Aliases for MFN1 Gene
External Ids for MFN1 Gene
Previous GeneCards Identifiers for MFN1 Gene
The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. [provided by RefSeq, Jul 2008]
GeneCards Summary for MFN1 Gene
MFN1 (Mitofusin 1) is a Protein Coding gene. Diseases associated with MFN1 include Optic Atrophy 1 and 3-Methylglutaconic Aciduria, Type Iii. Among its related pathways are Pink/Parkin Mediated Mitophagy and Glucose / Energy Metabolism. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is MFN2.
UniProtKB/Swiss-Prot Summary for MFN1 Gene
Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303).