Aliases for MFSD13A Gene

Aliases for MFSD13A Gene

  • Major Facilitator Superfamily Domain Containing 13A 2 3 5
  • Transmembrane Protein 180 2 3 4
  • C10orf77 3 4
  • TMEM180 3 4
  • Major Facilitator Superfamily Domain-Containing 13A 4
  • BA18I14.8 3

External Ids for MFSD13A Gene

Previous HGNC Symbols for MFSD13A Gene

  • C10orf77
  • TMEM180

Summaries for MFSD13A Gene

GeneCards Summary for MFSD13A Gene

MFSD13A (Major Facilitator Superfamily Domain Containing 13A) is a Protein Coding gene.

Additional gene information for MFSD13A Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MFSD13A Gene

Genomics for MFSD13A Gene

GeneHancer (GH) Regulatory Elements for MFSD13A Gene

Promoters and enhancers for MFSD13A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J102460 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 516.7 +0.2 192 2.1 ZNF217 NRF1 MYC POLR2G USF1 SP1 SIX5 REST POLR2A ZBTB26 MFSD13A lnc-SUFU-1 RPARP-AS1 piR-46501-010 ACTR1A
GH10J102501 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 45.6 +42.0 42020 5.2 FOXK2 ZBTB40 ZNF217 EP300 CTCF ZSCAN5C SIN3A NRF1 POLR2G USF1 ACTR1A SUFU MFSD13A PDCD11 PPRC1 PCGF6 RNU6-43P C10orf95 FBXL15 PSD
GH10J102641 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 26.6 +186.3 186332 12.7 FOXK2 HNRNPK ZBTB40 ZNF217 EP300 CTCF SIN3A NRF1 TCF12 MYC TRIM8 SFXN2 MFSD13A AS3MT ARL3 NOLC1 ARMH3 NFKB2 ENSG00000272933 LOC105378460
GH10J102592 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 42.3 +138.1 138148 14.1 FOXK2 CTCF TCF12 POLR2G NCOR1 JUND FOS ZIC2 KDM6A ZBTB11 MFSD13A SFXN2 ACTR1A SUFU C10orf95 PSD FBXL15 MIR146B CUEDC2 ARL3
GH10J102462 Promoter/Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas 40.6 +2.1 2126 1.7 FOXK2 USF1 NCOR1 ZIC2 TOE1 MYC CTBP1 SKI RAD51 SIN3A MFSD13A MIR146B CUEDC2 PSD FBXL15 SUFU RNU6-43P NFKB2 ELOVL3 lnc-SUFU-1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MFSD13A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MFSD13A

Genomic Locations for MFSD13A Gene

Genomic Locations for MFSD13A Gene
chr10:102,461,381-102,480,118
(GRCh38/hg38)
Size:
18,738 bases
Orientation:
Plus strand
chr10:104,221,149-104,236,802
(GRCh37/hg19)
Size:
15,654 bases
Orientation:
Plus strand

Genomic View for MFSD13A Gene

Genes around MFSD13A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD13A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD13A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD13A Gene

Proteins for MFSD13A Gene

  • Protein details for MFSD13A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14CX5-MF13A_HUMAN
    Recommended name:
    Transmembrane protein 180
    Protein Accession:
    Q14CX5
    Secondary Accessions:
    • Q6NWM8
    • Q6NWM9
    • Q6PEZ7
    • Q9H679

    Protein attributes for MFSD13A Gene

    Size:
    517 amino acids
    Molecular mass:
    57381 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH67530.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH67531.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15385.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MFSD13A Gene

Post-translational modifications for MFSD13A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MFSD13A Gene

Domains & Families for MFSD13A Gene

Gene Families for MFSD13A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for MFSD13A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD13A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60636 (B4DKJ1_HUMAN)
  • cDNA FLJ61437 (B4DWN6_HUMAN)
  • Transmembrane protein 180 (TM180_HUMAN)
genes like me logo Genes that share domains with MFSD13A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for MFSD13A Gene

Function for MFSD13A Gene

Phenotypes From GWAS Catalog for MFSD13A Gene

genes like me logo Genes that share phenotypes with MFSD13A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MFSD13A

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD13A Gene

Localization for MFSD13A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD13A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD13A gene
Compartment Confidence
plasma membrane 3
cytosol 2
golgi apparatus 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MFSD13A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD13A: view

Pathways & Interactions for MFSD13A Gene

PathCards logo

SuperPathways for MFSD13A Gene

No Data Available

Interacting Proteins for MFSD13A Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000238936 Q14CX5-MF13A_HUMAN for MFSD13A Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for MFSD13A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MFSD13A Gene

Drugs & Compounds for MFSD13A Gene

No Compound Related Data Available

Transcripts for MFSD13A Gene

mRNA/cDNA for MFSD13A Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD13A Gene

No ASD Table

Relevant External Links for MFSD13A Gene

GeneLoc Exon Structure for
MFSD13A

Expression for MFSD13A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MFSD13A

genes like me logo Genes that share expression patterns with MFSD13A: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFSD13A Gene

Orthologs for MFSD13A Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD13A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM180 31 30
  • 96.7 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM180 31 30
  • 90.46 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM180 31 30
  • 89.88 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem180 31 30
  • 86.59 (n)
OneToOne
Mfsd13a 17
oppossum
(Monodelphis domestica)
Mammalia TMEM180 31
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM180 31
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM180 31 30
  • 70.44 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM180 31
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem180 30
  • 65.87 (n)
Str.2014 30
zebrafish
(Danio rerio)
Actinopterygii tmem180 31 30
  • 69.24 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C27H5.4 31 30
  • 39.46 (n)
OneToMany
F10E7.3 31
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 54 (a)
OneToOne
Species where no ortholog for MFSD13A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MFSD13A Gene

ENSEMBL:
Gene Tree for MFSD13A (if available)
TreeFam:
Gene Tree for MFSD13A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MFSD13A: view image

Paralogs for MFSD13A Gene

No data available for Paralogs for MFSD13A Gene

Variants for MFSD13A Gene

Additional dbSNP identifiers (rs#s) for MFSD13A Gene

Structural Variations from Database of Genomic Variants (DGV) for MFSD13A Gene

Variant ID Type Subtype PubMed ID
nsv1129499 CNV tandem duplication 24896259

Variation tolerance for MFSD13A Gene

Residual Variation Intolerance Score: 11.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MFSD13A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD13A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MFSD13A Gene

Disorders for MFSD13A Gene

Additional Disease Information for MFSD13A

No disorders were found for MFSD13A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFSD13A Gene

Publications for MFSD13A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  5. BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein. (PMID: 27433848) Malik S … Nakanishi A (Cell cycle (Georgetown, Tex.) 2016) 3 54

Products for MFSD13A Gene

Sources for MFSD13A Gene