MEX3B Gene (Protein Coding)

Mex-3 RNA Binding Family Member B

GC15M082041
GIFtS:
38
This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute ... See more...

Aliases for MEX3B Gene

Aliases for MEX3B Gene

  • Mex-3 RNA Binding Family Member B 2 3 5
  • RNF195 2 3 4
  • Ring Finger And KH Domain Containing 3 2 3
  • RNA-Binding Protein MEX3B 3 4
  • RING Finger Protein 195 3 4
  • RKHD3 3 4
  • RING Finger And KH Domain-Containing Protein 3 4
  • Mex-3 Homolog B (C. Elegans) 2
  • DKFZp434J0617 2
  • KIAA2009 4
  • MEX-3B 3
  • MEX3B 5

External Ids for MEX3B Gene

Previous HGNC Symbols for MEX3B Gene

  • RKHD3

Previous GeneCards Identifiers for MEX3B Gene

  • GC15M080122
  • GC15M082334
  • GC15M059092

Summaries for MEX3B Gene

Entrez Gene Summary for MEX3B Gene

  • This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies. [provided by RefSeq, Oct 2012]

GeneCards Summary for MEX3B Gene

MEX3B (Mex-3 RNA Binding Family Member B) is a Protein Coding gene. Diseases associated with MEX3B include Autosomal Recessive Congenital Cerebellar Ataxia. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and calcium ion binding. An important paralog of this gene is MEX3C.

UniProtKB/Swiss-Prot Summary for MEX3B Gene

  • RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.

Gene Wiki entry for MEX3B Gene

Additional gene information for MEX3B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MEX3B Gene

Genomics for MEX3B Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for MEX3B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH15J082043 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 259.3 +0.1 147 5.9 TBP MNT IKZF1 HES1 MBD2 ZNF217 CTCF BHLHE40 ZEB1 ELF1 MEX3B HSALNG0107668 piR-60849 TMC3
GH15J081944 Enhancer 1.1 Ensembl ENCODE 11.7 +101.1 101131 1.2 IKZF1 HES1 MBD2 BHLHE40 ARNT ZNF395 NFATC3 VEZF1 NBN TRIM25 MEX3B LOC102724001 piR-32023-089 ENSG00000259692 TMC3
GH15J081951 Enhancer 1.1 Ensembl ENCODE 11.4 +94.8 94819 0.6 ZSCAN16 FEZF1 IKZF1 ZIC2 ZNF610 ZNF513 ZNF639 KLF7 ZNF341 TAL1 MEX3B ENSG00000259442 LOC102724001 piR-32023-089 ENSG00000259692 TMC3
GH15J081947 Enhancer 0.9 Ensembl ENCODE 11.7 +97.9 97918 2 IKZF1 ZEB2 TAL1 HLTF HDAC2 ZBTB33 TCF12 MTA2 ZNF384 TEAD4 MEX3B EFL1 GOLGA2P10 LOC102724001 piR-32023-089 ENSG00000259692 TMC3
GH15J081942 Enhancer 0.9 ENCODE 11.7 +103.7 103744 0.2 IKZF1 HES1 MBD2 VEZF1 ZEB2 TAL1 NCOR1 ADNP FOSL1 ATF1 WHAMM GOLGA6L9 MEX3B RPL9P8 LOC102724001 piR-32023-089 ENSG00000259692 TMC3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MEX3B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MEX3B

Top Transcription factor binding sites by QIAGEN in the MEX3B gene promoter:
  • AhR
  • Arnt
  • c-Myc
  • HOXA9
  • HOXA9B
  • Max1
  • p300
  • Pax-2
  • Pax-2a
  • Pax-5

Genomic Locations for MEX3B Gene

Latest Assembly
chr15:82,041,778-82,046,119
(GRCh38/hg38)
Size:
4,342 bases
Orientation:
Minus strand

Previous Assembly
chr15:82,334,119-82,338,359
(GRCh37/hg19 by Entrez Gene)
Size:
4,241 bases
Orientation:
Minus strand

chr15:82,334,119-82,338,482
(GRCh37/hg19 by Ensembl)
Size:
4,364 bases
Orientation:
Minus strand

Genomic View for MEX3B Gene

Genes around MEX3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEX3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEX3B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MEX3B Gene

Proteins for MEX3B Gene

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  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for MEX3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZN04-MEX3B_HUMAN
    Recommended name:
    RNA-binding protein MEX3B
    Protein Accession:
    Q6ZN04
    Secondary Accessions:
    • Q4G0W1
    • Q8IVG2
    • Q9H0J0

    Protein attributes for MEX3B Gene

    Size:
    569 amino acids
    Molecular mass:
    58832 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC23105.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for MEX3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEX3B Gene

Protein Expression for MEX3B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for MEX3B Gene

  • Phosphorylation at Ser-462 creates a docking site for 14-3-3, which stabilizes the protein and modulates its ability to bind RNA.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MEX3B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Boster Bio Antibodies for MEX3B

No data available for DME Specific Peptides for MEX3B Gene

Domains & Families for MEX3B Gene

Gene Families for MEX3B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MEX3B Gene

InterPro:
Blocks:
  • Zn-finger, RING
ProtoNet:

Suggested Antigen Peptide Sequences for MEX3B Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 195 (MEX3B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6ZN04

UniProtKB/Swiss-Prot:

MEX3B_HUMAN :
  • Binds RNA through its KH domains.
Domain:
  • Binds RNA through its KH domains.
genes like me logo Genes that share domains with MEX3B: view

Function for MEX3B Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for MEX3B Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.

Phenotypes From GWAS Catalog for MEX3B Gene

Gene Ontology (GO) - Molecular Function for MEX3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA 23408853
GO:0005509 calcium ion binding ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MEX3B: view
genes like me logo Genes that share phenotypes with MEX3B: view

Animal Models for MEX3B Gene

MGI Knock Outs for MEX3B:
  • Mex3b Mex3b<tm1.2Mbld>
  • Mex3b Mex3b<tm1b(KOMP)Wtsi>

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEX3B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEX3B Gene

Localization for MEX3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEX3B Gene

Nucleus. Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEX3B gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MEX3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA,IDA 23408853
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MEX3B: view

Pathways & Interactions for MEX3B Gene

PathCards logo

SuperPathways for MEX3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEX3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation ISS --
GO:0046777 protein autophosphorylation ISS --
genes like me logo Genes that share ontologies with MEX3B: view

No data available for Pathways by source and SIGNOR curated interactions for MEX3B Gene

Drugs & Compounds for MEX3B Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for MEX3B Gene

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  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for MEX3B Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEX3B

Alternative Splicing Database (ASD) splice patterns (SP) for MEX3B Gene

No ASD Table

Relevant External Links for MEX3B Gene

GeneLoc Exon Structure for
MEX3B

Expression for MEX3B Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MEX3B Gene

mRNA expression in normal human tissues for MEX3B Gene
mRNA expression by BioGPS for MEX3B GenemRNA expression by GTEx for MEX3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEX3B Gene

This gene is overexpressed in Testis (x17.0).

Protein differential expression in normal tissues from HIPED for MEX3B Gene

This gene is overexpressed in Platelet (44.1) and Saliva (24.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MEX3B Gene



Protein tissue co-expression partners for MEX3B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MEX3B

SOURCE GeneReport for Unigene cluster for MEX3B Gene:

Hs.104744

mRNA Expression by UniProt/SwissProt for MEX3B Gene:

Q6ZN04-MEX3B_HUMAN
Tissue specificity: Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level.

Evidence on tissue expression from TISSUES for MEX3B Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with MEX3B: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MEX3B Gene

Orthologs for MEX3B Gene

This gene was present in the common ancestor of animals.

Orthologs for MEX3B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia MEX3B 30 31
  • 99.06 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia MEX3B 30 31
  • 91.14 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia MEX3B 30 31
  • 89.05 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Mex3b 30 17 31
  • 88.85 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Mex3b 30
  • 88.67 (n)
Oppossum
(Monodelphis domestica)
 Mammalia MEX3B 31
  • 85 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia MEX3B 31
  • 69 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia mex3b 30
  • 74.84 (n)
Zebrafish
(Danio rerio)
 Actinopterygii mex3b 30 31
  • 73.06 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta CG11360 31
  • 32 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea mex-3 31
  • 35 (a)
 OneToMany
Species where no ortholog for MEX3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for MEX3B Gene

ENSEMBL:
Gene Tree for MEX3B (if available)
TreeFam:
Gene Tree for MEX3B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MEX3B: view image

Paralogs for MEX3B Gene

Paralogs for MEX3B Gene

(3) SIMAP similar genes for MEX3B Gene using alignment to 1 proteins:

  • MEX3B_HUMAN
genes like me logo Genes that share paralogs with MEX3B: view

Variants for MEX3B Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for MEX3B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for MEX3B Gene

Variant ID Type Subtype PubMed ID
esv2422504 CNV duplication 17116639
nsv1070287 CNV deletion 25765185
nsv827415 CNV gain 20364138
nsv833067 CNV gain+loss 17160897

Variation tolerance for MEX3B Gene

Residual Variation Intolerance Score: 5.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEX3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEX3B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MEX3B Gene

Disorders for MEX3B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MEX3B Gene - From: GCD

- elite association - COSMIC cancer census association via MalaCards
Search MEX3B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MEX3B

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with MEX3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEX3B Gene

Publications for MEX3B Gene

  1. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PMID: 17267406) Buchet-Poyau K … Billaud M (Nucleic acids research 2007) 2 3 4
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4
  3. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. (PMID: 19079261) Willer CJ … Genetic Investigation of ANthropometric Traits Consortium (Nature genetics 2009) 3 41
  4. Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules. (PMID: 18779327) Courchet J … Billaud M (The Journal of biological chemistry 2008) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

ExternalLinks

View latest publications for MEX3B gene in Mastermind

Products for MEX3B Gene

  • Addgene plasmids for MEX3B

Sources for MEX3B Gene