Aliases for MFSD11 Gene

Aliases for MFSD11 Gene

  • Major Facilitator Superfamily Domain Containing 11 2 3 5
  • Major Facilitator Superfamily Domain-Containing Protein 11 3 4
  • UNC93-Like Protein MFSD11 3 4
  • Protein ET 3 4
  • ET 3 4
  • FLJ22196 2
  • FLJ20226 2
  • MFSD11 5

External Ids for MFSD11 Gene

Previous GeneCards Identifiers for MFSD11 Gene

  • GC17P072245
  • GC17P074733
  • GC17P070161

Summaries for MFSD11 Gene

GeneCards Summary for MFSD11 Gene

MFSD11 (Major Facilitator Superfamily Domain Containing 11) is a Protein Coding gene. Diseases associated with MFSD11 include Immature Cataract.

Additional gene information for MFSD11 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MFSD11 Gene

Genomics for MFSD11 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for MFSD11 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MFSD11 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MFSD11

Top Transcription factor binding sites by QIAGEN in the MFSD11 gene promoter:
  • AML1a
  • c-Myc
  • Max
  • Max1
  • MyoD

Genomic Locations for MFSD11 Gene

Genomic Locations for MFSD11 Gene
chr17:76,735,865-76,803,805
(GRCh38/hg38)
Size:
67,941 bases
Orientation:
Plus strand
chr17:74,731,947-74,777,531
(GRCh37/hg19)
Size:
45,585 bases
Orientation:
Plus strand

Genomic View for MFSD11 Gene

Genes around MFSD11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFSD11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFSD11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFSD11 Gene

Proteins for MFSD11 Gene

  • Protein details for MFSD11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43934-MFS11_HUMAN
    Recommended name:
    UNC93-like protein MFSD11
    Protein Accession:
    O43934
    Secondary Accessions:
    • O43442
    • Q9NXI5

    Protein attributes for MFSD11 Gene

    Size:
    449 amino acids
    Molecular mass:
    49202 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MFSD11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MFSD11 Gene

Post-translational modifications for MFSD11 Gene

  • Glycosylation at Asn40
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MFSD11 Gene

Domains & Families for MFSD11 Gene

Gene Families for MFSD11 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for MFSD11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MFSD11 Gene

GenScript: Design optimal peptide antigens:
  • Protein ET (MFS11_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43934

UniProtKB/Swiss-Prot:

MFS11_HUMAN :
  • Belongs to the unc-93 family.
Family:
  • Belongs to the unc-93 family.
genes like me logo Genes that share domains with MFSD11: view

Function for MFSD11 Gene

Phenotypes From GWAS Catalog for MFSD11 Gene

Gene Ontology (GO) - Molecular Function for MFSD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MFSD11: view
genes like me logo Genes that share phenotypes with MFSD11: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MFSD11

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MFSD11

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFSD11 Gene

Localization for MFSD11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFSD11 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFSD11 gene
Compartment Confidence
plasma membrane 3
nucleus 3
cytosol 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MFSD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFSD11: view

Pathways & Interactions for MFSD11 Gene

PathCards logo

SuperPathways for MFSD11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MFSD11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MFSD11: view

No data available for Pathways by source and SIGNOR curated interactions for MFSD11 Gene

Drugs & Compounds for MFSD11 Gene

No Compound Related Data Available

Transcripts for MFSD11 Gene

mRNA/cDNA for MFSD11 Gene

10 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
20 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MFSD11

Alternative Splicing Database (ASD) splice patterns (SP) for MFSD11 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d · 16e ^ 17
SP1: - - - -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6: - - - -
SP7: - - - - -
SP8: - - - -

Relevant External Links for MFSD11 Gene

GeneLoc Exon Structure for
MFSD11

Expression for MFSD11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MFSD11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MFSD11 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MFSD11 Gene



Protein tissue co-expression partners for MFSD11 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MFSD11

SOURCE GeneReport for Unigene cluster for MFSD11 Gene:

Hs.73965

Evidence on tissue expression from TISSUES for MFSD11 Gene

  • Nervous system(4.6)
  • Intestine(4.5)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with MFSD11: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFSD11 Gene

Orthologs for MFSD11 Gene

This gene was present in the common ancestor of animals.

Orthologs for MFSD11 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia MFSD11 30 31
  • 99.85 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia MFSD11 31
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia MFSD11 30 31
  • 90.65 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia MFSD11 31
  • 90 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia MFSD11 31
  • 89 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Mfsd11 30 17 31
  • 87.53 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Mfsd11 30
  • 86.93 (n)
Chicken
(Gallus gallus)
Aves MFSD11 30 31
  • 76.91 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia MFSD11 31
  • 82 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mfsd11 30
  • 69.14 (n)
Str.14929 30
African clawed frog
(Xenopus laevis)
Amphibia MGC68544 30
Zebrafish
(Danio rerio)
Actinopterygii mfsd11 31
  • 66 (a)
OneToOne
LOC799265 30
  • 59.72 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG18549 30 31
  • 52.69 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000311 30
  • 51.7 (n)
Worm
(Caenorhabditis elegans)
Secernentea C27C12.4 30 31
  • 44.91 (n)
OneToMany
M153.2 31
  • 32 (a)
OneToMany
C08D8.1 31
  • 30 (a)
OneToMany
F36G9.3 31
  • 29 (a)
OneToMany
F31D5.2 31
  • 28 (a)
OneToMany
Y52E8A.6 31
  • 27 (a)
OneToMany
F31D5.1 31
  • 24 (a)
OneToMany
Y52E8A.4 31
  • 23 (a)
OneToMany
Y39D8A.1 31
  • 23 (a)
OneToMany
B0554.5 31
  • 22 (a)
OneToMany
B0554.7 31
  • 21 (a)
OneToMany
Y39B6A.29 31
  • 20 (a)
OneToMany
ZK6.8 31
  • 19 (a)
OneToMany
Y39B6A.27 31
  • 19 (a)
OneToMany
Y11D7A.3 31
  • 19 (a)
OneToMany
Y37A1A.2 31
  • 18 (a)
OneToMany
ZK6.6 31
  • 18 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 47 (a)
OneToOne
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.10944 30
Species where no ortholog for MFSD11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MFSD11 Gene

ENSEMBL:
Gene Tree for MFSD11 (if available)
TreeFam:
Gene Tree for MFSD11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MFSD11: view image

Paralogs for MFSD11 Gene

No data available for Paralogs for MFSD11 Gene

Variants for MFSD11 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MFSD11 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs3198672 - p.Ser428Phe

Additional dbSNP identifiers (rs#s) for MFSD11 Gene

Structural Variations from Database of Genomic Variants (DGV) for MFSD11 Gene

Variant ID Type Subtype PubMed ID
nsv1110921 OTHER inversion 24896259
nsv828110 CNV gain 20364138
nsv833550 CNV loss 17160897

Variation tolerance for MFSD11 Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MFSD11 Gene

Human Gene Mutation Database (HGMD)
MFSD11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MFSD11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFSD11 Gene

Disorders for MFSD11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MFSD11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
immature cataract
  • incipient cataract
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MFSD11

genes like me logo Genes that share disorders with MFSD11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MFSD11 Gene

Publications for MFSD11 Gene

  1. Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264/SC35 splicing factor gene. (PMID: 9358160) Sureau A … Perbal B (Nucleic acids research 1997) 2 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. (PMID: 28986522) Antoniali G … Tell G (Nature communications 2017) 3

Products for MFSD11 Gene

Sources for MFSD11 Gene