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Aliases for MFSD14A Gene

Aliases for MFSD14A Gene

  • Major Facilitator Superfamily Domain Containing 14A 2 3 5
  • Putative Tetracycline Transporter-Like Protein 3 4
  • HIAT1 3 4
  • Major Facilitator Superfamily Domain-Containing 14A 4
  • Hippocampus Abundant Transcript 1 Protein 3
  • Hippocampus Abundant Gene Transcript 1 3
  • Tetracycline Transporter-Like Protein 3
  • Hippocampus Abundant Transcript 1 2

External Ids for MFSD14A Gene

Previous HGNC Symbols for MFSD14A Gene

  • HIAT1

Summaries for MFSD14A Gene

GeneCards Summary for MFSD14A Gene

MFSD14A (Major Facilitator Superfamily Domain Containing 14A) is a Protein Coding gene. An important paralog of this gene is ENSG00000283761.

Additional gene information for MFSD14A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFSD14A Gene

Genomics for MFSD14A Gene

GeneHancer (GH) Regulatory Elements for MFSD14A Gene

Promoters and enhancers for MFSD14A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J100036 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 674.9 +0.6 649 4.1 SMAD1 ARNT MLX ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 MFSD14A SASS6 LRRC39 TRMT13 SLC30A7 BRI3P1 RTCA AGL ENSG00000241073 ENSG00000283761
GH01J100046 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 653.3 +10.4 10372 4.5 HDAC1 PKNOX1 FOXA2 ZNF133 TCF12 POLR3A ATF7 IKZF2 RUNX3 ZNF202 MFSD14A SASS6 LRRC39 HNRNPA1P68 TRMT13 RTCA FRRS1 ENSG00000241073 ENSG00000283761
GH01J100058 Promoter 0.6 EPDnew 650.3 +20.2 20239 0.1 ZNF664 MFSD14A ENSG00000241073 ENSG00000283761
GH01J100035 Enhancer 0.4 Ensembl 650.7 -2.0 -1977 0.6 ZNF600 MLLT1 MFSD14A AGL GC01P100031 ENSG00000283761
GH01J100348 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 67.8 +314.2 314155 7.1 FEZF1 DMAP1 YBX1 YY1 ZNF213 ZNF143 ZNF263 SP3 NFYC MEF2D CDC14A MFSD14A SLC30A7 BRI3P1 TRMT13 SASS6 HNRNPA1P68 ENSG00000235795 LOC646970 ENSG00000226952
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MFSD14A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MFSD14A Gene

Genomic Locations for MFSD14A Gene
chr1:100,038,078-100,083,377
(GRCh38/hg38)
Size:
45,300 bases
Orientation:
Plus strand
chr1:100,503,653-100,548,933
(GRCh37/hg19)
Size:
45,281 bases
Orientation:
Plus strand

Genomic View for MFSD14A Gene

Genes around MFSD14A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD14A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD14A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD14A Gene

Proteins for MFSD14A Gene

  • Protein details for MFSD14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MC6-MF14A_HUMAN
    Recommended name:
    Hippocampus abundant transcript 1 protein
    Protein Accession:
    Q96MC6
    Secondary Accessions:
    • Q6P2N7
    • Q8N8K2
    • Q8NBV3
    • Q96NY0
    • Q9NT25

    Protein attributes for MFSD14A Gene

    Size:
    490 amino acids
    Molecular mass:
    53027 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04836.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11473.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MFSD14A Gene

Post-translational modifications for MFSD14A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MFSD14A Gene

No data available for DME Specific Peptides for MFSD14A Gene

Domains & Families for MFSD14A Gene

Gene Families for MFSD14A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MFSD14A Gene

Suggested Antigen Peptide Sequences for MFSD14A Gene

Graphical View of Domain Structure for InterPro Entry

Q96MC6

UniProtKB/Swiss-Prot:

MF14A_HUMAN :
  • Belongs to the major facilitator superfamily.
Family:
  • Belongs to the major facilitator superfamily.
genes like me logo Genes that share domains with MFSD14A: view

Function for MFSD14A Gene

Gene Ontology (GO) - Molecular Function for MFSD14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IBA --
genes like me logo Genes that share ontologies with MFSD14A: view
genes like me logo Genes that share phenotypes with MFSD14A: view

Animal Models for MFSD14A Gene

MGI Knock Outs for MFSD14A:

Animal Model Products

  • Taconic Biosciences Mouse Models for MFSD14A

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MFSD14A Gene

Localization for MFSD14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD14A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD14A gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MFSD14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD14A: view

Pathways & Interactions for MFSD14A Gene

SuperPathways for MFSD14A Gene

No Data Available

Interacting Proteins for MFSD14A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359171%0d%0a9606.ENSP00000253144%0d%0a
Selected Interacting proteins: Q96MC6-MF14A_HUMAN ENSP00000359171 for MFSD14A Gene via IID STRING

Gene Ontology (GO) - Biological Process for MFSD14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport IBA --
genes like me logo Genes that share ontologies with MFSD14A: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD14A Gene

Drugs & Compounds for MFSD14A Gene

No Compound Related Data Available

Transcripts for MFSD14A Gene

mRNA/cDNA for MFSD14A Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD14A Gene

No ASD Table

Relevant External Links for MFSD14A Gene

GeneLoc Exon Structure for
MFSD14A
ECgene alternative splicing isoforms for
MFSD14A

Expression for MFSD14A Gene

NURSA nuclear receptor signaling pathways regulating expression of MFSD14A Gene:

MFSD14A

Evidence on tissue expression from TISSUES for MFSD14A Gene

  • Nervous system(4.4)
  • Intestine(4.3)
  • Stomach(4.3)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFSD14A Gene

Orthologs for MFSD14A Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD14A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIAT1 34 33
  • 99.93 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HIAT1 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HIAT1 34 33
  • 94.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia HIAT1 34 33
  • 93.8 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HIAT1 34
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hiat1 33
  • 92.45 (n)
mouse
(Mus musculus)
Mammalia Hiat1 34 33
  • 92.24 (n)
OneToOne
Mfsd14a 16
chicken
(Gallus gallus)
Aves HIAT1 34
  • 84 (a)
OneToOne
LOC428335 33
  • 71.86 (n)
lizard
(Anolis carolinensis)
Reptilia HIAT1 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hiat1 33
  • 78.71 (n)
Str.8911 33
African clawed frog
(Xenopus laevis)
Amphibia hiat1-A-prov 33
zebrafish
(Danio rerio)
Actinopterygii hiat1b 34
  • 86 (a)
OneToOne
hiat1a 33
  • 72.04 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.869 33
fruit fly
(Drosophila melanogaster)
Insecta CG5078 34
  • 48 (a)
ManyToMany
CG11537 34
  • 39 (a)
ManyToMany
CG17637 34
  • 32 (a)
ManyToMany
CG18281 34
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T25D3.4 34
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6723 34
  • 56 (a)
OneToMany
Species where no ortholog for MFSD14A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MFSD14A Gene

ENSEMBL:
Gene Tree for MFSD14A (if available)
TreeFam:
Gene Tree for MFSD14A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MFSD14A: view image

Paralogs for MFSD14A Gene

Paralogs for MFSD14A Gene

genes like me logo Genes that share paralogs with MFSD14A: view

Variants for MFSD14A Gene

Sequence variations from dbSNP and Humsavar for MFSD14A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000055421 -- 100,049,185(+) G/A/C intron_variant
rs1000089439 -- 100,059,707(+) T/C intron_variant
rs1000166467 -- 100,076,570(+) C/T intron_variant
rs1000167955 -- 100,072,779(+) T/G intron_variant
rs1000220454 -- 100,069,606(+) C/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MFSD14A Gene

Variant ID Type Subtype PubMed ID
nsv546888 CNV loss 21841781
nsv830804 CNV gain 17160897

Variation tolerance for MFSD14A Gene

Residual Variation Intolerance Score: 13.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MFSD14A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD14A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD14A Gene

Disorders for MFSD14A Gene

No disorders were found for MFSD14A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD14A Gene

Publications for MFSD14A Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Cloning of a cDNA encoding a novel sugar transporter expressed in the neonatal mouse hippocampus. (PMID: 9299464) Matsuo N … Okubo K (Biochemical and biophysical research communications 1997) 2 3 58
  4. An organellar nα-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity. (PMID: 25732826) Aksnes H … Arnesen T (Cell reports 2015) 4 58
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58

Products for MFSD14A Gene

Sources for MFSD14A Gene

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