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Aliases for MEX3C Gene

Aliases for MEX3C Gene

  • Mex-3 RNA Binding Family Member C 2 3 5
  • RING Finger And KH Domain-Containing Protein 2 3 4
  • RING-Type E3 Ubiquitin Transferase MEX3C 3 4
  • Ring Finger And KH Domain Containing 2 2 3
  • RING Finger Protein 194 3 4
  • RNF194 3 4
  • RKHD2 3 4
  • RNA-Binding E3 Ubiquitin-Protein Ligase MEX3C 3
  • Mex-3 Homolog C (C. Elegans) 2
  • RNA-Binding Protein MEX3C 3
  • MEX3C Variant 1 3
  • MEX3C Variant 2 3
  • EC 4
  • BM-013 3
  • MEX-3C 3

External Ids for MEX3C Gene

Previous HGNC Symbols for MEX3C Gene

  • RKHD2

Previous GeneCards Identifiers for MEX3C Gene

  • GC18M046955
  • GC18M048700
  • GC18M045556

Summaries for MEX3C Gene

Entrez Gene Summary for MEX3C Gene

  • This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. [provided by RefSeq, Oct 2009]

GeneCards Summary for MEX3C Gene

MEX3C (Mex-3 RNA Binding Family Member C) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MEX3B.

UniProtKB/Swiss-Prot for MEX3C Gene

  • E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3 UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.

Additional gene information for MEX3C Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEX3C Gene

Genomics for MEX3C Gene

GeneHancer (GH) Regulatory Elements for MEX3C Gene

Promoters and enhancers for MEX3C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I051189 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 590 +23.7 23743 9.4 HDGF FOXA2 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 MEX3C LOC105372118 MBD1 SMAD4 PIR40243 GC18P050945
GH18I051151 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 29.1 +65.3 65252 4 RB1 BMI1 IRF4 EGR1 ZNF143 ATF7 ZNF548 ETV6 IKZF2 RUNX3 MEX3C SMAD4 ME2 SRSF10P1 GC18M051129 GC18P050945
GH18I050277 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 17 +938.4 938436 5.4 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B MBD1 SMAD4 RPL17 CXXC1 MEX3C ELAC1 CFAP53
GH18I050283 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 17 +932.1 932148 5 HDGF FOXA2 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 CXXC1 SMAD4 RPL17 MBD1 ELAC1 MEX3C CFAP53
GH18I050877 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 16.4 +339.3 339330 3.3 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 SLC30A9 POLR2B ZNF207 ZNF143 ME2 MBD1 MEX3C CXXC1 GC18P050945
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MEX3C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MEX3C gene promoter:

Genomic Locations for MEX3C Gene

Genomic Locations for MEX3C Gene
43,755 bases
Minus strand

Genomic View for MEX3C Gene

Genes around MEX3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEX3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEX3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEX3C Gene

Proteins for MEX3C Gene

  • Protein details for MEX3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding E3 ubiquitin-protein ligase MEX3C
    Protein Accession:
    Secondary Accessions:
    • A1L022
    • Q9NZE3

    Protein attributes for MEX3C Gene

    659 amino acids
    Molecular mass:
    69366 Da
    Quaternary structure:
    • Interacts with USP7, which antagonizes the ability to degrade mRNA.
    • Sequence=AAF64269.1; Type=Erroneous termination; Positions=514; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=AAF64269.1; Type=Frameshift; Positions=520, 525; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MEX3C Gene

neXtProt entry for MEX3C Gene

Post-translational modifications for MEX3C Gene

Other Protein References for MEX3C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEX3C Gene

Domains & Families for MEX3C Gene

Gene Families for MEX3C Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for MEX3C Gene

Suggested Antigen Peptide Sequences for MEX3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Binds RNA through its KH domains.
  • Binds RNA through its KH domains.
genes like me logo Genes that share domains with MEX3C: view

Function for MEX3C Gene

Molecular function for MEX3C Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3 UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.

Enzyme Numbers (IUBMB) for MEX3C Gene

Phenotypes From GWAS Catalog for MEX3C Gene

Gene Ontology (GO) - Molecular Function for MEX3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA,HDA 22658674
GO:0005515 protein binding IPI 22863774
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MEX3C: view
genes like me logo Genes that share phenotypes with MEX3C: view

Animal Models for MEX3C Gene

MGI Knock Outs for MEX3C:

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEX3C Gene

Localization for MEX3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEX3C Gene

Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEX3C gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MEX3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MEX3C: view

Pathways & Interactions for MEX3C Gene

genes like me logo Genes that share pathways with MEX3C: view

Gene Ontology (GO) - Biological Process for MEX3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003415 chondrocyte hypertrophy IEA --
GO:0045598 regulation of fat cell differentiation IEA --
GO:0097009 energy homeostasis IEA --
genes like me logo Genes that share ontologies with MEX3C: view

No data available for SIGNOR curated interactions for MEX3C Gene

Drugs & Compounds for MEX3C Gene

(1) Drugs for MEX3C Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bisphosphonates Pharma 0
genes like me logo Genes that share compounds with MEX3C: view

Transcripts for MEX3C Gene

Unigene Clusters for MEX3C Gene

Mex-3 homolog C (C. elegans):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEX3C Gene

No ASD Table

Relevant External Links for MEX3C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MEX3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEX3C Gene

mRNA differential expression in normal tissues according to GTEx for MEX3C Gene

This gene is overexpressed in Testis (x5.4).

Protein differential expression in normal tissues from HIPED for MEX3C Gene

This gene is overexpressed in Testis (25.3), Fetal Brain (18.2), Fetal ovary (13.2), and Ovary (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MEX3C Gene

Protein tissue co-expression partners for MEX3C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MEX3C Gene:


SOURCE GeneReport for Unigene cluster for MEX3C Gene:


mRNA Expression by UniProt/SwissProt for MEX3C Gene:

Tissue specificity: Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus. Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine.

Evidence on tissue expression from TISSUES for MEX3C Gene

  • Bone marrow(4.3)
  • Lung(4.3)
genes like me logo Genes that share expression patterns with MEX3C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEX3C Gene

Orthologs for MEX3C Gene

This gene was present in the common ancestor of animals.

Orthologs for MEX3C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MEX3C 33 34
  • 99.78 (n)
(Ornithorhynchus anatinus)
Mammalia MEX3C 34
  • 97 (a)
(Bos Taurus)
Mammalia MEX3C 33 34
  • 94.1 (n)
(Rattus norvegicus)
Mammalia Mex3c 33
  • 94.04 (n)
(Canis familiaris)
Mammalia MEX3C 33 34
  • 93.04 (n)
(Mus musculus)
Mammalia Mex3c 33 16 34
  • 92.22 (n)
(Monodelphis domestica)
Mammalia MEX3C 34
  • 72 (a)
(Anolis carolinensis)
Reptilia MEX3C 34
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mex3c 33
  • 74.69 (n)
Str.993 33
(Danio rerio)
Actinopterygii MEX3C 34
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11360 34
  • 32 (a)
(Caenorhabditis elegans)
Secernentea mex-3 34
  • 37 (a)
Species where no ortholog for MEX3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEX3C Gene

Gene Tree for MEX3C (if available)
Gene Tree for MEX3C (if available)

Paralogs for MEX3C Gene

Paralogs for MEX3C Gene

(4) SIMAP similar genes for MEX3C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MEX3C: view

Variants for MEX3C Gene

Sequence variations from dbSNP and Humsavar for MEX3C Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000095906 -- 51,198,958(-) T/C upstream_transcript_variant
rs1000192189 -- 51,198,977(-) C/G upstream_transcript_variant
rs1000635662 -- 51,192,520(-) C/T intron_variant
rs1000666929 -- 51,192,366(-) C/T intron_variant
rs1000841503 -- 51,181,322(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MEX3C Gene

Variant ID Type Subtype PubMed ID
nsv953543 CNV duplication 24416366
nsv833652 CNV loss 17160897
nsv1123178 CNV deletion 24896259
nsv1121951 CNV deletion 24896259
nsv1055468 CNV gain 25217958

Variation tolerance for MEX3C Gene

Residual Variation Intolerance Score: 27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.84; 58.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEX3C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEX3C Gene

Disorders for MEX3C Gene


  • Note=Genetic variations in MEX3C may be associated with susceptibility to essential hypertension. {ECO:0000269 PubMed:17015768}.

Additional Disease Information for MEX3C

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MEX3C Gene.

No data available for MalaCards and Genatlas for MEX3C Gene

Publications for MEX3C Gene

  1. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PMID: 17267406) Buchet-Poyau K … Billaud M (Nucleic acids research 2007) 2 3 4 58
  2. The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation. (PMID: 22863774) Cano F … Lehner PJ (The EMBO journal 2012) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Implication of chromosome 18 in hypertension by sibling pair and association analyses: putative involvement of the RKHD2 gene. (PMID: 17015768) Guzmán B … Poch E (Hypertension (Dallas, Tex. : 1979) 2006) 3 4 58
  5. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C … Lander ES (Nature 2005) 3 4 58

Products for MEX3C Gene

Sources for MEX3C Gene

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