Aliases for MFSD14B Gene

Aliases for MFSD14B Gene

  • Major Facilitator Superfamily Domain Containing 14B 2 3 5
  • Hippocampus Abundant Transcript-Like Protein 1 3 4
  • Hippocampus Abundant Transcript-Like 1 2 3
  • HIATL1 3 4
  • Major Facilitator Superfamily Domain-Containing 14B 4
  • FLJ14753 2
  • MFSD14B 5

External Ids for MFSD14B Gene

Previous HGNC Symbols for MFSD14B Gene

  • HIATL1

Summaries for MFSD14B Gene

GeneCards Summary for MFSD14B Gene

MFSD14B (Major Facilitator Superfamily Domain Containing 14B) is a Protein Coding gene. Diseases associated with MFSD14B include Endometrioid Ovary Carcinoma. An important paralog of this gene is MFSD14A.

Additional gene information for MFSD14B Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MFSD14B Gene

Genomics for MFSD14B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MFSD14B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J094373 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 639.6 +1.0 974 3.8 CREB1 PRDM10 ZNF629 BACH1 LARP7 GABPA MTA2 ZNF143 PHF21A RBFOX2 MFSD14B ENSG00000232063 ZNF169 YRDCP1 FBP2 RF00017-7724
GH09J094332 Promoter 1.2 Ensembl CraniofacialAtlas 29.9 -41.3 -41326 1.6 REST NRF1 MGA POLR2A MTA3 CTBP1 NFIC BCOR CEBPG MNT ENSG00000232063 LOC100132077 MFSD14B NUTM2F piR-61153-001 RF00017-7724
GH09J094409 Enhancer 0.9 Ensembl dbSUPER 38.8 +37.1 37074 8.4 LEF1 PKNOX1 BRD9 HDAC1 SOX6 TCF12 CTBP1 HDAC2 PHB2 AFF1 MFSD14B ENSG00000232063 ZNF169 YRDCP1 FBP2 RF00017-7724
GH09J094385 Enhancer 0.9 Ensembl dbSUPER 38.8 +19.8 19773 21.4 RFX1 ZNF740 DPF2 NFE2 ZNF316 MEF2D ZNF592 ZBTB17 NCOR1 MAFG MFSD14B ENSG00000232063 YRDCP1 FBP2 RF00017-7724
GH09J094346 Enhancer 0.6 Ensembl 38.5 -20.5 -20526 15.2 DDX20 MEF2D ZNF592 NR2F1 ZBTB33 DIDO1 IRF9 TAF7 SP1 PYGO2 MFSD14B ENSG00000232063 NUTM2F ZNF169 PTMAP12 lnc-MFSD14B-2 LOC100132077 RF00017-7724
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MFSD14B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MFSD14B

Genomic Locations for MFSD14B Gene

Genomic Locations for MFSD14B Gene
chr9:94,374,327-94,461,042
(GRCh38/hg38)
Size:
86,716 bases
Orientation:
Plus strand
chr9:97,136,833-97,223,324
(GRCh37/hg19)
Size:
86,492 bases
Orientation:
Plus strand

Genomic View for MFSD14B Gene

Genes around MFSD14B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD14B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD14B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD14B Gene

Proteins for MFSD14B Gene

  • Protein details for MFSD14B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SR56-MF14B_HUMAN
    Recommended name:
    Hippocampus abundant transcript-like protein 1
    Protein Accession:
    Q5SR56
    Secondary Accessions:
    • B4DUE6
    • E9PD58
    • Q3KQT4
    • Q53GU5
    • Q8WU95
    • Q96SM4

    Protein attributes for MFSD14B Gene

    Size:
    506 amino acids
    Molecular mass:
    54545 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI06063.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55274.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96556.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MFSD14B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MFSD14B Gene

Post-translational modifications for MFSD14B Gene

  • Glycosylation at Asn463
  • Modification sites at PhosphoSitePlus

Other Protein References for MFSD14B Gene

No data available for DME Specific Peptides for MFSD14B Gene

Domains & Families for MFSD14B Gene

Gene Families for MFSD14B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for MFSD14B Gene

Suggested Antigen Peptide Sequences for MFSD14B Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ55868, highly similar to Hippocampus abundant transcript-like protein1 (B4DUE6_HUMAN)
  • Hippocampus abundant transcript-like protein 1 (HIAL1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5SR56

UniProtKB/Swiss-Prot:

MF14B_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD14B: view

Function for MFSD14B Gene

Phenotypes From GWAS Catalog for MFSD14B Gene

Gene Ontology (GO) - Molecular Function for MFSD14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with MFSD14B: view
genes like me logo Genes that share phenotypes with MFSD14B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MFSD14B

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MFSD14B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD14B Gene

Localization for MFSD14B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD14B Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD14B gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MFSD14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD14B: view

Pathways & Interactions for MFSD14B Gene

PathCards logo

SuperPathways for MFSD14B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MFSD14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with MFSD14B: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD14B Gene

Drugs & Compounds for MFSD14B Gene

No Compound Related Data Available

Transcripts for MFSD14B Gene

mRNA/cDNA for MFSD14B Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MFSD14B

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD14B Gene

No ASD Table

Relevant External Links for MFSD14B Gene

GeneLoc Exon Structure for
MFSD14B

Expression for MFSD14B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MFSD14B

Evidence on tissue expression from TISSUES for MFSD14B Gene

  • Skin(4.4)
  • Liver(4.3)
  • Nervous system(3.4)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFSD14B Gene

Orthologs for MFSD14B Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD14B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia HIATL1 30 31
  • 99.32 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 93 (a)
OneToMany
HIATL1 30
  • 92.29 (n)
Cow
(Bos Taurus)
Mammalia HIATL1 30 31
  • 89.84 (n)
OneToMany
Mouse
(Mus musculus)
Mammalia Hiatl1 30 31
  • 87.78 (n)
OneToMany
Mfsd14b 17
Rat
(Rattus norvegicus)
Mammalia Hiatl1 30
  • 87.38 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 78 (a)
OneToMany
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 70 (a)
ManyToMany
Chicken
(Gallus gallus)
Aves HCN2 31
  • 72 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 80 (a)
OneToMany
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100216076 30
  • 70.88 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-87m7.2 31
  • 70 (a)
ManyToMany
CU856539.1 31
  • 70 (a)
ManyToMany
LOC557306 30
  • 67.84 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG5078 31
  • 47 (a)
ManyToMany
CG11537 31
  • 38 (a)
ManyToMany
CG17637 31
  • 30 (a)
ManyToMany
CG18281 31
  • 29 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea T25D3.4 30 31
  • 56.49 (n)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.6723 31
  • 53 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.6571 30
Species where no ortholog for MFSD14B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MFSD14B Gene

ENSEMBL:
Gene Tree for MFSD14B (if available)
TreeFam:
Gene Tree for MFSD14B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MFSD14B: view image

Paralogs for MFSD14B Gene

Paralogs for MFSD14B Gene

Pseudogenes.org Pseudogenes for MFSD14B Gene

genes like me logo Genes that share paralogs with MFSD14B: view

Variants for MFSD14B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MFSD14B Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs17851857 - p.Val406Leu

Additional dbSNP identifiers (rs#s) for MFSD14B Gene

Structural Variations from Database of Genomic Variants (DGV) for MFSD14B Gene

Variant ID Type Subtype PubMed ID
dgv1491e214 CNV gain 21293372
esv2675142 CNV deletion 23128226
esv2761545 CNV gain 21179565
esv33917 CNV gain 17666407
esv3576685 CNV gain 25503493
esv3621113 CNV gain 21293372
esv3621120 CNV gain 21293372
esv3621121 CNV gain 21293372
esv3621123 CNV loss 21293372
nsv1046906 CNV gain 25217958
nsv1141012 CNV deletion 24896259
nsv1147999 OTHER inversion 26484159
nsv415866 CNV deletion 16902084
nsv982323 CNV duplication 23825009
nsv982324 CNV duplication 23825009

Variation tolerance for MFSD14B Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MFSD14B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD14B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD14B Gene

Disorders for MFSD14B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MFSD14B Gene - From: DISEASES

Disorder Aliases PubMed IDs
endometrioid ovary carcinoma
  • endometrioid carcinoma of ovary
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with MFSD14B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MFSD14B Gene

Publications for MFSD14B Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3

Products for MFSD14B Gene

Sources for MFSD14B Gene