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This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] See more...
Aliases for MFF Gene
Aliases for MFF Gene
External Ids for MFF Gene
- HGNC: 24858
- Entrez Gene: 56947
- Ensembl: ENSG00000168958
- OMIM: 614785
- UniProtKB: Q9GZY8
Previous HGNC Symbols for MFF Gene
- C2orf33
Previous GeneCards Identifiers for MFF Gene
- GC02P227899
- GC02P228189
- GC02P220036
Summaries for MFF Gene
-
This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
GeneCards Summary for MFF Gene
MFF (Mitochondrial Fission Factor) is a Protein Coding gene. Diseases associated with MFF include Encephalopathy Due To Defective Mitochondrial And Peroxisomal Fission 2 and Mitochondrial Encephalomyopathy. Among its related pathways are Apoptosis and Autophagy. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity.
UniProtKB/Swiss-Prot Summary for MFF Gene
-
Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
Additional gene information for MFF Gene
- HGNC(24858)
- Entrez Gene(56947)
- Ensembl(ENSG00000168958)
- OMIM(614785)
- UniProtKB(Q9GZY8)
- Open Targets Platform(ENSG00000168958)
- Monarch Initiative
- Search for MFF at DataMed
- Search for MFF at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MFF Gene
Genomics for MFF Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for MFF Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around MFF on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MFF
- Top Transcription factor binding sites by QIAGEN in the MFF gene promoter:
-
- aMEF-2
- C/EBPbeta
- MEF-2
- MEF-2A
- Meis-1
- Meis-1a
- Meis-1b
- MRF-2
- MyoD
- Pax-6
Genomic Locations for MFF Gene
Genomic Locations for MFF Gene
- chr2:227,325,151-227,357,836
- (GRCh38/hg38)
- Size:
- 32,686 bases
- Orientation:
- Plus strand
- chr2:228,189,867-228,222,550
- (GRCh37/hg19)
- Size:
- 32,684 bases
- Orientation:
- Plus strand
Genomic View for MFF Gene
Genes around MFF on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2q36.3 by HGNC
- 2q36.3 by Entrez Gene
- 2q36.3 by Ensembl
MFF Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MFF Gene
Proteins for MFF Gene
-
Protein details for MFF Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9GZY8-MFF_HUMAN
- Recommended name:
- Mitochondrial fission factor
- Protein Accession:
- Q9GZY8
- Q567U1
- Q658R6
- Q9BVZ1
- Q9H690
- Q9NRG8
Protein attributes for MFF Gene
- Size:
- 342 amino acids
- Molecular mass:
- 38465 Da
- Quaternary structure:
-
- Homodimer. Interacts with DNM1L. Interacts with C11orf65/MFI; the interaction inhibits MFF interaction with DNM1L.
Protein Expression for MFF Gene
Post-translational modifications for MFF Gene
Other Protein References for MFF Gene
- ENSEMBL proteins:
-
- ENSP00000390165
- ENSP00000304898
- ENSP00000302037
- ENSP00000346498
- ENSP00000431725
- ENSP00000432447
- ENSP00000386964
- ENSP00000415996
- ENSP00000386641
- ENSP00000338412
- ENSP00000436920
- ENSP00000435354
- ENSP00000436289
- ENSP00000304134
- ENSP00000411386
- ENSP00000391829
- ENSP00000407547
- ENSP00000415313
- ENSP00000375912
- REFSEQ proteins:
-
- XP_005246738.1
- XP_005246739.1
- XP_005246740.1
- XP_005246741.1
- XP_005246742.1
- XP_005246743.1
- XP_005246744.1
- XP_005246745.1
- XP_006712700.1
- XP_006712701.1
- XP_006712702.1
- XP_011509802.1
- XP_011509803.1
- XP_016860001.1
- XP_016860002.1
- XP_016860003.1
- XP_016860004.1
- XP_024308776.1
- XP_024308777.1
- NP_001263990.1
- NP_001263991.1
- NP_001263992.1
- NP_001263993.1
- NP_001263994.1
- NP_001263995.1
- NP_001263996.1
- NP_001263997.1
- NP_064579.3
Antibody Products
- G Biosciences Immunotag™ MFF Antibody and Immunotag™ Phospho-MFF (Ser172) Antibody
- HUABIO MFF Antibody (ER2001-01)
- BioLegend Purified anti-MFF (857502) and Purified anti-MFF (857501)
- Novus Biologicals Antibodies for MFF
-
Abcam antibodies for MFF
- Invitrogen Antibodies for MFF (AFLGC-MFF)
-
Santa Cruz Biotechnology (SCBT) Antibodies for MFF
Protein Products
-
OriGene Purified Proteins for MFF
- Search Origene for MassSpec and Protein Over-expression Lysates for MFF
- Origene Custom Protein Services for MFF
- antibodies-online: Show 7 available MFF Proteins ranked by validation data
- Compare Top MFF Proteins
-
Quality Products:
Assay Products
- antibodies-online: Search results for available MFF related products ranked by validation data
-
Signalway ELISA kits for MFF
No data available for DME Specific Peptides for MFF Gene
Domains & Families for MFF Gene
Gene Families for MFF Gene
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for MFF Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for MFF Gene
- GenScript: Design optimal peptide antigens:
-
- Mitochondrial fission factor (MFF_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9GZY8- Family:
-
- Belongs to the Tango11 family.
Function for MFF Gene
Molecular function for MFF Gene
- UniProtKB/Swiss-Prot Function:
- Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles.
Phenotypes From GWAS Catalog for MFF Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 21149567 |
| GO:0042802 | identical protein binding | IPI | 18353969 |
| GO:0042803 | protein homodimerization activity | IDA | 23530241 |
Phenotypes for MFF Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MFF - Select products 50% OFF >
- * MFF CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MFF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MFF
-
Santa Cruz Biotechnology (SCBT) CRISPR for MFF
miRNA for MFF Gene
- miRTarBase miRNAs that target MFF
-
- mmu-miR-362-5p (MIRT008879)
- hsa-miR-155-5p (MIRT020583)
- hsa-miR-32-5p (MIRT028269)
- hsa-miR-27b-3p (MIRT054898)
- hsa-miR-5589-3p (MIRT459528)
- hsa-miR-8064 (MIRT459529)
- hsa-miR-4738-3p (MIRT459530)
- hsa-miR-1279 (MIRT459531)
- hsa-miR-92b-3p (MIRT459532)
- hsa-miR-92a-3p (MIRT459533)
- hsa-miR-367-3p (MIRT459534)
- hsa-miR-363-3p (MIRT459535)
- hsa-miR-25-3p (MIRT459536)
- hsa-miR-5580-3p (MIRT459537)
- hsa-miR-4789-3p (MIRT459538)
- hsa-miR-548av-3p (MIRT459539)
- hsa-miR-548aw (MIRT544975)
- hsa-miR-19b-3p (MIRT544976)
- hsa-miR-19a-3p (MIRT544977)
- hsa-miR-1468-3p (MIRT544978)
- hsa-miR-548x-5p (MIRT544979)
- hsa-miR-548g-5p (MIRT544980)
- hsa-miR-548f-5p (MIRT544981)
- hsa-miR-548aj-5p (MIRT544982)
- hsa-miR-548o-3p (MIRT544983)
- hsa-miR-1323 (MIRT544984)
- hsa-miR-4295 (MIRT544985)
- hsa-miR-454-3p (MIRT544986)
- hsa-miR-3666 (MIRT544987)
- hsa-miR-301b-3p (MIRT544988)
- hsa-miR-301a-3p (MIRT544989)
- hsa-miR-130b-3p (MIRT544990)
- hsa-miR-130a-3p (MIRT544991)
- hsa-miR-519c-3p (MIRT544992)
- hsa-miR-519b-3p (MIRT544993)
- hsa-miR-519a-3p (MIRT544994)
- hsa-miR-3646 (MIRT544995)
- hsa-miR-186-5p (MIRT544996)
- hsa-miR-3662 (MIRT544997)
- hsa-miR-548t-3p (MIRT544998)
- hsa-miR-548ap-3p (MIRT544999)
- hsa-miR-548aa (MIRT545000)
- hsa-miR-106a-3p (MIRT556139)
- hsa-miR-200a-3p (MIRT733772)
- hsa-miR-593-5p (MIRT735020)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MFF
- Browse OriGene Inhibitory RNA Products For MFF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MFF
Clone Products
- Applied Biological Materials (abm): Clones for MFF - Select products 50% OFF >
- * MFF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203974
- MR203974
- MR203974L1
- MR203974L2
- MR203974L3
- MR203974L4
- RC221492
- RC221492L1
- RC221492L2
- RC221492L3
- RC221492L4
- RC232175
- RC232176
- RC232255
- RC232262
- RC232387
- RC232536
- RC236684
- RC236953
- RG221492
- RG232175
- RG232176
- RG232255
- RG232262
- RG232387
- RG232536
- RR209522
- RR209522L3
- RR209522L4
- RR216125
- RR216263
- MR203974L1V
- MR203974L2V
- MR203974L3V
- MR203974L4V
- RC221492L1V
- RC221492L2V
- RC221492L3V
- RC221492L4V
- RR209522L3V
- RR209522L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MFF
- Addgene plasmids for MFF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MFF
Cell Line Products
-
Horizon Cell Lines for MFF
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MFF Gene
Localization for MFF Gene
Subcellular locations from UniProtKB/Swiss-Prot for MFF Gene
- Mitochondrion outer membrane. Single-pass type IV membrane protein. Peroxisome. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| peroxisome | 5 |
| nucleus | 3 |
| cytosol | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| extracellular | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Mitochondria (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IDA | -- |
| GO:0005741 | mitochondrial outer membrane | IEA,IDA | 21149567 |
| GO:0005777 | peroxisome | IEA,IDA | 18353969 |
| GO:0008021 | synaptic vesicle | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for MFF Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Apoptosis and Autophagy | ||
Pathways by source for MFF Gene
3 Cell Signaling Technology pathways for MFF Gene
Interacting Proteins for MFF Gene
Selected Interacting proteins:
Q9GZY8-MFF_HUMAN
ENSP00000302037
for MFF Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for MFF
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000266 | mitochondrial fission | ISS | -- |
| GO:0001836 | release of cytochrome c from mitochondria | IMP | 18353969 |
| GO:0006626 | protein targeting to mitochondrion | ISS | -- |
| GO:0008053 | mitochondrial fusion | IMP | 23921378 |
| GO:0010821 | regulation of mitochondrion organization | IMP | 18353969 |
Transcripts for MFF Gene
mRNA/cDNA for MFF Gene
- 9 REFSEQ mRNAs :
- 15 NCBI additional mRNA sequence :
- 27 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000304593 1921 nts (view in UCSC)
- ENST00000337110 1760 nts (view in UCSC)
- ENST00000349901 1716 nts (view in UCSC)
- ENST00000353339 2186 nts (view in UCSC)
- ENST00000354503 1085 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for MFF - Select products 50% OFF >
- * MFF CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for MFF
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MFF
-
Santa Cruz Biotechnology (SCBT) CRISPR for MFF
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MFF
- Browse OriGene Inhibitory RNA Products For MFF
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MFF
Clone Products
- Applied Biological Materials (abm): Clones for MFF - Select products 50% OFF >
- * MFF as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203974
- MR203974
- MR203974L1
- MR203974L2
- MR203974L3
- MR203974L4
- RC221492
- RC221492L1
- RC221492L2
- RC221492L3
- RC221492L4
- RC232175
- RC232176
- RC232255
- RC232262
- RC232387
- RC232536
- RC236684
- RC236953
- RG221492
- RG232175
- RG232176
- RG232255
- RG232262
- RG232387
- RG232536
- RR209522
- RR209522L3
- RR209522L4
- RR216125
- RR216263
- MR203974L1V
- MR203974L2V
- MR203974L3V
- MR203974L4V
- RC221492L1V
- RC221492L2V
- RC221492L3V
- RC221492L4V
- RR209522L3V
- RR209522L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for MFF
- Addgene plasmids for MFF
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MFF
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | · | 1h | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP13: | - | - | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP14: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP15: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP16: | - |
| ExUns: | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | · | 14d | · | 14e | · | 14f |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||
| SP2: | |||||||||||||||||||
| SP3: | - | - | |||||||||||||||||
| SP4: | |||||||||||||||||||
| SP5: | |||||||||||||||||||
| SP6: | - | ||||||||||||||||||
| SP7: | - | - | |||||||||||||||||
| SP8: | |||||||||||||||||||
| SP9: | |||||||||||||||||||
| SP10: | |||||||||||||||||||
| SP11: | - | ||||||||||||||||||
| SP12: | |||||||||||||||||||
| SP13: | |||||||||||||||||||
| SP14: | |||||||||||||||||||
| SP15: | |||||||||||||||||||
| SP16: |
Relevant External Links for MFF Gene
- GeneLoc Exon Structure for
- MFF
Expression for MFF Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Peripheral blood mononuclear cells (16.8) and Testis (9.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MFF Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MFF
SOURCE GeneReport for Unigene cluster for MFF Gene:
Hs.471528mRNA Expression by UniProt/SwissProt for MFF Gene:
Q9GZY8-MFF_HUMAN
Tissue specificity:
Highly expressed in heart, kidney, liver, brain, muscle, and stomach.
Evidence on tissue expression from TISSUES for MFF Gene
- Nervous system(4.8)
- Liver(4.5)
- Stomach(4.5)
- Adrenal gland(4.4)
- Lung(3.5)
- Muscle(3)
- Heart(3)
- Kidney(2.9)
- Skin(2.8)
- Intestine(2.4)
- Blood(2.3)
- Pancreas(2.3)
- Spleen(2.2)
- Thyroid gland(2.1)
- Bone marrow(2)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for MFF
-
OriGene qPCR primer pairs and template standards for MFF
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFF Gene
Orthologs for MFF Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | MFF 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Mff 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | MFF 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | LOC102556337 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | MFF 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | MFF 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | MFF 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | MFF 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.31432 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.2181 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | mff 30 31 |
|
OneToMany | |
| MFF (1 of 2) 31 |
|
OneToMany | |||
| zgc66022 30 |
|
- Species where no ortholog for MFF was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for MFF Gene
- ENSEMBL:
- Gene Tree for MFF (if available)
- TreeFam:
- Gene Tree for MFF (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MFF: view image
Paralogs for MFF Gene
Pseudogenes.org Pseudogenes for MFF Gene
No data available for Paralogs for MFF Gene
Variants for MFF Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MFF Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 668501 | Likely Benign: not provided | 227,330,854(+) | A/G | INTRON_VARIANT | |
| 669177 | Likely Benign: not provided | 227,330,862(+) | T/C | INTRON_VARIANT | |
| 669500 | Benign: not provided | 227,332,252(+) | G/A | INTRON_VARIANT | |
| 669501 | Benign: not provided | 227,355,445(+) | C/T | INTRON_VARIANT | |
| 669502 | Benign: not provided | 227,355,511(+) | T/C | INTRON_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv2163n106 | CNV | deletion | 24896259 |
| dgv2164n106 | CNV | deletion | 24896259 |
| esv2721554 | CNV | deletion | 23290073 |
| esv2721555 | CNV | deletion | 23290073 |
| esv2721556 | CNV | deletion | 23290073 |
| esv2721557 | CNV | deletion | 23290073 |
| esv2721558 | CNV | deletion | 23290073 |
| esv3594532 | CNV | loss | 21293372 |
| esv3594533 | CNV | loss | 21293372 |
| nsv1072076 | CNV | deletion | 25765185 |
| nsv1072077 | CNV | deletion | 25765185 |
| nsv1072499 | CNV | deletion | 25765185 |
| nsv1073016 | CNV | deletion | 25765185 |
| nsv1127804 | CNV | deletion | 24896259 |
| nsv1152322 | CNV | deletion | 26484159 |
| nsv1153358 | CNV | deletion | 26484159 |
| nsv584594 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
57.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
13.87;
95.90% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MFF Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFF Gene
Disorders for MFF Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| encephalopathy due to defective mitochondrial and peroxisomal fission 2 |
|
|
| mitochondrial encephalomyopathy |
|
|
| optic atrophy 1 |
|
|
| 3-methylglutaconic aciduria, type iii |
|
|
| loiasis |
|
|
Search MFF in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
MFF_HUMAN- Encephalopathy due to defective mitochondrial and peroxisomal fission 2 (EMPF2) [MIM:617086]: An autosomal recessive disorder characterized by delayed psychomotor development, severe hypotonia with inability to walk, microcephaly, and abnormal signals in the basal ganglia. More variable features include early-onset seizures, optic atrophy, and peripheral neuropathy. {ECO:0000269 PubMed:26783368}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for MFF
No data available for Genatlas for MFF Gene
Publications for MFF Gene
- The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. (PMID: 18353969) Gandre-Babbe S … van der Bliek AM (Molecular biology of the cell 2008) 2 3 4
- Disturbed mitochondrial and peroxisomal dynamics due to loss of MFF causes Leigh-like encephalopathy, optic atrophy and peripheral neuropathy. (PMID: 26783368) Koch J … Haack TB (Journal of medical genetics 2016) 3 4
- Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. (PMID: 23921378) Palmer CS … Ryan MT (The Journal of biological chemistry 2013) 3 4
- Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. (PMID: 23530241) Koirala S … Shaw JM (Proceedings of the National Academy of Sciences of the United States of America 2013) 3 4
- A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
ExternalLinks
Products for MFF Gene
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Sources for MFF Gene
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