Aliases for MEX3C Gene
External Ids for MEX3C Gene
Previous HGNC Symbols for MEX3C Gene
Previous GeneCards Identifiers for MEX3C Gene
This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009]
GeneCards Summary for MEX3C Gene
MEX3C (Mex-3 RNA Binding Family Member C) is a Protein Coding gene. Diseases associated with MEX3C include Smallpox and Protoplasmic Astrocytoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MEX3B.
UniProtKB/Swiss-Prot Summary for MEX3C Gene
E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.