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Aliases for MFSD14B Gene

Aliases for MFSD14B Gene

  • Major Facilitator Superfamily Domain Containing 14B 2 3 5
  • Hippocampus Abundant Transcript-Like 1 2 3
  • HIATL1 3 4
  • Major Facilitator Superfamily Domain-Containing 14B 4
  • Hippocampus Abundant Transcript-Like Protein 1 3

External Ids for MFSD14B Gene

Previous HGNC Symbols for MFSD14B Gene

  • HIATL1

Summaries for MFSD14B Gene

GeneCards Summary for MFSD14B Gene

MFSD14B (Major Facilitator Superfamily Domain Containing 14B) is a Protein Coding gene. An important paralog of this gene is MFSD14A.

Additional gene information for MFSD14B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD14B Gene

Genomics for MFSD14B Gene

GeneHancer (GH) Regulatory Elements for MFSD14B Gene

Promoters and enhancers for MFSD14B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I094373 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 589.7 +0.6 579 2.2 HDGF ATF1 ARID4B SIN3A ZNF2 ZNF48 GLIS2 ZNF213 E2F8 ZNF207 MFSD14B LOC100132077 ZNF169 YRDCP1 NUTM2F
GH09I094164 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 15.2 -206.7 -206721 5.7 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 ENSG00000269946 MFSD14B LOC100132077 PIR42143 GC09P094199
GH09I094332 Promoter 1 Ensembl 29.9 -41.6 -41621 0.6 BCOR MEIS2 KLF1 RB1 CEBPG ZBTB40 POLR2B CTBP1 MTA3 POLR2A LOC100132077 MFSD14B PIR56152 NUTM2F
GH09I094387 Enhancer 0.7 Ensembl dbSUPER 38.6 +13.1 13079 0.8 ATF4 ZNF316 MAFG NFE2 FOS EMSY MFSD14B LOC100132077 YRDCP1 NUTM2F
GH09I093574 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 11.1 -797.5 -797519 4.3 HDGF HDAC1 CLOCK NFRKB SIN3A YY1 ZNF335 ZNF766 GLIS2 EGR1 GC09M093574 PHF2 ENSG00000227603 MFSD14B MIR548AU
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MFSD14B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MFSD14B Gene

Genomic Locations for MFSD14B Gene
chr9:94,374,322-94,461,042
(GRCh38/hg38)
Size:
86,721 bases
Orientation:
Plus strand
chr9:97,136,833-97,223,324
(GRCh37/hg19)

Genomic View for MFSD14B Gene

Genes around MFSD14B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD14B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD14B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD14B Gene

Proteins for MFSD14B Gene

  • Protein details for MFSD14B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SR56-MF14B_HUMAN
    Recommended name:
    Hippocampus abundant transcript-like protein 1
    Protein Accession:
    Q5SR56
    Secondary Accessions:
    • B4DUE6
    • E9PD58
    • Q3KQT4
    • Q53GU5
    • Q8WU95
    • Q96SM4

    Protein attributes for MFSD14B Gene

    Size:
    506 amino acids
    Molecular mass:
    54545 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI06063.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55274.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD96556.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MFSD14B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MFSD14B Gene

Post-translational modifications for MFSD14B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MFSD14B Gene

Domains & Families for MFSD14B Gene

Gene Families for MFSD14B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for MFSD14B Gene

Graphical View of Domain Structure for InterPro Entry

Q5SR56

UniProtKB/Swiss-Prot:

MF14B_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD14B: view

Function for MFSD14B Gene

Phenotypes From GWAS Catalog for MFSD14B Gene

Gene Ontology (GO) - Molecular Function for MFSD14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IBA --
genes like me logo Genes that share ontologies with MFSD14B: view
genes like me logo Genes that share phenotypes with MFSD14B: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD14B Gene

Localization for MFSD14B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD14B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD14B gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MFSD14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD14B: view

Pathways & Interactions for MFSD14B Gene

SuperPathways for MFSD14B Gene

No Data Available

Interacting Proteins for MFSD14B Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000364493%0d%0a9606.ENSP00000293218%0d%0a9606.ENSP00000378792%0d%0a9606.ENSP00000364405%0d%0a9606.ENSP00000302855%0d%0a9606.ENSP00000353586%0d%0a
Selected Interacting proteins: ENSP00000364493 Q5SR56-MF14B_HUMAN for MFSD14B Gene via STRING IID

Gene Ontology (GO) - Biological Process for MFSD14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0055085 transmembrane transport IBA --
genes like me logo Genes that share ontologies with MFSD14B: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD14B Gene

Drugs & Compounds for MFSD14B Gene

No Compound Related Data Available

Transcripts for MFSD14B Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD14B Gene

No ASD Table

Relevant External Links for MFSD14B Gene

GeneLoc Exon Structure for
MFSD14B
ECgene alternative splicing isoforms for
MFSD14B

Expression for MFSD14B Gene

NURSA nuclear receptor signaling pathways regulating expression of MFSD14B Gene:

MFSD14B

Evidence on tissue expression from TISSUES for MFSD14B Gene

  • Skin(4.3)
  • Liver(4.2)
  • Nervous system(3.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFSD14B Gene

Orthologs for MFSD14B Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD14B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIATL1 33 34
  • 99.32 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 93 (a)
OneToMany
HIATL1 33
  • 92.29 (n)
cow
(Bos Taurus)
Mammalia HIATL1 33 34
  • 89.84 (n)
mouse
(Mus musculus)
Mammalia Hiatl1 33 34
  • 87.78 (n)
Mfsd14b 16
rat
(Rattus norvegicus)
Mammalia Hiatl1 33
  • 87.38 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 70 (a)
ManyToMany
chicken
(Gallus gallus)
Aves HCN2 34
  • 72 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 80 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100216076 33
  • 70.88 (n)
zebrafish
(Danio rerio)
Actinopterygii CU856539.1 34
  • 70 (a)
ManyToMany
si:ch211-87m7.2 34
  • 70 (a)
ManyToMany
LOC557306 33
  • 67.84 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5078 34
  • 47 (a)
ManyToMany
CG11537 34
  • 38 (a)
ManyToMany
CG17637 34
  • 30 (a)
ManyToMany
CG18281 34
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T25D3.4 33 34
  • 56.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6723 34
  • 53 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6571 33
Species where no ortholog for MFSD14B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MFSD14B Gene

ENSEMBL:
Gene Tree for MFSD14B (if available)
TreeFam:
Gene Tree for MFSD14B (if available)

Paralogs for MFSD14B Gene

Paralogs for MFSD14B Gene

Pseudogenes.org Pseudogenes for MFSD14B Gene

genes like me logo Genes that share paralogs with MFSD14B: view

Variants for MFSD14B Gene

Sequence variations from dbSNP and Humsavar for MFSD14B Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000013177 -- 94,402,222(+) C/G intron_variant
rs1000049978 -- 94,459,854(+) C/A 3_prime_UTR_variant
rs1000080909 -- 94,408,586(+) G/C intron_variant
rs1000102293 -- 94,449,002(+) A/C intron_variant
rs1000119178 -- 94,377,149(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MFSD14B Gene

Variant ID Type Subtype PubMed ID
nsv982324 CNV duplication 23825009
nsv982323 CNV duplication 23825009
nsv415866 CNV deletion 16902084
nsv1147999 OTHER inversion 26484159
nsv1141012 CNV deletion 24896259
nsv1046906 CNV gain 25217958
esv3621123 CNV loss 21293372
esv3621121 CNV gain 21293372
esv3621120 CNV gain 21293372
esv3621113 CNV gain 21293372
esv3576685 CNV gain 25503493
esv33917 CNV gain 17666407
esv2761545 CNV gain 21179565
esv2675142 CNV deletion 23128226
dgv1491e214 CNV gain 21293372

Variation tolerance for MFSD14B Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MFSD14B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD14B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD14B Gene

Disorders for MFSD14B Gene

No disorders were found for MFSD14B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD14B Gene

Publications for MFSD14B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Genome-Wide Interaction Analyses between Genetic Variants and Alcohol Consumption and Smoking for Risk of Colorectal Cancer. (PMID: 27723779) Gong J … CCFR and GECCO (PLoS genetics 2016) 3 58
  5. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J … Shi Y (Genes & development 2015) 3 58

Products for MFSD14B Gene

Sources for MFSD14B Gene

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