Aliases for MEX3A Gene

Aliases for MEX3A Gene

  • Mex-3 RNA Binding Family Member A 2 3 5
  • RING Finger And KH Domain-Containing Protein 4 3 4
  • Ring Finger And KH Domain Containing 4 2 3
  • RNA-Binding Protein MEX3A 3 4
  • RKHD4 3 4
  • Ring Finger And KH Domain Containing Protein 3
  • Mex-3 Homolog A (C. Elegans) 2
  • MEX-3A 3
  • RNF162 3

External Ids for MEX3A Gene

Previous HGNC Symbols for MEX3A Gene

  • RKHD4

Previous GeneCards Identifiers for MEX3A Gene

  • GC01M154310
  • GC01M156041
  • GC01M127404

Summaries for MEX3A Gene

GeneCards Summary for MEX3A Gene

MEX3A (Mex-3 RNA Binding Family Member A) is a Protein Coding gene. Diseases associated with MEX3A include Koolen-De Vries Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MEX3B.

UniProtKB/Swiss-Prot Summary for MEX3A Gene

  • RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.

Additional gene information for MEX3A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for MEX3A Gene

Genomics for MEX3A Gene

GeneHancer (GH) Regulatory Elements for MEX3A Gene

Promoters and enhancers for MEX3A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around MEX3A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for MEX3A

Top Transcription factor binding sites by QIAGEN in the MEX3A gene promoter:
  • CREB
  • E4BP4
  • MRF-2
  • Nkx2-5
  • p53
  • Pax-3
  • Pax-4a
  • SEF-1 (1)
  • Sox9
  • SRY

Genomic Locations for MEX3A Gene

Genomic Locations for MEX3A Gene
chr1:156,072,013-156,082,465
(GRCh38/hg38)
Size:
10,453 bases
Orientation:
Minus strand
chr1:156,041,804-156,051,789
(GRCh37/hg19)
Size:
9,986 bases
Orientation:
Minus strand

Genomic View for MEX3A Gene

Genes around MEX3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEX3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEX3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEX3A Gene

Proteins for MEX3A Gene

  • Protein details for MEX3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A1L020-MEX3A_HUMAN
    Recommended name:
    RNA-binding protein MEX3A
    Protein Accession:
    A1L020

    Protein attributes for MEX3A Gene

    Size:
    520 amino acids
    Molecular mass:
    54173 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MEX3A Gene

Post-translational modifications for MEX3A Gene

Other Protein References for MEX3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEX3A Gene

Domains & Families for MEX3A Gene

Gene Families for MEX3A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MEX3A Gene

Suggested Antigen Peptide Sequences for MEX3A Gene

GenScript: Design optimal peptide antigens:
  • RING finger and KH domain-containing protein 4 (MEX3A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A1L020

UniProtKB/Swiss-Prot:

MEX3A_HUMAN :
  • Binds RNA through its KH domains.
Domain:
  • Binds RNA through its KH domains.
genes like me logo Genes that share domains with MEX3A: view

Function for MEX3A Gene

Molecular function for MEX3A Gene

UniProtKB/Swiss-Prot Function:
RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.

Phenotypes From GWAS Catalog for MEX3A Gene

Gene Ontology (GO) - Molecular Function for MEX3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA 22681889
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MEX3A: view
genes like me logo Genes that share phenotypes with MEX3A: view

miRNA for MEX3A Gene

miRTarBase miRNAs that target MEX3A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MEX3A Gene

Localization for MEX3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEX3A Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEX3A gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MEX3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MEX3A: view

Pathways & Interactions for MEX3A Gene

PathCards logo

SuperPathways for MEX3A Gene

No Data Available

Interacting Proteins for MEX3A Gene

;

Gene Ontology (GO) - Biological Process for MEX3A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MEX3A Gene

Drugs & Compounds for MEX3A Gene

No Compound Related Data Available

Transcripts for MEX3A Gene

mRNA/cDNA for MEX3A Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEX3A Gene

No ASD Table

Relevant External Links for MEX3A Gene

GeneLoc Exon Structure for
MEX3A

Expression for MEX3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MEX3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEX3A Gene

This gene is overexpressed in Ovary (x5.8).

Protein differential expression in normal tissues from HIPED for MEX3A Gene

This gene is overexpressed in Colon (18.0), Testis (14.3), and Gallbladder (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MEX3A Gene



Protein tissue co-expression partners for MEX3A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for MEX3A

SOURCE GeneReport for Unigene cluster for MEX3A Gene:

Hs.591496

mRNA Expression by UniProt/SwissProt for MEX3A Gene:

A1L020-MEX3A_HUMAN
Tissue specificity: Highest levels found in fetal brain and testis. Detected also in thymus, salivary gland and uterus.
genes like me logo Genes that share expression patterns with MEX3A: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEX3A Gene

Orthologs for MEX3A Gene

This gene was present in the common ancestor of animals.

Orthologs for MEX3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEX3A 31 30
  • 99.87 (n)
OneToOne
cow
(Bos Taurus)
Mammalia MEX3A 31 30
  • 94.29 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MEX3A 31
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mex3a 17 31 30
  • 90.56 (n)
oppossum
(Monodelphis domestica)
Mammalia MEX3A 31
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mex3a 30
  • 88.35 (n)
chicken
(Gallus gallus)
Aves MEX3A 31 30
  • 74.64 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEX3A 31
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mex3a 30
  • 70.66 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100332760 30
  • 60.16 (n)
CABZ01027547.1 31
  • 46 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11360 31
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea mex-3 31
  • 34 (a)
OneToMany
Species where no ortholog for MEX3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEX3A Gene

ENSEMBL:
Gene Tree for MEX3A (if available)
TreeFam:
Gene Tree for MEX3A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for MEX3A: view image

Paralogs for MEX3A Gene

Paralogs for MEX3A Gene

(3) SIMAP similar genes for MEX3A Gene using alignment to 1 proteins:

  • MEX3A_HUMAN
genes like me logo Genes that share paralogs with MEX3A: view

Variants for MEX3A Gene

Additional dbSNP identifiers (rs#s) for MEX3A Gene

Structural Variations from Database of Genomic Variants (DGV) for MEX3A Gene

Variant ID Type Subtype PubMed ID
dgv79n67 CNV gain 20364138
nsv1078975 CNV deletion 25765185
nsv1130977 CNV deletion 24896259
nsv509513 CNV insertion 20534489
nsv824831 CNV gain 20364138

Variation tolerance for MEX3A Gene

Residual Variation Intolerance Score: 17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEX3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MEX3A

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for MEX3A Gene

Disorders for MEX3A Gene

MalaCards: The human disease database

(1) MalaCards diseases for MEX3A Gene - From: DISEASES

Disorder Aliases PubMed IDs
koolen-de vries syndrome
  • kdvs
- elite association - COSMIC cancer census association via MalaCards
Search MEX3A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MEX3A

genes like me logo Genes that share disorders with MEX3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEX3A Gene

Publications for MEX3A Gene

  1. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PMID: 17267406) Buchet-Poyau K … Billaud M (Nucleic acids research 2007) 2 3 4 54
  2. Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity. (PMID: 29643511) Pao KC … Virdee S (Nature 2018) 3 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways. (PMID: 26972000) Rodriguez J … von Kriegsheim A (Cell reports 2016) 3 54
  5. ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. (PMID: 26777405) Jain S … Parker R (Cell 2016) 3 54

Products for MEX3A Gene

Sources for MEX3A Gene