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Aliases for MEX3A Gene

Aliases for MEX3A Gene

  • Mex-3 RNA Binding Family Member A 2 3 5
  • RING Finger And KH Domain-Containing Protein 4 3 4
  • Ring Finger And KH Domain Containing 4 2 3
  • RKHD4 3 4
  • Ring Finger And KH Domain Containing Protein 3
  • Mex-3 Homolog A (C. Elegans) 2
  • RNA-Binding Protein MEX3A 3
  • MEX-3A 3
  • RNF162 3

External Ids for MEX3A Gene

Previous HGNC Symbols for MEX3A Gene

  • RKHD4

Previous GeneCards Identifiers for MEX3A Gene

  • GC01M154310
  • GC01M127404

Summaries for MEX3A Gene

GeneCards Summary for MEX3A Gene

MEX3A (Mex-3 RNA Binding Family Member A) is a Protein Coding gene. Diseases associated with MEX3A include Wilson-Turner X-Linked Mental Retardation Syndrome. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is MEX3B.

UniProtKB/Swiss-Prot for MEX3A Gene

  • RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.

Additional gene information for MEX3A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEX3A Gene

Genomics for MEX3A Gene

GeneHancer (GH) Regulatory Elements for MEX3A Gene

Promoters and enhancers for MEX3A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I156079 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 550.8 -1.8 -1775 7.9 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 MEX3A LMNA CLK2 KHDC4 SYT11 RIT1 GC01M156123
GH01I156099 Promoter/Enhancer 2.7 VISTA FANTOM5 Ensembl ENCODE dbSUPER 22.9 -22.2 -22168 8.4 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF213 ZNF207 LMNA KHDC4 MEX3A ENSG00000271267 LAMTOR2 UBQLN4 BGLAP RXFP4 MSTO1 MSTO2P
GH01I156111 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.1 -39.4 -39391 19.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 LMNA GON4L CLK2 RRNAD1 KHDC4 LOC246784 MSTO1 MSTO2P PRCC ISG20L2
GH01I156052 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.1 +27.6 27622 3.7 CLOCK FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC UBQLN4 LAMTOR2 KHDC4 CLK2 GON4L RRNAD1 ENSG00000271267 RUSC1-AS1 THBS3 LMNA
GH01I156145 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.8 -67.4 -67355 7.7 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 SEMA4A SLC25A44 ENSG00000252236 LMNA MEX3A BGLAP PAQR6 TSACC CCT3 SMG5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MEX3A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MEX3A gene promoter:

Genomic Locations for MEX3A Gene

Genomic Locations for MEX3A Gene
9,986 bases
Minus strand

Genomic View for MEX3A Gene

Genes around MEX3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEX3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEX3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEX3A Gene

Proteins for MEX3A Gene

  • Protein details for MEX3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein MEX3A
    Protein Accession:

    Protein attributes for MEX3A Gene

    520 amino acids
    Molecular mass:
    54173 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MEX3A Gene

Post-translational modifications for MEX3A Gene

Other Protein References for MEX3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEX3A Gene

Domains & Families for MEX3A Gene

Gene Families for MEX3A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MEX3A Gene

Suggested Antigen Peptide Sequences for MEX3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Binds RNA through its KH domains.
  • Binds RNA through its KH domains.
genes like me logo Genes that share domains with MEX3A: view

Function for MEX3A Gene

Molecular function for MEX3A Gene

UniProtKB/Swiss-Prot Function:
RNA binding protein, may be involved in post-transcriptional regulatory mechanisms.

Phenotypes From GWAS Catalog for MEX3A Gene

Gene Ontology (GO) - Molecular Function for MEX3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA,IDA 22681889
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MEX3A: view

Phenotypes for MEX3A Gene

genes like me logo Genes that share phenotypes with MEX3A: view

miRNA for MEX3A Gene

miRTarBase miRNAs that target MEX3A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MEX3A Gene

Localization for MEX3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEX3A Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MEX3A gene
Compartment Confidence
cytosol 4
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MEX3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with MEX3A: view

Pathways & Interactions for MEX3A Gene

SuperPathways for MEX3A Gene

No Data Available

Interacting Proteins for MEX3A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: A1L020-MEX3A_HUMAN ENSP00000432845 for MEX3A Gene via IID STRING

Gene Ontology (GO) - Biological Process for MEX3A Gene


No data available for Pathways by source and SIGNOR curated interactions for MEX3A Gene

Drugs & Compounds for MEX3A Gene

No Compound Related Data Available

Transcripts for MEX3A Gene

mRNA/cDNA for MEX3A Gene

Unigene Clusters for MEX3A Gene

Mex-3 homolog A (C. elegans):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MEX3A Gene

No ASD Table

Relevant External Links for MEX3A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MEX3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MEX3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEX3A Gene

This gene is overexpressed in Ovary (x5.8).

Protein differential expression in normal tissues from HIPED for MEX3A Gene

This gene is overexpressed in Colon (18.0), Testis (14.3), and Gallbladder (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for MEX3A Gene

Protein tissue co-expression partners for MEX3A Gene

NURSA nuclear receptor signaling pathways regulating expression of MEX3A Gene:


SOURCE GeneReport for Unigene cluster for MEX3A Gene:


mRNA Expression by UniProt/SwissProt for MEX3A Gene:

Tissue specificity: Highest levels found in fetal brain and testis. Detected also in thymus, salivary gland and uterus.
genes like me logo Genes that share expression patterns with MEX3A: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MEX3A Gene

Orthologs for MEX3A Gene

This gene was present in the common ancestor of animals.

Orthologs for MEX3A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MEX3A 33 34
  • 99.87 (n)
(Bos Taurus)
Mammalia MEX3A 33 34
  • 94.29 (n)
(Canis familiaris)
Mammalia MEX3A 34
  • 93 (a)
(Mus musculus)
Mammalia Mex3a 33 16 34
  • 90.56 (n)
(Monodelphis domestica)
Mammalia MEX3A 34
  • 89 (a)
(Rattus norvegicus)
Mammalia Mex3a 33
  • 88.35 (n)
(Gallus gallus)
Aves MEX3A 33 34
  • 74.64 (n)
(Anolis carolinensis)
Reptilia MEX3A 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mex3a 33
  • 70.66 (n)
(Danio rerio)
Actinopterygii LOC100332760 33
  • 60.16 (n)
CABZ01027547.1 34
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11360 34
  • 29 (a)
(Caenorhabditis elegans)
Secernentea mex-3 34
  • 34 (a)
Species where no ortholog for MEX3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MEX3A Gene

Gene Tree for MEX3A (if available)
Gene Tree for MEX3A (if available)

Paralogs for MEX3A Gene

Paralogs for MEX3A Gene

(3) SIMAP similar genes for MEX3A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MEX3A: view

Variants for MEX3A Gene

Sequence variations from dbSNP and Humsavar for MEX3A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000052361 -- 156,073,741(-) AAAAAAAAA/AAAAAAAA 3_prime_UTR_variant
rs1000109884 -- 156,081,652(-) C/T coding_sequence_variant, missense_variant
rs1000134001 -- 156,078,422(-) C/G intron_variant
rs1000222586 -- 156,074,026(-) G/A 3_prime_UTR_variant
rs1000296361 -- 156,073,772(-) C/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for MEX3A Gene

Variant ID Type Subtype PubMed ID
nsv824831 CNV gain 20364138
nsv509513 CNV insertion 20534489
nsv1130977 CNV deletion 24896259
nsv1078975 CNV deletion 25765185
dgv79n67 CNV gain 20364138

Variation tolerance for MEX3A Gene

Residual Variation Intolerance Score: 17.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MEX3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEX3A Gene

Disorders for MEX3A Gene

MalaCards: The human disease database

(1) MalaCards diseases for MEX3A Gene - From: DISEASES

Disorder Aliases PubMed IDs
wilson-turner x-linked mental retardation syndrome
  • wts
- elite association - COSMIC cancer census association via MalaCards
Search MEX3A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MEX3A

genes like me logo Genes that share disorders with MEX3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEX3A Gene

Publications for MEX3A Gene

  1. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. (PMID: 17267406) Buchet-Poyau K … Billaud M (Nucleic acids research 2007) 2 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 58
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. (PMID: 22681889) Baltz AG … Landthaler M (Molecular cell 2012) 3 58

Products for MEX3A Gene

Sources for MEX3A Gene

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