
(GRCh37/hg19)

Genomic View for MFSD14C Gene

Genes around MFSD14C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD14C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD14C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD14C Gene

Proteins for MFSD14C Gene

  • Protein details for MFSD14C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VZR4-MF14C_HUMAN
    Recommended name:
    Hippocampus abundant transcript-like protein 2
    Protein Accession:
    Q5VZR4
    Secondary Accessions:
    • Q9BSG7

    Protein attributes for MFSD14C Gene

    Size:
    134 amino acids
    Molecular mass:
    14477 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BC005058; Type=Miscellaneous discrepancy; Note=The sequence differs at the 3 end.; Evidence={ECO:0000305};

neXtProt entry for MFSD14C Gene

Post-translational modifications for MFSD14C Gene

No Post-translational modifications

Other Protein References for MFSD14C Gene

No data available for DME Specific Peptides for MFSD14C Gene

Domains & Families for MFSD14C Gene

Gene Families for MFSD14C Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MFSD14C Gene

Suggested Antigen Peptide Sequences for MFSD14C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VZR4

UniProtKB/Swiss-Prot:

MF14C_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD14C: view

Function for MFSD14C Gene

Phenotypes From GWAS Catalog for MFSD14C Gene

Gene Ontology (GO) - Molecular Function for MFSD14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IBA --
genes like me logo Genes that share ontologies with MFSD14C: view

Phenotypes for MFSD14C Gene

GenomeRNAi human phenotypes for MFSD14C:
genes like me logo Genes that share phenotypes with MFSD14C: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD14C Gene

Localization for MFSD14C Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD14C Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD14C gene
Compartment Confidence
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MFSD14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD14C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MFSD14C Gene

Pathways & Interactions for MFSD14C Gene

SuperPathways for MFSD14C Gene

No Data Available

Interacting Proteins for MFSD14C Gene

Gene Ontology (GO) - Biological Process for MFSD14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0055085 transmembrane transport IBA --
genes like me logo Genes that share ontologies with MFSD14C: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD14C Gene

Drugs & Compounds for MFSD14C Gene

No Compound Related Data Available

Transcripts for MFSD14C Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD14C Gene

No ASD Table

Relevant External Links for MFSD14C Gene

GeneLoc Exon Structure for
MFSD14C
ECgene alternative splicing isoforms for
MFSD14C

Expression for MFSD14C Gene

NURSA nuclear receptor signaling pathways regulating expression of MFSD14C Gene:

MFSD14C

Evidence on tissue expression from TISSUES for MFSD14C Gene

  • Skin(4.1)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFSD14C Gene

Orthologs for MFSD14C Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD14C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIATL2 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 24 (a)
OneToMany
cow
(Bos Taurus)
Mammalia HIATL1 34
  • 23 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Hiatl1 34
  • 21 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 19 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 19 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CU856539.1 34
  • 17 (a)
ManyToMany
si:ch211-87m7.2 34
  • 17 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5078 34
  • 14 (a)
ManyToMany
CG11537 34
  • 10 (a)
ManyToMany
CG17637 34
  • 9 (a)
ManyToMany
CG18281 34
  • 8 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T25D3.4 34
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6723 34
  • 15 (a)
OneToMany
Species where no ortholog for MFSD14C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MFSD14C Gene

ENSEMBL:
Gene Tree for MFSD14C (if available)
TreeFam:
Gene Tree for MFSD14C (if available)

Paralogs for MFSD14C Gene

Paralogs for MFSD14C Gene

genes like me logo Genes that share paralogs with MFSD14C: view

Variants for MFSD14C Gene

Sequence variations from dbSNP and Humsavar for MFSD14C Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000048418 -- 96,993,657(-) A/G intron_variant
rs1000050105 -- 96,956,416(-) A/G intron_variant
rs1000064461 -- 96,962,545(-) A/G intron_variant
rs1000183504 -- 96,951,061(-) C/T intron_variant
rs1000245088 -- 96,961,984(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MFSD14C Gene

Variant ID Type Subtype PubMed ID
nsv972790 CNV duplication 23825009
nsv972789 CNV duplication 23825009
nsv831662 CNV gain 17160897
nsv831661 CNV loss 17160897
nsv6625 CNV insertion 18451855
nsv520001 CNV loss 19592680
nsv1147999 OTHER inversion 26484159
nsv1075257 CNV deletion 25765185
esv3621177 CNV loss 21293372
esv3621176 CNV loss 21293372
esv2738813 CNV deletion 23290073

Variation tolerance for MFSD14C Gene

Gene Damage Index Score: 3.64; 56.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MFSD14C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD14C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD14C Gene

Disorders for MFSD14C Gene

No disorders were found for MFSD14C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD14C Gene

Publications for MFSD14C Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for MFSD14C Gene

Sources for MFSD14C Gene

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