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Aliases for MFAP3L Gene

Aliases for MFAP3L Gene

  • Microfibril Associated Protein 3 Like 2 3 5
  • Microfibrillar Associated Protein 3 Like 2 3
  • Testis Development Protein NYD-SP9 3 4
  • Microfi Brillar-Associated Protein 3-Like 3
  • Microfibrillar-Associated Protein 3-Like 3
  • KIAA0626 4
  • NYD-Sp9 3

External Ids for MFAP3L Gene

Previous GeneCards Identifiers for MFAP3L Gene

  • GC04M171604
  • GC04M171282
  • GC04M171144
  • GC04M170907
  • GC04M166662

Summaries for MFAP3L Gene

GeneCards Summary for MFAP3L Gene

MFAP3L (Microfibril Associated Protein 3 Like) is a Protein Coding gene. An important paralog of this gene is MFAP3.

UniProtKB/Swiss-Prot for MFAP3L Gene

  • May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis.

Additional gene information for MFAP3L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MFAP3L Gene

Genomics for MFAP3L Gene

GeneHancer (GH) Regulatory Elements for MFAP3L Gene

Promoters and enhancers for MFAP3L Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I170025 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 589.8 +6.3 6293 2.3 ARNT ARID4B NEUROD1 SIN3A FEZF1 ZNF2 YY1 ZNF207 ZNF143 KLF13 MFAP3L AADAT ENSG00000251200 GC04M169997
GH04I170003 Promoter/Enhancer 0.8 EPDnew dbSUPER 561 +29.2 29244 0.1 EMSY MFAP3L ENSG00000249955 LINC02275 ENSG00000251200 GC04M169997
GH04I170013 Enhancer 0.5 dbSUPER 81 +16.5 16518 5.8 ZFHX2 ZSCAN16 WT1 EGR2 MFAP3L AADAT ENSG00000251200 GC04M169997
GH04I169989 Enhancer 0.5 dbSUPER 44.2 +38.0 37971 10.5 SMARCE1 ATF4 GATA3 USF1 DPF2 MFAP3L AADAT ENSG00000251200 GC04M169997 ENSG00000249955
GH04I169983 Enhancer 0.5 dbSUPER 42.4 +46.4 46389 5.6 JUND CEBPB DACH1 CEBPG NFE2 FOS ATF2 MFAP3L AADAT ENSG00000251200 ENSG00000249955 GC04M169997
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MFAP3L on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MFAP3L gene promoter:

Genomic Locations for MFAP3L Gene

Genomic Locations for MFAP3L Gene
46,435 bases
Minus strand

Genomic View for MFAP3L Gene

Genes around MFAP3L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MFAP3L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MFAP3L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MFAP3L Gene

Proteins for MFAP3L Gene

  • Protein details for MFAP3L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Microfibrillar-associated protein 3-like
    Protein Accession:
    Secondary Accessions:
    • A8K1X6
    • D3DP35
    • Q4W5N7
    • Q4W5N9
    • Q6TNA8
    • Q9BVE1
    • Q9BXK0

    Protein attributes for MFAP3L Gene

    409 amino acids
    Molecular mass:
    45380 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA31601.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for MFAP3L Gene


neXtProt entry for MFAP3L Gene

Post-translational modifications for MFAP3L Gene

  • Glycosylation at isoforms=333, isoforms=337, posLast=6767, isoforms=2111, and isoforms=2135
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for MFAP3L

No data available for DME Specific Peptides for MFAP3L Gene

Domains & Families for MFAP3L Gene

Gene Families for MFAP3L Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for MFAP3L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MFAP3L: view

No data available for UniProtKB/Swiss-Prot for MFAP3L Gene

Function for MFAP3L Gene

Molecular function for MFAP3L Gene

UniProtKB/Swiss-Prot Function:
May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis.

Phenotypes From GWAS Catalog for MFAP3L Gene

Gene Ontology (GO) - Molecular Function for MFAP3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24735981
genes like me logo Genes that share ontologies with MFAP3L: view
genes like me logo Genes that share phenotypes with MFAP3L: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MFAP3L

CRISPR Products

miRNA for MFAP3L Gene

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MFAP3L Gene

Localization for MFAP3L Gene

Subcellular locations from UniProtKB/Swiss-Prot for MFAP3L Gene

Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm. Note=Mainly localized in the nucleus (PubMed:24735981). {ECO:0000269 PubMed:24735981}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MFAP3L gene
Compartment Confidence
plasma membrane 5
nucleus 5
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MFAP3L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 24735981
GO:0005737 cytoplasm IDA,IEA 24735981
GO:0005886 plasma membrane IDA,IEA 24735981
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MFAP3L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MFAP3L Gene

Pathways & Interactions for MFAP3L Gene

SuperPathways for MFAP3L Gene

No Data Available

Interacting Proteins for MFAP3L Gene

Gene Ontology (GO) - Biological Process for MFAP3L Gene


No data available for Pathways by source and SIGNOR curated interactions for MFAP3L Gene

Drugs & Compounds for MFAP3L Gene

No Compound Related Data Available

Transcripts for MFAP3L Gene

Unigene Clusters for MFAP3L Gene

Microfibrillar-associated protein 3-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MFAP3L Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e · 4f · 4g ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - - - - - - -
SP2: - - - - - -
SP3: -
SP4: - - - - - - -
SP5: -
SP7: - -
SP8: - - -
SP9: - - - - - - - - - - - - -

Relevant External Links for MFAP3L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MFAP3L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MFAP3L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MFAP3L Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MFAP3L Gene

Protein tissue co-expression partners for MFAP3L Gene

NURSA nuclear receptor signaling pathways regulating expression of MFAP3L Gene:


SOURCE GeneReport for Unigene cluster for MFAP3L Gene:


mRNA Expression by UniProt/SwissProt for MFAP3L Gene:

Tissue specificity: Highly expressed in testis.

Evidence on tissue expression from TISSUES for MFAP3L Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with MFAP3L: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MFAP3L Gene

Orthologs for MFAP3L Gene

This gene was present in the common ancestor of chordates.

Orthologs for MFAP3L Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MFAP3L 33 34
  • 99.59 (n)
(Canis familiaris)
Mammalia MFAP3L 33 34
  • 90.03 (n)
(Rattus norvegicus)
Mammalia Mfap3l 33
  • 87.04 (n)
(Mus musculus)
Mammalia Mfap3l 33 16 34
  • 86.88 (n)
(Bos Taurus)
Mammalia MFAP3L 33 34
  • 79.18 (n)
(Monodelphis domestica)
Mammalia MFAP3L 34
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia MFAP3L 34
  • 59 (a)
(Gallus gallus)
Aves MFAP3L 33 34
  • 71.32 (n)
(Anolis carolinensis)
Reptilia MFAP3L 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mfap3l 33
  • 67.55 (n)
(Danio rerio)
Actinopterygii LOC557798 33
  • 72.22 (n)
  • 55 (a)
Dr.13816 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4128 33
Species where no ortholog for MFAP3L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MFAP3L Gene

Gene Tree for MFAP3L (if available)
Gene Tree for MFAP3L (if available)

Paralogs for MFAP3L Gene

Paralogs for MFAP3L Gene

(1) SIMAP similar genes for MFAP3L Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MFAP3L: view

Variants for MFAP3L Gene

Sequence variations from dbSNP and Humsavar for MFAP3L Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000033622 -- 170,023,665(-) T/G genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000064115 -- 170,020,236(-) T/C genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000086269 -- 169,995,622(-) A/AA 5_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000120126 -- 170,026,134(-) A/T genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000142270 -- 169,992,777(-) A/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MFAP3L Gene

Variant ID Type Subtype PubMed ID
esv2661256 CNV deletion 23128226
esv3603133 CNV loss 21293372
nsv1020188 CNV loss 25217958
nsv1131843 CNV deletion 24896259
nsv822827 CNV gain 20364138
nsv830149 CNV loss 17160897

Variation tolerance for MFAP3L Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MFAP3L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MFAP3L Gene

Disorders for MFAP3L Gene

Additional Disease Information for MFAP3L

No disorders were found for MFAP3L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MFAP3L Gene

Publications for MFAP3L Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  2. MFAP3L activation promotes colorectal cancer cell invasion and metastasis. (PMID: 24735981) Lou X … Liu S (Biochimica et biophysica acta 2014) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Genome-wide and gene-based association studies of anxiety disorders in European and African American samples. (PMID: 25390645) Otowa T … Hettema JM (PloS one 2014) 3 58
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 58

Products for MFAP3L Gene

Sources for MFAP3L Gene

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