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This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies. [provided by RefSeq, Oct 2012]
MEX3B (Mex-3 RNA Binding Family Member B) is a Protein Coding gene. Diseases associated with MEX3B include Autosomal Recessive Congenital Cerebellar Ataxia. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and calcium ion binding. An important paralog of this gene is MEX3C.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003723 | RNA binding | IDA | 23408853 |
GO:0005509 | calcium ion binding | ISS | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000932 | P-body | IEA,IDA | 23408853 |
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | IDA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006468 | protein phosphorylation | ISS | -- |
GO:0046777 | protein autophosphorylation | ISS | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | MEX3B 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | MEX3B 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | MEX3B 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Mex3b 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Mex3b 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | MEX3B 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | MEX3B 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | mex3b 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | mex3b 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG11360 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | mex-3 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2422504 | CNV | duplication | 17116639 |
nsv1070287 | CNV | deletion | 25765185 |
nsv827415 | CNV | gain | 20364138 |
nsv833067 | CNV | gain+loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
autosomal recessive congenital cerebellar ataxia |
|
|