Aliases for METTL9 Gene

Aliases for METTL9 Gene

  • Methyltransferase Like 9 2 3 5
  • DREV1 2 3 4
  • Methyltransferase-Like Protein 9 3 4
  • DORA Reverse Strand Protein 1 2 3
  • DREV 3 4
  • DORA Reverse Strand Protein 4
  • P53 Activated Protein 1 3
  • CTB-31N19.3 3
  • CGI-81 3
  • METTL9 5
  • PAP1 3

External Ids for METTL9 Gene

Previous GeneCards Identifiers for METTL9 Gene

  • GC16P021519
  • GC16P021610
  • GC16P019992

Summaries for METTL9 Gene

GeneCards Summary for METTL9 Gene

METTL9 (Methyltransferase Like 9) is a Protein Coding gene. Diseases associated with METTL9 include Deafness, Autosomal Recessive 22 and Inflammatory Bowel Disease 1. Gene Ontology (GO) annotations related to this gene include methyltransferase activity.

Additional gene information for METTL9 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for METTL9 Gene

Genomics for METTL9 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for METTL9 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around METTL9 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for METTL9

Top Transcription factor binding sites by QIAGEN in the METTL9 gene promoter:
  • AML1a
  • Egr-2
  • HEN1
  • Hlf
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • RP58
  • SRY

Genomic Locations for METTL9 Gene

Genomic Locations for METTL9 Gene
60,256 bases
Plus strand
60,256 bases
Plus strand

Genomic View for METTL9 Gene

Genes around METTL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
METTL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for METTL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for METTL9 Gene

Proteins for METTL9 Gene

  • Protein details for METTL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Methyltransferase-like protein 9
    Protein Accession:
    Secondary Accessions:
    • Q8NBT8
    • Q9BWJ7
    • Q9H1A2
    • Q9Y390

    Protein attributes for METTL9 Gene

    318 amino acids
    Molecular mass:
    36536 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD34076.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for METTL9 Gene


neXtProt entry for METTL9 Gene

Post-translational modifications for METTL9 Gene

  • Glycosylation at Asn35
  • Ubiquitination at Lys51
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for METTL9 Gene

Domains & Families for METTL9 Gene

Gene Families for METTL9 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for METTL9 Gene

Suggested Antigen Peptide Sequences for METTL9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the DREV family.
  • Belongs to the DREV family.
genes like me logo Genes that share domains with METTL9: view

Function for METTL9 Gene

Phenotypes From GWAS Catalog for METTL9 Gene

Gene Ontology (GO) - Molecular Function for METTL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21784977
genes like me logo Genes that share ontologies with METTL9: view
genes like me logo Genes that share phenotypes with METTL9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL9

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for METTL9 Gene

Localization for METTL9 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for METTL9 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for METTL9 Gene

Pathways & Interactions for METTL9 Gene

PathCards logo

SuperPathways for METTL9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for METTL9 Gene


No data available for Pathways by source and SIGNOR curated interactions for METTL9 Gene

Drugs & Compounds for METTL9 Gene

No Compound Related Data Available

Transcripts for METTL9 Gene

mRNA/cDNA for METTL9 Gene

16 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for METTL9

Alternative Splicing Database (ASD) splice patterns (SP) for METTL9 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - - - - -
SP4: -
SP5: - - -
SP6: -
SP7: - -

Relevant External Links for METTL9 Gene

GeneLoc Exon Structure for

Expression for METTL9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for METTL9 Gene

mRNA differential expression in normal tissues according to GTEx for METTL9 Gene

This gene is overexpressed in Whole Blood (x7.6).

Protein differential expression in normal tissues from HIPED for METTL9 Gene

This gene is overexpressed in Bone (33.0), Monocytes (17.5), and Platelet (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for METTL9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for METTL9

SOURCE GeneReport for Unigene cluster for METTL9 Gene:


Evidence on tissue expression from TISSUES for METTL9 Gene

  • Nervous system(3.9)
  • Skin(3.8)
  • Lung(2.4)
  • Blood(2.3)
genes like me logo Genes that share expression patterns with METTL9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for METTL9 Gene

Orthologs for METTL9 Gene

This gene was present in the common ancestor of animals.

Orthologs for METTL9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia METTL9 30 31
  • 99.68 (n)
(Bos Taurus)
Mammalia METTL9 30 31
  • 96.33 (n)
(Canis familiaris)
Mammalia METTL9 30 31
  • 96.23 (n)
(Mus musculus)
Mammalia Mettl9 30 17 31
  • 92.87 (n)
(Rattus norvegicus)
Mammalia Mettl9 30
  • 92.77 (n)
(Monodelphis domestica)
Mammalia METTL9 31
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia METTL9 31
  • 92 (a)
(Gallus gallus)
Aves METTL9 30 31
  • 83.07 (n)
(Anolis carolinensis)
Reptilia METTL9 31
  • 85 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia mettl9 30
  • 72.76 (n)
Str.3222 30
African clawed frog
(Xenopus laevis)
Amphibia MGC53836 30
(Danio rerio)
Actinopterygii mettl9 30 31
  • 58.2 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003602 30
  • 46.96 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG5339 30 31
  • 46.35 (n)
(Caenorhabditis elegans)
Secernentea T03G11.6 30 31
  • 49.43 (n)
Species where no ortholog for METTL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for METTL9 Gene

Gene Tree for METTL9 (if available)
Gene Tree for METTL9 (if available)
Evolutionary constrained regions (ECRs) for METTL9: view image

Paralogs for METTL9 Gene

(1) SIMAP similar genes for METTL9 Gene using alignment to 7 proteins:

  • H3BM54_HUMAN
  • H3BN86_HUMAN
genes like me logo Genes that share paralogs with METTL9: view

No data available for Paralogs for METTL9 Gene

Variants for METTL9 Gene

Additional dbSNP identifiers (rs#s) for METTL9 Gene

Structural Variations from Database of Genomic Variants (DGV) for METTL9 Gene

Variant ID Type Subtype PubMed ID
dgv116e55 CNV loss 17911159
dgv2800n100 CNV gain 25217958
dgv2803n100 CNV loss 25217958
dgv2804n100 CNV gain 25217958
dgv2805n100 CNV gain+loss 25217958
dgv2806n100 CNV gain 25217958
dgv2807n100 CNV loss 25217958
dgv2808n100 CNV gain+loss 25217958
dgv2809n100 CNV loss 25217958
dgv2810n100 CNV loss 25217958
dgv347n27 CNV gain 19166990
dgv348n27 CNV loss 19166990
dgv3n1 OTHER inversion 15895083
dgv3n29 CNV loss 16826518
dgv47n16 OTHER inversion 17901297
dgv4944n54 CNV loss 21841781
dgv4946n54 CNV gain+loss 21841781
dgv4947n54 CNV loss 21841781
dgv806e212 CNV loss 25503493
esv25717 CNV gain+loss 19812545
esv2751551 CNV gain 17911159
esv2751552 CNV loss 17911159
esv2758636 CNV gain+loss 17122850
esv2762010 CNV gain+loss 21179565
esv2763135 CNV gain 21179565
esv3368991 OTHER inversion 20981092
esv34235 CNV gain 17911159
esv3427100 CNV insertion 20981092
esv34544 CNV gain 17911159
esv3570431 CNV gain 25503493
esv3582094 CNV loss 25503493
esv3638186 CNV loss 21293372
esv3638187 CNV gain 21293372
esv3638188 CNV loss 21293372
esv3892812 CNV gain+loss 25118596
esv998989 OTHER inversion 20482838
nsv1077770 OTHER inversion 25765185
nsv1131233 CNV deletion 24896259
nsv1140248 OTHER inversion 24896259
nsv428322 CNV gain 18775914
nsv433438 CNV gain 18776910
nsv457460 CNV loss 19166990
nsv471086 CNV loss 18288195
nsv499139 OTHER inversion 21111241
nsv517713 CNV gain+loss 19592680
nsv571631 CNV loss 21841781
nsv571634 CNV gain 21841781
nsv571635 CNV gain 21841781
nsv571639 CNV loss 21841781
nsv571640 CNV loss 21841781
nsv7280 OTHER inversion 18451855
nsv817726 CNV gain 17921354
nsv9397 CNV gain+loss 18304495

Variation tolerance for METTL9 Gene

Residual Variation Intolerance Score: 35.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for METTL9 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for METTL9 Gene

Disorders for METTL9 Gene

MalaCards: The human disease database

(3) MalaCards diseases for METTL9 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for METTL9

genes like me logo Genes that share disorders with METTL9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for METTL9 Gene

Publications for METTL9 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai CH … Lin W (Genome research 2000) 2 3 4
  2. The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function. (PMID: 11132146) Bates EE … Lebecque S (Immunogenetics 2000) 2 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape. (PMID: 30833792) Hubel P … Pichlmair A (Nature immunology 2019) 3
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3

Products for METTL9 Gene

Sources for METTL9 Gene