Aliases for MEX3B Gene
Aliases for MEX3B Gene
External Ids for MEX3B Gene
- HGNC: 25297
- Entrez Gene: 84206
- Ensembl: ENSG00000183496
- OMIM: 611008
- UniProtKB: Q6ZN04
Previous HGNC Symbols for MEX3B Gene
- RKHD3
Previous GeneCards Identifiers for MEX3B Gene
- GC15M080122
- GC15M082334
- GC15M059092
Summaries for MEX3B Gene
-
This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies. [provided by RefSeq, Oct 2012]
GeneCards Summary for MEX3B Gene
MEX3B (Mex-3 RNA Binding Family Member B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and calcium ion binding. An important paralog of this gene is MEX3D.
UniProtKB/Swiss-Prot for MEX3B Gene
-
RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEX3B Gene
Genomics for MEX3B Gene
GeneHancer (GH) Regulatory Elements for MEX3B Gene
Promoters and enhancers for MEX3B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around MEX3B on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the MEX3B gene promoter:
-
- Arnt
- AhR
- Pax-5
- p300
- Pax-2
- Pax-2a
- c-Myc
- Max1
- HOXA9
- HOXA9B
Regulatory Element Products
Genomic Locations for MEX3B Gene
Genomic Locations for MEX3B Gene
- chr15:82,041,778-82,046,143
- (GRCh38/hg38)
- Size:
- 4,366 bases
- Orientation:
- Minus strand
- chr15:82,334,119-82,338,482
- (GRCh37/hg19)
- Size:
- 4,364 bases
- Orientation:
- Minus strand
Genomic View for MEX3B Gene
Genes around MEX3B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q25.2 by Entrez Gene
- 15q25.2 by HGNC
- 15q25.2 by Ensembl
MEX3B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MEX3B Gene
Proteins for MEX3B Gene
-
Protein details for MEX3B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6ZN04-MEX3B_HUMAN
- Recommended name:
- RNA-binding protein MEX3B
- Protein Accession:
- Q6ZN04
- Q4G0W1
- Q8IVG2
- Q9H0J0
Protein attributes for MEX3B Gene
- Size:
- 569 amino acids
- Molecular mass:
- 58832 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAC23105.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
Protein Expression for MEX3B Gene
Post-translational modifications for MEX3B Gene
- Phosphorylation at Ser-462 creates a docking site for 14-3-3, which stabilizes the protein and modulates its ability to bind RNA.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for MEX3B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MEX3B
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-
Abcam antibodies for MEX3B
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-
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-
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Protein Products
-
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- antibodies-online: Search results for 4 available MEX3B Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for MEX3B
Assay Products
No data available for DME Specific Peptides for MEX3B Gene
Domains & Families for MEX3B Gene
Gene Families for MEX3B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for MEX3B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MEX3B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6ZN04- Domain:
-
- Binds RNA through its KH domains.
Function for MEX3B Gene
Molecular function for MEX3B Gene
- UniProtKB/Swiss-Prot Function:
- RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms.
Phenotypes From GWAS Catalog for MEX3B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003723 | RNA binding | HDA | 22681889 |
| GO:0003727 | single-stranded RNA binding | IBA | -- |
| GO:0005509 | calcium ion binding | ISS | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for MEX3B Gene
- MGI mutant phenotypes for MEX3B:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for MEX3B:
-
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Upregulation of RLR pathway after Sendai virus (SeV) infection
- shRNA abundance <= 50%
- Increased viability
Animal Models for MEX3B Gene
- MGI Knock Outs for MEX3B:
-
- Mex3b Mex3b<tm1.2Mbld>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MEX3B
-
CRISPR Products
-
OriGene CRISPR knockouts for MEX3B
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- Overview of 67 available MEX3B gene related products
- Applied Biological Materials CRISPR for MEX3B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MEX3B
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miRNA for MEX3B Gene
- miRTarBase miRNAs that target MEX3B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MEX3B
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- genomics-online: shRNA clones - Search results for 67 available MEX3B gene related products
- Overview of 67 available MEX3B gene related products
Clone Products
- Sino Biological Human cDNA Clone for MEX3B
- VectorBuilder custom plasmid, inducible vectors for MEX3B
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MEX3B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MEX3B
- Applied Biological Materials Clones for MEX3B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for MEX3B
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEX3B Gene
Localization for MEX3B Gene
Subcellular locations from UniProtKB/Swiss-Prot for MEX3B Gene
- Nucleus. Cytoplasm. Cytoplasm, P-body. Cytoplasmic granule. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. Localization to P-bodies is dependent on 14-3-3.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| endosome | 1 |
- Cytosol (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000932 | P-body | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for MEX3B Gene
No Data Available
Interacting Proteins for MEX3B Gene
Selected Interacting proteins:
Q6ZN04-MEX3B_HUMAN
ENSP00000329918
for MEX3B Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for MEX3B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006468 | protein phosphorylation | ISS | -- |
| GO:0017148 | negative regulation of translation | IBA | -- |
| GO:0046777 | protein autophosphorylation | ISS | -- |
No data available for Pathways by source and SIGNOR curated interactions for MEX3B Gene
Transcripts for MEX3B Gene
mRNA/cDNA for MEX3B Gene
- (1) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (50) Selected AceView cDNA sequences:
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000329713 3528 bps (uc002bgq.3)
- ENST00000558133 4333 bps (uc059mml.1)
Unigene Clusters for MEX3B Gene
- Mex-3 homolog B (C. elegans):
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for MEX3B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for MEX3B
- genomics-online: gRNA clones - Search results for 67 available MEX3B gene related products
- Overview of 67 available MEX3B gene related products
- Applied Biological Materials CRISPR for MEX3B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MEX3B
- GenScript: Design CRISPR guide RNA sequences for MEX3B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MEX3B
- Browse OriGene Inhibitory RNA Products For MEX3B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for MEX3B
- genomics-online: shRNA clones - Search results for 67 available MEX3B gene related products
- Overview of 67 available MEX3B gene related products
Clone Products
- Sino Biological Human cDNA Clone for MEX3B
- VectorBuilder custom plasmid, inducible vectors for MEX3B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MEX3B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MEX3B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for MEX3B
- Applied Biological Materials Clones for MEX3B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MEX3B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Limb (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Bone (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Cartilage (Muscoskeletal System)
- Mesenchymal Condensate Cells Zeugopod
-
Testis (Reproductive System)
mRNA differential expression in normal tissues according to GTEx for MEX3B Gene
This gene is overexpressed in Testis (x17.0).
This gene is overexpressed in Platelet (44.1) and Saliva (24.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MEX3B Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of MEX3B Gene:
MEX3BSOURCE GeneReport for Unigene cluster for MEX3B Gene:
Hs.104744mRNA Expression by UniProt/SwissProt for MEX3B Gene:
Q6ZN04-MEX3B_HUMAN
Tissue specificity:
Highest levels found in fetal brain and testis. Detected in the adult intestinal epithelium, specifically in goblet cell at protein level.
Evidence on tissue expression from TISSUES for MEX3B Gene
- Nervous system(4.1)
Primer Products
-
OriGene qPCR primer pairs for MEX3B
- genomics-online: primer clones - Search results for 67 available MEX3B gene related products
- Overview of 67 available MEX3B gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for MEX3B Gene
Orthologs for MEX3B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | MEX3B 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | MEX3B 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | MEX3B 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Mex3b 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Mex3b 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | MEX3B 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | MEX3B 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | mex3b 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | mex3b 34 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | CG11360 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | mex-3 34 |
|
OneToMany |
- Species where no ortholog for MEX3B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for MEX3B Gene
- ENSEMBL:
- Gene Tree for MEX3B (if available)
- TreeFam:
- Gene Tree for MEX3B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for MEX3B: view image
Paralogs for MEX3B Gene
Variants for MEX3B Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000524415 | -- | 82,041,723(-) | T/G | downstream_transcript_variant | |
| rs1000819819 | -- | 82,046,298(-) | GAGAGAGAG/GAGAGAG | upstream_transcript_variant | |
| rs1001077648 | -- | 82,044,880(-) | G/A | intron_variant | |
| rs1001238891 | -- | 82,045,121(-) | C/G | intron_variant | |
| rs1002087386 | -- | 82,047,021(-) | G/T | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2422504 | CNV | duplication | 17116639 |
| nsv1070287 | CNV | deletion | 25765185 |
| nsv827415 | CNV | gain | 20364138 |
| nsv833067 | CNV | gain+loss | 17160897 |
Residual Variation Intolerance Score:
5.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.20;
24.21% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for MEX3B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MEX3B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEX3B Gene
Disorders for MEX3B Gene
Additional Disease Information for MEX3B
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for MEX3B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MEX3B Gene
Publications for MEX3B Gene
- Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PMID: 17267406) Buchet-Poyau K … Billaud M (Nucleic acids research 2007) 2 3 4 58
- Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
- Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. (PMID: 19079261) Willer CJ … Genetic Investigation of ANthropometric Traits Consortium (Nature genetics 2009) 3 44 58
- Interaction with 14-3-3 adaptors regulates the sorting of hMex-3B RNA-binding protein to distinct classes of RNA granules. (PMID: 18779327) Courchet J … Billaud M (The Journal of biological chemistry 2008) 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
Products for MEX3B Gene
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- VectorBuilder custom plasmid, inducible vectors for MEX3B
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for MEX3B
- antibodies-online: Search results for 28 available MEX3B Antibodies ranked by validation data
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- antibodies-online: Search results for available MEX3B related products ranked by validation data
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- Quality Products:
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Sources for MEX3B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
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